The effect of long-term continuous positive airway pressure treatment on systolic and diastolic function in patients with obstructive sleep apnoea syndrome: A five year observational study

Dalgıç, Onur; BİLGE, ALİ RIZA; YAVUZ, Veysel; KUM, Gökmen; ÇETİN, NURULLAH; YILMAZ, HIKMET; TIKIZ, Hakan

The effect of long-term continuous positive airway pressure treatment on systolic and diastolic function in patients with obstructive sleep apnoea syndrome: A five year observational study

Ali Rıza BİLGE, (Celal Bayar Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Manisa, Türkiye)

Veysel YAVUZ, (Celal Bayar Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Manisa, Türkiye)

Nurullah ÇETİN, (Celal Bayar Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Manisa, Türkiye)

Onur DALGIÇ, (Celal Bayar Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Manisa, Türkiye)

Gökmen KUM, (Celal Bayar Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Manisa, Türkiye)

Hikmet YILMAZ, (Celal Bayar Üniversitesi, Tıp Fakültesi, Nöroloji Anabilim Dalı, Manisa, Türkiye)

Hakan TIKIZ (Celal Bayar Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Manisa, Türkiye)

Anadolu Kardiyoloji Dergisi

0 1

Yıl: 2014 Cilt: 14 Sayı: 3 Sayfa Aralığı: 265 - 271 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

The effect of long-term continuous positive airway pressure treatment on systolic and diastolic function in patients with obstructive sleep apnoea syndrome: A five year observational study

Öz:

Objective: Evaluation of the long-term effects of continuous positive airway presure (CPAP) on mean heart rate and left ventricular systolic and diastolic parameters in obstructive sleep apnea syndrome (OSAS) using conventional and tissue Doppler techniques. Methods: This prospective cohort study is designed to evaluate the long-term effects of CPAP treatments in normotensive OSAS patients. Initially 40 patients aged from eighteen to fifty five with documented OSAS syndrome were evaluated within one month of CPAP treatment. All had high self-reported compliance with treatment. From the latter, 21 patients with uninterrupted CPAP therapy (for at least 5 years, 5 hours per day) were included in the study and further evaluated with treatment. The left ventricular systolic function was assessed on apical four- cham- ber view using modified Simpson method and diastolic function was evaluated with classic transmitral pulsed and tissue Doppler techniques. Paired t test and Wilcoxon signed rank test had been used to compare the clinical and echocardiography data before and after treatment period. Results: A comparison of values assessed after one month and after 5 years of CPAP therapy, revealed a significant increase in the acceleration time(AT) Em/Am ratio and ejection time (ET) (AT: p=0.04; Em/Am ratio p=0.03 ET: p=0.04) while a significant decrease was observed on decel- eration time (DT), isovolumetric relaxation time (IRT), myocardial performance index (MPI), mitral regurgitation (MR) and 24 hour mean heart rate (HR) in all subjects (DT: p=0.02; IVRT: p=0,04; MPI: p=0,01; MR: p≤0.001; HR: p=0.004). Conclusion: We observed a significant improvement in the left ventricular systolic and diastolic function and a significant decrease of 24-hour heart rate and mitral regurgitation with unchanged ejection fraction of the left ventricle with long-term CPAP treatment similar to short-term treatment studies. The long-term maintenance of the beneficial effect of CPAP throughout the 5 year long-term treatment can be one of the pathophysiologic mechanisms that may explain the decrease of cardiovascular mortality observed with long-term CPAP therapy in OSAS patients.

Anahtar Kelime:

Konular: Kalp ve Kalp Damar Sistemi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	BİLGE A, YAVUZ V, ÇETİN N, Dalgıç O, KUM G, YILMAZ H, TIKIZ H (2014). The effect of long-term continuous positive airway pressure treatment on systolic and diastolic function in patients with obstructive sleep apnoea syndrome: A five year observational study. , 265 - 271.
Chicago	BİLGE ALİ RIZA,YAVUZ Veysel,ÇETİN NURULLAH,Dalgıç Onur,KUM Gökmen,YILMAZ HIKMET,TIKIZ Hakan The effect of long-term continuous positive airway pressure treatment on systolic and diastolic function in patients with obstructive sleep apnoea syndrome: A five year observational study. (2014): 265 - 271.
MLA	BİLGE ALİ RIZA,YAVUZ Veysel,ÇETİN NURULLAH,Dalgıç Onur,KUM Gökmen,YILMAZ HIKMET,TIKIZ Hakan The effect of long-term continuous positive airway pressure treatment on systolic and diastolic function in patients with obstructive sleep apnoea syndrome: A five year observational study. , 2014, ss.265 - 271.
AMA	BİLGE A,YAVUZ V,ÇETİN N,Dalgıç O,KUM G,YILMAZ H,TIKIZ H The effect of long-term continuous positive airway pressure treatment on systolic and diastolic function in patients with obstructive sleep apnoea syndrome: A five year observational study. . 2014; 265 - 271.
Vancouver	BİLGE A,YAVUZ V,ÇETİN N,Dalgıç O,KUM G,YILMAZ H,TIKIZ H The effect of long-term continuous positive airway pressure treatment on systolic and diastolic function in patients with obstructive sleep apnoea syndrome: A five year observational study. . 2014; 265 - 271.
IEEE	BİLGE A,YAVUZ V,ÇETİN N,Dalgıç O,KUM G,YILMAZ H,TIKIZ H "The effect of long-term continuous positive airway pressure treatment on systolic and diastolic function in patients with obstructive sleep apnoea syndrome: A five year observational study." , ss.265 - 271, 2014.
ISNAD	BİLGE, ALİ RIZA vd. "The effect of long-term continuous positive airway pressure treatment on systolic and diastolic function in patients with obstructive sleep apnoea syndrome: A five year observational study". (2014), 265-271.

APA	BİLGE A, YAVUZ V, ÇETİN N, Dalgıç O, KUM G, YILMAZ H, TIKIZ H (2014). The effect of long-term continuous positive airway pressure treatment on systolic and diastolic function in patients with obstructive sleep apnoea syndrome: A five year observational study. Anadolu Kardiyoloji Dergisi, 14(3), 265 - 271.
Chicago	BİLGE ALİ RIZA,YAVUZ Veysel,ÇETİN NURULLAH,Dalgıç Onur,KUM Gökmen,YILMAZ HIKMET,TIKIZ Hakan The effect of long-term continuous positive airway pressure treatment on systolic and diastolic function in patients with obstructive sleep apnoea syndrome: A five year observational study. Anadolu Kardiyoloji Dergisi 14, no.3 (2014): 265 - 271.
MLA	BİLGE ALİ RIZA,YAVUZ Veysel,ÇETİN NURULLAH,Dalgıç Onur,KUM Gökmen,YILMAZ HIKMET,TIKIZ Hakan The effect of long-term continuous positive airway pressure treatment on systolic and diastolic function in patients with obstructive sleep apnoea syndrome: A five year observational study. Anadolu Kardiyoloji Dergisi, vol.14, no.3, 2014, ss.265 - 271.
AMA	BİLGE A,YAVUZ V,ÇETİN N,Dalgıç O,KUM G,YILMAZ H,TIKIZ H The effect of long-term continuous positive airway pressure treatment on systolic and diastolic function in patients with obstructive sleep apnoea syndrome: A five year observational study. Anadolu Kardiyoloji Dergisi. 2014; 14(3): 265 - 271.
Vancouver	BİLGE A,YAVUZ V,ÇETİN N,Dalgıç O,KUM G,YILMAZ H,TIKIZ H The effect of long-term continuous positive airway pressure treatment on systolic and diastolic function in patients with obstructive sleep apnoea syndrome: A five year observational study. Anadolu Kardiyoloji Dergisi. 2014; 14(3): 265 - 271.
IEEE	BİLGE A,YAVUZ V,ÇETİN N,Dalgıç O,KUM G,YILMAZ H,TIKIZ H "The effect of long-term continuous positive airway pressure treatment on systolic and diastolic function in patients with obstructive sleep apnoea syndrome: A five year observational study." Anadolu Kardiyoloji Dergisi, 14, ss.265 - 271, 2014.
ISNAD	BİLGE, ALİ RIZA vd. "The effect of long-term continuous positive airway pressure treatment on systolic and diastolic function in patients with obstructive sleep apnoea syndrome: A five year observational study". Anadolu Kardiyoloji Dergisi 14/3 (2014), 265-271.