Effects of different therapies on articular cartilage in experimental severe osteoarthritis

Hepgüler, Simin; eyigor, sibel; ÇAPACI, KAZIM; ÖZTOP, Fikri; SEZAK, Murat

Effects of different therapies on articular cartilage in experimental severe osteoarthritis

Sibel EYİGÖR, (Ege Üniversitesi, Tıp Fakültesi, Fiziksel Tıp ve Rehabilitasyon Anabilim Dalı, İzmir, Türkiye)

Simin HEPGÜLER, (Ege Üniversitesi, Tıp Fakültesi, Fiziksel Tıp ve Rehabilitasyon Anabilim Dalı, İzmir, Türkiye)

Murat SEZAK, (Ege Üniversitesi, Tıp Fakültesi, Patoloji Anabilim Dalı, İzmir, Türkiye)

Fikri ÖZTOP, (Ege Üniversitesi, Tıp Fakültesi, Patoloji Anabilim Dalı, İzmir, Türkiye)

Kazım ÇAPACI (Ege Üniversitesi, Tıp Fakültesi, Fiziksel Tıp ve Rehabilitasyon Anabilim Dalı, İzmir, Türkiye)

Türkiye Fiziksel Tıp ve Rehabilitasyon Dergisi

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Yıl: 2006 Cilt: 52 Sayı: 3 Sayfa Aralığı: 90 - 95 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Effects of different therapies on articular cartilage in experimental severe osteoarthritis

Öz:

Amaç: Deneysel şiddetli osteoartritte (OA), intraartiküler metilprednizalon, hyaluronik asit (HA) ve terapötik ultrasonun, osteoartrit lezyonları üzerine etkisini incelemek. Gereç ve Yöntem: Otuzbeş adet New Zealand tipi yetişkin tavşan çalışmaya alındı. Her iki dize, 2 mg papain enjeksiyonu ile deneysel OA oluşturuldu. İntraartiküler papain enjeksiyonundan 5 hafta sonra tavşanlar 3 gruba ayrıldı. Grup 1'deki 12 tavşanın sağ dizine, 1 hafta ara ile 3 hafta boyunca, 20 mg metilprednizolon enjekte edildi. Grup 2'deki 10 tavşanın sağ dizine, 1 hafta ara ile 3 hafta boyunca, 0,4 ml HA (konsantrasyon; 15 mg/ml) enjekte edildi. Grup 3'deki 10 tavşanın sağ dizine, yoğunluğu 0,5 W/cm2 olmak üzere, 7 dakika puls US tedavisi 10 kez uygulandı. Sol dizler kontrol olarak alındı. Kondil ve platolardaki kartilaj lezyonlarının ölçümü makroskobik değerlendirme ile, lezyon şiddeti ise histolojik değerlendirme ile yapıldı. Bulgular: Tedavi sonunda, kondil ve platodaki kartilaj lezyonlarının makroskobik ve histolojik evreleri arasında gruplar arasında istatistiksel anlamlı fark gözlenmedi (p>0,05). Her gruptaki tavşanların tedavi edilen ve kontrol dizleri arasında da anlamlı değişiklik saptanmadı (p>0,05). Sonuç: Bu çalışmada, şiddetli osteoartritteki kartilaj lezyonlarında, uygulanan tedavilerden hiçbiri etkili bulunmamıştır.

Anahtar Kelime: Osteoartrit Kıkırdak, eklem Hastalık modelleri, hayvan Hastalık ciddiyet indeksi Tavşanlar Tedavi

Konular: Rehabilitasyon

Deneysel şiddetli osteoartritte farklı tedavilerin eklem kartilajına etkisi

Öz:

Objective: To examine the effect of intraarticular injections of methylprednisolone, hyaluronic acid and therapeutic ultrasound on osteoarthritic lesions in experimental severe osteoarthritis (OA). Materials and Methods: Thirty five adult white New Zealand rabbits were used in this study. The experimental OA was induced by the injection of papain (2 mg) to the knee joints bilaterally. Five weeks after the intraarticular injection of papain, rabbits were divided into 3 groups. Group 1: In 12 rabbits, 20 mg methylprednisolone was injected into the right knee once weekly for three weeks. Group 2: In 10 rabbits, 0.4 ml of HA (concentration 15 mg per ml) was injected into the right knee once weekly for three weeks. Group 3: In 10 rabbits 7 min. pulse sonication (US) was applied to the right knees with an intensity of 0.5 W/cm2 once daily for a total of 10 times. The left knee joints were used as controls. Surface cartilage lesions on the condyles and plateaus was evaluated macroscobically, where as lesion severity was evaluated histologically. Results: There were no significant differences between the groups for macroscopic and histologic grades of cartilage lesions on condyles and plateaus at the end of the treatment (p>0.05). Furthermore no statistically significant difference was observed between the treated and control knees of the rabbits in each group (p>0.05). Conclusion: In this study, none of the treatments applied were found to be effective in cartilage lesions in severe OA.

Anahtar Kelime: Therapy Osteoarthritis Cartilage, Articular Disease Models, Animal Severity of Illness Index Rabbits

Konular: Rehabilitasyon

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	eyigor s, Hepgüler S, SEZAK M, ÖZTOP F, ÇAPACI K (2006). Effects of different therapies on articular cartilage in experimental severe osteoarthritis. , 90 - 95.
Chicago	eyigor sibel,Hepgüler Simin,SEZAK Murat,ÖZTOP Fikri,ÇAPACI KAZIM Effects of different therapies on articular cartilage in experimental severe osteoarthritis. (2006): 90 - 95.
MLA	eyigor sibel,Hepgüler Simin,SEZAK Murat,ÖZTOP Fikri,ÇAPACI KAZIM Effects of different therapies on articular cartilage in experimental severe osteoarthritis. , 2006, ss.90 - 95.
AMA	eyigor s,Hepgüler S,SEZAK M,ÖZTOP F,ÇAPACI K Effects of different therapies on articular cartilage in experimental severe osteoarthritis. . 2006; 90 - 95.
Vancouver	eyigor s,Hepgüler S,SEZAK M,ÖZTOP F,ÇAPACI K Effects of different therapies on articular cartilage in experimental severe osteoarthritis. . 2006; 90 - 95.
IEEE	eyigor s,Hepgüler S,SEZAK M,ÖZTOP F,ÇAPACI K "Effects of different therapies on articular cartilage in experimental severe osteoarthritis." , ss.90 - 95, 2006.
ISNAD	eyigor, sibel vd. "Effects of different therapies on articular cartilage in experimental severe osteoarthritis". (2006), 90-95.

APA	eyigor s, Hepgüler S, SEZAK M, ÖZTOP F, ÇAPACI K (2006). Effects of different therapies on articular cartilage in experimental severe osteoarthritis. Türkiye Fiziksel Tıp ve Rehabilitasyon Dergisi, 52(3), 90 - 95.
Chicago	eyigor sibel,Hepgüler Simin,SEZAK Murat,ÖZTOP Fikri,ÇAPACI KAZIM Effects of different therapies on articular cartilage in experimental severe osteoarthritis. Türkiye Fiziksel Tıp ve Rehabilitasyon Dergisi 52, no.3 (2006): 90 - 95.
MLA	eyigor sibel,Hepgüler Simin,SEZAK Murat,ÖZTOP Fikri,ÇAPACI KAZIM Effects of different therapies on articular cartilage in experimental severe osteoarthritis. Türkiye Fiziksel Tıp ve Rehabilitasyon Dergisi, vol.52, no.3, 2006, ss.90 - 95.
AMA	eyigor s,Hepgüler S,SEZAK M,ÖZTOP F,ÇAPACI K Effects of different therapies on articular cartilage in experimental severe osteoarthritis. Türkiye Fiziksel Tıp ve Rehabilitasyon Dergisi. 2006; 52(3): 90 - 95.
Vancouver	eyigor s,Hepgüler S,SEZAK M,ÖZTOP F,ÇAPACI K Effects of different therapies on articular cartilage in experimental severe osteoarthritis. Türkiye Fiziksel Tıp ve Rehabilitasyon Dergisi. 2006; 52(3): 90 - 95.
IEEE	eyigor s,Hepgüler S,SEZAK M,ÖZTOP F,ÇAPACI K "Effects of different therapies on articular cartilage in experimental severe osteoarthritis." Türkiye Fiziksel Tıp ve Rehabilitasyon Dergisi, 52, ss.90 - 95, 2006.
ISNAD	eyigor, sibel vd. "Effects of different therapies on articular cartilage in experimental severe osteoarthritis". Türkiye Fiziksel Tıp ve Rehabilitasyon Dergisi 52/3 (2006), 90-95.