Yıl: 2008 Cilt: 32 Sayı: 2 Sayfa Aralığı: 147 - 155 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

Synthesis and antimicrobial activites of 1,2,4-oxadiazin-5-one, 6-one and 5-thiones

Öz:
N-Substituted pyridine carboxamide oximes (2) were obtained from the reactions of pyridine hydroxamic acid chloride hydrochlorides (1) with primary amines. The reactions of carboxamide oximes with chloroacetyl chloride in the presence of triethylamine gave the corresponding 3,4-disubstituted- 1,2,4-oxadiazin-5-ones (3), which on treatment with P2S5 gave in moderate yielded the corresponding 3,4-disubstituted-1,2,4-oxadiazin-5-thiones (4). The reaction of pyridine carboxamide oximes with $alpha$- aminoacid ester led to the formation of 3,5-disubstituted-1,2,4-oxadiazin-6-ones (5) in moderate yields. The structures of the prepared compound were evaluated by spectroscopy. Some of the representatives of 3,4-disubstituted-1,2,4-oxadiazin-5-ones, thiones, and 3,5-disubstituted-1,2,4-oxadiazin-6-ones were screened for antibacterial activity using disc diffusion. It was found that all the tested compounds have good antimicrobial activities.
Anahtar Kelime:

Konular: Mühendislik, Kimya
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA ARIKAN ÖLMEZ N, SÜMENGEN D, Dulger B (2008). Synthesis and antimicrobial activites of 1,2,4-oxadiazin-5-one, 6-one and 5-thiones. , 147 - 155.
Chicago ARIKAN ÖLMEZ NEVİN,SÜMENGEN Doğan,Dulger Basaran Synthesis and antimicrobial activites of 1,2,4-oxadiazin-5-one, 6-one and 5-thiones. (2008): 147 - 155.
MLA ARIKAN ÖLMEZ NEVİN,SÜMENGEN Doğan,Dulger Basaran Synthesis and antimicrobial activites of 1,2,4-oxadiazin-5-one, 6-one and 5-thiones. , 2008, ss.147 - 155.
AMA ARIKAN ÖLMEZ N,SÜMENGEN D,Dulger B Synthesis and antimicrobial activites of 1,2,4-oxadiazin-5-one, 6-one and 5-thiones. . 2008; 147 - 155.
Vancouver ARIKAN ÖLMEZ N,SÜMENGEN D,Dulger B Synthesis and antimicrobial activites of 1,2,4-oxadiazin-5-one, 6-one and 5-thiones. . 2008; 147 - 155.
IEEE ARIKAN ÖLMEZ N,SÜMENGEN D,Dulger B "Synthesis and antimicrobial activites of 1,2,4-oxadiazin-5-one, 6-one and 5-thiones." , ss.147 - 155, 2008.
ISNAD ARIKAN ÖLMEZ, NEVİN vd. "Synthesis and antimicrobial activites of 1,2,4-oxadiazin-5-one, 6-one and 5-thiones". (2008), 147-155.
APA ARIKAN ÖLMEZ N, SÜMENGEN D, Dulger B (2008). Synthesis and antimicrobial activites of 1,2,4-oxadiazin-5-one, 6-one and 5-thiones. Turkish Journal of Chemistry, 32(2), 147 - 155.
Chicago ARIKAN ÖLMEZ NEVİN,SÜMENGEN Doğan,Dulger Basaran Synthesis and antimicrobial activites of 1,2,4-oxadiazin-5-one, 6-one and 5-thiones. Turkish Journal of Chemistry 32, no.2 (2008): 147 - 155.
MLA ARIKAN ÖLMEZ NEVİN,SÜMENGEN Doğan,Dulger Basaran Synthesis and antimicrobial activites of 1,2,4-oxadiazin-5-one, 6-one and 5-thiones. Turkish Journal of Chemistry, vol.32, no.2, 2008, ss.147 - 155.
AMA ARIKAN ÖLMEZ N,SÜMENGEN D,Dulger B Synthesis and antimicrobial activites of 1,2,4-oxadiazin-5-one, 6-one and 5-thiones. Turkish Journal of Chemistry. 2008; 32(2): 147 - 155.
Vancouver ARIKAN ÖLMEZ N,SÜMENGEN D,Dulger B Synthesis and antimicrobial activites of 1,2,4-oxadiazin-5-one, 6-one and 5-thiones. Turkish Journal of Chemistry. 2008; 32(2): 147 - 155.
IEEE ARIKAN ÖLMEZ N,SÜMENGEN D,Dulger B "Synthesis and antimicrobial activites of 1,2,4-oxadiazin-5-one, 6-one and 5-thiones." Turkish Journal of Chemistry, 32, ss.147 - 155, 2008.
ISNAD ARIKAN ÖLMEZ, NEVİN vd. "Synthesis and antimicrobial activites of 1,2,4-oxadiazin-5-one, 6-one and 5-thiones". Turkish Journal of Chemistry 32/2 (2008), 147-155.