Aryl butenoic acid derivatives as a new class of histone deacetylase inhibitors: synthesis, in vitro evaluation, and molecular docking studies

Peruze EŞIYOK AYHAN, (Orta Doğu Teknik Üniversitesi, Fen Edebiyat Fakültesi, Kimya Bölümü, Ankara, Türkiye)
Özlem SEVEN, (Orta Doğu Teknik Üniversitesi, Fen Edebiyat Fakültesi, Kimya Bölümü, Ankara, Türkiye)
Gülüzar EYMUR, (Orta Doğu Teknik Üniversitesi, Fen Edebiyat Fakültesi, Kimya Bölümü, Ankara, Türkiye)
Gamze TATAR BORA, (Hacettepe Üniversitesi Tıp Fakültesi Tıbbi Biyoloji Anabilim Dalı, Ankara, Türkiye)
Didem DAYANGAÇ ERDEN, (Hacettepe Üniversitesi Tıp Fakültesi Tıbbi Biyoloji Anabilim Dalı, Ankara, Türkiye)
Kemal YELEKÇİ, (Kadir Has Üniversitesi, İstanbul, Türkiye)
Hayat YURTER, (Hacettepe Üniversitesi Tıp Fakültesi Tıbbi Biyoloji Anabilim Dalı, Ankara, Türkiye)
Ayhan Sıtkı DEMİR (Orta Doğu Teknik Üniversitesi, Fen Edebiyat Fakültesi, Kimya Bölümü, Ankara, Türkiye)
Turkish Journal of Chemistry
5 0
Yıl: 2014 Cilt: 38 Sayı: 2 Sayfa Aralığı: 338 - 344 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

Aryl butenoic acid derivatives as a new class of histone deacetylase inhibitors: synthesis, in vitro evaluation, and molecular docking studies

Öz:
New aryl butenoic acid derivatives have been synthesized by combining hydroxy- or methoxy-substituted phenyl rings as the capping group, with a double bond in the short linker as well as metal binding groups, enoic ester, and salts bearing either methyl or morpholine. These compounds have been shown to possess promising histone deacetylase inhibition activities via in vitro fluorometric assay and molecular docking studies.
Anahtar Kelime:

Konular: Mühendislik, Kimya
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA EŞIYOK AYHAN P, SEVEN Ö, EYMUR G, TATAR BORA G, DAYANGAÇ ERDEN D, Yelekci K, Erdem Yurter H, DEMİR A (2014). Aryl butenoic acid derivatives as a new class of histone deacetylase inhibitors: synthesis, in vitro evaluation, and molecular docking studies. , 338 - 344.
Chicago EŞIYOK AYHAN Peruze,SEVEN Özlem,EYMUR GÜLÜZAR,TATAR BORA Gamze,DAYANGAÇ ERDEN Didem,Yelekci Kemal,Erdem Yurter Hayat,DEMİR Ayhan Sıtkı Aryl butenoic acid derivatives as a new class of histone deacetylase inhibitors: synthesis, in vitro evaluation, and molecular docking studies. (2014): 338 - 344.
MLA EŞIYOK AYHAN Peruze,SEVEN Özlem,EYMUR GÜLÜZAR,TATAR BORA Gamze,DAYANGAÇ ERDEN Didem,Yelekci Kemal,Erdem Yurter Hayat,DEMİR Ayhan Sıtkı Aryl butenoic acid derivatives as a new class of histone deacetylase inhibitors: synthesis, in vitro evaluation, and molecular docking studies. , 2014, ss.338 - 344.
AMA EŞIYOK AYHAN P,SEVEN Ö,EYMUR G,TATAR BORA G,DAYANGAÇ ERDEN D,Yelekci K,Erdem Yurter H,DEMİR A Aryl butenoic acid derivatives as a new class of histone deacetylase inhibitors: synthesis, in vitro evaluation, and molecular docking studies. . 2014; 338 - 344.
Vancouver EŞIYOK AYHAN P,SEVEN Ö,EYMUR G,TATAR BORA G,DAYANGAÇ ERDEN D,Yelekci K,Erdem Yurter H,DEMİR A Aryl butenoic acid derivatives as a new class of histone deacetylase inhibitors: synthesis, in vitro evaluation, and molecular docking studies. . 2014; 338 - 344.
IEEE EŞIYOK AYHAN P,SEVEN Ö,EYMUR G,TATAR BORA G,DAYANGAÇ ERDEN D,Yelekci K,Erdem Yurter H,DEMİR A "Aryl butenoic acid derivatives as a new class of histone deacetylase inhibitors: synthesis, in vitro evaluation, and molecular docking studies." , ss.338 - 344, 2014.
ISNAD EŞIYOK AYHAN, Peruze vd. "Aryl butenoic acid derivatives as a new class of histone deacetylase inhibitors: synthesis, in vitro evaluation, and molecular docking studies". (2014), 338-344.
APA EŞIYOK AYHAN P, SEVEN Ö, EYMUR G, TATAR BORA G, DAYANGAÇ ERDEN D, Yelekci K, Erdem Yurter H, DEMİR A (2014). Aryl butenoic acid derivatives as a new class of histone deacetylase inhibitors: synthesis, in vitro evaluation, and molecular docking studies. Turkish Journal of Chemistry, 38(2), 338 - 344.
Chicago EŞIYOK AYHAN Peruze,SEVEN Özlem,EYMUR GÜLÜZAR,TATAR BORA Gamze,DAYANGAÇ ERDEN Didem,Yelekci Kemal,Erdem Yurter Hayat,DEMİR Ayhan Sıtkı Aryl butenoic acid derivatives as a new class of histone deacetylase inhibitors: synthesis, in vitro evaluation, and molecular docking studies. Turkish Journal of Chemistry 38, no.2 (2014): 338 - 344.
MLA EŞIYOK AYHAN Peruze,SEVEN Özlem,EYMUR GÜLÜZAR,TATAR BORA Gamze,DAYANGAÇ ERDEN Didem,Yelekci Kemal,Erdem Yurter Hayat,DEMİR Ayhan Sıtkı Aryl butenoic acid derivatives as a new class of histone deacetylase inhibitors: synthesis, in vitro evaluation, and molecular docking studies. Turkish Journal of Chemistry, vol.38, no.2, 2014, ss.338 - 344.
AMA EŞIYOK AYHAN P,SEVEN Ö,EYMUR G,TATAR BORA G,DAYANGAÇ ERDEN D,Yelekci K,Erdem Yurter H,DEMİR A Aryl butenoic acid derivatives as a new class of histone deacetylase inhibitors: synthesis, in vitro evaluation, and molecular docking studies. Turkish Journal of Chemistry. 2014; 38(2): 338 - 344.
Vancouver EŞIYOK AYHAN P,SEVEN Ö,EYMUR G,TATAR BORA G,DAYANGAÇ ERDEN D,Yelekci K,Erdem Yurter H,DEMİR A Aryl butenoic acid derivatives as a new class of histone deacetylase inhibitors: synthesis, in vitro evaluation, and molecular docking studies. Turkish Journal of Chemistry. 2014; 38(2): 338 - 344.
IEEE EŞIYOK AYHAN P,SEVEN Ö,EYMUR G,TATAR BORA G,DAYANGAÇ ERDEN D,Yelekci K,Erdem Yurter H,DEMİR A "Aryl butenoic acid derivatives as a new class of histone deacetylase inhibitors: synthesis, in vitro evaluation, and molecular docking studies." Turkish Journal of Chemistry, 38, ss.338 - 344, 2014.
ISNAD EŞIYOK AYHAN, Peruze vd. "Aryl butenoic acid derivatives as a new class of histone deacetylase inhibitors: synthesis, in vitro evaluation, and molecular docking studies". Turkish Journal of Chemistry 38/2 (2014), 338-344.
Sayfa Oluşturulma Tarihi
22-04-2024 20:25

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