Cerebrospinal fluid and serum levels of insulin-like growth factor-1 and insulin-like growth factor binding protein-3 in patients with severe head injury

IS, Melih; COŞKUN, Abdurahman; HANIMOĞLU, Hakan; UZAN, Mustafa; Sanus, Galip Zihni; TANRIVERDİ, Taner

Cerebrospinal fluid and serum levels of insulin-like growth factor-1 and insulin-like growth factor binding protein-3 in patients with severe head injury

Galip Zihni SANUS, (İstanbul Üniversitesi, Cerrahpaşa Tıp Fakültesi, Nöroşirürji Anabilim Dalı, İstanbul, Türkiye)

Taner TANRIVERDİ, (İstanbul Üniversitesi, Cerrahpaşa Tıp Fakültesi, Nöroşirürji Anabilim Dalı, İstanbul, Türkiye)

Abdurahman COŞKUN, (İstanbul Üniversitesi, Cerrahpaşa Tıp Fakültesi, Nöroşirürji Anabilim Dalı, İstanbul, Türkiye)

Hakan HANIMOĞLU, (İstanbul Üniversitesi, Cerrahpaşa Tıp Fakültesi, Nöroşirürji Anabilim Dalı, İstanbul, Türkiye)

Melih IS, (İstanbul Üniversitesi, Cerrahpaşa Tıp Fakültesi, Biyokimya Anabilim Dalı, İstanbul)

Mustafa UZAN (İstanbul Üniversitesi, Cerrahpaşa Tıp Fakültesi, Nöroşirürji Anabilim Dalı, İstanbul, Türkiye)

Ulusal Travma ve Acil Cerrahi Dergisi

1 1

Yıl: 2007 Cilt: 13 Sayı: 4 Sayfa Aralığı: 281 - 287 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Cerebrospinal fluid and serum levels of insulin-like growth factor-1 and insulin-like growth factor binding protein-3 in patients with severe head injury

Öz:

AMAÇ: Bu çalışmanın amacı, insülin benzeri büyüme faktörü-1 (IGF-1) ve insülin-benzeri bağlama protein-3 (IGFBP-3) moleküllerinin ciddi kafa travması sonrası serumda ve beyin omurlik sıvısı’ndaki (BOS) seviyelerini ölçmek ve kontrol grubu ile karşılaştırmaktır. GEREÇ-YÖNTEM: Travma ve kontrol gruplarımızı sırası ile ağır kafa travmalı 11 hasta ile 9 hidrosefalili (bir hasta normal basınçlı diğer sekiz hasta akuaduktus stenozuna bağlı hidrosefali) hasta oluşturdu. Hastalardan alınan serum ve BOS örneklerinde IGF-1 ve IGFBP-3 seviyeleri kafa travması sonrası ölçüldü ve seviyeleri kontrol grubu ile karşılaştırıldı. BULGULAR: Gerek hasta ve gerekse de kontrol grubunda BOS, IGF-1 ve IGFBP-3 seviyeleri ölçülemeyecek derecede düşüktü. Serum seviyelerine bakıldığında ise, hasta grubu kontrol grubuna göre her zaman daha yüksek IGF-1 ve IGFBP-3 değerleri saptandı. SONUÇ: Ağır kafa travmasının akut veya kronik dönemlerde IGF-1 verilmesi yarar sağlayabilir ve insanlarda mortalite ve morbiditeyi azaltabilir.

Anahtar Kelime: Yaralanma şiddeti skoru Beyin omurilik sıvısı İnsülin-benzeri büyüme faktörü I Kranioserebral travma Orta yaşlı İnsülin-benzeri büyüme faktörü bağlayıcı protein 3

Konular: Cerrahi

Ağır kafa travmalı hastalarda beyin omurilik sıvısı ve serum IGF-1 ve IGFBP-3 değerleri

Öz:

BACKGROUND: The aim of this study is to present time course of insulin like growth factor-1 (IGF-1) and insulin-like growth factor binding protein-3 (IGFBP-3) levels in both cerebrospinal fluid (CSF) and serum of patients after severe head injury (SHI) and to compare with controls. METHODS: Our trauma and control groups included 11 consecutive patients with isolated SHI and 9 patients with hydrocephalus (one with normotensive and eight with hydrocephalus due to aqueduct stenosis), respectively. Both serum and cerebrospinal fluid levels of IGF-1 and IGFBP-3 were measured during post-traumatic days and we compared the levels with controls. RESULTS: Patients and controls showed undetectable levels of both IGF-1 and IGFBP-3 in their CSF. When considering serum levels, patients with SHI had always lower levels of both molecules than that of controls. CONCLUSION: Administration of IGF-1 during acute, as well as chronic phase of severe head trauma may provide beneficial effects and may decrease both mortality and morbidity in humans with SHI.

Anahtar Kelime: Middle Aged Insulin-Like Growth Factor Binding Protein 3 Injury Severity Score Cerebrospinal Fluid Insulin-Like Growth Factor I Craniocerebral Trauma

Konular: Cerrahi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

1. Walter HJ, Berry M, Hill DJ, Logan A. Spatial and temporal changes in the insulin-like growth factor (IGF) axis indicate autocrine/paracrine actions of IGF-I within wounds of the rat brain. Endocrinology 1997;138:3024-34.
2. Saatman KE, Contreras PC, Smith DH, Raghupathi R, McDermott KL, Fernandez SC, et al. Insulin-like growth factor-1 (IGF-1) improves both neurological motor and cognitive outcome following experimental brain injury. Exp Neurol 1997;147:418-27.
3. Kazanis I, Bozas E, Philippidis H, Stylianopoulou F. Neuroprotective effects of insulin-like growth factor-I (IGF-I) following a penetrating brain injury in rats. Brain Res 2003;991:34-45.
4. Kazanis I, Giannakopoulou M, Philippidis H, Stylianopoulou F. Alterations in IGF-I, BDNF and NT-3 levels following experimental brain trauma and the effect of IGF-I administration. Exp Neurol 2004;186:221-34.
5. de Pablo F, de la Rosa EJ. The developing CNS: a scenario for the action of proinsulin, insulin and insulin-like growth factors. Trends Neurosci 1995;18:143-50.
6. Jones JI, Clemmons DR. Insulin-like growth factors and their binding proteins: biological actions. Endocr Rev 1995;16:3-34.
7. Sandberg Nordqvist AC, von Holst H, Holmin S, Sara VR, Bellander BM, Schalling M. Increase of insulin-like growth factor (IGF)-1, IGF binding protein-2 and -4 mRNAs following cerebral contusion. Brain Res Mol Brain Res 1996;38:285-93.
8. Yao DL, West NR, Bondy CA, Brenner M, Hudson LD, Zhou J, et al. Cryogenic spinal cord injury induces astrocytic gene expression of insulin-like growth factor I and insulin-like growth factor binding protein 2 during myelin regeneration. J Neurosci Res 1995;40:647-59.
9. Lalou C, Lassarre C, Binoux M. A proteolytic fragment of insulin-like growth factor (IGF) binding protein-3 that fails to bind IGFs inhibits the mitogenic effects of IGF-I and insulin. Endocrinology 1996;137:3206-12.
10. Booth BA, Boes M, Bar RS. IGFBP-3 proteolysis by plasmin, thrombin, serum: heparin binding, IGF binding, and structure of fragments. Am J Physiol 1996;271(3 Pt1):E465-70.
11. Beeton CA, Brooks RA, Chatfield D, Human M, Rushton N. Circulating levels of insulin-like growth factor-1 and insulin-like growth factor binding protein-3 in patients with severe head injury. J Bone Joint Surg [Br] 2002;84:434-9.
12. Yu H, Mistry J, Nicar MJ, Khosravi MJ, Diamandis A, van Doorn J, et al. Insulin-like growth factors (IGF-I, free IGF-I and IGF-II) and insulin-like growth factor binding proteins (IGFBP-2, IGFBP-3, IGFBP-6, and ALS) in blood circulation. J Clin Lab Anal 1999;13:166-72.
13. Van den Berghe G, de Zegher F. Anterior pituitary function during critical illness and dopamine treatment. Crit Care Med 1996;24:1580-90.
14. Gibson FA, Hinds CJ. Growth hormone and insulin-like growth factors in critical illness. Intensive Care Med 1997;23:369-78.
15. Bondanelli M, Ambrosio MR, Margutti A, Boldrini P, Basaglia N, Franceschetti P, et al. Evidence for integrity of the growth hormone/insulin-like growth factor-1 axis in patients with severe head trauma during rehabilitation. Metabolism 2002;51:1363-9.
16. De Marinis L, Mancini A, Valle D, Bianchi A, Gentilella R, Liberale I, et al. Hypothalamic derangement in traumatized patients: growth hormone (GH) and prolactin response to thyrotrophin-releasing hormone and GHreleasing hormone. Clin Endocrinol (Oxf) 1999;50:741-7.
17. King LR, Knowles HC Jr, McLaurin RL, Brielmaier J, Perisutti G, Piziak VK. Pituitary hormone response to head injury. Neurosurgery 1981;9:229-35.
18. Knusel B, Michel PP, Schwaber JS, Hefti F. Selective and nonselective stimulation of central cholinergic and dopaminergic development in vitro by nerve growth factor, basic fibroblast growth factor, epidermal growth factor, insulin and the insulin-like growth factors I and II. J Neurosci 1990;10:558-70.
19. Nakao N, Odin P, Lindvall O, Brundin P. Differential trophic effects of basic fibroblast growth factor, insulinlike growth factor-1, and neurotrophin-3 on striatal neurons in culture. Exp Neurol 1996;138:144-57.
20. Svrzic D, Schubert D. Insulin-like growth factor 1 supports embryonic nerve cell survival. Biochem Biophys Res Commun 1990;172:54-60.
21. Mattson MP, Cheng B. Growth factors protect neurons against excitotoxic/ischemic damage by stabilizing calcium homeostasis. Stroke 1993;24(12 Suppl):I136-40.
22. Zhang Y, Tatsuno T, Carney JM, Mattson MP. Basic FGF, NGF, and IGFs protect hippocampal and cortical neurons against iron-induced degeneration. J Cereb Blood Flow Metab 1993;13:378-88.
23. Kanje M, Skottner A, Sjöberg J, Lundborg G. Insulin-like growth factor I (IGF-I) stimulates regeneration of the rat sciatic nerve. Brain Res 1989;486:396-8
24. Sjöberg J, Kanje M. Insulin-like growth factor (IGF-1) as a stimulator of regeneration in the freeze-injured rat sciatic nerve. Brain Res 1989;485:102-8.
25. Gluckman P, Klempt N, Guan J, Mallard C, Sirimanne E, Dragunow M, et al. A role for IGF-1 in the rescue of CNS neurons following hypoxic-ischemic injury. Biochem Biophys Res Commun 1992;182:593-9.
26. Guan J, Williams C, Gunning M, Mallard C, Gluckman P. The effects of IGF-1 treatment after hypoxic-ischemic brain injury in adult rats. J Cereb Blood Flow Metab 1993;13:609-16.
27. Mason JL, Ye P, Suzuki K, D'Ercole AJ, Matsushima GK. Insulin-like growth factor-1 inhibits mature oligodendrocyte apoptosis during primary demyelination. J Neurosci 2000;20:5703-8.
28. Woods AG, Guthrie KM, Kurlawalla MA, Gall CM. Deafferentation-induced increases in hippocampal insulin-like growth factor-1 messenger RNA expression are severely attenuated in middle aged and aged rats. Neuroscience 1998;83:663-8.

APA	Sanus G, TANRIVERDİ T, COŞKUN A, HANIMOĞLU H, IS M, UZAN M (2007). Cerebrospinal fluid and serum levels of insulin-like growth factor-1 and insulin-like growth factor binding protein-3 in patients with severe head injury. , 281 - 287.
Chicago	Sanus Galip Zihni,TANRIVERDİ Taner,COŞKUN Abdurahman,HANIMOĞLU Hakan,IS Melih,UZAN Mustafa Cerebrospinal fluid and serum levels of insulin-like growth factor-1 and insulin-like growth factor binding protein-3 in patients with severe head injury. (2007): 281 - 287.
MLA	Sanus Galip Zihni,TANRIVERDİ Taner,COŞKUN Abdurahman,HANIMOĞLU Hakan,IS Melih,UZAN Mustafa Cerebrospinal fluid and serum levels of insulin-like growth factor-1 and insulin-like growth factor binding protein-3 in patients with severe head injury. , 2007, ss.281 - 287.
AMA	Sanus G,TANRIVERDİ T,COŞKUN A,HANIMOĞLU H,IS M,UZAN M Cerebrospinal fluid and serum levels of insulin-like growth factor-1 and insulin-like growth factor binding protein-3 in patients with severe head injury. . 2007; 281 - 287.
Vancouver	Sanus G,TANRIVERDİ T,COŞKUN A,HANIMOĞLU H,IS M,UZAN M Cerebrospinal fluid and serum levels of insulin-like growth factor-1 and insulin-like growth factor binding protein-3 in patients with severe head injury. . 2007; 281 - 287.
IEEE	Sanus G,TANRIVERDİ T,COŞKUN A,HANIMOĞLU H,IS M,UZAN M "Cerebrospinal fluid and serum levels of insulin-like growth factor-1 and insulin-like growth factor binding protein-3 in patients with severe head injury." , ss.281 - 287, 2007.
ISNAD	Sanus, Galip Zihni vd. "Cerebrospinal fluid and serum levels of insulin-like growth factor-1 and insulin-like growth factor binding protein-3 in patients with severe head injury". (2007), 281-287.

APA	Sanus G, TANRIVERDİ T, COŞKUN A, HANIMOĞLU H, IS M, UZAN M (2007). Cerebrospinal fluid and serum levels of insulin-like growth factor-1 and insulin-like growth factor binding protein-3 in patients with severe head injury. Ulusal Travma ve Acil Cerrahi Dergisi, 13(4), 281 - 287.
Chicago	Sanus Galip Zihni,TANRIVERDİ Taner,COŞKUN Abdurahman,HANIMOĞLU Hakan,IS Melih,UZAN Mustafa Cerebrospinal fluid and serum levels of insulin-like growth factor-1 and insulin-like growth factor binding protein-3 in patients with severe head injury. Ulusal Travma ve Acil Cerrahi Dergisi 13, no.4 (2007): 281 - 287.
MLA	Sanus Galip Zihni,TANRIVERDİ Taner,COŞKUN Abdurahman,HANIMOĞLU Hakan,IS Melih,UZAN Mustafa Cerebrospinal fluid and serum levels of insulin-like growth factor-1 and insulin-like growth factor binding protein-3 in patients with severe head injury. Ulusal Travma ve Acil Cerrahi Dergisi, vol.13, no.4, 2007, ss.281 - 287.
AMA	Sanus G,TANRIVERDİ T,COŞKUN A,HANIMOĞLU H,IS M,UZAN M Cerebrospinal fluid and serum levels of insulin-like growth factor-1 and insulin-like growth factor binding protein-3 in patients with severe head injury. Ulusal Travma ve Acil Cerrahi Dergisi. 2007; 13(4): 281 - 287.
Vancouver	Sanus G,TANRIVERDİ T,COŞKUN A,HANIMOĞLU H,IS M,UZAN M Cerebrospinal fluid and serum levels of insulin-like growth factor-1 and insulin-like growth factor binding protein-3 in patients with severe head injury. Ulusal Travma ve Acil Cerrahi Dergisi. 2007; 13(4): 281 - 287.
IEEE	Sanus G,TANRIVERDİ T,COŞKUN A,HANIMOĞLU H,IS M,UZAN M "Cerebrospinal fluid and serum levels of insulin-like growth factor-1 and insulin-like growth factor binding protein-3 in patients with severe head injury." Ulusal Travma ve Acil Cerrahi Dergisi, 13, ss.281 - 287, 2007.
ISNAD	Sanus, Galip Zihni vd. "Cerebrospinal fluid and serum levels of insulin-like growth factor-1 and insulin-like growth factor binding protein-3 in patients with severe head injury". Ulusal Travma ve Acil Cerrahi Dergisi 13/4 (2007), 281-287.