Efficacy of amphotericin-b, clinicopathologic variables and oxidative stress markers in three staffordshire bull terrier dogs with visceral leishmaniasis

ÖZKANLAR, Yunusemre; Hanedan, Başak; AYDIN, AHMET; HAYDARDEDEOĞLU, Ali Evren; Börkü, Mehmet Kazim; GAZYAGCI, SERKAL; ÖZKANLAR, Seçkin

Efficacy of amphotericin-b, clinicopathologic variables and oxidative stress markers in three staffordshire bull terrier dogs with visceral leishmaniasis

Başak HANEDAN, (Atatürk Üniversitesi, Veteriner Fakültesi, İç Hastalıkları Anabilim Dalı, Erzurum, Türkiye)

Mehmet Kazım Börkü, (Ankara Üniversitesi, Veteriner Fakültesi, İç Hastalıkları Anabilim Dalı, Ankara, Türkiye)

Yunusemre ÖZKANLAR, (Atatürk Üniversitesi, Veteriner Fakültesi, İç Hastalıkları Anabilim Dalı, Erzurum, Türkiye)

Ali Evren HAYDARDEDEOĞLU, (Aksaray Üniversitesi, Veteriner Fakültesi, İç Hastalıkları Anabilim Dalı, Aksaray, Türkiye)

Serkal GAZYAĞCI, (Kırıkkale Üniversitesi, Veteriner Fakültesi, İç Hastalıkları Anabilim Dalı, Kırıkkale, Türkiye)

Ahmet AYDIN, (Yeditepe Üniversitesi, Eczacılık Fakültesi, Farmasötik Toksikoloji Bölümü, İstanbul, Türkiye)

Seçkin ÖZKANLAR (Atatürk Üniversitesi, Veteriner Fakültesi, Biyokimya Ana Bilim Dalı, Erzurum, Türkiye)

Atatürk Üniversitesi Veteriner Bilimleri Dergisi

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Yıl: 2015 Cilt: 10 Sayı: 1 Sayfa Aralığı: 33 - 38 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Efficacy of amphotericin-b, clinicopathologic variables and oxidative stress markers in three staffordshire bull terrier dogs with visceral leishmaniasis

Öz:

BuçalışmadavisseralLeishmaniasisli(VL)üçStaffordshireBullTerrierköpekteLeishmaniaenfeksiyonuveAMB(amfoterisin-B)tedavisininhematolojik,biyokimyasalveoksidatifstresparametreleriüzerineetkilerinideğerlendirmekamaçlandı.Buköpeklerkilokaybı,halsizlikvederilezyonlarıilekliniğegetirildi.Kaninkala-azartestkitiVLliköpeklerdepozitifti.VisseralLeishmaniasisliolgularaAMB0.6-1.5mg/kg/haftadozunda4aysüreileuygulandı.Leishmaniaetkenleriolgu1ve2deALTdüzeyindeartışabağlıolarakkaraciğerhasarına,olgu3teeritrosit,hemoglobinvehematokritdüzeydeazalmayaveMDAdaartışaveGSH-PxdeazalmayanedenoldufakatVLliköpeklerdenormalürevekreatinindüzeyinebağlıolarakböbrekfonksiyonlarınıetkilemedi.AMBtedavisinekademeliyanıtgözlendi.TedaviseyrininsonundaVLliolgularklinikolarakiyileşti.Sonuçolarak6aysüreiletakiptekliniknüksolmamasınabağlıolarakvisseralLeishmaniasisitedavietmekiçin4aysüreliAMBuygulamasınınetkiliolabileceğikanısınavarıldı.

Anahtar Kelime:

Konular: Veterinerlik

Visseral leishmaniasis li üç staffordshire bull terrier köpekte amfoterisin- b nin etkinliği, klinik-patolojik değişkenler ve oksidatif stres belirteçleri

Öz:

This study was aimed at evaluating the effects of Leishmania infection and AMB (amphotericin-B) treatment onhematological, biochemical and oxidative stress parameters in three Staffordshire Bull Terrier dogs with visceralleishmaniasis (VL). These dogs were presented with weight loss, weakness, and cutaneous lesions. Canine kala-azardetection kit was positive in dogs with VL. AMB was administered to cases with VL at a dose of 0.6 to 1.5 mg/kg/week for 4months. Leishmania agents caused the liver injury due to increase in the ALT level in cases 1 and 2, decrease in erythrocyte,hemoglobin, and hematocrit level and increase inthe MDA, and decrease in the GSH-Px in case 3, but Leishmania agentsdid not affect the kidney functions due to normal urea and creatinine level in the dogs with VL. A gradual response to theAMB treatment was observed. At the end of treatment course, cases with VL were treatedclinically. It was concluded thattheAMB administrationfor 4 months might be effective to treat VL due to no clinical recurrence for 6-month follow-upperiod.

Anahtar Kelime:

Konular: Veterinerlik

Belge Türü: Makale Makale Türü: Olgu Sunumu Erişim Türü: Erişime Açık

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APA	Hanedan B, Börkü M, ÖZKANLAR Y, HAYDARDEDEOĞLU A, GAZYAGCI S, AYDIN A, ÖZKANLAR S (2015). Efficacy of amphotericin-b, clinicopathologic variables and oxidative stress markers in three staffordshire bull terrier dogs with visceral leishmaniasis. , 33 - 38.
Chicago	Hanedan Başak,Börkü Mehmet Kazim,ÖZKANLAR Yunusemre,HAYDARDEDEOĞLU Ali Evren,GAZYAGCI SERKAL,AYDIN AHMET,ÖZKANLAR Seçkin Efficacy of amphotericin-b, clinicopathologic variables and oxidative stress markers in three staffordshire bull terrier dogs with visceral leishmaniasis. (2015): 33 - 38.
MLA	Hanedan Başak,Börkü Mehmet Kazim,ÖZKANLAR Yunusemre,HAYDARDEDEOĞLU Ali Evren,GAZYAGCI SERKAL,AYDIN AHMET,ÖZKANLAR Seçkin Efficacy of amphotericin-b, clinicopathologic variables and oxidative stress markers in three staffordshire bull terrier dogs with visceral leishmaniasis. , 2015, ss.33 - 38.
AMA	Hanedan B,Börkü M,ÖZKANLAR Y,HAYDARDEDEOĞLU A,GAZYAGCI S,AYDIN A,ÖZKANLAR S Efficacy of amphotericin-b, clinicopathologic variables and oxidative stress markers in three staffordshire bull terrier dogs with visceral leishmaniasis. . 2015; 33 - 38.
Vancouver	Hanedan B,Börkü M,ÖZKANLAR Y,HAYDARDEDEOĞLU A,GAZYAGCI S,AYDIN A,ÖZKANLAR S Efficacy of amphotericin-b, clinicopathologic variables and oxidative stress markers in three staffordshire bull terrier dogs with visceral leishmaniasis. . 2015; 33 - 38.
IEEE	Hanedan B,Börkü M,ÖZKANLAR Y,HAYDARDEDEOĞLU A,GAZYAGCI S,AYDIN A,ÖZKANLAR S "Efficacy of amphotericin-b, clinicopathologic variables and oxidative stress markers in three staffordshire bull terrier dogs with visceral leishmaniasis." , ss.33 - 38, 2015.
ISNAD	Hanedan, Başak vd. "Efficacy of amphotericin-b, clinicopathologic variables and oxidative stress markers in three staffordshire bull terrier dogs with visceral leishmaniasis". (2015), 33-38.

APA	Hanedan B, Börkü M, ÖZKANLAR Y, HAYDARDEDEOĞLU A, GAZYAGCI S, AYDIN A, ÖZKANLAR S (2015). Efficacy of amphotericin-b, clinicopathologic variables and oxidative stress markers in three staffordshire bull terrier dogs with visceral leishmaniasis. Atatürk Üniversitesi Veteriner Bilimleri Dergisi, 10(1), 33 - 38.
Chicago	Hanedan Başak,Börkü Mehmet Kazim,ÖZKANLAR Yunusemre,HAYDARDEDEOĞLU Ali Evren,GAZYAGCI SERKAL,AYDIN AHMET,ÖZKANLAR Seçkin Efficacy of amphotericin-b, clinicopathologic variables and oxidative stress markers in three staffordshire bull terrier dogs with visceral leishmaniasis. Atatürk Üniversitesi Veteriner Bilimleri Dergisi 10, no.1 (2015): 33 - 38.
MLA	Hanedan Başak,Börkü Mehmet Kazim,ÖZKANLAR Yunusemre,HAYDARDEDEOĞLU Ali Evren,GAZYAGCI SERKAL,AYDIN AHMET,ÖZKANLAR Seçkin Efficacy of amphotericin-b, clinicopathologic variables and oxidative stress markers in three staffordshire bull terrier dogs with visceral leishmaniasis. Atatürk Üniversitesi Veteriner Bilimleri Dergisi, vol.10, no.1, 2015, ss.33 - 38.
AMA	Hanedan B,Börkü M,ÖZKANLAR Y,HAYDARDEDEOĞLU A,GAZYAGCI S,AYDIN A,ÖZKANLAR S Efficacy of amphotericin-b, clinicopathologic variables and oxidative stress markers in three staffordshire bull terrier dogs with visceral leishmaniasis. Atatürk Üniversitesi Veteriner Bilimleri Dergisi. 2015; 10(1): 33 - 38.
Vancouver	Hanedan B,Börkü M,ÖZKANLAR Y,HAYDARDEDEOĞLU A,GAZYAGCI S,AYDIN A,ÖZKANLAR S Efficacy of amphotericin-b, clinicopathologic variables and oxidative stress markers in three staffordshire bull terrier dogs with visceral leishmaniasis. Atatürk Üniversitesi Veteriner Bilimleri Dergisi. 2015; 10(1): 33 - 38.
IEEE	Hanedan B,Börkü M,ÖZKANLAR Y,HAYDARDEDEOĞLU A,GAZYAGCI S,AYDIN A,ÖZKANLAR S "Efficacy of amphotericin-b, clinicopathologic variables and oxidative stress markers in three staffordshire bull terrier dogs with visceral leishmaniasis." Atatürk Üniversitesi Veteriner Bilimleri Dergisi, 10, ss.33 - 38, 2015.
ISNAD	Hanedan, Başak vd. "Efficacy of amphotericin-b, clinicopathologic variables and oxidative stress markers in three staffordshire bull terrier dogs with visceral leishmaniasis". Atatürk Üniversitesi Veteriner Bilimleri Dergisi 10/1 (2015), 33-38.