Yıl: 2000 Cilt: 30 Sayı: 3 Sayfa Aralığı: 281 - 283 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

Decreased placental adrenomedullin may play role in preeclampsia

Öz:
Adrenomedullin (AdM) is a novel peptide that elicits a long-lasting vasorelaxant activity. It is expressed in several tissues, including adrenal medulla, heart, lung, kidneys, and cultured vascular smooth muscle cells. Also in large amounts, it is present in amniotic fluid and cord blood. The aim of this study was to assess placental AdM secretion in preeclampsia. Placental tissues were collected from seven preeclamptic patients and ten healthy gravidas. Tissue concentration of rat AdM was measured by using reverse-phase high performance liquid chromatography (Cecil 1100). Mann Whitney U test was used for statistical significance. Significance was set at p<0.05. AdM concentrations were 144.1±3.20 pmol/ml and 178.7±4.4 pmol/ml in preeclamptics and healthy gravidas respectively. This difference was significant (p<0.05). These data suggest that placental synthesis of AdM in preeclampsia is reduced, and low production of AdM may be responsible for placental pathology in preeclampsia.
Anahtar Kelime: Placenta Vasodilator Agents Pregnancy Amniotic Fluid Pregnancy Complications Vasorelaxant activity Fetal Blood Adrenomedullin Pathology Vasodilation Peptides Pre-Eclampsia

Konular: Cerrahi
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA GÖKDENİZ R, Yurekli M, MENEKŞE A, BAZOĞLU N (2000). Decreased placental adrenomedullin may play role in preeclampsia. , 281 - 283.
Chicago GÖKDENİZ Remzi,Yurekli Muhittin,MENEKŞE Alanur,BAZOĞLU Nursel Decreased placental adrenomedullin may play role in preeclampsia. (2000): 281 - 283.
MLA GÖKDENİZ Remzi,Yurekli Muhittin,MENEKŞE Alanur,BAZOĞLU Nursel Decreased placental adrenomedullin may play role in preeclampsia. , 2000, ss.281 - 283.
AMA GÖKDENİZ R,Yurekli M,MENEKŞE A,BAZOĞLU N Decreased placental adrenomedullin may play role in preeclampsia. . 2000; 281 - 283.
Vancouver GÖKDENİZ R,Yurekli M,MENEKŞE A,BAZOĞLU N Decreased placental adrenomedullin may play role in preeclampsia. . 2000; 281 - 283.
IEEE GÖKDENİZ R,Yurekli M,MENEKŞE A,BAZOĞLU N "Decreased placental adrenomedullin may play role in preeclampsia." , ss.281 - 283, 2000.
ISNAD GÖKDENİZ, Remzi vd. "Decreased placental adrenomedullin may play role in preeclampsia". (2000), 281-283.
APA GÖKDENİZ R, Yurekli M, MENEKŞE A, BAZOĞLU N (2000). Decreased placental adrenomedullin may play role in preeclampsia. Turkish Journal of Medical Sciences, 30(3), 281 - 283.
Chicago GÖKDENİZ Remzi,Yurekli Muhittin,MENEKŞE Alanur,BAZOĞLU Nursel Decreased placental adrenomedullin may play role in preeclampsia. Turkish Journal of Medical Sciences 30, no.3 (2000): 281 - 283.
MLA GÖKDENİZ Remzi,Yurekli Muhittin,MENEKŞE Alanur,BAZOĞLU Nursel Decreased placental adrenomedullin may play role in preeclampsia. Turkish Journal of Medical Sciences, vol.30, no.3, 2000, ss.281 - 283.
AMA GÖKDENİZ R,Yurekli M,MENEKŞE A,BAZOĞLU N Decreased placental adrenomedullin may play role in preeclampsia. Turkish Journal of Medical Sciences. 2000; 30(3): 281 - 283.
Vancouver GÖKDENİZ R,Yurekli M,MENEKŞE A,BAZOĞLU N Decreased placental adrenomedullin may play role in preeclampsia. Turkish Journal of Medical Sciences. 2000; 30(3): 281 - 283.
IEEE GÖKDENİZ R,Yurekli M,MENEKŞE A,BAZOĞLU N "Decreased placental adrenomedullin may play role in preeclampsia." Turkish Journal of Medical Sciences, 30, ss.281 - 283, 2000.
ISNAD GÖKDENİZ, Remzi vd. "Decreased placental adrenomedullin may play role in preeclampsia". Turkish Journal of Medical Sciences 30/3 (2000), 281-283.