Is there a relationship between serum heart- type fatty acid binding protein level and clinical severity in patients with subarachnoid hemorrhage?

BAYDIN, Ahmet; GÜNAY, Murat; MERİÇ, Murat; YILMAN, Metehan; KATI, CELAL; YARDAN, Türker; ÇOKLUK, Cengiz

Is there a relationship between serum heart- type fatty acid binding protein level and clinical severity in patients with subarachnoid hemorrhage?

Metehan YILMAN, (Ondokuz Mayıs Üniversitesi, Tıp Fakültesi, Samsun, Türkiye)

Cengiz ÇOKLUK, (Ondokuz Mayıs Üniversitesi, Tıp Fakültesi, Samsun, Türkiye)

Ahmet BAYDIN, (Ondokuz Mayıs Üniversitesi, Tıp Fakültesi, Samsun, Türkiye)

Türker YARDAN, (Ondokuz Mayıs Üniversitesi, Tıp Fakültesi, Samsun, Türkiye)

Celal KATI, (Ondokuz Mayıs Üniversitesi, Tıp Fakültesi, Samsun, Türkiye)

Murat GÜNAY, (Ondokuz Mayıs Üniversitesi, Tıp Fakültesi, Samsun, Türkiye)

Murat MERİÇ (Ondokuz Mayıs Üniversitesi, Tıp Fakültesi, Samsun, Türkiye)

Turkish Neurosurgery

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Yıl: 2012 Cilt: 22 Sayı: 6 Sayfa Aralığı: 695 - 700 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Is there a relationship between serum heart- type fatty acid binding protein level and clinical severity in patients with subarachnoid hemorrhage?

Öz:

AMAÇ: Bu çalışmanın amacı, subaraknoid kanama (SAK) ile başvuran hastalarda serum H-FABP seviyesini ve kardiyak etkileri belirlemek ve kardiyak etkileri ile H-FABP arasında ilişkili olup olmadığını araştırmaktır. YÖNTEM ve GEREÇLER: Acil serviste SAK tanısı alan 46 hasta çalışmaya alındı. Ayrıca kontrol grubunu oluşturmak üzere 20 sağlıklı erişkin çalışmaya dahil edildi. Tüm hastalara başvuru anında 12 derivasyonlu EKG çekildi. Hastalardan başvuru anında alınan kan örneklerinden H-FABP düzeyleri belirlendi. BULGULAR: Hastaların serum H-FABP düzeylerinin kontrol grubuna göre anlamlı derecede yüksek olduğu tespit edildi (p<0.05). Serum H-FABP seviyesi ve EKG değişiklikleri arasında anlamlı bir ilişki yoktu. Serum H-FABP düzeyleri ile Hunt Hess sınıflamasına göre evre artışı arasında orta derecede pozitif korelasyon vardı (r=0.43, p<0.05). Serum H-FABP düzeyleri ile Fisher radyolojik sınıflamasına göre evre artışı arasında zayıf bir pozitif korelasyon vardı (r =0.38, p<0.05). SONUÇ: SAK’lı hastalarda serum H-FABP düzeyleri artmaktadır. Serum H-FABP düzeylerindeki artış ile Hunt-Hess ve Fisher Ölçeği arasında korelasyon vardır.

Anahtar Kelime:

Konular: Cerrahi

Subaraknoid kanamalı hastaların klinik şiddeti ile kalp tipi yağ asidi bağlayıcı proteinin serum düzeyi arasında ilişki var mıdır?

Öz:

AIM: The aim of this study was to determine the serum heart-type fatty acid binding protein (H-FABP) levels and cardiac effects in patients presenting with subarachnoid hemorrhage (SAH) and to investigate whether any correlation exists between the cardiac effects and H-FABP. MaterIal and Methods: Forty-six patients diagnosed as acute SAH in the emergency department were included in this study. Twenty healthy adults were included in the study to serve as controls. Twelve-lead ECG was performed on all patients on admission. H-FABP levels of patients were determined in serum samples taken on admission. Results: Serum H-FABP levels of patients were found to be significantly higher than those of controls (p<0.05). There was no significant correlation between serum H-FABP levels and ECG changes. There was a moderate positive correlation between H-FABP serum levels and the grade according to the Hunt and Hess classification (r=0.43, p<0.05). There was a weak positive correlation between H-FABP serum levels and the grade according to the Fisher radiological classification (r=0.38, p<0.05). ConclusIon: Serum H-FABP levels are increased in patients with SAH. Grades according to the Hunt and Hess and Fisher grading scales were shown to increase in conjunction with an increase in H-FABP levels.

Anahtar Kelime:

Konular: Cerrahi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	YILMAN M, ÇOKLUK C, BAYDIN A, YARDAN T, KATI C, GÜNAY M, MERİÇ M (2012). Is there a relationship between serum heart- type fatty acid binding protein level and clinical severity in patients with subarachnoid hemorrhage?. , 695 - 700.
Chicago	YILMAN Metehan,ÇOKLUK Cengiz,BAYDIN Ahmet,YARDAN Türker,KATI CELAL,GÜNAY Murat,MERİÇ Murat Is there a relationship between serum heart- type fatty acid binding protein level and clinical severity in patients with subarachnoid hemorrhage?. (2012): 695 - 700.
MLA	YILMAN Metehan,ÇOKLUK Cengiz,BAYDIN Ahmet,YARDAN Türker,KATI CELAL,GÜNAY Murat,MERİÇ Murat Is there a relationship between serum heart- type fatty acid binding protein level and clinical severity in patients with subarachnoid hemorrhage?. , 2012, ss.695 - 700.
AMA	YILMAN M,ÇOKLUK C,BAYDIN A,YARDAN T,KATI C,GÜNAY M,MERİÇ M Is there a relationship between serum heart- type fatty acid binding protein level and clinical severity in patients with subarachnoid hemorrhage?. . 2012; 695 - 700.
Vancouver	YILMAN M,ÇOKLUK C,BAYDIN A,YARDAN T,KATI C,GÜNAY M,MERİÇ M Is there a relationship between serum heart- type fatty acid binding protein level and clinical severity in patients with subarachnoid hemorrhage?. . 2012; 695 - 700.
IEEE	YILMAN M,ÇOKLUK C,BAYDIN A,YARDAN T,KATI C,GÜNAY M,MERİÇ M "Is there a relationship between serum heart- type fatty acid binding protein level and clinical severity in patients with subarachnoid hemorrhage?." , ss.695 - 700, 2012.
ISNAD	YILMAN, Metehan vd. "Is there a relationship between serum heart- type fatty acid binding protein level and clinical severity in patients with subarachnoid hemorrhage?". (2012), 695-700.

APA	YILMAN M, ÇOKLUK C, BAYDIN A, YARDAN T, KATI C, GÜNAY M, MERİÇ M (2012). Is there a relationship between serum heart- type fatty acid binding protein level and clinical severity in patients with subarachnoid hemorrhage?. Turkish Neurosurgery, 22(6), 695 - 700.
Chicago	YILMAN Metehan,ÇOKLUK Cengiz,BAYDIN Ahmet,YARDAN Türker,KATI CELAL,GÜNAY Murat,MERİÇ Murat Is there a relationship between serum heart- type fatty acid binding protein level and clinical severity in patients with subarachnoid hemorrhage?. Turkish Neurosurgery 22, no.6 (2012): 695 - 700.
MLA	YILMAN Metehan,ÇOKLUK Cengiz,BAYDIN Ahmet,YARDAN Türker,KATI CELAL,GÜNAY Murat,MERİÇ Murat Is there a relationship between serum heart- type fatty acid binding protein level and clinical severity in patients with subarachnoid hemorrhage?. Turkish Neurosurgery, vol.22, no.6, 2012, ss.695 - 700.
AMA	YILMAN M,ÇOKLUK C,BAYDIN A,YARDAN T,KATI C,GÜNAY M,MERİÇ M Is there a relationship between serum heart- type fatty acid binding protein level and clinical severity in patients with subarachnoid hemorrhage?. Turkish Neurosurgery. 2012; 22(6): 695 - 700.
Vancouver	YILMAN M,ÇOKLUK C,BAYDIN A,YARDAN T,KATI C,GÜNAY M,MERİÇ M Is there a relationship between serum heart- type fatty acid binding protein level and clinical severity in patients with subarachnoid hemorrhage?. Turkish Neurosurgery. 2012; 22(6): 695 - 700.
IEEE	YILMAN M,ÇOKLUK C,BAYDIN A,YARDAN T,KATI C,GÜNAY M,MERİÇ M "Is there a relationship between serum heart- type fatty acid binding protein level and clinical severity in patients with subarachnoid hemorrhage?." Turkish Neurosurgery, 22, ss.695 - 700, 2012.
ISNAD	YILMAN, Metehan vd. "Is there a relationship between serum heart- type fatty acid binding protein level and clinical severity in patients with subarachnoid hemorrhage?". Turkish Neurosurgery 22/6 (2012), 695-700.