Are angiotensin converting enzyme (ACE1/ ACE2) gene variants associated with the clinical severity of COVID-19 pneumonia? A singlecenter cohort study
Yıl: 2022 Cilt: 26 Sayı: 2 Sayfa Aralığı: 133 - 140 Metin Dili: İngilizce DOI: 10.5152/AnatolJCardiol.2021.502 İndeks Tarihi: 17-06-2022
Are angiotensin converting enzyme (ACE1/ ACE2) gene variants associated with the clinical severity of COVID-19 pneumonia? A singlecenter cohort study
Öz: Objective: The impact of the coronavirus disease 2019 (COVID-19) pandemic has been unceasingly ongoing worldwide. Recent bioinformatics analysis and epidemiologic studies
have highlighted that the functional polymorphisms on the angiotensin converting enzyme
(ACE) gene may have an impact on the clinical progress of COVID-19. In this study, we aimed
to determine the impact of the ACE1 gene I/D polymorphism and ACE2 peptidase-2 domain
variants on disease severity.
Methods: Hundred patients with confirmed COVID-19 related pneumonia [50 patients
with severe disease in intensive care unit (ICU) and 50 patients not in ICU] were compared
on the basis of genetic and clinical characteristics. Genomic DNA was purified from peripheral blood lymphocytes with an automated QIA symphony DSP DNA Mini-Kit. The Sanger
sequencing analysis was performed. The frequencies of ACE1 gene polymorphism and
ACE2 PD variants were compared in patients hospitalized in ICU and those not in ICU. The
Statistical Package for Social Sciences version 22.0 was used for statistical analysis.
Results: The sequencing analysis of the ACE2 gene exon 1 and 2 revealed none of the polymorphisms investigated or any other variants in the present cohort. The frequencies of the
ACE1 ID, DD, and II genotypes were 51%, 31%, and 18%, respectively. The frequency of the D
allele was similar between the ICU and non-ICU groups (50.4% versus 49.6%). Older age and
the presence of advanced stage radiologic abnormalities on admission were detected as
independent predictors of ICU requirement.
Conclusion: No effect of any ACE1 gene polymorphism on predicting ICU requirement was
detected. To the best of our knowledge, this is the first study investigating the impact of
ACE gene polymorphisms on clinical severity of COVID-19 in a Turkish cohort.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA | baştuğ s, Çavdarlı B, Bastug A, Sencan İ, tuncez e, Cakir E, kemirtlek n, SAKAR C, Erdem D, Güleç Ceylan G, özkoçak turan ı, kazancıoğlu s, Bodur H (2022). Are angiotensin converting enzyme (ACE1/ ACE2) gene variants associated with the clinical severity of COVID-19 pneumonia? A singlecenter cohort study. , 133 - 140. 10.5152/AnatolJCardiol.2021.502 |
Chicago | baştuğ serdal,Çavdarlı Büşranur,Bastug Aliye,Sencan İrfan,tuncez ebru,Cakir Esra,kemirtlek nizamettin,SAKAR Cihad,Erdem Deniz,Güleç Ceylan Gülay,özkoçak turan ışıl,kazancıoğlu sümeyye,Bodur Hurrem Are angiotensin converting enzyme (ACE1/ ACE2) gene variants associated with the clinical severity of COVID-19 pneumonia? A singlecenter cohort study. (2022): 133 - 140. 10.5152/AnatolJCardiol.2021.502 |
MLA | baştuğ serdal,Çavdarlı Büşranur,Bastug Aliye,Sencan İrfan,tuncez ebru,Cakir Esra,kemirtlek nizamettin,SAKAR Cihad,Erdem Deniz,Güleç Ceylan Gülay,özkoçak turan ışıl,kazancıoğlu sümeyye,Bodur Hurrem Are angiotensin converting enzyme (ACE1/ ACE2) gene variants associated with the clinical severity of COVID-19 pneumonia? A singlecenter cohort study. , 2022, ss.133 - 140. 10.5152/AnatolJCardiol.2021.502 |
AMA | baştuğ s,Çavdarlı B,Bastug A,Sencan İ,tuncez e,Cakir E,kemirtlek n,SAKAR C,Erdem D,Güleç Ceylan G,özkoçak turan ı,kazancıoğlu s,Bodur H Are angiotensin converting enzyme (ACE1/ ACE2) gene variants associated with the clinical severity of COVID-19 pneumonia? A singlecenter cohort study. . 2022; 133 - 140. 10.5152/AnatolJCardiol.2021.502 |
Vancouver | baştuğ s,Çavdarlı B,Bastug A,Sencan İ,tuncez e,Cakir E,kemirtlek n,SAKAR C,Erdem D,Güleç Ceylan G,özkoçak turan ı,kazancıoğlu s,Bodur H Are angiotensin converting enzyme (ACE1/ ACE2) gene variants associated with the clinical severity of COVID-19 pneumonia? A singlecenter cohort study. . 2022; 133 - 140. 10.5152/AnatolJCardiol.2021.502 |
IEEE | baştuğ s,Çavdarlı B,Bastug A,Sencan İ,tuncez e,Cakir E,kemirtlek n,SAKAR C,Erdem D,Güleç Ceylan G,özkoçak turan ı,kazancıoğlu s,Bodur H "Are angiotensin converting enzyme (ACE1/ ACE2) gene variants associated with the clinical severity of COVID-19 pneumonia? A singlecenter cohort study." , ss.133 - 140, 2022. 10.5152/AnatolJCardiol.2021.502 |
ISNAD | baştuğ, serdal vd. "Are angiotensin converting enzyme (ACE1/ ACE2) gene variants associated with the clinical severity of COVID-19 pneumonia? A singlecenter cohort study". (2022), 133-140. https://doi.org/10.5152/AnatolJCardiol.2021.502 |
APA | baştuğ s, Çavdarlı B, Bastug A, Sencan İ, tuncez e, Cakir E, kemirtlek n, SAKAR C, Erdem D, Güleç Ceylan G, özkoçak turan ı, kazancıoğlu s, Bodur H (2022). Are angiotensin converting enzyme (ACE1/ ACE2) gene variants associated with the clinical severity of COVID-19 pneumonia? A singlecenter cohort study. The Anatolian Journal of Cardiology, 26(2), 133 - 140. 10.5152/AnatolJCardiol.2021.502 |
Chicago | baştuğ serdal,Çavdarlı Büşranur,Bastug Aliye,Sencan İrfan,tuncez ebru,Cakir Esra,kemirtlek nizamettin,SAKAR Cihad,Erdem Deniz,Güleç Ceylan Gülay,özkoçak turan ışıl,kazancıoğlu sümeyye,Bodur Hurrem Are angiotensin converting enzyme (ACE1/ ACE2) gene variants associated with the clinical severity of COVID-19 pneumonia? A singlecenter cohort study. The Anatolian Journal of Cardiology 26, no.2 (2022): 133 - 140. 10.5152/AnatolJCardiol.2021.502 |
MLA | baştuğ serdal,Çavdarlı Büşranur,Bastug Aliye,Sencan İrfan,tuncez ebru,Cakir Esra,kemirtlek nizamettin,SAKAR Cihad,Erdem Deniz,Güleç Ceylan Gülay,özkoçak turan ışıl,kazancıoğlu sümeyye,Bodur Hurrem Are angiotensin converting enzyme (ACE1/ ACE2) gene variants associated with the clinical severity of COVID-19 pneumonia? A singlecenter cohort study. The Anatolian Journal of Cardiology, vol.26, no.2, 2022, ss.133 - 140. 10.5152/AnatolJCardiol.2021.502 |
AMA | baştuğ s,Çavdarlı B,Bastug A,Sencan İ,tuncez e,Cakir E,kemirtlek n,SAKAR C,Erdem D,Güleç Ceylan G,özkoçak turan ı,kazancıoğlu s,Bodur H Are angiotensin converting enzyme (ACE1/ ACE2) gene variants associated with the clinical severity of COVID-19 pneumonia? A singlecenter cohort study. The Anatolian Journal of Cardiology. 2022; 26(2): 133 - 140. 10.5152/AnatolJCardiol.2021.502 |
Vancouver | baştuğ s,Çavdarlı B,Bastug A,Sencan İ,tuncez e,Cakir E,kemirtlek n,SAKAR C,Erdem D,Güleç Ceylan G,özkoçak turan ı,kazancıoğlu s,Bodur H Are angiotensin converting enzyme (ACE1/ ACE2) gene variants associated with the clinical severity of COVID-19 pneumonia? A singlecenter cohort study. The Anatolian Journal of Cardiology. 2022; 26(2): 133 - 140. 10.5152/AnatolJCardiol.2021.502 |
IEEE | baştuğ s,Çavdarlı B,Bastug A,Sencan İ,tuncez e,Cakir E,kemirtlek n,SAKAR C,Erdem D,Güleç Ceylan G,özkoçak turan ı,kazancıoğlu s,Bodur H "Are angiotensin converting enzyme (ACE1/ ACE2) gene variants associated with the clinical severity of COVID-19 pneumonia? A singlecenter cohort study." The Anatolian Journal of Cardiology, 26, ss.133 - 140, 2022. 10.5152/AnatolJCardiol.2021.502 |
ISNAD | baştuğ, serdal vd. "Are angiotensin converting enzyme (ACE1/ ACE2) gene variants associated with the clinical severity of COVID-19 pneumonia? A singlecenter cohort study". The Anatolian Journal of Cardiology 26/2 (2022), 133-140. https://doi.org/10.5152/AnatolJCardiol.2021.502 |