A rare side effect of metformin: metformin-ınduced hepatotoxicity
Yıl: 2007 Cilt: 37 Sayı: 3 Sayfa Aralığı: 173 - 175 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022
A rare side effect of metformin: metformin-ınduced hepatotoxicity
Öz: Özet: Metformin, tip 2 diabetes mellitus tedavisinde sık kullanılan bir oral hipoglisemik ajandır. Her ne kadar, metformin ilişkili laktik asidoz, bu ilacın iyi bilinen bir yan etkisi iken, metforminin yol açtığı hepatotoksisite literatürde nadiren bildirilmiştir. Metformin ilişkili laktik asidoz ve metforminin yol açtığı hepatotoksisite geliştiren 52 yaşındaki erkek vaka sunulmaktadır.
Anahtar Kelime: Konular:
Metforminin nadir yan etkisi: metforminin indüklediği hepatotoksisite
Öz: Metformin is an oral hypoglycemic agent that is commonly used in the treatment of type 2 diabetes mellitus. While metformin-associated metabolic acidosis is a widely recognized side effect of this drug, metformin-induced hepatotoxicity has been rarely reported in the literature. We present herein the case of a 52-year-old male in whom metformin-associated lactic acidosis and metformin-induced hepatotoxicity developed.
Anahtar Kelime: Konular:
Belge Türü: Makale Makale Türü: Olgu Sunumu Erişim Türü: Erişime Açık
- 1. The UK Prospective Diabetes Study (UKPDS) Group. Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes. Lancet 1998; 352: 854-865.
- 2. Charles MA, Eschwege E. Prevention of type 2 diabetes: role of metformin. Drugs 1999; 58: 71-73.
- 3. Muth S, Norman J, Sattar N, Fleming R. Women with polycystic ovary syndrome (PCOS) often undergo protracted treatment with metformin and are disinclined to stop: indications for a change in licensing arrangements? Hum Reprod 2004; 19: 2718-2720.
- 4. Bailey CJ. Biguanides and NIDDM. Diabetes Care 1992; 15: 755- 772.
- 5. Brown JB, Pedula K, Barzilay J, Herson MK, Latare P. Lactic acidosis rates in type 2 diabetes. Diabetes Care 1998; 21: 1659- 1663.
- 6. Lalau JD, Lacroix C, Compagnon P, de Cagny B, Rigaud JP, Bleichner G et al. Role of metformin accumulation in metforminassociated lactic acidosis. Diabetes Care 1995; 18: 779-784.
- 7. Teale KF, Devine A, Stewart H, Harper NJ. The management of metformin overdose. Anaesthesia 1998; 53: 698-701.
- 8. Nammour FE, Fayad NF, Peikin SR. Metformin-induced cholestatic hepatitis. Endocr Pract 2003; 9: 307-309.
- 9. Babich MM, Pike I, Shiffman ML. Metformin-induced acute hepatitis. Am J Med 1998; 104: 490-492.
- 10. Deutsch M, Kountouras D, Dourakis SP. Metformin hepatotoxicity. Ann Intern Med 2004; 140: W25.
| APA | AKSAY E, KIYAN S, YANTURALI S, HOCAOĞLU AKSAY N (2007). A rare side effect of metformin: metformin-ınduced hepatotoxicity. , 173 - 175. |
| Chicago | AKSAY Ersin,KIYAN Selahattin,YANTURALI Sedat,HOCAOĞLU AKSAY NİL A rare side effect of metformin: metformin-ınduced hepatotoxicity. (2007): 173 - 175. |
| MLA | AKSAY Ersin,KIYAN Selahattin,YANTURALI Sedat,HOCAOĞLU AKSAY NİL A rare side effect of metformin: metformin-ınduced hepatotoxicity. , 2007, ss.173 - 175. |
| AMA | AKSAY E,KIYAN S,YANTURALI S,HOCAOĞLU AKSAY N A rare side effect of metformin: metformin-ınduced hepatotoxicity. . 2007; 173 - 175. |
| Vancouver | AKSAY E,KIYAN S,YANTURALI S,HOCAOĞLU AKSAY N A rare side effect of metformin: metformin-ınduced hepatotoxicity. . 2007; 173 - 175. |
| IEEE | AKSAY E,KIYAN S,YANTURALI S,HOCAOĞLU AKSAY N "A rare side effect of metformin: metformin-ınduced hepatotoxicity." , ss.173 - 175, 2007. |
| ISNAD | AKSAY, Ersin vd. "A rare side effect of metformin: metformin-ınduced hepatotoxicity". (2007), 173-175. |
| APA | AKSAY E, KIYAN S, YANTURALI S, HOCAOĞLU AKSAY N (2007). A rare side effect of metformin: metformin-ınduced hepatotoxicity. Turkish Journal of Medical Sciences, 37(3), 173 - 175. |
| Chicago | AKSAY Ersin,KIYAN Selahattin,YANTURALI Sedat,HOCAOĞLU AKSAY NİL A rare side effect of metformin: metformin-ınduced hepatotoxicity. Turkish Journal of Medical Sciences 37, no.3 (2007): 173 - 175. |
| MLA | AKSAY Ersin,KIYAN Selahattin,YANTURALI Sedat,HOCAOĞLU AKSAY NİL A rare side effect of metformin: metformin-ınduced hepatotoxicity. Turkish Journal of Medical Sciences, vol.37, no.3, 2007, ss.173 - 175. |
| AMA | AKSAY E,KIYAN S,YANTURALI S,HOCAOĞLU AKSAY N A rare side effect of metformin: metformin-ınduced hepatotoxicity. Turkish Journal of Medical Sciences. 2007; 37(3): 173 - 175. |
| Vancouver | AKSAY E,KIYAN S,YANTURALI S,HOCAOĞLU AKSAY N A rare side effect of metformin: metformin-ınduced hepatotoxicity. Turkish Journal of Medical Sciences. 2007; 37(3): 173 - 175. |
| IEEE | AKSAY E,KIYAN S,YANTURALI S,HOCAOĞLU AKSAY N "A rare side effect of metformin: metformin-ınduced hepatotoxicity." Turkish Journal of Medical Sciences, 37, ss.173 - 175, 2007. |
| ISNAD | AKSAY, Ersin vd. "A rare side effect of metformin: metformin-ınduced hepatotoxicity". Turkish Journal of Medical Sciences 37/3 (2007), 173-175. |
