The influence of alpha-tocopherol on cytokine levels and gastric intramucosal ph in severe sepsis

BAYRAK, Fatma; BATMAZ, Emrah; Memiş, Dilek; ESKİOCAK, Sevgi

The influence of alpha-tocopherol on cytokine levels and gastric intramucosal ph in severe sepsis

Dilek MEMİŞ, (Trakya Üniversitesi, Tıp Fakültesi, Ortopedi ve Travmatoloji Anabilim Dalı, Edirne, Türkiye)

Sevgi ESKİOCAK, (Trakya Üniversitesi, Tıp Fakültesi, Biyokimya Anabilim Dalı, Edirne, Türkiye)

Fatma BAYRAK, (Malatya Devlet Hastanesi, Anesteziyoloji ve Reanimasyon Kliniği, Malatya, Türkiye)

Emrah BATMAZ (Trakya Üniversitesi, Tıp Fakültesi, Biyokimya Anabilim Dalı, Edirne, Türkiye)

Trakya Üniversitesi Tıp Fakültesi Dergisi

2 0

Yıl: 2008 Cilt: 25 Sayı: 1 Sayfa Aralığı: 26 - 33 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

The influence of alpha-tocopherol on cytokine levels and gastric intramucosal ph in severe sepsis

Öz:

Amaç: Ağır sepsis gelişen olgularda alfa-tokoferol’ün sitokin düzeylerine ve gastrik intramukozal pH üzerine etkisi araştırıldı. Hastalar ve Yöntemler: Çalışmada ağır sepisli 40 hasta rastgele iki gruba ayrıldı. Grup I’deki (n=20) olgulara üç gün 600 mg alfa tokoferol intramusküler, grup II’deki (n=20) olgulara aynı volümde serum fizyolojik uygulandı. Her iki grupta hemodinamik parametreler, glutatyon, katalaz düzeyleri, nazofarengeal vücut ısısı, arteryel kan gazı değişiklikleri, plazma sitokin düzeyleri (interlökin 1≤ ve 6), biyokimyasal parametreler ve intramukozal pH, yoğun bakım ünitesinde ve mekanik ventilatöre bağlı kalış süresi ve mortalite oranı kaydedildi. Bütün ölçümler başlangıç (çalışmaya başlamadan 15 dakika önce) ve alfa-tokoferol verildikten 24, 48, 72 ve 96 saat sonra yapıldı.Bulgular: İki grup arasında ölçülen parametrelerin hiçbirinde anlamlı fark saptanmadı (p>0.05).Sonuç: Ağır sepsisli olgularda üç gün süreyle verilen 600 mg alfa-tokoferol’ün hemodinamik ve biyokimyasal parametreler, gastrik intramukozal pH veya sitokin düzeylerine veya hasta prognozu üzerine herhangi bir etkisini saptamadık.

Anahtar Kelime: Hemodinamikler Hidrojen-iyon konsantrasyonu Sepsis Sitokinler Kan gazı analizi Glutatyon Katalaz alfa-Tokoferol

Konular: Genel ve Dahili Tıp

Alfa-tokoferol’ün ağır sepsiste sitokin düzeyleri ve gastrik intramukozal ph üzerine etkisi

Öz:

Objectives: We evaluated the effects of alpha-tocopherol on serum cytokine levels and gastric intramucosal pH in patients with severe sepsis. Patients ve Methods: Forty patients with severe sepsis were randomized to two groups. Group I (n=20) received 600 mg alpha-tocopherol intramuscularly, and group II (control group, n=20) received the same dose physiological saline solution for three days. The following data were recorded for both groups: hemodynamic parameters, glutathione, catalase levels, nasopharyngeal body temperature, arterial blood gas changes, plasma cytokine levels (interleukin 1≤ and 6), biochemical parameters and intramucosal pH, length of stay in the intensive care unit, duration of mechanical ventilation support, and mortality. All measurements were made at baseline (15 min before alpha-tocopherol administration) and 24, 48, 72, and 96 hours after alpha-tocopherol administration.Results: None of the parameters evaluated differed significantly between the two groups (p>0.05).Conclusion: We found that intramuscular alpha-tocopherol 600 mg did not affect hemodynamic and biochemical parameters, gastric intramucosal pH, cytokine levels, or prognosis in patients with severe sepsis.

Anahtar Kelime: Catalase alpha-Tocopherol Hemodynamics Hydrogen-Ion Concentration Sepsis Cytokines Blood Gas Analysis Glutathione

Konular: Genel ve Dahili Tıp

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Memiş D, ESKİOCAK S, BAYRAK F, BATMAZ E (2008). The influence of alpha-tocopherol on cytokine levels and gastric intramucosal ph in severe sepsis. , 26 - 33.
Chicago	Memiş Dilek,ESKİOCAK Sevgi,BAYRAK Fatma,BATMAZ Emrah The influence of alpha-tocopherol on cytokine levels and gastric intramucosal ph in severe sepsis. (2008): 26 - 33.
MLA	Memiş Dilek,ESKİOCAK Sevgi,BAYRAK Fatma,BATMAZ Emrah The influence of alpha-tocopherol on cytokine levels and gastric intramucosal ph in severe sepsis. , 2008, ss.26 - 33.
AMA	Memiş D,ESKİOCAK S,BAYRAK F,BATMAZ E The influence of alpha-tocopherol on cytokine levels and gastric intramucosal ph in severe sepsis. . 2008; 26 - 33.
Vancouver	Memiş D,ESKİOCAK S,BAYRAK F,BATMAZ E The influence of alpha-tocopherol on cytokine levels and gastric intramucosal ph in severe sepsis. . 2008; 26 - 33.
IEEE	Memiş D,ESKİOCAK S,BAYRAK F,BATMAZ E "The influence of alpha-tocopherol on cytokine levels and gastric intramucosal ph in severe sepsis." , ss.26 - 33, 2008.
ISNAD	Memiş, Dilek vd. "The influence of alpha-tocopherol on cytokine levels and gastric intramucosal ph in severe sepsis". (2008), 26-33.

APA	Memiş D, ESKİOCAK S, BAYRAK F, BATMAZ E (2008). The influence of alpha-tocopherol on cytokine levels and gastric intramucosal ph in severe sepsis. Trakya Üniversitesi Tıp Fakültesi Dergisi, 25(1), 26 - 33.
Chicago	Memiş Dilek,ESKİOCAK Sevgi,BAYRAK Fatma,BATMAZ Emrah The influence of alpha-tocopherol on cytokine levels and gastric intramucosal ph in severe sepsis. Trakya Üniversitesi Tıp Fakültesi Dergisi 25, no.1 (2008): 26 - 33.
MLA	Memiş Dilek,ESKİOCAK Sevgi,BAYRAK Fatma,BATMAZ Emrah The influence of alpha-tocopherol on cytokine levels and gastric intramucosal ph in severe sepsis. Trakya Üniversitesi Tıp Fakültesi Dergisi, vol.25, no.1, 2008, ss.26 - 33.
AMA	Memiş D,ESKİOCAK S,BAYRAK F,BATMAZ E The influence of alpha-tocopherol on cytokine levels and gastric intramucosal ph in severe sepsis. Trakya Üniversitesi Tıp Fakültesi Dergisi. 2008; 25(1): 26 - 33.
Vancouver	Memiş D,ESKİOCAK S,BAYRAK F,BATMAZ E The influence of alpha-tocopherol on cytokine levels and gastric intramucosal ph in severe sepsis. Trakya Üniversitesi Tıp Fakültesi Dergisi. 2008; 25(1): 26 - 33.
IEEE	Memiş D,ESKİOCAK S,BAYRAK F,BATMAZ E "The influence of alpha-tocopherol on cytokine levels and gastric intramucosal ph in severe sepsis." Trakya Üniversitesi Tıp Fakültesi Dergisi, 25, ss.26 - 33, 2008.
ISNAD	Memiş, Dilek vd. "The influence of alpha-tocopherol on cytokine levels and gastric intramucosal ph in severe sepsis". Trakya Üniversitesi Tıp Fakültesi Dergisi 25/1 (2008), 26-33.