Yeni 6-metilpiridin-2-karboksilik Asit İçeren Karışık Ligantlı Farklı Metal Komplekslerin Sentezi, Yapılarının Detaylı Analizi ve α-Glukozidaz Enzim İnhibisyonunun in vitro İncelenmesi

BAŞOĞLU, Adil; TAMER, Ömer; Sönmez, Fatih; ATALAY, Yusuf; AVCI, Davut

Yeni 6-metilpiridin-2-karboksilik Asit İçeren Karışık Ligantlı Farklı Metal Komplekslerin Sentezi, Yapılarının Detaylı Analizi ve α-Glukozidaz Enzim İnhibisyonunun in vitro İncelenmesi

Yürütücü

Davut AVCI (Sakarya Üniversitesi, Fen Edebiyat Fakültesi, Fizik Bölümü, Sakarya, Türkiye)

Araştırmacı(lar)

Adil BAŞOĞLU, (Adres Yazılmamış)

Ömer TAMER, (Adres Yazılmamış)

FATİH SÖNMEZ, (Adres Yazılmamış)

Yusuf ATALAY (Adres Yazılmamış)

27 0

Proje Grubu: MFAG Sayfa Sayısı: 0 Proje No: 117F234 Proje Bitiş Tarihi: 01.01.2019 Metin Dili: Türkçe İndeks Tarihi: 18-03-2020

Yeni 6-metilpiridin-2-karboksilik Asit İçeren Karışık Ligantlı Farklı Metal Komplekslerin Sentezi, Yapılarının Detaylı Analizi ve α-Glukozidaz Enzim İnhibisyonunun in vitro İncelenmesi

Öz:

Bu projenin amacı, yeni 6-metilpiridin-2-karboksilik asit içeren karışık ligantlı farklı metal komplekslerinin sentezi, deneysel ve kuramsal olarak yapılarının belirlenmesi ve bu komplekslerin antidiyabetik özelliklerinin alfa-glukozidaz enzim aktivite yöntemiyle araştırılmasıdır. Bu proje kapsamında, daha önce sentezlenmemiş olan 6-metilpiridin-2-karboksilik asit (6- mpa) içeren karışık ligantlı farklı metal kompleksleri sentezlenerek elde edilen komplekslerin antidiyabetik özellikleri alfa-glukozidaz enzimi üzerine etkileri incelenerek araştırılmıştır. Yapılan sentez çalışmaları sonucunda, 30 adet yeni kompleks yapıdan 12 tanesi tek kristal yapı olarak elde edilmiştir. Ayrıca, daha önce literatürde olmayan 6-mpa?nın kendisi ile Mn, Hg, Cr ve Fe?li metal kompleksleri ve 3-metilpiridin-2-karboksilik asit (3-mpa) içeren Co, Cr, V ve Fe metal kompleksleri sentezlenmiştir. Bu proje kapsamında, toplamda 40 adet kompleks yapının 18 adeti tek kristal olup, bunların yapıları X-ışını kırınımı yöntemi ile diğer 22 adet toz olarak elde edilen komplekslerin yapıları da kütle spektroskopisi ile belirlenmiştir. Bu komplekslerin yapısal, titreşimsel, elektronik özellikler hem deneysel hem de hibrit DFT metodu olan HSEh1PBE yöntemi kullanılarak detaylı olarak incelenmiştir. Alfa-glukozidaz enzim aktivite sonuçlarına göre, sentezlenen kompleksler (1-40) arasında en iyi inhibe edici yapıların liganda bakılmaksızın Hg metali içeren kompleksler olduğu sonucuna varılmıştır. Cu içeren tüm kompleks yapılarda (2, 11, 15, 19, 20, 23) aktivite sonuçları ligantlara bağlı olarak sırasıyla 4(5)MeI, NCS, Py, dipya, bpy azalan inhibisyon değerlerinde gözlenmiştir. Bu değişimin kullanılan diğer metaller için aynı olmadığı belirlenmiştir. Elde edilen sonuçlara göre farklı metal içeren ligandların yapı aktivite ilişkileri karşılaştırıldığında, Hg, Cu ve Fe içeren metal komplekslerin in vitro sonuçları kayda değer olarak bulunmuştur. Bu metalleri içeren komplekslerin iyi inhibitör özelliği göstermesi, in vivo araştırmalar için yeni çalışma ve akademik iş birliği alanlarının ortaya çıkmasına olanak sağlamaktadır. Ayrıca, in vivo araştırma sonuçlarına göre yeni iş birliği alanlarında ticari olarak yeni alfa-glukozidaz inhibitörlerinin ülkemize kazandırılması hedeflenmektedir.

Anahtar Kelime: DFT IR ve UV-vis Antidiyabetik Geçiş metalleri Kristal yapı 6-metilpiridin-2-karboksilik asit

Konular: Fizik, Uygulamalı Fizik, Atomik ve Moleküler Kimya

Erişim Türü: Erişime Açık

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APA	AVCI D, BAŞOĞLU A, TAMER Ö, Sönmez F, ATALAY Y (2019). Yeni 6-metilpiridin-2-karboksilik Asit İçeren Karışık Ligantlı Farklı Metal Komplekslerin Sentezi, Yapılarının Detaylı Analizi ve α-Glukozidaz Enzim İnhibisyonunun in vitro İncelenmesi. , 1 - 0.
Chicago	AVCI Davut,BAŞOĞLU Adil,TAMER Ömer,Sönmez Fatih,ATALAY Yusuf Yeni 6-metilpiridin-2-karboksilik Asit İçeren Karışık Ligantlı Farklı Metal Komplekslerin Sentezi, Yapılarının Detaylı Analizi ve α-Glukozidaz Enzim İnhibisyonunun in vitro İncelenmesi. (2019): 1 - 0.
MLA	AVCI Davut,BAŞOĞLU Adil,TAMER Ömer,Sönmez Fatih,ATALAY Yusuf Yeni 6-metilpiridin-2-karboksilik Asit İçeren Karışık Ligantlı Farklı Metal Komplekslerin Sentezi, Yapılarının Detaylı Analizi ve α-Glukozidaz Enzim İnhibisyonunun in vitro İncelenmesi. , 2019, ss.1 - 0.
AMA	AVCI D,BAŞOĞLU A,TAMER Ö,Sönmez F,ATALAY Y Yeni 6-metilpiridin-2-karboksilik Asit İçeren Karışık Ligantlı Farklı Metal Komplekslerin Sentezi, Yapılarının Detaylı Analizi ve α-Glukozidaz Enzim İnhibisyonunun in vitro İncelenmesi. . 2019; 1 - 0.
Vancouver	AVCI D,BAŞOĞLU A,TAMER Ö,Sönmez F,ATALAY Y Yeni 6-metilpiridin-2-karboksilik Asit İçeren Karışık Ligantlı Farklı Metal Komplekslerin Sentezi, Yapılarının Detaylı Analizi ve α-Glukozidaz Enzim İnhibisyonunun in vitro İncelenmesi. . 2019; 1 - 0.
IEEE	AVCI D,BAŞOĞLU A,TAMER Ö,Sönmez F,ATALAY Y "Yeni 6-metilpiridin-2-karboksilik Asit İçeren Karışık Ligantlı Farklı Metal Komplekslerin Sentezi, Yapılarının Detaylı Analizi ve α-Glukozidaz Enzim İnhibisyonunun in vitro İncelenmesi." , ss.1 - 0, 2019.
ISNAD	AVCI, Davut vd. "Yeni 6-metilpiridin-2-karboksilik Asit İçeren Karışık Ligantlı Farklı Metal Komplekslerin Sentezi, Yapılarının Detaylı Analizi ve α-Glukozidaz Enzim İnhibisyonunun in vitro İncelenmesi". (2019), 1-0.

APA	AVCI D, BAŞOĞLU A, TAMER Ö, Sönmez F, ATALAY Y (2019). Yeni 6-metilpiridin-2-karboksilik Asit İçeren Karışık Ligantlı Farklı Metal Komplekslerin Sentezi, Yapılarının Detaylı Analizi ve α-Glukozidaz Enzim İnhibisyonunun in vitro İncelenmesi. , 1 - 0.
Chicago	AVCI Davut,BAŞOĞLU Adil,TAMER Ömer,Sönmez Fatih,ATALAY Yusuf Yeni 6-metilpiridin-2-karboksilik Asit İçeren Karışık Ligantlı Farklı Metal Komplekslerin Sentezi, Yapılarının Detaylı Analizi ve α-Glukozidaz Enzim İnhibisyonunun in vitro İncelenmesi. (2019): 1 - 0.
MLA	AVCI Davut,BAŞOĞLU Adil,TAMER Ömer,Sönmez Fatih,ATALAY Yusuf Yeni 6-metilpiridin-2-karboksilik Asit İçeren Karışık Ligantlı Farklı Metal Komplekslerin Sentezi, Yapılarının Detaylı Analizi ve α-Glukozidaz Enzim İnhibisyonunun in vitro İncelenmesi. , 2019, ss.1 - 0.
AMA	AVCI D,BAŞOĞLU A,TAMER Ö,Sönmez F,ATALAY Y Yeni 6-metilpiridin-2-karboksilik Asit İçeren Karışık Ligantlı Farklı Metal Komplekslerin Sentezi, Yapılarının Detaylı Analizi ve α-Glukozidaz Enzim İnhibisyonunun in vitro İncelenmesi. . 2019; 1 - 0.
Vancouver	AVCI D,BAŞOĞLU A,TAMER Ö,Sönmez F,ATALAY Y Yeni 6-metilpiridin-2-karboksilik Asit İçeren Karışık Ligantlı Farklı Metal Komplekslerin Sentezi, Yapılarının Detaylı Analizi ve α-Glukozidaz Enzim İnhibisyonunun in vitro İncelenmesi. . 2019; 1 - 0.
IEEE	AVCI D,BAŞOĞLU A,TAMER Ö,Sönmez F,ATALAY Y "Yeni 6-metilpiridin-2-karboksilik Asit İçeren Karışık Ligantlı Farklı Metal Komplekslerin Sentezi, Yapılarının Detaylı Analizi ve α-Glukozidaz Enzim İnhibisyonunun in vitro İncelenmesi." , ss.1 - 0, 2019.
ISNAD	AVCI, Davut vd. "Yeni 6-metilpiridin-2-karboksilik Asit İçeren Karışık Ligantlı Farklı Metal Komplekslerin Sentezi, Yapılarının Detaylı Analizi ve α-Glukozidaz Enzim İnhibisyonunun in vitro İncelenmesi". (2019), 1-0.