Vitamin D Deficiency Prevalence in Late Neonatal Hypocalcemia: A Multicenter Study

Yıl: 2021 Cilt: 13 Sayı: 4 Sayfa Aralığı: 384 - 390 Metin Dili: İngilizce DOI: 10.4274/jcrpe.galenos.2020.2021.0169 İndeks Tarihi: 18-06-2022

Vitamin D Deficiency Prevalence in Late Neonatal Hypocalcemia: A Multicenter Study

Öz:
Objective: Late neonatal hypocalcemia (LNH) is a common metabolic problem associated with hypoparathyroidism, high phosphate intake and vitamin D deficiency, often presenting with seizures. In this cross-sectional study, we aimed to evaluate the role of vitamin D deficiency in LNH in Turkey and to describe the characteristics of affected newborns. Methods: Conducted with a cross-sectional design and with the participation of 61 neonatal centers from December 2015 to December 2016, the study included term neonates with LNH (n=96) and their mothers (n=93). Data were registered on the FAVOR Web Registry System. Serum samples of newborns and mothers were analyzed for calcium, phosphate, magnesium, albumin, alkaline phosphatase, intact parathyroid hormone (iPTH) and 25 hydroxyvitamin D [25(OH)D] levels. Results: The median (range) onset time of hypocalcemia was 5.0 (4.0-8.0) days of age, with a male preponderance (60.4%). The median (range) serum 25(OH)D levels of the neonates and their mothers were 6.3 (4.1-9.05) and 5.2 (4.7-8.8) ng/mL, respectively. The prevalence of vitamin D deficiency (<12 ng/mL) was high in both the neonates (86.5%) and mothers (93%). Serum 25(OH)D levels of the infants and mothers showed a strong correlation (p<0.001). While the majority (93.7%) of the neonates had normal/high phosphorus levels, iPTH levels were low or inappropriately normal in 54.2% of the patients. Conclusion: Vitamin D deficiency prevalence was found to be high in LNH. Efforts to provide vitamin D supplementation during pregnancy should be encouraged. Evaluation of vitamin D status should be included in the workup of LNH.
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APA Seymen G, GÜNLEMEZ A, Gökalp A, Hatun S, Narter F, Mutlu M, aslan y, kılıçbay f, KADER S, Terek D, Hanta D, Okulu E, KARADENİZ L, Kanmaz Kutman H, ZENCIROGLU A, Özdemir Ö, Sarici D, Celik m, demir n, TURAN O, çelik k, Uslu S, erol s, Ertuğrul S, ER İ, CELIK H, AKTÜRK ACAR F, Tunç G, Guran O, Arısoy A (2021). Vitamin D Deficiency Prevalence in Late Neonatal Hypocalcemia: A Multicenter Study. , 384 - 390. 10.4274/jcrpe.galenos.2020.2021.0169
Chicago Seymen Gulcan,GÜNLEMEZ AYLA,Gökalp Ayşe Sevim,Hatun Sukru,Narter Fatma,Mutlu Mehmet,aslan yakup,kılıçbay fatih,KADER SEBNEM,Terek Demet,Hanta Deniz,Okulu Emel,KARADENİZ Leyla,Kanmaz Kutman H. Gozde,ZENCIROGLU AYSEGÜL,Özdemir Özmert M.A.,Sarici Dilek,Celik muhittin,demir nihat,TURAN Ozden,çelik kıymet,Uslu Sinan,erol sara,Ertuğrul Sabahattin,ER İlkay,CELIK HASAN TOLGA,AKTÜRK ACAR FİLİZ,Tunç Gaffari,Guran Omer,Arısoy Ayşe Engin Vitamin D Deficiency Prevalence in Late Neonatal Hypocalcemia: A Multicenter Study. (2021): 384 - 390. 10.4274/jcrpe.galenos.2020.2021.0169
MLA Seymen Gulcan,GÜNLEMEZ AYLA,Gökalp Ayşe Sevim,Hatun Sukru,Narter Fatma,Mutlu Mehmet,aslan yakup,kılıçbay fatih,KADER SEBNEM,Terek Demet,Hanta Deniz,Okulu Emel,KARADENİZ Leyla,Kanmaz Kutman H. Gozde,ZENCIROGLU AYSEGÜL,Özdemir Özmert M.A.,Sarici Dilek,Celik muhittin,demir nihat,TURAN Ozden,çelik kıymet,Uslu Sinan,erol sara,Ertuğrul Sabahattin,ER İlkay,CELIK HASAN TOLGA,AKTÜRK ACAR FİLİZ,Tunç Gaffari,Guran Omer,Arısoy Ayşe Engin Vitamin D Deficiency Prevalence in Late Neonatal Hypocalcemia: A Multicenter Study. , 2021, ss.384 - 390. 10.4274/jcrpe.galenos.2020.2021.0169
AMA Seymen G,GÜNLEMEZ A,Gökalp A,Hatun S,Narter F,Mutlu M,aslan y,kılıçbay f,KADER S,Terek D,Hanta D,Okulu E,KARADENİZ L,Kanmaz Kutman H,ZENCIROGLU A,Özdemir Ö,Sarici D,Celik m,demir n,TURAN O,çelik k,Uslu S,erol s,Ertuğrul S,ER İ,CELIK H,AKTÜRK ACAR F,Tunç G,Guran O,Arısoy A Vitamin D Deficiency Prevalence in Late Neonatal Hypocalcemia: A Multicenter Study. . 2021; 384 - 390. 10.4274/jcrpe.galenos.2020.2021.0169
Vancouver Seymen G,GÜNLEMEZ A,Gökalp A,Hatun S,Narter F,Mutlu M,aslan y,kılıçbay f,KADER S,Terek D,Hanta D,Okulu E,KARADENİZ L,Kanmaz Kutman H,ZENCIROGLU A,Özdemir Ö,Sarici D,Celik m,demir n,TURAN O,çelik k,Uslu S,erol s,Ertuğrul S,ER İ,CELIK H,AKTÜRK ACAR F,Tunç G,Guran O,Arısoy A Vitamin D Deficiency Prevalence in Late Neonatal Hypocalcemia: A Multicenter Study. . 2021; 384 - 390. 10.4274/jcrpe.galenos.2020.2021.0169
IEEE Seymen G,GÜNLEMEZ A,Gökalp A,Hatun S,Narter F,Mutlu M,aslan y,kılıçbay f,KADER S,Terek D,Hanta D,Okulu E,KARADENİZ L,Kanmaz Kutman H,ZENCIROGLU A,Özdemir Ö,Sarici D,Celik m,demir n,TURAN O,çelik k,Uslu S,erol s,Ertuğrul S,ER İ,CELIK H,AKTÜRK ACAR F,Tunç G,Guran O,Arısoy A "Vitamin D Deficiency Prevalence in Late Neonatal Hypocalcemia: A Multicenter Study." , ss.384 - 390, 2021. 10.4274/jcrpe.galenos.2020.2021.0169
ISNAD Seymen, Gulcan vd. "Vitamin D Deficiency Prevalence in Late Neonatal Hypocalcemia: A Multicenter Study". (2021), 384-390. https://doi.org/10.4274/jcrpe.galenos.2020.2021.0169
APA Seymen G, GÜNLEMEZ A, Gökalp A, Hatun S, Narter F, Mutlu M, aslan y, kılıçbay f, KADER S, Terek D, Hanta D, Okulu E, KARADENİZ L, Kanmaz Kutman H, ZENCIROGLU A, Özdemir Ö, Sarici D, Celik m, demir n, TURAN O, çelik k, Uslu S, erol s, Ertuğrul S, ER İ, CELIK H, AKTÜRK ACAR F, Tunç G, Guran O, Arısoy A (2021). Vitamin D Deficiency Prevalence in Late Neonatal Hypocalcemia: A Multicenter Study. Journal of Clinical Research in Pediatric Endocrinology, 13(4), 384 - 390. 10.4274/jcrpe.galenos.2020.2021.0169
Chicago Seymen Gulcan,GÜNLEMEZ AYLA,Gökalp Ayşe Sevim,Hatun Sukru,Narter Fatma,Mutlu Mehmet,aslan yakup,kılıçbay fatih,KADER SEBNEM,Terek Demet,Hanta Deniz,Okulu Emel,KARADENİZ Leyla,Kanmaz Kutman H. Gozde,ZENCIROGLU AYSEGÜL,Özdemir Özmert M.A.,Sarici Dilek,Celik muhittin,demir nihat,TURAN Ozden,çelik kıymet,Uslu Sinan,erol sara,Ertuğrul Sabahattin,ER İlkay,CELIK HASAN TOLGA,AKTÜRK ACAR FİLİZ,Tunç Gaffari,Guran Omer,Arısoy Ayşe Engin Vitamin D Deficiency Prevalence in Late Neonatal Hypocalcemia: A Multicenter Study. Journal of Clinical Research in Pediatric Endocrinology 13, no.4 (2021): 384 - 390. 10.4274/jcrpe.galenos.2020.2021.0169
MLA Seymen Gulcan,GÜNLEMEZ AYLA,Gökalp Ayşe Sevim,Hatun Sukru,Narter Fatma,Mutlu Mehmet,aslan yakup,kılıçbay fatih,KADER SEBNEM,Terek Demet,Hanta Deniz,Okulu Emel,KARADENİZ Leyla,Kanmaz Kutman H. Gozde,ZENCIROGLU AYSEGÜL,Özdemir Özmert M.A.,Sarici Dilek,Celik muhittin,demir nihat,TURAN Ozden,çelik kıymet,Uslu Sinan,erol sara,Ertuğrul Sabahattin,ER İlkay,CELIK HASAN TOLGA,AKTÜRK ACAR FİLİZ,Tunç Gaffari,Guran Omer,Arısoy Ayşe Engin Vitamin D Deficiency Prevalence in Late Neonatal Hypocalcemia: A Multicenter Study. Journal of Clinical Research in Pediatric Endocrinology, vol.13, no.4, 2021, ss.384 - 390. 10.4274/jcrpe.galenos.2020.2021.0169
AMA Seymen G,GÜNLEMEZ A,Gökalp A,Hatun S,Narter F,Mutlu M,aslan y,kılıçbay f,KADER S,Terek D,Hanta D,Okulu E,KARADENİZ L,Kanmaz Kutman H,ZENCIROGLU A,Özdemir Ö,Sarici D,Celik m,demir n,TURAN O,çelik k,Uslu S,erol s,Ertuğrul S,ER İ,CELIK H,AKTÜRK ACAR F,Tunç G,Guran O,Arısoy A Vitamin D Deficiency Prevalence in Late Neonatal Hypocalcemia: A Multicenter Study. Journal of Clinical Research in Pediatric Endocrinology. 2021; 13(4): 384 - 390. 10.4274/jcrpe.galenos.2020.2021.0169
Vancouver Seymen G,GÜNLEMEZ A,Gökalp A,Hatun S,Narter F,Mutlu M,aslan y,kılıçbay f,KADER S,Terek D,Hanta D,Okulu E,KARADENİZ L,Kanmaz Kutman H,ZENCIROGLU A,Özdemir Ö,Sarici D,Celik m,demir n,TURAN O,çelik k,Uslu S,erol s,Ertuğrul S,ER İ,CELIK H,AKTÜRK ACAR F,Tunç G,Guran O,Arısoy A Vitamin D Deficiency Prevalence in Late Neonatal Hypocalcemia: A Multicenter Study. Journal of Clinical Research in Pediatric Endocrinology. 2021; 13(4): 384 - 390. 10.4274/jcrpe.galenos.2020.2021.0169
IEEE Seymen G,GÜNLEMEZ A,Gökalp A,Hatun S,Narter F,Mutlu M,aslan y,kılıçbay f,KADER S,Terek D,Hanta D,Okulu E,KARADENİZ L,Kanmaz Kutman H,ZENCIROGLU A,Özdemir Ö,Sarici D,Celik m,demir n,TURAN O,çelik k,Uslu S,erol s,Ertuğrul S,ER İ,CELIK H,AKTÜRK ACAR F,Tunç G,Guran O,Arısoy A "Vitamin D Deficiency Prevalence in Late Neonatal Hypocalcemia: A Multicenter Study." Journal of Clinical Research in Pediatric Endocrinology, 13, ss.384 - 390, 2021. 10.4274/jcrpe.galenos.2020.2021.0169
ISNAD Seymen, Gulcan vd. "Vitamin D Deficiency Prevalence in Late Neonatal Hypocalcemia: A Multicenter Study". Journal of Clinical Research in Pediatric Endocrinology 13/4 (2021), 384-390. https://doi.org/10.4274/jcrpe.galenos.2020.2021.0169