Yıl: 2022 Cilt: 5 Sayı: 2 Sayfa Aralığı: 109 - 115 Metin Dili: İngilizce DOI: 10.14744/ijmb.2022.52714 İndeks Tarihi: 18-06-2022

Evaluation of oxidative stress in gout disease; thiol-disulfide homeostasis and ischemia-modified albumin levels

Öz:
Objectives: Gout is a common and easily treated disease characterized by the accumulation of monosodium urate crystals in both joints and other tissues. Monosodium urate crystals are the main stimulants for initiating and maintaining an inflammatory response. Oxidative stress is also an early change in gout pathogenesis together with inflammation. This study aimed to investigate the presence of oxidative stress in gout together with thiol–disulfide homeostasis and ischemia- modified albumin (IMA) levels. We aimed to compare these parameters with inflammation marker C-reactive protein (CRP) and high-sensitivity C-reactive protein (hsCRP). Methods: Levels of native thiol, total thiol, disulfide, IMA, CRP, and hsCRP were detected in patients with gout (n=50) and healthy subjects (n=50). Student’s t-test and the Mann-Whitney U test were used for istatistical analysis. Results: Native thiol, total thiol, and index 3 (native thiol/total thiol×100) were significantly lower in the patient group, while disulfide, index 1 (disulfide/native thiol×100), index 2 disulfide/total thiol×100), IMA, CRP, and hsCRP were significantly higher. In addition, elevation in native thiol, total thiol, and disulfide levels was detected as disease duration increased. Conclusion: The present study has shown the role of oxidant damage in gout disease. Additional studies are needed to identify sources of oxidative stress in gout.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA BALIK A, Omma A, CAN SANDIKCI S, yücel ç, Kizilgun M, Balık Z, Fırat Oğuz E, neselioglu s, EREL O (2022). Evaluation of oxidative stress in gout disease; thiol-disulfide homeostasis and ischemia-modified albumin levels. , 109 - 115. 10.14744/ijmb.2022.52714
Chicago BALIK Ahmet Rifat,Omma Ahmet,CAN SANDIKCI Sevinc,yücel çiğdem,Kizilgun Murat,Balık Zeynep Büşra,Fırat Oğuz Esra,neselioglu salim,EREL Ozcan Evaluation of oxidative stress in gout disease; thiol-disulfide homeostasis and ischemia-modified albumin levels. (2022): 109 - 115. 10.14744/ijmb.2022.52714
MLA BALIK Ahmet Rifat,Omma Ahmet,CAN SANDIKCI Sevinc,yücel çiğdem,Kizilgun Murat,Balık Zeynep Büşra,Fırat Oğuz Esra,neselioglu salim,EREL Ozcan Evaluation of oxidative stress in gout disease; thiol-disulfide homeostasis and ischemia-modified albumin levels. , 2022, ss.109 - 115. 10.14744/ijmb.2022.52714
AMA BALIK A,Omma A,CAN SANDIKCI S,yücel ç,Kizilgun M,Balık Z,Fırat Oğuz E,neselioglu s,EREL O Evaluation of oxidative stress in gout disease; thiol-disulfide homeostasis and ischemia-modified albumin levels. . 2022; 109 - 115. 10.14744/ijmb.2022.52714
Vancouver BALIK A,Omma A,CAN SANDIKCI S,yücel ç,Kizilgun M,Balık Z,Fırat Oğuz E,neselioglu s,EREL O Evaluation of oxidative stress in gout disease; thiol-disulfide homeostasis and ischemia-modified albumin levels. . 2022; 109 - 115. 10.14744/ijmb.2022.52714
IEEE BALIK A,Omma A,CAN SANDIKCI S,yücel ç,Kizilgun M,Balık Z,Fırat Oğuz E,neselioglu s,EREL O "Evaluation of oxidative stress in gout disease; thiol-disulfide homeostasis and ischemia-modified albumin levels." , ss.109 - 115, 2022. 10.14744/ijmb.2022.52714
ISNAD BALIK, Ahmet Rifat vd. "Evaluation of oxidative stress in gout disease; thiol-disulfide homeostasis and ischemia-modified albumin levels". (2022), 109-115. https://doi.org/10.14744/ijmb.2022.52714
APA BALIK A, Omma A, CAN SANDIKCI S, yücel ç, Kizilgun M, Balık Z, Fırat Oğuz E, neselioglu s, EREL O (2022). Evaluation of oxidative stress in gout disease; thiol-disulfide homeostasis and ischemia-modified albumin levels. International Journal of Medical Biochemistry, 5(2), 109 - 115. 10.14744/ijmb.2022.52714
Chicago BALIK Ahmet Rifat,Omma Ahmet,CAN SANDIKCI Sevinc,yücel çiğdem,Kizilgun Murat,Balık Zeynep Büşra,Fırat Oğuz Esra,neselioglu salim,EREL Ozcan Evaluation of oxidative stress in gout disease; thiol-disulfide homeostasis and ischemia-modified albumin levels. International Journal of Medical Biochemistry 5, no.2 (2022): 109 - 115. 10.14744/ijmb.2022.52714
MLA BALIK Ahmet Rifat,Omma Ahmet,CAN SANDIKCI Sevinc,yücel çiğdem,Kizilgun Murat,Balık Zeynep Büşra,Fırat Oğuz Esra,neselioglu salim,EREL Ozcan Evaluation of oxidative stress in gout disease; thiol-disulfide homeostasis and ischemia-modified albumin levels. International Journal of Medical Biochemistry, vol.5, no.2, 2022, ss.109 - 115. 10.14744/ijmb.2022.52714
AMA BALIK A,Omma A,CAN SANDIKCI S,yücel ç,Kizilgun M,Balık Z,Fırat Oğuz E,neselioglu s,EREL O Evaluation of oxidative stress in gout disease; thiol-disulfide homeostasis and ischemia-modified albumin levels. International Journal of Medical Biochemistry. 2022; 5(2): 109 - 115. 10.14744/ijmb.2022.52714
Vancouver BALIK A,Omma A,CAN SANDIKCI S,yücel ç,Kizilgun M,Balık Z,Fırat Oğuz E,neselioglu s,EREL O Evaluation of oxidative stress in gout disease; thiol-disulfide homeostasis and ischemia-modified albumin levels. International Journal of Medical Biochemistry. 2022; 5(2): 109 - 115. 10.14744/ijmb.2022.52714
IEEE BALIK A,Omma A,CAN SANDIKCI S,yücel ç,Kizilgun M,Balık Z,Fırat Oğuz E,neselioglu s,EREL O "Evaluation of oxidative stress in gout disease; thiol-disulfide homeostasis and ischemia-modified albumin levels." International Journal of Medical Biochemistry, 5, ss.109 - 115, 2022. 10.14744/ijmb.2022.52714
ISNAD BALIK, Ahmet Rifat vd. "Evaluation of oxidative stress in gout disease; thiol-disulfide homeostasis and ischemia-modified albumin levels". International Journal of Medical Biochemistry 5/2 (2022), 109-115. https://doi.org/10.14744/ijmb.2022.52714