Yıl: 2022 Cilt: 5 Sayı: 2 Sayfa Aralığı: 96 - 100 Metin Dili: İngilizce DOI: 10.14744/ijmb.2022.40427 İndeks Tarihi: 18-06-2022

Effects of electronic cigarettes on oxidative stress markers in the rat kidney tissues

Öz:
Objectives: Electronic cigarettes (e-cigarettes) are an alternative to traditional cigarettes. Although numerous studies have been conducted regarding the effects of traditional cigarettes on oxidative stress biomarkers in the kidney, there are only a few studies on the effects of e-cigarettes. Methods: A total of 24 male Wistar albino rats were separated into three groups: Group 1 was treated with traditional cigarettes, Group 2 with e-cigarettes, and Group 3 formed the control group. Kidney homogenates and plasma samples were obtained, and the glutathione peroxidase, protein carbonyl, superoxide dismutase (SOD), catalase (CAT), lipid hydroperoxide (LPO), and symmetric dimethylarginine (SDMA) levels were examined. Results: Higher plasma SDMA levels were determined in Group 1 and Group 2 compared with Group 3 (<0.0001). Higher SOD activity was found in Group 1 compared with Group 2 (p=0.0094). Lower CAT activity was found in Group 1 compared with both Group 2 (p=0.0035) and Group 3 (p<0.0001). Higher LPO levels were determined in the traditional cigarette smoking group compared with the control group (p=0.028), and no statistically significant difference was found between the e-cigarette and the control groups. Conclusion: E-cigarettes and traditional cigarettes are associated with the dysregulation of particular oxidative stress markers in the kidney. However, e-cigarettes have less effect on some oxidative stress markers than traditional cigarettes. Long-term use of traditional cigarettes and e-cigarettes causes oxidative stress, which may lead to renal tissue damage and diminished kidney function.
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  • 1. Braun M, Koger F, Klingelhöfer D, Müller R, Groneberg DA. Particulate matter emissions of four different cigarette types of one popular brand: influence of tobacco strength and additives. Int J Environ Res Public Health 2019;16(2):263.
  • 2. Golli NE, Jrad-Lamine A, Neffati H, Dkhili H, Rahali D, Dallagi Y, et al. Impact of e-cigarette refill liquid exposure on rat kidney. Regul Toxicol Pharmacol 2016;77:109-16.
  • 3. Hagimoto A, Nakamura M, Morita T, Masui S, Oshima A. Smoking cessation patterns and predictors of quitting smoking among the Japanese general population: a 1-year follow-up study. Addiction 2010;105(1):164–73.
  • 4. Azzopardi D, Patel K, Jaunky T, Santopietro S, Camacho OM, McAughey J, et al. Electronic cigarette aerosol induces significantly less cytotoxicity than tobacco smoke. Toxicol Mech Methods 2016;26(6):477–91.
  • 5. Callison K, Kaestner R. Do higher tobacco taxes reduce adult smoking? New evidence of the effect of recent cigarette tax increases on adult smoking. Economic Inquiry 2014;52(1):155–72.
  • 6. Polosa R, Caponnetto P, Morjaria JB, Papale G, Campagna D, Russo C. Effect of an electronic nicotine delivery device (e-Cigarette) on smoking reduction and cessation: a prospective 6-month pilot study. BMC Public Health 2011;11:786.
  • 7. Kuntic M, Oelze M, Steven S, Kröller-Schön S, Stamm P, Kalinovic S, et al. Short-term e-cigarette vapour exposure causes vascular oxidative stress and dysfunction: evidence for a close connection to brain damage and a key role of the phagocytic NADPH oxidase (NOX-2). Eur Heart J 2020;41(26):2472–83.
  • 8. Manzoli L, La Vecchia C, Flacco ME, Capasso L, Simonetti V, Boccia S, et al. Multicentric cohort study on the long-term efficacy and safety of electronic cigarettes: study design and methodology. BMC Public Health 2013;13:883.
  • 9. Jankowski M, Brożek G, Lawson J, Skoczyński S, Zejda JE. Esmoking: Emerging public health problem? Int J Occup Med Environ Health 2017;30(3):329–44.
  • 10. Phaniendra A, Jestadi DB, Periyasamy L. Free radicals: properties, sources, targets, and their implication in various diseases. Indian J Clin Biochem 2015;30(1):11–26.
  • 11. Cipak Gasparovic A, Zarkovic N, Zarkovic K, Semen K, Kaminskyy D, Yelisyeyeva O, et al. Biomarkers of oxidative and nitro- oxidative stress: conventional and novel approaches. Br J Pharmacol 2017;174(12):1771–83.
  • 12. Ighodaro O, Akinloye O. First line defence antioxidants-superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX): Their fundamental role in the entire antioxidant defence grid. Alexandria J Med 2018;54(4):287–93.
  • 13. Sahoo DK. Protocols for evaluating antioxidant defence and oxidative stress parameters in rat testis. WebmedCentral BIOCHEMISTRY 2013;4(5):WMC004265.
  • 14. Oliva-Damaso E, Oliva-Damaso N, Rodriguez-Esparragon F, Payan J, Baamonde-Laborda E, Gonzalez-Cabrera F, et al. Asymmetric (ADMA) and symmetric (SDMA) Dimethylarginines in chronic kidney disease: a clinical approach. Int J Mol Sci 2019;20(15):3668.
  • 15. Zhang L, Zhang K, Dong W, Li R, Huang R, Zhang H, et al. Raised plasma levels of asymmetric dimethylarginine are associated with pathological type and predict the therapeutic effect in lupus nephritis patients treated with cyclophosphamide. Kidney Dis (Basel) 2020;6(5):355–63.
  • 16. Taylor M, Carr T, Oke O, Jaunky T, Breheny D, Lowe F, et al. E-cigarette aerosols induce lower oxidative stress in vitro when compared to tobacco smoke. Toxicol Mech Methods 2016;26(6):465–76.
  • 17. Foronjy R, D'Armiento J. The effect of cigarette smoke-derived oxidants on the inflammatory response of the lung. Clin Appl Immunol Rev 2006;6(1):53–72.
  • 18. Suryadinata RV, Wirjatmadi B, Adriani M, Sumarmi S. The effects of exposure duration to electronic cigarette smoke on differences in superoxide dismutase and malondialdehyde in blood of Wistar rats. Int J Curr Pharm Res 2019;11(3):13–6.
  • 19. Matthews JB, Chen FM, Milward MR, Ling MR, Chapple IL. Neutrophil superoxide production in the presence of cigarette smoke extract, nicotine and cotinine. J Clin Periodontol 2012;39(7):626–34.
  • 20. Agnihotri R, Pandurang P, Kamath SU, Goyal R, Ballal S, Shanbhogue AY, et al. Association of cigarette smoking with superoxide dismutase enzyme levels in subjects with chronic periodontitis. J Periodontol 2009;80(4):657–62.
  • 21. Padmavathi P, Raghu PS, Reddy VD, Bulle S, Marthadu SB, Maturu P, et al. Chronic cigarette smoking-induced oxidative/ nitrosative stress in human erythrocytes and platelets. Mol Cell Toxicol 2018;14(1):27–34.
  • 22. Manafa P, Okafor C, Okeke C, Chukwuma G, Ibeh N, Ogenyi S, et al. Assessment of superoxide dismutase activity and total antioxidant capacity in adult male cigarette smokers in Nnewi metropolis, Nigeria JMR 2017;3(1):23–6.
  • 23. Jenifer HD, Bhola S, Kalburgi V, Warad S, Kokatnur VM. The influence of cigarette smoking on blood and salivary super oxide dismutase enzyme levels among smokers and nonsmokers-A cross sectional study. J Tradit Complement Med 2015;5(2):100–5.
  • 24. Foronjy RF, Mirochnitchenko O, Propokenko O, Lemaitre V, Jia Y, Inouye M, et al. Superoxide dismutase expression attenuates cigarette smoke- or elastase-generated emphysema in mice. Am J Respir Crit Care Med 2006;173(6):623–31.
  • 25. Yildiz L, Kayaoğlu N, Aksoy H. The changes of superoxide dismutase, catalase and glutathione peroxidase activities in erythrocytes of active and passive smokers. Clin Chem Lab Med 2002;40(6):612–5.
  • 26. Aspera-Werz RH, Ehnert S, Heid D, Zhu S, Chen T, Braun B, et al. Nicotine and cotinine inhibit catalase and glutathione reductase activity contributing to the impaired osteogenesis of SCP-1 cells exposed to cigarette smoke. Oxid Med Cell Longev 2018;2018:3172480.
  • 27. Reiter RJ, Tan DX, Galano A. Melatonin reduces lipid peroxidation and membrane viscosity. Front Physiol 2014;5:377.
  • 28. Miller III ER, Appel LJ, Jiang L, Risby TH. Association between cigarette smoking and lipid peroxidation in a controlled feeding study. Circulation 1997;96(4):1097–101.
  • 29. Aslaner O. Comparison of oxidative effects of electronic cigarette and tobacco smoke exposure performed experimentally. Eur Addict Res 2022;28(1):41–7.
  • 30. Gyurászová M, Gurecká R, Bábíčková J, Tóthová Ľ. Oxidative stress in the pathophysiology of kidney disease: implications for noninvasive monitoring and identification of biomarkers. Oxid Med Cell Longev 2020;2020:5478708.
APA DOĞAN K, SAYGIN H, yalman y (2022). Effects of electronic cigarettes on oxidative stress markers in the rat kidney tissues. , 96 - 100. 10.14744/ijmb.2022.40427
Chicago DOĞAN Kübra,SAYGIN Hüseyin,yalman yücel Effects of electronic cigarettes on oxidative stress markers in the rat kidney tissues. (2022): 96 - 100. 10.14744/ijmb.2022.40427
MLA DOĞAN Kübra,SAYGIN Hüseyin,yalman yücel Effects of electronic cigarettes on oxidative stress markers in the rat kidney tissues. , 2022, ss.96 - 100. 10.14744/ijmb.2022.40427
AMA DOĞAN K,SAYGIN H,yalman y Effects of electronic cigarettes on oxidative stress markers in the rat kidney tissues. . 2022; 96 - 100. 10.14744/ijmb.2022.40427
Vancouver DOĞAN K,SAYGIN H,yalman y Effects of electronic cigarettes on oxidative stress markers in the rat kidney tissues. . 2022; 96 - 100. 10.14744/ijmb.2022.40427
IEEE DOĞAN K,SAYGIN H,yalman y "Effects of electronic cigarettes on oxidative stress markers in the rat kidney tissues." , ss.96 - 100, 2022. 10.14744/ijmb.2022.40427
ISNAD DOĞAN, Kübra vd. "Effects of electronic cigarettes on oxidative stress markers in the rat kidney tissues". (2022), 96-100. https://doi.org/10.14744/ijmb.2022.40427
APA DOĞAN K, SAYGIN H, yalman y (2022). Effects of electronic cigarettes on oxidative stress markers in the rat kidney tissues. International Journal of Medical Biochemistry, 5(2), 96 - 100. 10.14744/ijmb.2022.40427
Chicago DOĞAN Kübra,SAYGIN Hüseyin,yalman yücel Effects of electronic cigarettes on oxidative stress markers in the rat kidney tissues. International Journal of Medical Biochemistry 5, no.2 (2022): 96 - 100. 10.14744/ijmb.2022.40427
MLA DOĞAN Kübra,SAYGIN Hüseyin,yalman yücel Effects of electronic cigarettes on oxidative stress markers in the rat kidney tissues. International Journal of Medical Biochemistry, vol.5, no.2, 2022, ss.96 - 100. 10.14744/ijmb.2022.40427
AMA DOĞAN K,SAYGIN H,yalman y Effects of electronic cigarettes on oxidative stress markers in the rat kidney tissues. International Journal of Medical Biochemistry. 2022; 5(2): 96 - 100. 10.14744/ijmb.2022.40427
Vancouver DOĞAN K,SAYGIN H,yalman y Effects of electronic cigarettes on oxidative stress markers in the rat kidney tissues. International Journal of Medical Biochemistry. 2022; 5(2): 96 - 100. 10.14744/ijmb.2022.40427
IEEE DOĞAN K,SAYGIN H,yalman y "Effects of electronic cigarettes on oxidative stress markers in the rat kidney tissues." International Journal of Medical Biochemistry, 5, ss.96 - 100, 2022. 10.14744/ijmb.2022.40427
ISNAD DOĞAN, Kübra vd. "Effects of electronic cigarettes on oxidative stress markers in the rat kidney tissues". International Journal of Medical Biochemistry 5/2 (2022), 96-100. https://doi.org/10.14744/ijmb.2022.40427