Apoptosisinbovineocularsquamousecellcarcinomas

Aim: Cell death, especially apoptosis, is one of the most studied topics regarding cells. Understanding the mechanism of apoptosis in diseases will help understand the pathogenesis of diseases, as well as the treatment. This study aims to grade the Bovine ocular squamous cell carcinoma (BOSCC) and to evaluate apoptosis in tumors with different anaplastic features. Materials and Methods: A total of 30 formalin-fixed tumor tissues consisting of 10 poorly-differentiated, 10 moderately-differentiated, and 10 well-differentiated tissues were used to examine apoptosis in BOSCCs. Hematoxylin & eosin (HE) was performed for histopathological examination and TUNEL staining was performed for detection of apoptosis in all BOSCCs. Results: It was determined that apoptosis decreased as the malignancy increased in BOSCCs (p<0.001). Although all the tumors examined were malignant, apoptosis, i.e. controlled cell death, was found to be severe in well-differentiated type and mild in moderate and poorly-differentiated types. Conclusion: It was concluded that this case observed in bovines should be considered in studies on the pathogenesis of cancer and treatment.

Anahtar Kelime:

Sığırlarınoküleryassıhücrelikarsinomlarındaapoptozis

Öz:

Amaç: Hücre ölümü özellikle de apoptozis hücre konusunda en çok çalışılan konular arasında yer almaktadır. Hastalıklardaki apoptozis mekanizmasının anlaşılması sadece hastalıkların patogenezinin anlaşılmasına değil hastalıkların tedavisine de yardımcı olacaktır. Bu çalışmada sığırlarda gözlenen oküler yassı hücreli karsinomların (Bovine ocular squamouse cell carcinoma, BOSCC) derecelendirilmesi ve farklı anaplastik özellikler gösteren bu tümörlerde apoptozisin değerlendirilmesi hedeflendi. Gereç ve Yöntem: BOSCC’lerde apoptozisin incelenmesi amacıyla, formalinde tespit edilmiş 10 adet kötü differensiye, 10 adet orta differensiye ve 10 iyi diferensiye olan toplam 30 adet tümör dokusu kullanıldı. Histopatolojik inceleme için hematoksilen & eozin (H&E); apoptozisin tespit için tüm BOSCC’lerde TUNEL (Terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling) boyaması yapıldı. Bulgular: BOSCC’lerde malignite artıkça apoptozisin azaldığı saptandı (p<0.001). İncelenen tüm tümörler malign olmasına rağmen iyi differensiye tipte kontrollü hücre ölümü olan apoptozun şiddetli olduğu ancak orta ve kötü differensiye tiplerde apoptozisin hafif şiddette olduğu saptandı. Öneri: Sığırlarda gözlenen bu durumun kanser patogenezi ve tedavisine yönelik çalışmalarda göz önünde bulundurulması gerektiği kanısına varıldı.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Kutlu T, Karakurt E, AYDIN U, BEYTUT E, Ozaydin I, DAĞ S, aksoy o, NUHOĞLU H, YILDIZ A (2022). Apoptosisinbovineocularsquamousecellcarcinomas. , 131 - 136. 10.15312/EurasianJVetSci.2022.374
Chicago	Kutlu Tuncer,Karakurt Emin,AYDIN Uğur,BEYTUT ENVER,Ozaydin Isa,DAĞ Serpil,aksoy ozgur,NUHOĞLU HİLMİ,YILDIZ Ayfer Apoptosisinbovineocularsquamousecellcarcinomas. (2022): 131 - 136. 10.15312/EurasianJVetSci.2022.374
MLA	Kutlu Tuncer,Karakurt Emin,AYDIN Uğur,BEYTUT ENVER,Ozaydin Isa,DAĞ Serpil,aksoy ozgur,NUHOĞLU HİLMİ,YILDIZ Ayfer Apoptosisinbovineocularsquamousecellcarcinomas. , 2022, ss.131 - 136. 10.15312/EurasianJVetSci.2022.374
AMA	Kutlu T,Karakurt E,AYDIN U,BEYTUT E,Ozaydin I,DAĞ S,aksoy o,NUHOĞLU H,YILDIZ A Apoptosisinbovineocularsquamousecellcarcinomas. . 2022; 131 - 136. 10.15312/EurasianJVetSci.2022.374
Vancouver	Kutlu T,Karakurt E,AYDIN U,BEYTUT E,Ozaydin I,DAĞ S,aksoy o,NUHOĞLU H,YILDIZ A Apoptosisinbovineocularsquamousecellcarcinomas. . 2022; 131 - 136. 10.15312/EurasianJVetSci.2022.374
IEEE	Kutlu T,Karakurt E,AYDIN U,BEYTUT E,Ozaydin I,DAĞ S,aksoy o,NUHOĞLU H,YILDIZ A "Apoptosisinbovineocularsquamousecellcarcinomas." , ss.131 - 136, 2022. 10.15312/EurasianJVetSci.2022.374
ISNAD	Kutlu, Tuncer vd. "Apoptosisinbovineocularsquamousecellcarcinomas". (2022), 131-136. https://doi.org/10.15312/EurasianJVetSci.2022.374

APA	Kutlu T, Karakurt E, AYDIN U, BEYTUT E, Ozaydin I, DAĞ S, aksoy o, NUHOĞLU H, YILDIZ A (2022). Apoptosisinbovineocularsquamousecellcarcinomas. Eurasian Journal of Veterinary Sciences, 38(2), 131 - 136. 10.15312/EurasianJVetSci.2022.374
Chicago	Kutlu Tuncer,Karakurt Emin,AYDIN Uğur,BEYTUT ENVER,Ozaydin Isa,DAĞ Serpil,aksoy ozgur,NUHOĞLU HİLMİ,YILDIZ Ayfer Apoptosisinbovineocularsquamousecellcarcinomas. Eurasian Journal of Veterinary Sciences 38, no.2 (2022): 131 - 136. 10.15312/EurasianJVetSci.2022.374
MLA	Kutlu Tuncer,Karakurt Emin,AYDIN Uğur,BEYTUT ENVER,Ozaydin Isa,DAĞ Serpil,aksoy ozgur,NUHOĞLU HİLMİ,YILDIZ Ayfer Apoptosisinbovineocularsquamousecellcarcinomas. Eurasian Journal of Veterinary Sciences, vol.38, no.2, 2022, ss.131 - 136. 10.15312/EurasianJVetSci.2022.374
AMA	Kutlu T,Karakurt E,AYDIN U,BEYTUT E,Ozaydin I,DAĞ S,aksoy o,NUHOĞLU H,YILDIZ A Apoptosisinbovineocularsquamousecellcarcinomas. Eurasian Journal of Veterinary Sciences. 2022; 38(2): 131 - 136. 10.15312/EurasianJVetSci.2022.374
Vancouver	Kutlu T,Karakurt E,AYDIN U,BEYTUT E,Ozaydin I,DAĞ S,aksoy o,NUHOĞLU H,YILDIZ A Apoptosisinbovineocularsquamousecellcarcinomas. Eurasian Journal of Veterinary Sciences. 2022; 38(2): 131 - 136. 10.15312/EurasianJVetSci.2022.374
IEEE	Kutlu T,Karakurt E,AYDIN U,BEYTUT E,Ozaydin I,DAĞ S,aksoy o,NUHOĞLU H,YILDIZ A "Apoptosisinbovineocularsquamousecellcarcinomas." Eurasian Journal of Veterinary Sciences, 38, ss.131 - 136, 2022. 10.15312/EurasianJVetSci.2022.374
ISNAD	Kutlu, Tuncer vd. "Apoptosisinbovineocularsquamousecellcarcinomas". Eurasian Journal of Veterinary Sciences 38/2 (2022), 131-136. https://doi.org/10.15312/EurasianJVetSci.2022.374