Yıl: 2022 Cilt: 62 Sayı: 1 Sayfa Aralığı: 87 - 92 Metin Dili: İngilizce DOI: 10.14744/hnhj.2020.82713 İndeks Tarihi: 21-06-2022

Is there a Difference between Typical and Atypical Hippocampal Sclerosis Regarding Pre-Operative Blood Inflammatory Markers?

Öz:
Introduction: The purpose of this retrospective study was to provide whether there was a difference regarding pre-operative inflammatory markers between typical and atypical hippocampal sclerosis (HS). Methods: For this purpose, 44 patients who underwent epilepsy surgery due to drug-resistant temporal lobe epilepsy were included. Pre-operative neutrophil, lymphocyte, monocyte, and platelet counts as well as neutrophil-lymphocyte ratio, platelet-lymphocyte ratio, lymphocyte-monocyte ratio, and systemic immune-inflammation index) were noted from peripheral blood tests. Results: Although the majority of inflammatory markers showed higher levels in typical HS, no significant differences were found. None of the markers studied showed a correlation with the degree of neuronal loss. Discussion and Conclusion: Although no differences between typical and atypical HS were demonstrated, there was a trend to increase in the levels of some inflammatory markers in typical HS which is severe form of neuronal loss compared to atypical HS and further studies with larger cohort of retrospective and preferably prospective are needed.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
  • 1. Tanriverdi T, Olivier A, Poulin N, Andermann F, Dubeau F. Longterm seizure outcome after mesial temporal lobe epilepsy surgery: Corticalamygdalohippocampectomy versus selective amygdalohippocampectomy. J Neurosurg 2008;108:517– 24.
  • 2. Kemerdere R, Ahmedov ML, Alizada O, Yeni SN, Oz B, Tanriverdi T. Effect of temporal neocortical pathology on seizure freeness in adult patients with temporal lobe epilepsy. World Neurosurg 2018;116:e801–5.
  • 3. Tanriverdi T, Poulin N, Olivier A. Life 12 years after temporal lobe epilepsy surgery: A long-term, prospective clinical study. Seizure 2008;17:339–49.
  • 4. Thom M, Eriksson S, Martinian L, Caboclo LO, McEvoy AW, Duncan JS, et al. Temporal lobe sclerosis associated with hippocampal sclerosis in temporal lobe epilepsy: Neuropathological features. J Neuropathol Exp Neurol 2009;68:928–38.
  • 5. Silverberg J, Ginsburg D, Orman R, Amassian V, Durkin HG, Stewart M. Lymphocyte infiltration of neocortex and hippocampus after a single brief seizure in mice. Brain Behav Immun 2010;24:263–72.
  • 6. Gales JM, Prayson RA. Chronic inflammation in refractory hippocampal sclerosis-related temporal lobe epilepsy. Ann Diagn Pathol 2017;30:12–6.
  • 7. Ahmedov ML, Kemerdere R, Baran O, Inal BB, Gumus A, Coskun C, et al. Tissue expressions of soluble human epoxide hydrolase-2 enzyme in patients with temporal lobe epilepsy. World Neurosurg 2017;106:46–50.
  • 8. Varvel NH, Neher JJ, Bosch A, Wang W, Ransohoff RM, Miller RJ, et al. Infiltrating monocytes promote brain inflammation and exacerbate neuronal damage after status epilepticus. Proc Natl Acad Sci USA 2016;113:E5665–74.
  • 9. Leal B, Chaves J, Carvalho C, Rangel R, Santos A, Bettencourt A, et al. Brain expression of inflammatory mediators in mesial temporal lobe epilepsy patients. J Neuroimmunol 2017;313:82–8.
  • 10. Vezzani A, French J, Bartfai T, Baram TZ. The role of inflammation in epilepsy. Nat Rev Neurol 2011;7:31–40.
  • 11. Rana A, Musto AE. The role of inflammation in the development of epilepsy. J Neuroinflammation 2018;15:144.
  • 12. Zattoni M, Mura ML, Deprez F, Schwendener RA, Engelhardt B, Frei K, et al. Brain infiltration of leukocytes contributes to the pathophysiology of temporal lobe epilepsy. J Neurosci 2011;31:4037–50.
  • 13. Zadora P, Dabrowski W, Czarko K, Smolen A, Kotlinska-Hasiec E, Wiorkowski K, et al. Preoperative neutrophil-lymphocyte count ratio helps predict the grade of glial tumor - a pilot study. Neurol Neurochir Pol 2015;49:41–4.
  • 14. Zheng SH, Huang JL, Chen M, Wang BL, Ou QS, Huang SY. Diagnostic value of preoperative inflammatory markers in patients with glioma: A multicenter cohort study. J Neurosurg 2018;129:583–92.
  • 15. Xu W, Wang D, Zheng X, Ou Q, Huang L. Sex-dependent association of preoperative hematologic markers with glioma grade and progression. J Neurooncol 2018;137:279–87.
  • 16. Liang R, Chen N, Li M, Wang X, Mao Q, Liu Y. Significance of systemic immune-inflammation index in the differential diagnosis of high- and low-grade gliomas. Clin Neurol Neurosurg 2018;164:50–52.
  • 17. Ozaydin E, Arhan E, Cetinkaya B, Ozdel S, Değerliyurt A, Güven A, et al. Differences in iron deficiency anemia and mean platelet volume between children with simple and complex febrile seizures. Seizure 2012;21:211–4.
  • 18. Goksugur SB, Kabakus N, Bekdas M, Demircioglu F. Neutrophilto- lymphocyte ratio and red blood cell distribution width is a practical predictor for differentiation of febrile seizure types. Eur Rev Med Pharmacol Sci 2014;18:3380–5.
  • 19. Yigit Y, Yilmaz S, Akdogan A, Halhalli HC, Ozbek AE, Gencer EG. The role of neutrophil-lymphocyte ratio and red blood cell distribution width in the classification of febrile seizures. Eur Rev Med Pharmacol Sci 2017;21:554–9.
  • 20. Nikkhah A, Salehiomran MR, Asefi SS. Differences in mean platelet volume and platelet count between children with simple and complex febrile seizures. Iran J Child Neurol 2017;11:44–7.
  • 21. Eroglu T, Turkoglu SA, Bolac ES, Yildiz S, Yildiz N. Hemogram parameters in epilepsy may be indicators of chronic inflammation and hypoxemia. J Neurol Clin Neurosci 2017;1:12–5.
  • 22. Hu B, Yang XR, Xu Y, Sun YF, Sun C, Guo W, et al. Systemic immune- inflammation index predicts prognosis of patients after curative resection for hepatocellular carcinoma. Clin Cancer Res 2014;20:6212–22.
  • 23. Kwan P, Arzimanoglou A, Berg AT, Brodie MJ, Allen Hauser W, Mathern G, et al. Definition of drug resistant epilepsy: Consensus proposal by the ad hoc task force of the ILAE commission on therapeutic strategies. Epilepsia 2010;51:1069–77.
  • 24. Grivennikov SI, Greten FR, Karin M. Immunity, inflammation, and cancer. Cell 2010;140:883–99.
  • 25. Del Prete A, Allavena P, Santoro G, Fumarulo R, Corsi MM, Mantovani A. Molecular pathways in cancer-related inflammation. Biochem Med (Zagreb) 2011;21:264–75.
  • 26. Gregory AD, Houghton AM. Tumor-associated neutrophils: New targets for cancer therapy. Cancer Res 2011;71:2411–6.
  • 27. Radu BM, Epureanu FB, Radu M, Fabene PF, Bertini G. Nonsteroidal anti-inflammatory drugs in clinical and experimental epilepsy. Epilepsy Res 2017;131:15–27.
  • 28. Dambach H, Hinkerohe D, Prochnow N, Stienen MN, Moinfar Z, Haase CG, et al. Glia and epilepsy: Experimental investigation of antiepileptic drugs in an astroglia/microglia co-culture model of inflammation. Epilepsia 2014;55:184–92.
APA Kemerdere R, Baran O, Alizada O, TOKLU S, Akgun M, Yeni S, Tanriverdi T (2022). Is there a Difference between Typical and Atypical Hippocampal Sclerosis Regarding Pre-Operative Blood Inflammatory Markers?. , 87 - 92. 10.14744/hnhj.2020.82713
Chicago Kemerdere Rahsan,Baran Oguz,Alizada Orkhan,TOKLU SUREYYA,Akgun Mehmet Yigit,Yeni Seher Naz,Tanriverdi Taner Is there a Difference between Typical and Atypical Hippocampal Sclerosis Regarding Pre-Operative Blood Inflammatory Markers?. (2022): 87 - 92. 10.14744/hnhj.2020.82713
MLA Kemerdere Rahsan,Baran Oguz,Alizada Orkhan,TOKLU SUREYYA,Akgun Mehmet Yigit,Yeni Seher Naz,Tanriverdi Taner Is there a Difference between Typical and Atypical Hippocampal Sclerosis Regarding Pre-Operative Blood Inflammatory Markers?. , 2022, ss.87 - 92. 10.14744/hnhj.2020.82713
AMA Kemerdere R,Baran O,Alizada O,TOKLU S,Akgun M,Yeni S,Tanriverdi T Is there a Difference between Typical and Atypical Hippocampal Sclerosis Regarding Pre-Operative Blood Inflammatory Markers?. . 2022; 87 - 92. 10.14744/hnhj.2020.82713
Vancouver Kemerdere R,Baran O,Alizada O,TOKLU S,Akgun M,Yeni S,Tanriverdi T Is there a Difference between Typical and Atypical Hippocampal Sclerosis Regarding Pre-Operative Blood Inflammatory Markers?. . 2022; 87 - 92. 10.14744/hnhj.2020.82713
IEEE Kemerdere R,Baran O,Alizada O,TOKLU S,Akgun M,Yeni S,Tanriverdi T "Is there a Difference between Typical and Atypical Hippocampal Sclerosis Regarding Pre-Operative Blood Inflammatory Markers?." , ss.87 - 92, 2022. 10.14744/hnhj.2020.82713
ISNAD Kemerdere, Rahsan vd. "Is there a Difference between Typical and Atypical Hippocampal Sclerosis Regarding Pre-Operative Blood Inflammatory Markers?". (2022), 87-92. https://doi.org/10.14744/hnhj.2020.82713
APA Kemerdere R, Baran O, Alizada O, TOKLU S, Akgun M, Yeni S, Tanriverdi T (2022). Is there a Difference between Typical and Atypical Hippocampal Sclerosis Regarding Pre-Operative Blood Inflammatory Markers?. Haydarpaşa Numune Medical Journal, 62(1), 87 - 92. 10.14744/hnhj.2020.82713
Chicago Kemerdere Rahsan,Baran Oguz,Alizada Orkhan,TOKLU SUREYYA,Akgun Mehmet Yigit,Yeni Seher Naz,Tanriverdi Taner Is there a Difference between Typical and Atypical Hippocampal Sclerosis Regarding Pre-Operative Blood Inflammatory Markers?. Haydarpaşa Numune Medical Journal 62, no.1 (2022): 87 - 92. 10.14744/hnhj.2020.82713
MLA Kemerdere Rahsan,Baran Oguz,Alizada Orkhan,TOKLU SUREYYA,Akgun Mehmet Yigit,Yeni Seher Naz,Tanriverdi Taner Is there a Difference between Typical and Atypical Hippocampal Sclerosis Regarding Pre-Operative Blood Inflammatory Markers?. Haydarpaşa Numune Medical Journal, vol.62, no.1, 2022, ss.87 - 92. 10.14744/hnhj.2020.82713
AMA Kemerdere R,Baran O,Alizada O,TOKLU S,Akgun M,Yeni S,Tanriverdi T Is there a Difference between Typical and Atypical Hippocampal Sclerosis Regarding Pre-Operative Blood Inflammatory Markers?. Haydarpaşa Numune Medical Journal. 2022; 62(1): 87 - 92. 10.14744/hnhj.2020.82713
Vancouver Kemerdere R,Baran O,Alizada O,TOKLU S,Akgun M,Yeni S,Tanriverdi T Is there a Difference between Typical and Atypical Hippocampal Sclerosis Regarding Pre-Operative Blood Inflammatory Markers?. Haydarpaşa Numune Medical Journal. 2022; 62(1): 87 - 92. 10.14744/hnhj.2020.82713
IEEE Kemerdere R,Baran O,Alizada O,TOKLU S,Akgun M,Yeni S,Tanriverdi T "Is there a Difference between Typical and Atypical Hippocampal Sclerosis Regarding Pre-Operative Blood Inflammatory Markers?." Haydarpaşa Numune Medical Journal, 62, ss.87 - 92, 2022. 10.14744/hnhj.2020.82713
ISNAD Kemerdere, Rahsan vd. "Is there a Difference between Typical and Atypical Hippocampal Sclerosis Regarding Pre-Operative Blood Inflammatory Markers?". Haydarpaşa Numune Medical Journal 62/1 (2022), 87-92. https://doi.org/10.14744/hnhj.2020.82713