Non-alkolik yağlı karaciğer hastalığı

GÖREN, Başak; FEN, Turgay

Non-alkolik yağlı karaciğer hastalığı

Başak GÖREN, (Ankara Onkoloji Eğitim ve Araştırma Hastanesi, Dahiliye Kliniği, Ankara, Türkiye)

Turgay FEN (Onkoloji Eğitim ve Araştırma Hastanesi, Hematoloji Kliniği, Ankara, Türkiye)

Türkiye Klinikleri Tıp Bilimleri Dergisi

100 0

Yıl: 2005 Cilt: 25 Sayı: 6 Sayfa Aralığı: 841 - 850 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Non-alkolik yağlı karaciğer hastalığı

Öz:

Non-alkolik yağlı karaciğer hastalığı, alkol almayan kişilerde alkole bağlı yağlı karaciğer hastalığının histolojik bulgularının olduğu bir karaciğer hastalığıdır. Non-alkolik yağlı karaciğer hastalığı basit steoatozdan steatohepatit, ilerlemiş fibrozis ve siroza kadar geniş spektrumlu bir karaciğer hasarını tanımlar. Non-alkolik yağlı karaciğer hastalığı, çoğunlukla obezite, tip 2 diyabet, hiperlipidemi ve insülin direnci sonucu olarak, gelişmiş ülkelerdeki en sık kronik karaciğer hastalığıdır. Non-alkolik yağlı karaciğer hastalığının klinik önemi toplumda sık görülmesi, siroza ve son dönem karaciğer hastalığına ilerleme potansiyelinden kaynaklanır. Basit steatozun benign klinik gidişi olmasına karşılık, non-alkolik steatohepatit daha çok ilerleyici fibrozis ve siroz riski ile spesifik tanısal özellikleri olan bir alt gruptur. Çift vuruş teorisi basit steatozdan non-alkolik steatohepatit, fibrozis ve siroza ilerleyişi en iyi tanımlar. Bu çift vuruşlar insülin direnci nedeniyle karaciğerde aşırı yağ birikmesi ve reaktif oksijen türleri nedeniyle oksidatif stresin birleşiminden oluşur. Laboratuvar testleri ve görüntüleme çalışmalarının steatozu, steatohepatitten ayırt edememesi karaciğer biyopsisini ve histopatolojik değerlendirmeyi zorunlu kılar. Günümüzde tedavi hiperlipidemi, diabetes mellitus, obezite gibi risk faktörlerini değiştirmeye odaklanmıştır. Olguların çoğunda tedavi 6 ayın üzerinde %10 civarında kilo vermeyi ve bunu sürdürmeyi başarmayı amaçlar. Vitamin E, N-astilsistein gibi antioksidanlar tedavide yararlı olabilirler. Bu makalede, non-alkolik yağlı karaciğer hastalığının günümüzdeki ve potansiyel gelecekteki tedavi stratejileri tartışılmıştır.

Anahtar Kelime: Yağlı karaciğer Hepatit Karaciğer hastalıkları

Konular: Gastroenteroloji ve Hepatoloji

Non-alcoholic fatty liver disease: Review

Öz:

Non-alcoholic fatty liver disease is a hepatic disorder with histological features of alcohol induced fatty liver disease in individuals who consume no alcohol. Non-alcoholic fatty liver disease refers to a wide spectrum of liver damage, ranging from simple steatosis to steatohepatitis, advanced fibrosis and cirrhosis. Non-alcoholic fatty liver disease is the most common chronic liver disease in developed countries, largely due to obesity, type 2 diabetes, hyperlipidemia and insulin resistance. The clinical importance of non-alcoholic fatty liver disease is derived mostly from its common occurrence in the general population and its potential to progress to cirrhosis and liver failure. Whereas simple steatosis has a benign clinical course, non-alcoholic steatohepatitis is a subgroup with specific diagnostic features and a greater risk of progressive fibrosis, cirrhosis and end-stage liver disease. The two-hit theory best describes the progression from simple steatosis to non-alcoholic steatohepatitis, fibrosis and cirrhosis. These two hits consist of the accumulation of excessive hepatic fat due to insulin resistance and oxidative stress attributed to reactive oxygen species. Laboratory tests and imaging studies are not able to distinguish steatosis from steatohepatitis, which requires liver biopsy and histopathological evaluation. Currently, treatment is focused on modifying risk factors such as obesity, diabetes mellitus, and hyperlipidemia. In most cases, treatment aims to achieve gradual weight loss of around 10% of body weight over 6 months and to maintain this. Antioxidants such as vitamin E, N-acetylcysteine may be beneficial in the treatment of non-alcoholic steatohepatitis. The current and potential future treatment strategies for nonalcoholic fatty liver disease are discussed in this article.

Anahtar Kelime: Fatty Liver Hepatitis Liver Diseases

Konular: Gastroenteroloji ve Hepatoloji

Belge Türü: Makale Makale Türü: Derleme Erişim Türü: Bibliyografik

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APA	GÖREN B, FEN T (2005). Non-alkolik yağlı karaciğer hastalığı. , 841 - 850.
Chicago	GÖREN Başak,FEN Turgay Non-alkolik yağlı karaciğer hastalığı. (2005): 841 - 850.
MLA	GÖREN Başak,FEN Turgay Non-alkolik yağlı karaciğer hastalığı. , 2005, ss.841 - 850.
AMA	GÖREN B,FEN T Non-alkolik yağlı karaciğer hastalığı. . 2005; 841 - 850.
Vancouver	GÖREN B,FEN T Non-alkolik yağlı karaciğer hastalığı. . 2005; 841 - 850.
IEEE	GÖREN B,FEN T "Non-alkolik yağlı karaciğer hastalığı." , ss.841 - 850, 2005.
ISNAD	GÖREN, Başak - FEN, Turgay. "Non-alkolik yağlı karaciğer hastalığı". (2005), 841-850.

APA	GÖREN B, FEN T (2005). Non-alkolik yağlı karaciğer hastalığı. Türkiye Klinikleri Tıp Bilimleri Dergisi, 25(6), 841 - 850.
Chicago	GÖREN Başak,FEN Turgay Non-alkolik yağlı karaciğer hastalığı. Türkiye Klinikleri Tıp Bilimleri Dergisi 25, no.6 (2005): 841 - 850.
MLA	GÖREN Başak,FEN Turgay Non-alkolik yağlı karaciğer hastalığı. Türkiye Klinikleri Tıp Bilimleri Dergisi, vol.25, no.6, 2005, ss.841 - 850.
AMA	GÖREN B,FEN T Non-alkolik yağlı karaciğer hastalığı. Türkiye Klinikleri Tıp Bilimleri Dergisi. 2005; 25(6): 841 - 850.
Vancouver	GÖREN B,FEN T Non-alkolik yağlı karaciğer hastalığı. Türkiye Klinikleri Tıp Bilimleri Dergisi. 2005; 25(6): 841 - 850.
IEEE	GÖREN B,FEN T "Non-alkolik yağlı karaciğer hastalığı." Türkiye Klinikleri Tıp Bilimleri Dergisi, 25, ss.841 - 850, 2005.
ISNAD	GÖREN, Başak - FEN, Turgay. "Non-alkolik yağlı karaciğer hastalığı". Türkiye Klinikleri Tıp Bilimleri Dergisi 25/6 (2005), 841-850.