Yıl: 2000 Cilt: 17 Sayı: 4 Sayfa Aralığı: 213 - 215 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

Paroxysmal nocturnal haemoglobinuria in the differential diagnosis of unresponsive iron deficiency anemia: A case report

Öz:
A 16-year-old male patient who was on oral iron treatment for iron deficiency anemia for the last one year was seen at the Haematology clinic with complaints of weakness, pallor, and jaundice. A complete blood count revealed Hb of 4.2 mmol/L, Hct of 0.14, and MCV of 76 fl. A blood smear showed 50% neutrophils, 40% lymphocytes, and 10% monocytes with anisocytosis, poikilocytosis, polichromasia in erythrocytes and normoblasts. Reticulocyte count was under 1%. There was a slight erythroid hyperplasia in the bone marrow aspiration. Biochemical examinations showed total bilirubin of 3.9 mg/dL, indirect bilirubin of 3.4 mg/dL, and lactate dehydrogenase (LDH) of 6085 U/L (220-450). In re-evaluating the history of the patient, he was seen to be complaining of dark discoloration of morning urine. Perl's reaction was found to be positive for hemosiderin in the urine sediment. Because Ham's test was positive, the levels of CD55, 58, and 59 proteins on erythrocyte membranes were found to be lower. The patient was started 32 mg of methylprednisolone and his anaemia was improved by the $14^th$ day of treatment. When evaluating iron deficiency anemia resistant to iron supplementation, PNH should be kept in mind.
Anahtar Kelime: Male Diagnosis, Differential Anemia, Iron-Deficiency Adolescence Hemoglobinuria, Paroxysmal Case report

Konular: Hematoloji
Belge Türü: Makale Makale Türü: Diğer Erişim Türü: Erişime Açık
APA SEVİNÇ A, KUKU İ, AYDOGDU I, ŞAVLI H, AYDIN N (2000). Paroxysmal nocturnal haemoglobinuria in the differential diagnosis of unresponsive iron deficiency anemia: A case report. , 213 - 215.
Chicago SEVİNÇ Alper,KUKU İrfan,AYDOGDU ISMET,ŞAVLI Haluk,AYDIN N. Engin Paroxysmal nocturnal haemoglobinuria in the differential diagnosis of unresponsive iron deficiency anemia: A case report. (2000): 213 - 215.
MLA SEVİNÇ Alper,KUKU İrfan,AYDOGDU ISMET,ŞAVLI Haluk,AYDIN N. Engin Paroxysmal nocturnal haemoglobinuria in the differential diagnosis of unresponsive iron deficiency anemia: A case report. , 2000, ss.213 - 215.
AMA SEVİNÇ A,KUKU İ,AYDOGDU I,ŞAVLI H,AYDIN N Paroxysmal nocturnal haemoglobinuria in the differential diagnosis of unresponsive iron deficiency anemia: A case report. . 2000; 213 - 215.
Vancouver SEVİNÇ A,KUKU İ,AYDOGDU I,ŞAVLI H,AYDIN N Paroxysmal nocturnal haemoglobinuria in the differential diagnosis of unresponsive iron deficiency anemia: A case report. . 2000; 213 - 215.
IEEE SEVİNÇ A,KUKU İ,AYDOGDU I,ŞAVLI H,AYDIN N "Paroxysmal nocturnal haemoglobinuria in the differential diagnosis of unresponsive iron deficiency anemia: A case report." , ss.213 - 215, 2000.
ISNAD SEVİNÇ, Alper vd. "Paroxysmal nocturnal haemoglobinuria in the differential diagnosis of unresponsive iron deficiency anemia: A case report". (2000), 213-215.
APA SEVİNÇ A, KUKU İ, AYDOGDU I, ŞAVLI H, AYDIN N (2000). Paroxysmal nocturnal haemoglobinuria in the differential diagnosis of unresponsive iron deficiency anemia: A case report. Turkish Journal of Hematology, 17(4), 213 - 215.
Chicago SEVİNÇ Alper,KUKU İrfan,AYDOGDU ISMET,ŞAVLI Haluk,AYDIN N. Engin Paroxysmal nocturnal haemoglobinuria in the differential diagnosis of unresponsive iron deficiency anemia: A case report. Turkish Journal of Hematology 17, no.4 (2000): 213 - 215.
MLA SEVİNÇ Alper,KUKU İrfan,AYDOGDU ISMET,ŞAVLI Haluk,AYDIN N. Engin Paroxysmal nocturnal haemoglobinuria in the differential diagnosis of unresponsive iron deficiency anemia: A case report. Turkish Journal of Hematology, vol.17, no.4, 2000, ss.213 - 215.
AMA SEVİNÇ A,KUKU İ,AYDOGDU I,ŞAVLI H,AYDIN N Paroxysmal nocturnal haemoglobinuria in the differential diagnosis of unresponsive iron deficiency anemia: A case report. Turkish Journal of Hematology. 2000; 17(4): 213 - 215.
Vancouver SEVİNÇ A,KUKU İ,AYDOGDU I,ŞAVLI H,AYDIN N Paroxysmal nocturnal haemoglobinuria in the differential diagnosis of unresponsive iron deficiency anemia: A case report. Turkish Journal of Hematology. 2000; 17(4): 213 - 215.
IEEE SEVİNÇ A,KUKU İ,AYDOGDU I,ŞAVLI H,AYDIN N "Paroxysmal nocturnal haemoglobinuria in the differential diagnosis of unresponsive iron deficiency anemia: A case report." Turkish Journal of Hematology, 17, ss.213 - 215, 2000.
ISNAD SEVİNÇ, Alper vd. "Paroxysmal nocturnal haemoglobinuria in the differential diagnosis of unresponsive iron deficiency anemia: A case report". Turkish Journal of Hematology 17/4 (2000), 213-215.