The effects of four different drugs administered through catheters on slime production in coagulase negative Staphylococci

GÖÇMEN, Jülide Sedef; ÇAĞLAYAN, Osman; Buyukkocak, Unase; AZAP, Alpay; PEKUZ, Yasemin Ö.

The effects of four different drugs administered through catheters on slime production in coagulase negative Staphylococci

Jülide Sedef GÖÇMEN, (Başkent Üniversitesi, Tıp Fakültesi, Tıbbi Mikrobiyoloji Anabilim Dalı, Ankara, Türkiye)

Ünase BÜYÜKKOÇAK, (Kırıkkale Üniversitesi, Tıp Fakültesi, Anesteziyoloji ve Reanimasyon Anabilim Dalı, Kırıkkale, Türkiye)

Alpay AZAP, (Ankara Üniversitesi, Tıp Fakültesi, Enfeksiyon Hastalıkları Anabilim Dalı, Ankara, Türkiye)

Yasemin Ö. PEKUZ, (Kırıkkale Üniversitesi, Tıp Fakültesi, Anesteziyoloji ve Reanimasyon Anabilim Dalı, Kırıkkale, Türkiye)

Osman ÇAĞLAYAN (Kırıkkale Üniversitesi, Tıp Fakültesi, Biyokimya Anabilim Dalı, Kırıkkale, Türkiye)

Journal of Microbiology and Infectious Diseases

1 0

Yıl: 2012 Cilt: 2 Sayı: 4 Sayfa Aralığı: 150 - 154 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

The effects of four different drugs administered through catheters on slime production in coagulase negative Staphylococci

Öz:

Amaç: Patojen bakteri suşlarında slime oluşturma oranı daha yüksek bulunmuştur. Slime oluşumunu artıran faktörler enfeksiyon riskini artırırken azaltanlar ise bu riski düşürmektedir. Çalışmamızda Yoğun Bakım Ünitelerinde kateter aracılığı infüzyon şeklinde uygulanan bazı ilaçların koagülaz negatif Stafilokok’larda slime oluşumuna etkisi araştırıldı. Gereç ve yöntem: Glyceryl trinitrate (Perlinganit®), Dexmedetomidine (Precedex®), Esmolol (Brevibloc®) ve Propofol (Propofol®)’un slime oluşumuna etkileri 24’ü kan kültürlerinden izole edil ve biri American Type Culture Collection (ATCC) 12228 kodlu referans Staphylococcus epidermidis suşu üzerinde araştırıldı. Slime oluşumu Christensen tarafından tarif edilmiş olan “Kantitatif mikrodilüsyon plak testi” yöntemi ile belirlendi. Bulgular: Kontrol kuyucuklarında 8 bakteri slime oluşturdu. Esmolol içeren besi yerinde 5, Glyceryl trinitrate’lı besiyerinde 21, dexmedetomidine olan besiyerinde 15, propofol’lü besiyerinde 18 bakteri slime pozitif bulundu. Glyceryl trinitrate, dexmedetomidine ve propofolün slime pozitifliğini kontrole göre anlamlı ölçüde arttırdığı saptandı. Sonuç: Bu çalışmanın sonuçlarının ışığında; ilaç ve/ veya katkı maddelerinin slime üretimine etkili olabileceği sonucuna varıldı. Kateter yoluyla uygulanan preparatların etkileri araştırılmalı ve kullanımları sırasında bu etkilerinin olabileceği akılda tutulmalıdır.

Anahtar Kelime:

Konular: Mikrobiyoloji Enfeksiyon Hastalıkları

Kateter aracılığıyla verilen dört farklı ilacın koagülaz negatif Stafilokoklarda slime oluşuma etkisi

Öz:

Objectives: Higher rate of slime production has been found in pathogen bacteria strains. Accordingly, the factors that contribute to higher slime production rate increase the infection risk, while the factors that reduce the slime production rate will reduce the infection risk. The effect of some drugs that are administered through catheters in intensive care units on slime production with coagulase negative Staphylococci was investigated. Materials and methods: In this study, the effect of four different preparations containing Glyceryl trinitrate (Perlinganit ®), Dexmedetomidine (Precedex®), Esmolol (Brevibloc®), and Propofol (Propofol®) on slime production of 24 Staphylococcus epidermidis strains isolated from blood cultures of patients, and reference strain were investigated. Slime production was determined using ‘the quantitative microdilution plaque test’ described by Christensen. Results: Under controlled medium, eight strains formed slimes, and in the media containing esmolol, glyceryl trinitrate, dexmedetomidine, and propofol slimes were positive for five, 21, 15, and 18 strains, respectively. The rate of slime production in glyceryl trinitrate, dexmedetomidine, and propofol containing media were higher than that of the controls. Conclusions: In the light of the results of this study, it is concluded that the drugs and/or additives increase the rate of slime production. The effects of the preparations administered through catheters on slime production should be investigated, and these effects should be kept in mind during their use.

Anahtar Kelime:

Konular: Mikrobiyoloji Enfeksiyon Hastalıkları

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	GÖÇMEN J, Buyukkocak U, AZAP A, PEKUZ Y, ÇAĞLAYAN O (2012). The effects of four different drugs administered through catheters on slime production in coagulase negative Staphylococci. , 150 - 154.
Chicago	GÖÇMEN Jülide Sedef,Buyukkocak Unase,AZAP Alpay,PEKUZ Yasemin Ö.,ÇAĞLAYAN Osman The effects of four different drugs administered through catheters on slime production in coagulase negative Staphylococci. (2012): 150 - 154.
MLA	GÖÇMEN Jülide Sedef,Buyukkocak Unase,AZAP Alpay,PEKUZ Yasemin Ö.,ÇAĞLAYAN Osman The effects of four different drugs administered through catheters on slime production in coagulase negative Staphylococci. , 2012, ss.150 - 154.
AMA	GÖÇMEN J,Buyukkocak U,AZAP A,PEKUZ Y,ÇAĞLAYAN O The effects of four different drugs administered through catheters on slime production in coagulase negative Staphylococci. . 2012; 150 - 154.
Vancouver	GÖÇMEN J,Buyukkocak U,AZAP A,PEKUZ Y,ÇAĞLAYAN O The effects of four different drugs administered through catheters on slime production in coagulase negative Staphylococci. . 2012; 150 - 154.
IEEE	GÖÇMEN J,Buyukkocak U,AZAP A,PEKUZ Y,ÇAĞLAYAN O "The effects of four different drugs administered through catheters on slime production in coagulase negative Staphylococci." , ss.150 - 154, 2012.
ISNAD	GÖÇMEN, Jülide Sedef vd. "The effects of four different drugs administered through catheters on slime production in coagulase negative Staphylococci". (2012), 150-154.

APA	GÖÇMEN J, Buyukkocak U, AZAP A, PEKUZ Y, ÇAĞLAYAN O (2012). The effects of four different drugs administered through catheters on slime production in coagulase negative Staphylococci. Journal of Microbiology and Infectious Diseases, 2(4), 150 - 154.
Chicago	GÖÇMEN Jülide Sedef,Buyukkocak Unase,AZAP Alpay,PEKUZ Yasemin Ö.,ÇAĞLAYAN Osman The effects of four different drugs administered through catheters on slime production in coagulase negative Staphylococci. Journal of Microbiology and Infectious Diseases 2, no.4 (2012): 150 - 154.
MLA	GÖÇMEN Jülide Sedef,Buyukkocak Unase,AZAP Alpay,PEKUZ Yasemin Ö.,ÇAĞLAYAN Osman The effects of four different drugs administered through catheters on slime production in coagulase negative Staphylococci. Journal of Microbiology and Infectious Diseases, vol.2, no.4, 2012, ss.150 - 154.
AMA	GÖÇMEN J,Buyukkocak U,AZAP A,PEKUZ Y,ÇAĞLAYAN O The effects of four different drugs administered through catheters on slime production in coagulase negative Staphylococci. Journal of Microbiology and Infectious Diseases. 2012; 2(4): 150 - 154.
Vancouver	GÖÇMEN J,Buyukkocak U,AZAP A,PEKUZ Y,ÇAĞLAYAN O The effects of four different drugs administered through catheters on slime production in coagulase negative Staphylococci. Journal of Microbiology and Infectious Diseases. 2012; 2(4): 150 - 154.
IEEE	GÖÇMEN J,Buyukkocak U,AZAP A,PEKUZ Y,ÇAĞLAYAN O "The effects of four different drugs administered through catheters on slime production in coagulase negative Staphylococci." Journal of Microbiology and Infectious Diseases, 2, ss.150 - 154, 2012.
ISNAD	GÖÇMEN, Jülide Sedef vd. "The effects of four different drugs administered through catheters on slime production in coagulase negative Staphylococci". Journal of Microbiology and Infectious Diseases 2/4 (2012), 150-154.