Preventive medicine is important to avert helminth diseases living in ruminants as endoparasite and to achieve maximum productivity. The usage of anthelmintic is still the most common method used that contributes to the reduction of production losses and prevention of zoonotic diseases because vaccine studies have not succeeded yet. However, the control of helminth infections in ruminants may be achieved by consciously and simultaneously applying anthelmintic and alternative control methods. Unconscious and irregular applications of anthelmintic prevent an effective control and lead to the development of drug resistance. The main purpose of anthelmintic drug use is to decrease to the parasite burden on the host as much as possible. The criteria that need to be taken into account/ consideration when choosing an antihelmintic drug are the growth period of parasite, the action spectrum of drug, therapeutic index, ease of administration, price, and whether it leaves a residue. Anthelmintic treatments should be performed with effective drugs at the right time. Narrow-spectrum drugs should be combined with other appropriate medications, or broad-spectrum drugs should be preferred for treatment. In practice, ruminants are treated twice a year. Attention to the application of the correct dose, frequency of use, and drug rotation in treatment will result in less usage of anthelmintic by preventing the development of drug resistance. In this review, the action mechanism of anthelmintic drugs, the action spectrum, the active ingredients and their commercial forms, as well as precautions for their usage during pregnancy, lactation, and pre-slaughter period are summarized in tables.