Influence of mercury chloride-renal failure on pharmacokinetics of sulphamethoxazole after oral administration in mice

PEKCAN, Mert; Arif, Altintas; Yarsan, Ender; EŞSİZ, Dinç; IBRAHİM, Ishraga G.; ALTINTAS, Levent; ÇİFTCİ, GÜLAY

Influence of mercury chloride-renal failure on pharmacokinetics of sulphamethoxazole after oral administration in mice

Ender YARSAN, (Ankara Üniversitesi, Veteriner Fakültesi, Ankara, Türkiye)

Arif ALTINTAŞ, (Ankara Üniversitesi, Veteriner Fakültesi, Ankara, Türkiye)

Dinç EŞSİZ, (Kafkas Üniversitesi, Veteriner Fakültesi, Kars, Türkiye)

LEVENT ALTINTAŞ, (Ankara Üniversitesi, Veteriner Fakültesi, Ankara, Türkiye)

Mert PEKCAN, (Ankara Üniversitesi, Veteriner Fakültesi, Ankara, Türkiye)

GÜLAY ÇİFTCİ, (Ondokuz Mayıs Üniversitesi, Veteriner Fakültesi, Samsun, Türkiye)

Ishraga G. IBRAHİM (Central Veterinary Research Laboratories, Khartoum, Sudan)

Eurasian Journal of Veterinary Sciences

2 0

Yıl: 2010 Cilt: 26 Sayı: 1 Sayfa Aralığı: 21 - 24 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Influence of mercury chloride-renal failure on pharmacokinetics of sulphamethoxazole after oral administration in mice

Öz:

Yarsan E, Altıntaş A, Eşsiz D, Altıntaş L, Pekcan M, Çiftci G, İbrahim IG. Farelerde Cıva Klorür ile Oluşturulan Böbrek Hasarının Oral Yolla Uygulanan Sülfametaksazolün Farmakokinetiği Üzerine Etkisi. Eurasian J Vet Sci, 2010, 26, 1, 21-24 Amaç: Bu çalışmada, deneysel olarak cıva klorür ile böbrek hasarı oluşturulmuş farelerde 100 mg/kg dozda oral yolla uygulanan sülfametoksazolün farmakokinetiği değerlendirildi. Gereç ve Yöntem: Cıva klorür farelere 3 ve 6 mg/kg dozlarında verildi. Plazma sülfametaksazol konsantrasyonları spektrofotometre ile ölçüldü. Plazma konsantrasyon-zaman verileri dikkate alındığında ilacın 2 kompartmanlı açık modele uygun olduğu görüldü. Bulgular: Böbrek hasarı ile ilişkili olarak sülfametoksazolün emilim (AUC and $t_{1/2a}$) ve eliminasyon ($t_{1/2beta}$ and MRT) fazlarında önemli bulgular (p<0.05) gözlendi. Hasara bağlı olarak eğrinin altında kalan alan değeri düşerken, ortalama kalış zamanında artış tespit edildi (p<0.05). Öneri: Böbrek hasarlı hastalarda, sülfametoksazolün doz ve uygulama aralıklarının hasarın derecesine göre belirlenmesi çok önemlidir.

Anahtar Kelime: fareler ilaçların etkileri farmakokinetik sulfametazol böbrek yetmezliği cıva

Konular: Veterinerlik

Deneysel olarak civa klorür ile böbrek hasarı oluşturulan farelerde sülfametaksazolün farmakokinetiğinin değerlendirilmesi

Öz:

Yarsan E, Altintas A, Essiz D, Altintas L, Pekcan M, Ciftci G, Ibrahim IG. Influence of mercury chloride-renal failure on pharmacokinetics of sulphamethoxazole after oral administration in mice. Eurasian J Vet Sci, 2010, 26, 1, 21-24 Aim: The effects of renal failure on the pharmacokinetics of sulphamethoxazole were investigated after oral administration of 100 mg/kg of the drug using a mice model of mercury chloride-induced renal failure. Materials and Methods: Mercury chloride was given to mice at the doses of 3 and 6 mg/kg. Plasma sulphamethoxazole concentrations were measured by spectrophotometer. Plasma concentration-time data were fitted to a two-compartment open model. Results: Significant findings (p<0.05) were observed for absorption (AUC and $t_{1/2a}$) and elimination ($t_{1/2beta}$ and MRT) phases of sulphamethoxazole related with renal failure. Also area under the curve value decreased, and mean residence time value increased with renal failure (p<0.05). Conclusion: Study result showed that dosage and administration intervals of sulphamethoxazole were important for patients with renal failure.

Anahtar Kelime: renal failure mercury mice drug effects pharmacokinetics sulfamethoxazole

Konular: Veterinerlik

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Yarsan E, Arif A, EŞSİZ D, ALTINTAS L, PEKCAN M, ÇİFTCİ G, IBRAHİM I (2010). Influence of mercury chloride-renal failure on pharmacokinetics of sulphamethoxazole after oral administration in mice. , 21 - 24.
Chicago	Yarsan Ender,Arif Altintas,EŞSİZ Dinç,ALTINTAS Levent,PEKCAN Mert,ÇİFTCİ GÜLAY,IBRAHİM Ishraga G. Influence of mercury chloride-renal failure on pharmacokinetics of sulphamethoxazole after oral administration in mice. (2010): 21 - 24.
MLA	Yarsan Ender,Arif Altintas,EŞSİZ Dinç,ALTINTAS Levent,PEKCAN Mert,ÇİFTCİ GÜLAY,IBRAHİM Ishraga G. Influence of mercury chloride-renal failure on pharmacokinetics of sulphamethoxazole after oral administration in mice. , 2010, ss.21 - 24.
AMA	Yarsan E,Arif A,EŞSİZ D,ALTINTAS L,PEKCAN M,ÇİFTCİ G,IBRAHİM I Influence of mercury chloride-renal failure on pharmacokinetics of sulphamethoxazole after oral administration in mice. . 2010; 21 - 24.
Vancouver	Yarsan E,Arif A,EŞSİZ D,ALTINTAS L,PEKCAN M,ÇİFTCİ G,IBRAHİM I Influence of mercury chloride-renal failure on pharmacokinetics of sulphamethoxazole after oral administration in mice. . 2010; 21 - 24.
IEEE	Yarsan E,Arif A,EŞSİZ D,ALTINTAS L,PEKCAN M,ÇİFTCİ G,IBRAHİM I "Influence of mercury chloride-renal failure on pharmacokinetics of sulphamethoxazole after oral administration in mice." , ss.21 - 24, 2010.
ISNAD	Yarsan, Ender vd. "Influence of mercury chloride-renal failure on pharmacokinetics of sulphamethoxazole after oral administration in mice". (2010), 21-24.

APA	Yarsan E, Arif A, EŞSİZ D, ALTINTAS L, PEKCAN M, ÇİFTCİ G, IBRAHİM I (2010). Influence of mercury chloride-renal failure on pharmacokinetics of sulphamethoxazole after oral administration in mice. Eurasian Journal of Veterinary Sciences, 26(1), 21 - 24.
Chicago	Yarsan Ender,Arif Altintas,EŞSİZ Dinç,ALTINTAS Levent,PEKCAN Mert,ÇİFTCİ GÜLAY,IBRAHİM Ishraga G. Influence of mercury chloride-renal failure on pharmacokinetics of sulphamethoxazole after oral administration in mice. Eurasian Journal of Veterinary Sciences 26, no.1 (2010): 21 - 24.
MLA	Yarsan Ender,Arif Altintas,EŞSİZ Dinç,ALTINTAS Levent,PEKCAN Mert,ÇİFTCİ GÜLAY,IBRAHİM Ishraga G. Influence of mercury chloride-renal failure on pharmacokinetics of sulphamethoxazole after oral administration in mice. Eurasian Journal of Veterinary Sciences, vol.26, no.1, 2010, ss.21 - 24.
AMA	Yarsan E,Arif A,EŞSİZ D,ALTINTAS L,PEKCAN M,ÇİFTCİ G,IBRAHİM I Influence of mercury chloride-renal failure on pharmacokinetics of sulphamethoxazole after oral administration in mice. Eurasian Journal of Veterinary Sciences. 2010; 26(1): 21 - 24.
Vancouver	Yarsan E,Arif A,EŞSİZ D,ALTINTAS L,PEKCAN M,ÇİFTCİ G,IBRAHİM I Influence of mercury chloride-renal failure on pharmacokinetics of sulphamethoxazole after oral administration in mice. Eurasian Journal of Veterinary Sciences. 2010; 26(1): 21 - 24.
IEEE	Yarsan E,Arif A,EŞSİZ D,ALTINTAS L,PEKCAN M,ÇİFTCİ G,IBRAHİM I "Influence of mercury chloride-renal failure on pharmacokinetics of sulphamethoxazole after oral administration in mice." Eurasian Journal of Veterinary Sciences, 26, ss.21 - 24, 2010.
ISNAD	Yarsan, Ender vd. "Influence of mercury chloride-renal failure on pharmacokinetics of sulphamethoxazole after oral administration in mice". Eurasian Journal of Veterinary Sciences 26/1 (2010), 21-24.