Göktürk MARALCAN
(Gaziantep Üniversitesi, Tıp Fakültesi, Genel Cerrahi Anabilim Dalı, Gaziantep, Türkiye)
Hayri ERKOL
(Abant İzzet Baysal Üniversitesi, İzzet Baysal Tıp Fakültesi, Genel Cerrahi Anabilim Dalı, Bolu, Türkiye)
Zerrin ERKOL
(Abant İzzet Baysal Üniversitesi, Bolu Tıp Fakültesi, Aile Tıp Anabilim Dalı, Bolu, Türkiye)
Fatih YANAR
(İstanbul Üniversitesi, İstanbul Tıp Fakültesi, Genel Cerrahi Anabilim Dalı, İstanbul, Türkiye)
Rebecca PLEVIN
(Los Angeles County, Univ of Soutthern California, Keck School of Medicine, Los Angeles, Ca, USA)
Yıl: 2008Cilt: 14Sayı: 2ISSN: 1306-696X / 1307-7945Sayfa Aralığı: 96 - 102İngilizce

55 0
The effects of low thyroid hormone levels on the formation of stress gastritis: an experimental study on the rats
Bu çalışmanın amacı, sıçanlarda akut stres gastritis gelişmesinde düşük serum tiroit hormon düzeylerinin etkisini araştırmaktır. GEREÇ VE YÖNTEM Altmış erişkin Sprague-Dawley cinsi sıçan onarlı altı gruba ayrıldı: Kontrol grubu, cerrahi tiroidektomi grubu, stres grubu, cerrahi tiroidektomi + stres grubu, cerrahi tiroidektomi + T4 + stress grubu ve cerrahi tiroidektomi + T3 + stres grubu. Gastrik mukoza hasarının sayı ve büyüklüğü milimetrik asetat kağıdı kullanılarak 3,5 kez büyütülmüş fotoğraf üzerinde belirlendi. BULGULAR Sadece stres altında olan sıçanlar (grup III) ile karşılaştırıldığında cerrahi tiroidektomi + stres grubunda (grup IV) akut stres gastriti, belirgin olarak artmıştı (stres gastriti skorları; grup IV: 44, grup III: 16, p<0,001). Grup IV'teki sıçanlarla karşılaştırıldığında stres gastriti skorunun grup VFda belirgin olarak azaldığı gözlendi (stres gastriti skorları; grup VI: 10, grup IV: 44, p<0,001). SONUÇ Sıçanlarda düşük serum tiroit hormon düzeyleri stres gastritinin gelişmesini artırmakta ve bu etki, tiroit hormon replasman tedavisi ile önlenebilmektedir.
Fen > Tıp > Cerrahi
DergiAraştırma MakalesiErişime Açık
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