Bioengineering functional copolymers. xx. synthesis of novel anticancer active poly(Maleic anhydride-alt-2-vinyl-1,3-dioxolane) and its organoboron amideester branched derivatives

Türk, Mustafa; RZAYEV, Zakir M. O.; KAHRAMAN, Gülten; SÖYLEMEZ, Ernur A; OĞUZTÜTÜN, Serpil

Bioengineering functional copolymers. xx. synthesis of novel anticancer active poly(Maleic anhydride-alt-2-vinyl-1,3-dioxolane) and its organoboron amideester branched derivatives

Gülten KAHRAMAN, (Türkiye Atom Enerjisi Kurumu, Sarayköy Nükleer Araştırma ve Eğitim Merkezi, Ankara, Türkiye)

Mustafa TÜRK, (Kırıkkale Üniversitesi, Fen Edebiyat Fakültesi, Biyoloji Bölümü, Kırıkkale, Türkiye)

Zakir M. O. RZAYEV, (Hacettepe Üniversitesi, Fen Bilimleri Enstitüsü, Nanoteknoloji ve Nanotıp Anabilim Dalı, Beytepe, Ankara, Türkiye)

Ernur A SÖYLEMEZ, (Hacettepe Üniversitesi, Fen Bilimleri Enstitüsü, Nanoteknoloji ve Nanotıp Anabilim Dalı, Beytepe, Ankara, Türkiye)

Serpil OĞUZTÜTÜN (Kırıkkale Üniversitesi, Fen Edebiyat Fakültesi, Biyoloji Bölümü, Kırıkkale, Türkiye)

Hacettepe Journal of Biology and Chemistry

4 0

Yıl: 2012 Cilt: 40 Sayı: 2 Sayfa Aralığı: 183 - 194 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Bioengineering functional copolymers. xx. synthesis of novel anticancer active poly(Maleic anhydride-alt-2-vinyl-1,3-dioxolane) and its organoboron amideester branched derivatives

Öz:

Yeni biyomühendislik alternatif kopolimerinin ve organobor amid ve a-hidroksi-w-metoksi-poli(etilen oksit) (PEO) ile dallanmış türevlerinin sentezi, (1) Seçilen reaksiyon şartlarında homopolimerleşmeyen maleik anhidriti (MA) ve 2-vinil-1,3-dioksolan (VDO) monomerlerinin kompleks-radikal alternatif kopolimerizasyonu, (2) sentezlenen poli(MA-alt-VDO) makromoleküllerinin 2-amino-etildifenilboronat ile amidolizi ve (3) PEO ile esterleşmesi yöntemleri kulllanarak gerçekleştirilmiştir. Monomerlerin kompleks oluşumu (Kc) ve kopolimerleşme sabitleri (r1 ve r2), çok fonksiyonel gruplar içeren kopolimerlerin yapısı, içeriği ve ısısal özellikleri kimyasal analiz (alkali titrasyon), FTIR-ATR and NMR spektroskopisi ve TGA-DSC ile karakterize edilmiştir. İyonize olabilen, hidrofilik/hidrofobik, organobor, anhidrit-karboksil-amid-ester-eter gibi gruplar içeren bu kopolimerlerin HeLa hücrelerine sitotoksik etkisi araştırılmış ve organobor-PEO kopolimer < poli(MAalt- VDO) < organobor kopolimer sırasında olduğu belirlenmiştir.

Anahtar Kelime: antikanserojenik bileşenler HeLa hücreleri esterleşme sitotoksisite

Konular: Biyoloji

Biyomühendislik fonksiyonel kopolimerleri. xx. yeni antikanser aktif poli(Maleik anhidrid-alt-2- vinil-1,3-dioxolan) ve organoboron amid-ester dallanmış türevleri

Öz:

Novel bioengineering alternating copolymer and its organoboron amide and a-hydroxy-wmethoxypoly (ethylene oxide) (PEO) branched derivatives were synthesized by (1) complex-radical alternating copolymerization of two non-homopolymerizable in chosen reaction conditions monomers such as maleic anhydride (MA) and 2-vinyl- 1,3-dioxolane (VDO), (2) amidolysis of synthesized poly(MA-alt-VDO) with 2-aminoethyldiphenylboronate and (3) esterification-grafting of organoboron copolymer with PEO. The complex-formation (Kc) and the monomer reactivity ratios (r1 and r2 copolymerization constants), structure and composition of the synthesized copolymers were characterized by chemical (alkali titration), FTIR-ATR and NMR spectroscopy, TGA-DSC thermal analysis methods. Cytotoxicity found as having an order as organoboron branched PEO copolymer < poly(MA-alt-VDO) < organoboron copolymer of these novel copolymers containing a combination of ionizable, hydrophilic/hydrophobic, organoboron, carboxyl-amide-ester-ether groups, toward HeLa cells was investigated.

Anahtar Kelime: esterification cytotoxicity anticancinogenic components HeLa cells

Konular: Biyoloji

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	KAHRAMAN G, Türk M, RZAYEV Z, SÖYLEMEZ E, OĞUZTÜTÜN S (2012). Bioengineering functional copolymers. xx. synthesis of novel anticancer active poly(Maleic anhydride-alt-2-vinyl-1,3-dioxolane) and its organoboron amideester branched derivatives. , 183 - 194.
Chicago	KAHRAMAN Gülten,Türk Mustafa,RZAYEV Zakir M. O.,SÖYLEMEZ Ernur A,OĞUZTÜTÜN Serpil Bioengineering functional copolymers. xx. synthesis of novel anticancer active poly(Maleic anhydride-alt-2-vinyl-1,3-dioxolane) and its organoboron amideester branched derivatives. (2012): 183 - 194.
MLA	KAHRAMAN Gülten,Türk Mustafa,RZAYEV Zakir M. O.,SÖYLEMEZ Ernur A,OĞUZTÜTÜN Serpil Bioengineering functional copolymers. xx. synthesis of novel anticancer active poly(Maleic anhydride-alt-2-vinyl-1,3-dioxolane) and its organoboron amideester branched derivatives. , 2012, ss.183 - 194.
AMA	KAHRAMAN G,Türk M,RZAYEV Z,SÖYLEMEZ E,OĞUZTÜTÜN S Bioengineering functional copolymers. xx. synthesis of novel anticancer active poly(Maleic anhydride-alt-2-vinyl-1,3-dioxolane) and its organoboron amideester branched derivatives. . 2012; 183 - 194.
Vancouver	KAHRAMAN G,Türk M,RZAYEV Z,SÖYLEMEZ E,OĞUZTÜTÜN S Bioengineering functional copolymers. xx. synthesis of novel anticancer active poly(Maleic anhydride-alt-2-vinyl-1,3-dioxolane) and its organoboron amideester branched derivatives. . 2012; 183 - 194.
IEEE	KAHRAMAN G,Türk M,RZAYEV Z,SÖYLEMEZ E,OĞUZTÜTÜN S "Bioengineering functional copolymers. xx. synthesis of novel anticancer active poly(Maleic anhydride-alt-2-vinyl-1,3-dioxolane) and its organoboron amideester branched derivatives." , ss.183 - 194, 2012.
ISNAD	KAHRAMAN, Gülten vd. "Bioengineering functional copolymers. xx. synthesis of novel anticancer active poly(Maleic anhydride-alt-2-vinyl-1,3-dioxolane) and its organoboron amideester branched derivatives". (2012), 183-194.

APA	KAHRAMAN G, Türk M, RZAYEV Z, SÖYLEMEZ E, OĞUZTÜTÜN S (2012). Bioengineering functional copolymers. xx. synthesis of novel anticancer active poly(Maleic anhydride-alt-2-vinyl-1,3-dioxolane) and its organoboron amideester branched derivatives. Hacettepe Journal of Biology and Chemistry, 40(2), 183 - 194.
Chicago	KAHRAMAN Gülten,Türk Mustafa,RZAYEV Zakir M. O.,SÖYLEMEZ Ernur A,OĞUZTÜTÜN Serpil Bioengineering functional copolymers. xx. synthesis of novel anticancer active poly(Maleic anhydride-alt-2-vinyl-1,3-dioxolane) and its organoboron amideester branched derivatives. Hacettepe Journal of Biology and Chemistry 40, no.2 (2012): 183 - 194.
MLA	KAHRAMAN Gülten,Türk Mustafa,RZAYEV Zakir M. O.,SÖYLEMEZ Ernur A,OĞUZTÜTÜN Serpil Bioengineering functional copolymers. xx. synthesis of novel anticancer active poly(Maleic anhydride-alt-2-vinyl-1,3-dioxolane) and its organoboron amideester branched derivatives. Hacettepe Journal of Biology and Chemistry, vol.40, no.2, 2012, ss.183 - 194.
AMA	KAHRAMAN G,Türk M,RZAYEV Z,SÖYLEMEZ E,OĞUZTÜTÜN S Bioengineering functional copolymers. xx. synthesis of novel anticancer active poly(Maleic anhydride-alt-2-vinyl-1,3-dioxolane) and its organoboron amideester branched derivatives. Hacettepe Journal of Biology and Chemistry. 2012; 40(2): 183 - 194.
Vancouver	KAHRAMAN G,Türk M,RZAYEV Z,SÖYLEMEZ E,OĞUZTÜTÜN S Bioengineering functional copolymers. xx. synthesis of novel anticancer active poly(Maleic anhydride-alt-2-vinyl-1,3-dioxolane) and its organoboron amideester branched derivatives. Hacettepe Journal of Biology and Chemistry. 2012; 40(2): 183 - 194.
IEEE	KAHRAMAN G,Türk M,RZAYEV Z,SÖYLEMEZ E,OĞUZTÜTÜN S "Bioengineering functional copolymers. xx. synthesis of novel anticancer active poly(Maleic anhydride-alt-2-vinyl-1,3-dioxolane) and its organoboron amideester branched derivatives." Hacettepe Journal of Biology and Chemistry, 40, ss.183 - 194, 2012.
ISNAD	KAHRAMAN, Gülten vd. "Bioengineering functional copolymers. xx. synthesis of novel anticancer active poly(Maleic anhydride-alt-2-vinyl-1,3-dioxolane) and its organoboron amideester branched derivatives". Hacettepe Journal of Biology and Chemistry 40/2 (2012), 183-194.