Yıl: 2006 Cilt: 13 Sayı: 4 Sayfa Aralığı: 221 - 226 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Comparative effects of ovariectomy and flutamid on body-uterus weight and uterine histology in the ovariectomized rat model

Öz:
Amaç: Ovarektomize ratlarda Flutamid kullanımının vücut ağırlığı ve uterus dokusu üzerine etkilerinin araştırılması. Materyal ve Metod: 36 adet Wistar Albino türü dişi sıçanlar Dicle Üniversitesi DÜSAM merkezinden seçildi. Sıçanlar 3 guruba ayrıldı. Grup 1 - kontrol grubu, grup 2 - sham-operasyon, grup 3-bilateral ovarektomi ve flutamid verilen grup. Bulgular: Çalışmada ovarektomize ratların vücut ağırlığı kontrol ratlardan daha fazla bulunurken, uterus ağırlığının azaldığı gözlemlenmiştir. Bununla birlikte flutamid kullanımı sonrasında vücut ağırlığı çok önemli olmamakla beraber azalırken uterus ağırlığı artmıştır. Flutamid uygulamasından sonra uterus epitelinin yüksekliği, uterinal bezlerin sayısı artarken bezlerin lumenlerinde genişleme gözlemlenmiştir. Sonuç: Bilateral ovarektomi ratların uterus epitelinde atrofi şekillendirirken flutamid uygulamasının düzeltici etkilerinin olduğu gözlemlenmiştir. Bu çalışmada bir androjen reseptörü olan flutamid ile dişi ratların üreme fonksiyonları arasındaki ilişkinin daha ilerki çalışmalara kaynak oluşturabileceği görüşündeyiz.
Anahtar Kelime: Sıçanlar Histoloji, karşılaştırmalı Vücut ağırlığı Karşılaştırmalı çalışma Modeller, hayvan Flutamid Overektomi

Konular: Genel ve Dahili Tıp

Ovarektomize ratlarda flutamid uygulamasının vücut ağırlığı ve uterus histolojisi üzerine etkilerinin karşılaştırılması

Öz:
Objective: To determine the effect of flutamide on uterine histology and to ascertain whether flutamide regulates body weight gain in the ovariectomized rat model. Materials and Methods: We used 36 sexually mature female Wistar-Albino rats in this study. The study was performed in the Department of Medical Science Application and Research Centre of Dicle University, Diyarbakir. We divided the model rats into 3 groups: group 1- control group, group 2- sham-operated group and group 3- bilaterally ovariectomized group. In addition, we gave flutamide to group 3. Results: We found that the body weight was higher in the ovariectomized rats than the control rats, unlike the decreased uterine net weight. Furthermore, body weight decreased slightly after flutamide therapy, however uterine net weight increased. After flutamide applications, the length of uterinal epithelium, the number of uterinal glands, infiltration of the stromal cells increased and the lumen of uterinal glands were dilateded. Conclusion: As a result, an improvement was observed after flutamide applications while bilateral ovariectomy was determined to cause atrophy in the uterine epithelium of rat. Our study may be source for further research examining the relationship between the androgen receptor antagonist flutamide and reproductive function in female rats
Anahtar Kelime: Body Weight Comparative Study Models, Animal Flutamide Ovariectomy Rats Histology, Comparative

Konular: Genel ve Dahili Tıp
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA SARUHAN G, Özbağ D, ÖZDEMİR N, GÜMÜŞALAN Y (2006). Comparative effects of ovariectomy and flutamid on body-uterus weight and uterine histology in the ovariectomized rat model. , 221 - 226.
Chicago SARUHAN Güney Berna,Özbağ Davut,ÖZDEMİR NURULLAH,GÜMÜŞALAN Yakup Comparative effects of ovariectomy and flutamid on body-uterus weight and uterine histology in the ovariectomized rat model. (2006): 221 - 226.
MLA SARUHAN Güney Berna,Özbağ Davut,ÖZDEMİR NURULLAH,GÜMÜŞALAN Yakup Comparative effects of ovariectomy and flutamid on body-uterus weight and uterine histology in the ovariectomized rat model. , 2006, ss.221 - 226.
AMA SARUHAN G,Özbağ D,ÖZDEMİR N,GÜMÜŞALAN Y Comparative effects of ovariectomy and flutamid on body-uterus weight and uterine histology in the ovariectomized rat model. . 2006; 221 - 226.
Vancouver SARUHAN G,Özbağ D,ÖZDEMİR N,GÜMÜŞALAN Y Comparative effects of ovariectomy and flutamid on body-uterus weight and uterine histology in the ovariectomized rat model. . 2006; 221 - 226.
IEEE SARUHAN G,Özbağ D,ÖZDEMİR N,GÜMÜŞALAN Y "Comparative effects of ovariectomy and flutamid on body-uterus weight and uterine histology in the ovariectomized rat model." , ss.221 - 226, 2006.
ISNAD SARUHAN, Güney Berna vd. "Comparative effects of ovariectomy and flutamid on body-uterus weight and uterine histology in the ovariectomized rat model". (2006), 221-226.
APA SARUHAN G, Özbağ D, ÖZDEMİR N, GÜMÜŞALAN Y (2006). Comparative effects of ovariectomy and flutamid on body-uterus weight and uterine histology in the ovariectomized rat model. İnönü Üniversitesi Tıp Fakültesi Dergisi, 13(4), 221 - 226.
Chicago SARUHAN Güney Berna,Özbağ Davut,ÖZDEMİR NURULLAH,GÜMÜŞALAN Yakup Comparative effects of ovariectomy and flutamid on body-uterus weight and uterine histology in the ovariectomized rat model. İnönü Üniversitesi Tıp Fakültesi Dergisi 13, no.4 (2006): 221 - 226.
MLA SARUHAN Güney Berna,Özbağ Davut,ÖZDEMİR NURULLAH,GÜMÜŞALAN Yakup Comparative effects of ovariectomy and flutamid on body-uterus weight and uterine histology in the ovariectomized rat model. İnönü Üniversitesi Tıp Fakültesi Dergisi, vol.13, no.4, 2006, ss.221 - 226.
AMA SARUHAN G,Özbağ D,ÖZDEMİR N,GÜMÜŞALAN Y Comparative effects of ovariectomy and flutamid on body-uterus weight and uterine histology in the ovariectomized rat model. İnönü Üniversitesi Tıp Fakültesi Dergisi. 2006; 13(4): 221 - 226.
Vancouver SARUHAN G,Özbağ D,ÖZDEMİR N,GÜMÜŞALAN Y Comparative effects of ovariectomy and flutamid on body-uterus weight and uterine histology in the ovariectomized rat model. İnönü Üniversitesi Tıp Fakültesi Dergisi. 2006; 13(4): 221 - 226.
IEEE SARUHAN G,Özbağ D,ÖZDEMİR N,GÜMÜŞALAN Y "Comparative effects of ovariectomy and flutamid on body-uterus weight and uterine histology in the ovariectomized rat model." İnönü Üniversitesi Tıp Fakültesi Dergisi, 13, ss.221 - 226, 2006.
ISNAD SARUHAN, Güney Berna vd. "Comparative effects of ovariectomy and flutamid on body-uterus weight and uterine histology in the ovariectomized rat model". İnönü Üniversitesi Tıp Fakültesi Dergisi 13/4 (2006), 221-226.