Background: Dermatoscope is used to increase the precision ratio of clinical pre-diagnosis in terms of dermatological lesions. This study aims to compare statistical significance of dermatoscopic versus pathological diagnoses in terms of melanocytic and non-melanocytic lesions in which surgical excision is recommended. Methods: Dermatological examinations were performed by the same doctor with 15mm (10x focus), 8 white LED hand dermatoscope (3GEN DermLite DL 100). A total of 184 patients were enrolled; 116 of them were (63.04%) women, 68 of them were (36.96%) male. A total of 300 excision materials were compared in this study. Findings: The youngest patient was 7 years old and the oldest patient was 80 years old (average age was 36,47 years). 220 of the lesions were melanocytic, and 80 of the lesions were non-melanocytic. 190 of the melanocytic (86.36%) lesions had the same pathological diagnoses. 30 of the melanocytic (%13.64) lesions had different pathological diagnoses. 30 of the non-melanocytic (%37.5) lesions have the same pathological diagnoses. 50 of the nonmelanocytic (62.5%) lesions had different pathological diagnoses. Results: Melanocytic lesions had statistically significant (p=0.001) higher ratio of same (precise) diagnosis than non-melanocytic lesions. Dermatoscopy provided significantly higher rates of success in cases of melanocytic lesions. We believe that increasing of precision ratio of clinical prediagnosis is very helpful for pathologists in finding right diagnoses. In addition, follow up of patients, planning of surgical interventions would be greatly improved by right diagnoses.