Helicobacter pylori and antibiotic resistance

Hilmioğlu, Fatih; KANTARÇEKEN, BÜLENT; ALADAĞ, Murat; Yıldırım, Bülent; Karincaoglu, Melih

Helicobacter pylori and antibiotic resistance

Bülent KANTARÇEKEN, (İnönü Üniversitesi, Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Malatya, Türkiye)

Bülent YILDIRIM, (Girilmedi)

Melih KARINCAOĞLU, (Girilmedi)

Murat ALADAĞ, (Girilmedi)

Fatih HİLMİOĞLU (Girilmedi)

Turkish Journal of Gastroenterology

14 0

Yıl: 2000 Cilt: 11 Sayı: 2 Sayfa Aralığı: 141 - 145 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Helicobacter pylori and antibiotic resistance

Öz:

Amaç: Helicobacter pylori tedavisinde sıklıkla kullanılan antibiyotiklere karşı oluşan direnç oranları araştırıldı. Yöntem: Gastroenteroloji kliniğimize üst gastrointestinal sistem şikayetleri ile başvuran 51 hastanın mide antral biyopsi kültürlerinden izole edilen Helicobacter pylori suşlarının amoksisilin, metronidazol, klaritromisin, tetrasiklin ve siprofloksasin'e duyarlılığı disk difüzyon yöntemi ile incelendi. Bulgular: Hastaların 29'unda (%57) antibiyotiklere karşı direnç saptanırken 22(%43) hastada antibiyotik direnci gözlenmedi. Metronidazol'e 25 hastada (%49), klaritromisin'e 5 hastada (%9.8), Tetrasiklin'e 2 hastada (%3.9), siprofloksasin'e 3 hastada (%5.9) direnç saptanırken amoksisilin'e karşı direnç gözlenmedi. Sonuç: Başta metronidazol ve klaritromisin olmak üzere, antibiyotikler için bulunan yüksek direnç oranları muhtemelen bu ilaçların yetersiz süre ve dozlarda gelişigüzel ve yaygın olarak kullanılmasından kaynaklanmaktadır.

Anahtar Kelime: Antibiyotikler Mikrobiyal duyarlılık testleri Helicobacter enfeksiyonları Antibiyotik direnci Gastrointestinal hastalıklar Helicobacter pylori İlaç direnci, mikrobiyal

Konular: Cerrahi

Helicobacter pylori ve antibiyotik direnci

Öz:

Background/Aims: This study investigated resistance rates to anibiotics commonly used to treat Helicobacter pylori. Methods: Helicobacter pylori isolates from gastric antral biopsy cultures of 51 patients, admitted to our gastroenterology department for upper gastrointestinal system complaints, were examined for sensitivity to amoxicillin, metronidazole, clarithromycin, tetracycline and ciprofloxacin by disk diffusion method. Results: Twentynine patients (57%) were resistant to antibiotics, while 22 patients (43%) showed no resistance. Resistance to metronidazole, clarithromycin, tetracycline and ciprofloxacin was found in 25 (49%), five (9.8%), two (3.9%) and three patients (5.9%) respectively. Conclusions: No resistance to amoxicillin was seen. The high resistance rates to antibiotics, especially metronidazole and clarithromycin, in our study is likely to originate from their widespread and inappropriate use at insufficient

Anahtar Kelime: Gastrointestinal Diseases Helicobacter pylori Drug Resistance, Microbial Antibiotics Microbial Sensitivity Tests Helicobacter Infections Antibiotic resistance

Konular: Cerrahi

Belge Türü: Makale Makale Türü: Diğer Erişim Türü: Erişime Açık

1) . Rathbone BJ, Heatley RV. The historical associations between bacteria and peptic-ulcer disease. In: BJ Rathborne, RV Heatley ed. Camphylobacter pylori and gastroduodenal disease. 1st edit., Oxford London: Blackwell Scientific Publications 1989; pp.1-4.
2) . Breger SA, Gorea A, Moskowitz M, et al. Effect of inoculum size on antimicrobial susceptibilty of Helicobacter pylori. Eur J Clin Microbiol Infect Dis 1993; 12: 782-3.
3) . European Study Group on Antibiotic Susceptibility of Helicobacter pylori. Results of a multicentre European survey in 1991 of metronidazole resistance in Helicobacter pylori. Eur J Clin Microbiol Infect Dis 1992; 11: 9: 777-81.
4) . Gotoh A, Kawakami Y, Akahane T, et al. Susceptibility of Helicobacter pylori isolates against agents commonly administered for eradication therapy and the efficiacy of chemotherapy. Microbiol Immunol 1997; 41 : 7-12.
5) . Glupczynskı Y. Culture of Helicobacter pylori from gastric biopsies and antimicrobial susceptibility testing. In: Helicobacter pylori: techniques for clinical diagnosis & basic research. Philedelphia: WB Saunders Company 1996 pp: 20-1.
6) . Xia H, Keane CT, Beattie S, Morain CO. Standardization of disk diffusion test and its clinical significance for susceptibility testing of metronidazole against Helicobacter pylori. Antimicrob Agents and Chemother 1994; 38: 10: 2357-61.
7) . Palabıyıkoğlu M, Şahin F, Çetinkaya H. Disk diffüzyon yöntemi ile Helicobacter pylori klinik izolatlarında amoksisiline ve klaritromisine karşı primer dirençliliğin araştırılması ve tedavi sonrası muhtemel duyarlılık değişikliğinin incelenmesi. 13. Ulusal Gastroenteroloji Kongresi Kitapçığı 1996; pp: B5.
8) . Büke AÇ, Aydın A, Tünger A, et al. Helicobacter pylori’nin amoksisilin, klaritromisin ve metronidazol’e karşı duyarlılığının disk difüzyon yöntemi ile araştırılması. Turk J Infect 1997; 11: 267-9.
9) . Megraud F. Epidemiology of Helicobacter Pylori. Gastroenterol Clin North Am 1993; 22: 73- 88.
10) . Duane T. Microbiology and epidemiology of Helicobacter pylori infection. Drug Benefit Trends 1996; 8: 10-5.
11) . Marshall B. Camphylobacter Pyloridis and gastritis. Lancet 1986; 153: 650.
12) . Miehlke S, Bayerdörffer E, Lehn N, et al. Recurrence of duodenal ulcers during five years of follow-up after cure of Helicobacter pylori infection. Eur J Gastroenterol&Hepatol 1995; 7: 975-8.
13) . Graham DY, Lew GM, Klein PD, et al. Effect of treatment of Helicobacter pylori infection on the long-term recurrence of gastric or duodenal ulcer. Ann Int Med 1992; 116: 705.
14) . Patchett S, Beattie S, Leen E, et al. Eradicating Helicobacter pylori and symptoms of non-ulcer dyspepsia. BMJ 1991; 303: 1238-40.
15) . Wotherspoon AC, Doglioni C, Diss TC, et al. Regression of primary low –grade B-cell lymphoma of mucosa-associated lymphoid tissue type after eradication of Helicobacter pylori. Lancet 1993; 342: 575-7.
16) . Boer WA, Tytgat NJ. How to treat Helicobacter pylori infection-should treatment strategies be based on testing bacterial susceptibility? A personal viewpoint. Eur J Gastroenterol& Hepatol 1996; 8: 709-16.
17) . De Cros AJ, Marshall BJ, Mc Callum RW, et al. Metronidazole susceptibilty testing for Helicobacter pylori: Comparison of disk, broth, and agar dilution methods and their clinical relevance. J Clin Microbiol 1993; 31: 8, 1971-4.
18) . Yamamoto I, Fukuda Y, Okui Masanori, et al. Proton pump inhibitors for Helicobacter pylori eradication in patients with peptic ulcer. J Clin Gastroenterol 1995; 20 : S38-42.
19) . Beşışık F, Çalışkan M, Sürücü F, et al. Helicobacter pylori infeksiyonu ve antibiyotik direnci İstanbul Tıp Fakültesi Deneyimi. 14. Ulusal Gastroenteroloji Kongresi Kitapçığı 1997. Pp: 62.
20) . Zwet AA, Thıjs JC, Vrıes WS. In vitro studies on stability and development of metronidazole resistance in Helicobacter pylori. Antimicrob Agents Cheomother 1994; 38: 360-2.
21) . Weil J, Bell Gd, Powell K, et al. Helicobacter pylori and metronidazole resistance. Lancet 1990; 336: 1445.
23) . Zwet AA, Boer WA, Schneeberger PM, et al. Prevalence of primary Helicobacter pylori resistance to metronidazole and clarithromycin in The Netherlands. Eur J Clin Microbiol Infect Dis 1996; 15: 861-4.
24) . Tompkins DS, Perkin J, Smith C. Failed treatment of Helicobacter pylori infection associated with resistance to clarithromycin. Helicobacter 1997; 2: 4: 185-7.

APA	KANTARÇEKEN B, Yıldırım B, Karincaoglu M, ALADAĞ M, Hilmioğlu F (2000). Helicobacter pylori and antibiotic resistance. , 141 - 145.
Chicago	KANTARÇEKEN BÜLENT,Yıldırım Bülent,Karincaoglu Melih,ALADAĞ Murat,Hilmioğlu Fatih Helicobacter pylori and antibiotic resistance. (2000): 141 - 145.
MLA	KANTARÇEKEN BÜLENT,Yıldırım Bülent,Karincaoglu Melih,ALADAĞ Murat,Hilmioğlu Fatih Helicobacter pylori and antibiotic resistance. , 2000, ss.141 - 145.
AMA	KANTARÇEKEN B,Yıldırım B,Karincaoglu M,ALADAĞ M,Hilmioğlu F Helicobacter pylori and antibiotic resistance. . 2000; 141 - 145.
Vancouver	KANTARÇEKEN B,Yıldırım B,Karincaoglu M,ALADAĞ M,Hilmioğlu F Helicobacter pylori and antibiotic resistance. . 2000; 141 - 145.
IEEE	KANTARÇEKEN B,Yıldırım B,Karincaoglu M,ALADAĞ M,Hilmioğlu F "Helicobacter pylori and antibiotic resistance." , ss.141 - 145, 2000.
ISNAD	KANTARÇEKEN, BÜLENT vd. "Helicobacter pylori and antibiotic resistance". (2000), 141-145.

APA	KANTARÇEKEN B, Yıldırım B, Karincaoglu M, ALADAĞ M, Hilmioğlu F (2000). Helicobacter pylori and antibiotic resistance. Turkish Journal of Gastroenterology, 11(2), 141 - 145.
Chicago	KANTARÇEKEN BÜLENT,Yıldırım Bülent,Karincaoglu Melih,ALADAĞ Murat,Hilmioğlu Fatih Helicobacter pylori and antibiotic resistance. Turkish Journal of Gastroenterology 11, no.2 (2000): 141 - 145.
MLA	KANTARÇEKEN BÜLENT,Yıldırım Bülent,Karincaoglu Melih,ALADAĞ Murat,Hilmioğlu Fatih Helicobacter pylori and antibiotic resistance. Turkish Journal of Gastroenterology, vol.11, no.2, 2000, ss.141 - 145.
AMA	KANTARÇEKEN B,Yıldırım B,Karincaoglu M,ALADAĞ M,Hilmioğlu F Helicobacter pylori and antibiotic resistance. Turkish Journal of Gastroenterology. 2000; 11(2): 141 - 145.
Vancouver	KANTARÇEKEN B,Yıldırım B,Karincaoglu M,ALADAĞ M,Hilmioğlu F Helicobacter pylori and antibiotic resistance. Turkish Journal of Gastroenterology. 2000; 11(2): 141 - 145.
IEEE	KANTARÇEKEN B,Yıldırım B,Karincaoglu M,ALADAĞ M,Hilmioğlu F "Helicobacter pylori and antibiotic resistance." Turkish Journal of Gastroenterology, 11, ss.141 - 145, 2000.
ISNAD	KANTARÇEKEN, BÜLENT vd. "Helicobacter pylori and antibiotic resistance". Turkish Journal of Gastroenterology 11/2 (2000), 141-145.