Oligospermik erkek infertilitesinde leptin'in yeri

TUNÇ ,Lütfi; TOKGÖZ ,Hüsnü; KORDAN ,Yakup; BİRİ ,Hasan; KARAOĞLAN ,Üstünol; BOZKIRLI ,İbrahim

Lütfi TUNÇ

(Gazi Üniversitesi, Tıp Fakültesi, Üroloji Anabilim Dalı, Ankara, Türkiye)

Hüsnü TOKGÖZ

(Gazi Üniversitesi, Tıp Fakültesi, Üroloji Anabilim Dalı, Ankara, Türkiye)

Yakup KORDAN

(Gazi Üniversitesi, Tıp Fakültesi, Üroloji Anabilim Dalı, Ankara, Türkiye)

Hasan BİRİ

(Gazi Üniversitesi, Tıp Fakültesi, Üroloji Anabilim Dalı, Ankara, Türkiye)

Üstünol KARAOĞLAN

(Gazi Üniversitesi, Tıp Fakültesi, Üroloji Anabilim Dalı, Ankara, Türkiye)

İbrahim BOZKIRLI

(Gazi Üniversitesi, Tıp Fakültesi, Üroloji Anabilim Dalı, Ankara, Türkiye)

Türk Üroloji Dergisi/Turkish Journal of Urology

Yıl: 2005Cilt: 31Sayı: 2ISSN: 1300-5804 / 1308-4631Sayfa Aralığı: 207 - 211Metin Dili: Türkçe

85 0

Türkçe
İngilizce

Oligospermik erkek infertilitesinde leptin'in yeri

Öz: Bu çalışmamızda infertil ve fertil erkeklerin serum leptin seviyelerinin karşılaştırılması ve infertil hastalarda serum leptin seviyesi ile sperm konsantrasyonu, serum FSH, LH, Testosteron düzeyleri ve testis volümü arasındaki ilişkinin araştırılmasını amaçladık. İnfertilite tanısı konulan 38 erkek hasta çalışmaya alındı. Kontrol grubu olarak, son bir yıl içerisinde fertil olduğu bilinen 28 sağlıklı erkek çalışmaya dahil edildi. İnfertil ve fertil erkeklerin vücut kitle indeksi (VKİ) ve serum leptin düzeylerine bakıldı. Ayrıca, infertil erkeklerde testis boyutu, sperm konsantrasyonu ve serum FSH, LH, testosteron düzeyleri incelendi. İnfertil ve fertil erkeklerde VKİ, yaş ve leptin düzeyi ortalamaları arasında fark bulunmadı. İstatistiksel olarak anlamlı olmamakla birlikte infertil erkeklerin serum leptin seviyesi literatürde bildirilen ortalama olan 5±0,4 ng/ml'den yüksek olarak bulundu. Kontrol grubumuzun leptin seviyesi ortalaması ise bu ortalamadan daha düşük bulundu. İnfertil erkeklerde serum leptin seviyesi ile testis hacmi, sperm konsantrasyonu, serum testosteron, FSH ve LH seviyeleri arasında korelasyon saptanmadı. Çalışmamızda, oligospermik erkek infertilitesinde serum leptin düzeylerinin herhangi bir tanısal kriter olarak kullanılamayacağı sonucu elde edilmiştir.

Anahtar Kelimeler: Testis Leptin Oligospermi Kısırlık, erkek Vücut kitle indeksi

Konu Alanı: Fen > Tıp > Tıbbi Araştırmalar Deneysel
Fen > Tıp > Üroloji ve Nefroloji

The place of leptin in oligozoospermiac male infertility

Abstract:Introduction: Leptin is a 16 KD protein which is mainly secreted from the adipose tissue and is known to be involved in the satiety process. Accordingly, the hormone also seems to play a role in the hypothalamo-hypophyseal-gonadal axis in order to modulate reproductive system. In our prospective study, we aimed to compare the mean serum leptin concentrations in infertile and fertile males and to investigate the relationship between serum leptin levels with the sperm density, serum FSH, LH, testosterone levels and the volumes of testis in infertile males. Materials and Methods: A total of 38 infertile males as a study group and 28 healthy men who had been proved to be fertile in last 1 year as a control group, were included in the study. Mean body mass index (BMI) and serum leptin levels of fertile and infertile males were evaluated. In addition, the volumes of testes, sperm densities and serum FSH, LH, testosterone levels were obtained from all patients in the study group. Patients having sperm concentrations between 1 million and 20 millions per milliliter of ejaculate were involved in the study. Patients with unilateral varicocele or bilateral varicoceles, urinary tract infection, congenital penil contracture, sexual dysfunction and retrograde ejaculation were excluded from the study. Statistically, the variations were compared with their relevant mean and standard deviation values. Student t-test was used as a parametric test and Mann Whitney U test was used as a non-parametric test. The correlation values were calculated by using Pearson correlation test. Results: Mean age for the study and the control groups were 33±5.1 (range 24-44) and 32±2.5 (range 27-36) respectively. Mean BMI value for fertile group was 24.9±2.4 kg/m2 and 24.8±2 kg/m2 for the control group (p>0.05). There were no statistically significant differences between the mean serum leptin concentrations of the fertile and the infertile group. Mean serum leptin concentration was 5.7±6.5 ng/ ml for the study and 3.9±2.4 ng/ ml for the control group. Mean leptin concentration was higher in infertile group than the mean values reported in the literature (5±0.4 ng/ml for fertile group). However, mean serum leptin concentration for the fertile group was lower than this value. In addition, in infertile males, no correlations were found between serum leptin levels and testis volume, sperm density, serum FSH, LH, testosterone levels. Conclusion: Our data suggest that although serum leptin concentrations tend to increase with the decrease in seminal sperm concentration, there were no statistically significant differences between the mean serum leptin levels of oligozoospermiac and fertile men. So, determination of serum leptin levels in oligozoospermiac males might not be used as diagnostic and prognostic criteria. However, it can be used as an additional parameter to predict the degree of testicular dysfunction in infertile males.

Keywords: Testis Leptin Oligospermia Infertility, Male Body Mass Index

Subject Area: SCIENCE > MEDICINE > MEDICINE, RESEARCH & EXPERIMENTAL
SCIENCE > MEDICINE > UROLOGY & NEPHROLOGY

Belge Türü: DergiMakale Türü: Araştırma MakalesiErişim Formatı: Erişime Açık

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