Does cardiopulmonary bypass change serum neuron-specific enolase levels?

ALTUN, Çağatay; BADAK, M. İsmail; ÖZKISACIK, Erdem A.; GÜRCÜN, Uğur; BOĞA, Mehmet; BÜYÜKÖZTÜRK KARUL, ASLIHAN; DİŞCİGİL, BERENT

Does cardiopulmonary bypass change serum neuron-specific enolase levels?

Erdem A. ÖZKISACIK, (Adnan Menderes Üniversitesi, Tıp Fakültesi, Kalp ve Damar Cerrahisi Anabilim Dalı, Aydın, Türkiye)

Çağatay ALTUN, (Adnan Menderes Üniversitesi, Tıp Fakültesi, Biyokimya Anabilim Dalı, Aydın, Türkiye)

BERENT DİŞCİGİL, (Adnan Menderes Üniversitesi, Tıp Fakültesi, Kalp ve Damar Cerrahisi Anabilim Dalı, Aydın, Türkiye)

Uğur GÜRCÜN, (Adnan Menderes Üniversitesi, Tıp Fakültesi, Kalp ve Damar Cerrahisi Anabilim Dalı, Aydın, Türkiye)

Mehmet BOĞA, (Adnan Menderes Üniversitesi, Tıp Fakültesi, Kalp ve Damar Cerrahisi Anabilim Dalı, Aydın, Türkiye)

M. İsmail BADAK, (Adnan Menderes Üniversitesi, Tıp Fakültesi, Kalp ve Damar Cerrahisi Anabilim Dalı, Aydın, Türkiye)

ASLIHAN BÜYÜKÖZTÜRK KARUL (Adnan Menderes Üniversitesi, Tıp Fakültesi, Biyokimya Anabilim Dalı, Aydın, Türkiye)

Anadolu Kardiyoloji Dergisi

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Yıl: 2007 Cilt: 7 Sayı: 4 Sayfa Aralığı: 411 - 414 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Does cardiopulmonary bypass change serum neuron-specific enolase levels?

Öz:

Amaç: Kardiyopulmoner baypasın (KPB) nörolojik fonksiyon bozukluğu olmayan hastalardaki etkisi henüz tam olarak açıklığa kavuşturulabilmiş değildir. Bu çalışma, nörolojik hasar bulgusu olmayan hastalarda, sadece ekstrakorporeal dolaşımın serum nöron spesifik enolaz (NSE) düzeyleri üzerine olan etkisini araştırmak için düzenlenmiştir.Yöntemler: Bu prospektif çalışmaya kliniğimizde elektif açık kalp cerrahisi uygulanan ardışık 32 hasta alındı. Hastaların preoperatif ve postoperatif dönem 24. ve 48. saatlerinde nörolojik muayeneleri yapıldı. Anestezi indüksiyonu sonrasında, kardiyopulmoner baypas’ın 1., 24. ve 48. saatlerinde kan örnekleri alındı. Tüm kan örneklerinde hemoglobin (Hb) ve NSE düzeylerine bakıldı. Preoperatif ve postoperatif, NSE ve Hb düzeylerinin karşılaştırılması için Friedman's Test ve post-hoc Tukey test kullanıldı. Nöron spesifik enolaz ve kardiyopulmoner baypas süresi, aortik kros-klemp süresi, hasta yaşı, hematokrit ve hemoglobin düzeyleri arasındaki ilişki için Pearson korelasyon testi uygulandı. Bulgular: Operasyondan hemen sonra ve postoperatif 1. günde bakılan serum nöron spesifik enolaz düzeyleri, preoperatif dönemdeki düzeylerine göre daha düşük bulundu, ancak istatistiksel olarak anlamlı bir fark saptanmadı (11.6±8.0 mg/dL, 8.7±4.7 mg/dL, 9.3±5.4 mg/dL ve 8.9±5.8 mg/dL). Serum NSE düzeyleri ile kardiyopulmoner baypas süreleri arasında anlamlı bir korelasyon saptanmadı. Sonuç: Çalışmamızda kardiyopulmoner baypas ile santral sinir sisteminde ve kan hücrelerinde, serum NSE düzeylerini yükseltecek düzeyde olumsuz etkisinin olmadığı görülmüştür.

Anahtar Kelime: Kalp septal defektleri, atrial Fosfopirüvat hidrataz Biyolojik belirteçler Olgu-kontrol çalışmaları Kardiyopulmoner bypass İskemik atak, geçici Koroner hastalık

Konular: Kalp ve Kalp Damar Sistemi

Kardiyopulmoner baypas serum nöron spesifik enolaz düzeyini değiştiriyor mu?

Öz:

Objective: The effects of cardiopulmonary bypass (CPB) on serum neuron-specific enolase (NSE) levels in patients without cognitive dysfunction and neurological deficit are not yet clarified. This study was designed to see the sole effect of extracorporeal circulation on serum NSE levels in patients without any clinically observed neurological deficit.Methods: Thirty-two consecutive patients undergoing first elective open-heart surgery were included in this prospective study. Neurological status was assessed by clinical examination before surgery, and on the postoperative first and second days. Blood samples were obtained afteranesthesia induction before the administration of heparin, within the first hour post CPB, 24 and 48 hours after the end of operation. Each bloodsample was assayed for hemoglobin (Hb), hematocrit and NSE levels. The Friedman's Test to compare the serial measurements of NSE andhemoglobin samples and the post-hoc Tukey test for paired comparisons between pre and postoperative values were applied Pearson correlation test was used to examine the correlation between NSE concentration and aortic cross-clamping time and CPB time, age, postoperative hematocrit and hemoglobin levels and the amount of blood products transfusion.Results: There were no significant differences between NSE values at any sampling time: 11.6±8.0 mg/dL, 8.7±4.7 mg/dL, 9.3±5.4 mg/dL and 8.9±5.8 mg/dL, measured preoperatively, at the end of operation, on the first and second post-operative days, respectively. There was no significantcorrelation between NSE values with any of the compared variables including CPB time.Conclusion: This study demonstrated that the possible damage of CPB on central nervous system and on blood cells did not reach to the extent ofcausing any significant increase in serum NSE levels in non-complicated patients undergoing open-heart surgery.

Anahtar Kelime: Biological Markers Case-Control Studies Cardiopulmonary Bypass Ischemic Attack, Transient Coronary Disease Heart Septal Defects, Atrial Phosphopyruvate Hydratase

Konular: Kalp ve Kalp Damar Sistemi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	ÖZKISACIK E, ALTUN Ç, DİŞCİGİL B, GÜRCÜN U, BOĞA M, BADAK M, BÜYÜKÖZTÜRK KARUL A (2007). Does cardiopulmonary bypass change serum neuron-specific enolase levels?. , 411 - 414.
Chicago	ÖZKISACIK Erdem A.,ALTUN Çağatay,DİŞCİGİL BERENT,GÜRCÜN Uğur,BOĞA Mehmet,BADAK M. İsmail,BÜYÜKÖZTÜRK KARUL ASLIHAN Does cardiopulmonary bypass change serum neuron-specific enolase levels?. (2007): 411 - 414.
MLA	ÖZKISACIK Erdem A.,ALTUN Çağatay,DİŞCİGİL BERENT,GÜRCÜN Uğur,BOĞA Mehmet,BADAK M. İsmail,BÜYÜKÖZTÜRK KARUL ASLIHAN Does cardiopulmonary bypass change serum neuron-specific enolase levels?. , 2007, ss.411 - 414.
AMA	ÖZKISACIK E,ALTUN Ç,DİŞCİGİL B,GÜRCÜN U,BOĞA M,BADAK M,BÜYÜKÖZTÜRK KARUL A Does cardiopulmonary bypass change serum neuron-specific enolase levels?. . 2007; 411 - 414.
Vancouver	ÖZKISACIK E,ALTUN Ç,DİŞCİGİL B,GÜRCÜN U,BOĞA M,BADAK M,BÜYÜKÖZTÜRK KARUL A Does cardiopulmonary bypass change serum neuron-specific enolase levels?. . 2007; 411 - 414.
IEEE	ÖZKISACIK E,ALTUN Ç,DİŞCİGİL B,GÜRCÜN U,BOĞA M,BADAK M,BÜYÜKÖZTÜRK KARUL A "Does cardiopulmonary bypass change serum neuron-specific enolase levels?." , ss.411 - 414, 2007.
ISNAD	ÖZKISACIK, Erdem A. vd. "Does cardiopulmonary bypass change serum neuron-specific enolase levels?". (2007), 411-414.

APA	ÖZKISACIK E, ALTUN Ç, DİŞCİGİL B, GÜRCÜN U, BOĞA M, BADAK M, BÜYÜKÖZTÜRK KARUL A (2007). Does cardiopulmonary bypass change serum neuron-specific enolase levels?. Anadolu Kardiyoloji Dergisi, 7(4), 411 - 414.
Chicago	ÖZKISACIK Erdem A.,ALTUN Çağatay,DİŞCİGİL BERENT,GÜRCÜN Uğur,BOĞA Mehmet,BADAK M. İsmail,BÜYÜKÖZTÜRK KARUL ASLIHAN Does cardiopulmonary bypass change serum neuron-specific enolase levels?. Anadolu Kardiyoloji Dergisi 7, no.4 (2007): 411 - 414.
MLA	ÖZKISACIK Erdem A.,ALTUN Çağatay,DİŞCİGİL BERENT,GÜRCÜN Uğur,BOĞA Mehmet,BADAK M. İsmail,BÜYÜKÖZTÜRK KARUL ASLIHAN Does cardiopulmonary bypass change serum neuron-specific enolase levels?. Anadolu Kardiyoloji Dergisi, vol.7, no.4, 2007, ss.411 - 414.
AMA	ÖZKISACIK E,ALTUN Ç,DİŞCİGİL B,GÜRCÜN U,BOĞA M,BADAK M,BÜYÜKÖZTÜRK KARUL A Does cardiopulmonary bypass change serum neuron-specific enolase levels?. Anadolu Kardiyoloji Dergisi. 2007; 7(4): 411 - 414.
Vancouver	ÖZKISACIK E,ALTUN Ç,DİŞCİGİL B,GÜRCÜN U,BOĞA M,BADAK M,BÜYÜKÖZTÜRK KARUL A Does cardiopulmonary bypass change serum neuron-specific enolase levels?. Anadolu Kardiyoloji Dergisi. 2007; 7(4): 411 - 414.
IEEE	ÖZKISACIK E,ALTUN Ç,DİŞCİGİL B,GÜRCÜN U,BOĞA M,BADAK M,BÜYÜKÖZTÜRK KARUL A "Does cardiopulmonary bypass change serum neuron-specific enolase levels?." Anadolu Kardiyoloji Dergisi, 7, ss.411 - 414, 2007.
ISNAD	ÖZKISACIK, Erdem A. vd. "Does cardiopulmonary bypass change serum neuron-specific enolase levels?". Anadolu Kardiyoloji Dergisi 7/4 (2007), 411-414.