Yıl: 2005 Cilt: 11 Sayı: 2 Sayfa Aralığı: 102 - 107 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

The effect of femoral lengthening on skeletal muscle: An experimental study in rats

Öz:
AMAÇ Kırk iki sıçanda femur uzatma işleminin müsküler etkilerini araştırmak ve çok düşük oranda uzatmanın bile kasta geri dönüşsüz patolojik değişikliklere, farklı evrelerde dejenerasyon odaklarının gelişimine neden olduğunu göstermek YÖNTEMLER Sıçanlar rastgele yöntemle altı gruba ayrılmış ve farklı oranda femur uzatma işlemleri uygulandıktan sonra distraksiyon sürecinin bitiminde feda edilmişlerdir. Tüm örnekler için histopatolojik ve histomorfometrik ölçümler yapılmıştır. Sonuçların istatistiksel analizi için Mann Whitney U testi kullanılmıştır BULGULAR Uzatma oranı yükseltilerek kas liflerinin dejenerasyonu, vakuollerin sayısı ve hücre infiltrasyonu gibi patolojik değişikliklerin şiddet derecesi artırılmıştır. On dört gün sonra yapılan incelemelerde dejenere olmuş kas liflerinde fagositoz gözlenmiş ve hücrede daha önce oluşmuş infiltrasyonun hızla azaldığı saptanmıştır. Yirmi bir gün süren uzatma işleminden sonra vakuollerde ve yine kas liflerinin etrafında fibroz oluşmuştur. Hücre infiltrasyonu giderek kaybolmuş, kas normal görünümünü kazanmış ve otuz bir gün izlenen grupta endomizyal, perimizyal ve epimizyal fibroz gibi patolojik değişiklikler oluşmuştur. Kas liflerinin % 2 l'i atrofiye uğramış olmasına rağmen tip 1/tip II kas lifi oram değişikliğe uğramamıştır. SONUÇLAR Bu çalışmanın bulguları aynı kasta farklı dejenerasyon dönemlerini gösteren farklı bölgelerin bulunabileceğini ve % 10 oranında bir uzatma işlemi sonrasında bile kasta geri dönüşsüz değişiklikler gelişebileceğini göstermiştir.
Anahtar Kelime: Fibroz Femur Kas, iskelet Kemik uzatma Sıçan, Wistar

Femur uzatma işleminin iskelet kası üzerine etkisi: Sıçanlarda yapılan deneysel bir çalışma

Öz:
BACKGROUND To investigate the muscular changes occurring during femoral lengthening performed in 42 rats. METHODS The rats were randomly divided into six groups and different rates of lengthening was utilized and sacrificed at the end of the distraction. Histopathologic and histo-morphometric measurements were done for all specimens. The results were analyzed statistically by Mann-Whitney U test. RESULTS By increasing the rate of lengthening, the severity of pathologic changes such as degeneration of muscle fibers, number of vacuoles and cellular infiltration were increased. Phagocytosis of degenerated muscle fibers was observed after 14 days and cellular infiltration decreased sharply and fibrosis formed in the vacuoles and around the muscle fibers after 21 days of lengthening. Cellular infiltration was lost, the muscle had gained its normal appearance and endomysial, perimysial and epimysial fibrosis formed in the group, which was observed for 31 days. Twenty one percent of muscle fibers were atrophic but the ratio of type I to type II muscle fibers did not change. CONCLUSIONS The findings of the current study showed that, different regions with different phases of degeneration occur in the same muscle and irreversible changes in the muscle may develop even in 10 percent lengthening.
Anahtar Kelime: Femur Muscle, Skeletal Bone Lengthening Rats, Wistar Fibrosis

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA Kalenderer Ö, DÜLGEROGLU A (2005). The effect of femoral lengthening on skeletal muscle: An experimental study in rats. , 102 - 107.
Chicago Kalenderer Önder,DÜLGEROGLU Ali Murat The effect of femoral lengthening on skeletal muscle: An experimental study in rats. (2005): 102 - 107.
MLA Kalenderer Önder,DÜLGEROGLU Ali Murat The effect of femoral lengthening on skeletal muscle: An experimental study in rats. , 2005, ss.102 - 107.
AMA Kalenderer Ö,DÜLGEROGLU A The effect of femoral lengthening on skeletal muscle: An experimental study in rats. . 2005; 102 - 107.
Vancouver Kalenderer Ö,DÜLGEROGLU A The effect of femoral lengthening on skeletal muscle: An experimental study in rats. . 2005; 102 - 107.
IEEE Kalenderer Ö,DÜLGEROGLU A "The effect of femoral lengthening on skeletal muscle: An experimental study in rats." , ss.102 - 107, 2005.
ISNAD Kalenderer, Önder - DÜLGEROGLU, Ali Murat. "The effect of femoral lengthening on skeletal muscle: An experimental study in rats". (2005), 102-107.
APA Kalenderer Ö, DÜLGEROGLU A (2005). The effect of femoral lengthening on skeletal muscle: An experimental study in rats. Ulusal Travma Dergisi, 11(2), 102 - 107.
Chicago Kalenderer Önder,DÜLGEROGLU Ali Murat The effect of femoral lengthening on skeletal muscle: An experimental study in rats. Ulusal Travma Dergisi 11, no.2 (2005): 102 - 107.
MLA Kalenderer Önder,DÜLGEROGLU Ali Murat The effect of femoral lengthening on skeletal muscle: An experimental study in rats. Ulusal Travma Dergisi, vol.11, no.2, 2005, ss.102 - 107.
AMA Kalenderer Ö,DÜLGEROGLU A The effect of femoral lengthening on skeletal muscle: An experimental study in rats. Ulusal Travma Dergisi. 2005; 11(2): 102 - 107.
Vancouver Kalenderer Ö,DÜLGEROGLU A The effect of femoral lengthening on skeletal muscle: An experimental study in rats. Ulusal Travma Dergisi. 2005; 11(2): 102 - 107.
IEEE Kalenderer Ö,DÜLGEROGLU A "The effect of femoral lengthening on skeletal muscle: An experimental study in rats." Ulusal Travma Dergisi, 11, ss.102 - 107, 2005.
ISNAD Kalenderer, Önder - DÜLGEROGLU, Ali Murat. "The effect of femoral lengthening on skeletal muscle: An experimental study in rats". Ulusal Travma Dergisi 11/2 (2005), 102-107.