The effects of antiepileptic drugs on serum and hair trace element levels

SARAYMEN, Recep; tekin, deniz; TAŞDEMİR, HAYDAR ALİ

The effects of antiepileptic drugs on serum and hair trace element levels

Deniz TEKİN, (Ondokuz Mayıs Üniversitesi, Tıp Fakültesi, Çocuk Sağlığı ve Hastalıkları Anabilim Dalı, Samsun, Türkiye)

Haydar Ali TAŞDEMİR, (Ondokuz Mayıs Üniversitesi, Tıp Fakültesi, Çocuk Sağlığı ve Hastalıkları Anabilim Dalı, Samsun, Türkiye)

Recep SARAYMEN (Erciyes Üniversitesi, Tıp Fakültesi, Biyokimya Anabilim Dalı, Kayseri, Türkiye)

Ankara Üniversitesi Tıp Fakültesi Mecmuası

2 0

Yıl: 2008 Cilt: 61 Sayı: 2 Sayfa Aralığı: 73 - 76 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

The effects of antiepileptic drugs on serum and hair trace element levels

Öz:

Amaç: Antiepileptik ilaçların serum ve saç eser element düzeylerini etkileyip etkilemediğini göstermek için epilepsi tanısı alan 40 çocuğu değerlendirdik. Gereç ve Yöntem: Serum Zn, Cu, Mg ile saç Zn düzeyleri fenobarbital veya valproik asit tedavisi başlanmadan önce ve 3 ay sonra değerlendirildi. Bulgular: Her iki tedavi ile de serum Zn düzeyleri düştü. Fenobarbital veya Valproik asit tedavisi alan epileptik hastalar karşılaştırıldığında, fenobarbital tedavisi alanlarda serum Zn düzeylerindeki düşme daha belirgindi. Sonuç: Hastalarımızın hiçbirinde Zn eksikliğine bağlı bulgular görmesek de, Fenobarbital veya Valproik asit tedavisi alan çocuklarda bu açıdan dikkatli olunmalıdır.When serum Zn levels were compared after VPA and PB therapies, those who received PB therapy were observed to have a less significant decrease in serum Zn level. Conclusion: Although none of our patients showed any symptoms of Zn deficiency, we should be cautious about this in patients who receive VPA and/or PB therapy.

Anahtar Kelime:

Konular: Cerrahi

Antiepileptik ilaçların serum ve saçta eser element düzeylerine etkileri

Öz:

Aim: To assess whether antiepileptic drugs (AEDs) could affect serum and hair trace element levels, we studied 40 children with epilepsy. Materials and Methods: Their serum zinc (Zn), copper (Cu), magnesium (Mg) and hair Zn levels were measured by atomic absorption spectrophotometer prior to and 3 months after therapy with VPA (sodium valproate) or PB (phenobarbital). Results: In both treatments, epileptic children were found to have lower serum Zn concentrations.

Anahtar Kelime:

Konular: Cerrahi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	tekin d, TAŞDEMİR H, SARAYMEN R (2008). The effects of antiepileptic drugs on serum and hair trace element levels. , 73 - 76.
Chicago	tekin deniz,TAŞDEMİR HAYDAR ALİ,SARAYMEN Recep The effects of antiepileptic drugs on serum and hair trace element levels. (2008): 73 - 76.
MLA	tekin deniz,TAŞDEMİR HAYDAR ALİ,SARAYMEN Recep The effects of antiepileptic drugs on serum and hair trace element levels. , 2008, ss.73 - 76.
AMA	tekin d,TAŞDEMİR H,SARAYMEN R The effects of antiepileptic drugs on serum and hair trace element levels. . 2008; 73 - 76.
Vancouver	tekin d,TAŞDEMİR H,SARAYMEN R The effects of antiepileptic drugs on serum and hair trace element levels. . 2008; 73 - 76.
IEEE	tekin d,TAŞDEMİR H,SARAYMEN R "The effects of antiepileptic drugs on serum and hair trace element levels." , ss.73 - 76, 2008.
ISNAD	tekin, deniz vd. "The effects of antiepileptic drugs on serum and hair trace element levels". (2008), 73-76.

APA	tekin d, TAŞDEMİR H, SARAYMEN R (2008). The effects of antiepileptic drugs on serum and hair trace element levels. Ankara Üniversitesi Tıp Fakültesi Mecmuası, 61(2), 73 - 76.
Chicago	tekin deniz,TAŞDEMİR HAYDAR ALİ,SARAYMEN Recep The effects of antiepileptic drugs on serum and hair trace element levels. Ankara Üniversitesi Tıp Fakültesi Mecmuası 61, no.2 (2008): 73 - 76.
MLA	tekin deniz,TAŞDEMİR HAYDAR ALİ,SARAYMEN Recep The effects of antiepileptic drugs on serum and hair trace element levels. Ankara Üniversitesi Tıp Fakültesi Mecmuası, vol.61, no.2, 2008, ss.73 - 76.
AMA	tekin d,TAŞDEMİR H,SARAYMEN R The effects of antiepileptic drugs on serum and hair trace element levels. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 2008; 61(2): 73 - 76.
Vancouver	tekin d,TAŞDEMİR H,SARAYMEN R The effects of antiepileptic drugs on serum and hair trace element levels. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 2008; 61(2): 73 - 76.
IEEE	tekin d,TAŞDEMİR H,SARAYMEN R "The effects of antiepileptic drugs on serum and hair trace element levels." Ankara Üniversitesi Tıp Fakültesi Mecmuası, 61, ss.73 - 76, 2008.
ISNAD	tekin, deniz vd. "The effects of antiepileptic drugs on serum and hair trace element levels". Ankara Üniversitesi Tıp Fakültesi Mecmuası 61/2 (2008), 73-76.