Investigation of Antiulcer and Antioxidant Activity of Moclobemide in Rats

ALBAYRAK, ABDULMECİT; ALP, Hamit H; Suleyman, Halis

Investigation of Antiulcer and Antioxidant Activity of Moclobemide in Rats

Abdulmecit ALBAYRAK, (Atatürk Üniversitesi, Tıp Fakültesi, Farmakoloji Anabilim Dalı, Erzurum, Türkiye)

Hamit H ALP, (Yüzüncü Yıl Üniversitesi, Tıp Fakültesi, Biyokimya Anabilim Dalı, Van, Türkiye)

Halis SÜLEYMAN (Recep Tayyip Erdoğan Üniversitesi, Tıp Fakültesi, Farmakoloji Bölümü, Rize, Türkiye)

Eurasian Journal of Medicine

5 0

Yıl: 2015 Cilt: 47 Sayı: 1 Sayfa Aralığı: 32 - 40 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Investigation of Antiulcer and Antioxidant Activity of Moclobemide in Rats

Öz:

Amaç: Peptik ülser tedavisinde kullanılan çok sayıda klasik antiülser ilaç grupları bulunsa da, bu ilaçlar ile ülserin kalıcı tedavisi sağlanamamaktadır. 1950'den beri antidepresan ilaçlar non - psikiyatrik bazı hastalıkların tedavisinde kullanılmaktadırlar. Birçok antidepresan ilacın antiülser aktiviteye sahip oldukları deneysel ve klinik çalışmalarla da gösterilmiştir. Moklobemid, monoaminooksidaz - A (MAO - A) enziminin selektif inhibitörü antidepresan bir ilaçtır. Klasik MAO inhibitörleri ile karşılaştırıldığında, etkinliğinin fazla olması ve yan etkilerinin az olması nedeni ile depresyon tedavisinde tercih edilmektedir. Bu çalışmada sıçan mide dokusunda moklobemidin antiülser etkilerinin araştırılması ve oksidan mekanizmalarla ilişkisinin belirlenmesi amaçlanmıştır. Gereç ve Yöntem: 10, 20, 40, 80 ve 150 mg/kg dozlarında kullanılan moklobemid ve 20 mg/kg dozunda kullanılan famotidinin antiülser aktivitesi sıçanlarda indometazin ile indüklenen ülser modelinde incelenmiş ve sonuçlar kontrol grubu ile karşılaştırılmıştır. Bulgular: Moklobemid kullanılan tüm dozlarda indometazin ülserlerinin oluşumunu anlamlı olarak azalttı. Moklobemid, kullanılan bu dozlarda sıçan mide dokusunda glutatyon (GSH), nitrik oksid (NO) seviyeleri ve süperoksid dismutaz (SOD) aktivitesini kontrol grubuna göre artırırken; malondialdehid (MDA) seviyesi ve myeloperoksidaz (MPO) aktivitesini ise azaltmıştır. Sonuç: Antidepresan bir ilaç olan moklobemidin, güçlü bir antiülser ajan olduğu tespit edilmiştir. Moklobemidin antiülser etki mekanizmasında toksik oksidan radikallerin baskılanması ve antioksidan mekanizmaların aktivasyonu rol oynamaktadır.

Anahtar Kelime:

Konular: Genel ve Dahili Tıp

Moklobemidin Sıçanlarda Antiülser ve Antioksidan Aktivitesinin Araştırılması

Öz:

Objective: Even though there are many drugs for the treatment of gastric ulcers, these drugs sometimes cannot succeed. Since the 1950s, antidepressant drugs have been used for several non-psychiatric indications. Many antidepressant drugs have been shown experimentally to produce antiulcer activity in various ulcer models. Moclobemide is an antidepressant drug which inhibits monoamine oxidase-A (MAO) enzyme selectively. When it is compared to the classic antidepressants drugs, moclobemide is the first choice in depression treatment because of its effectiveness and less side effects. This study aimed to investigate the antiulcer effects of moclobemide and to determine its relationship with antioxidant mechanisms in rat gastric tissue. Materials and Methods: The antiulcer activities of 10, 20, 40, 80, 150 mg/kg moclobemide and 20 mg/kg famotidine have been investigated on indomethacin-induced ulcers in rats, and the results have been compared with that of the control group. Results: Moclobemide decreased the indomethacin-induced ulcers significantly at all doses used. While used doses of moclobemide increased the glutathione (GSH), nitric oxide (NO) level and superoxide dismutase (SOD) activity, it decreased the malondialdehyde (MDA) level and myeloperoxidase (MPO) activity in stomach tissue when compared to the control group.Conclusion: It is determined that an antidepressant drug, moclobemide is a potent anti-ulcer agent. Inhibition of toxic oxidant radicals and activation of antioxidant mechanisms play a role in its antiulcer effect mechanisms.

Anahtar Kelime:

Konular: Genel ve Dahili Tıp

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	ALBAYRAK A, ALP H, Suleyman H (2015). Investigation of Antiulcer and Antioxidant Activity of Moclobemide in Rats. , 32 - 40.
Chicago	ALBAYRAK ABDULMECİT,ALP Hamit H,Suleyman Halis Investigation of Antiulcer and Antioxidant Activity of Moclobemide in Rats. (2015): 32 - 40.
MLA	ALBAYRAK ABDULMECİT,ALP Hamit H,Suleyman Halis Investigation of Antiulcer and Antioxidant Activity of Moclobemide in Rats. , 2015, ss.32 - 40.
AMA	ALBAYRAK A,ALP H,Suleyman H Investigation of Antiulcer and Antioxidant Activity of Moclobemide in Rats. . 2015; 32 - 40.
Vancouver	ALBAYRAK A,ALP H,Suleyman H Investigation of Antiulcer and Antioxidant Activity of Moclobemide in Rats. . 2015; 32 - 40.
IEEE	ALBAYRAK A,ALP H,Suleyman H "Investigation of Antiulcer and Antioxidant Activity of Moclobemide in Rats." , ss.32 - 40, 2015.
ISNAD	ALBAYRAK, ABDULMECİT vd. "Investigation of Antiulcer and Antioxidant Activity of Moclobemide in Rats". (2015), 32-40.

APA	ALBAYRAK A, ALP H, Suleyman H (2015). Investigation of Antiulcer and Antioxidant Activity of Moclobemide in Rats. Eurasian Journal of Medicine, 47(1), 32 - 40.
Chicago	ALBAYRAK ABDULMECİT,ALP Hamit H,Suleyman Halis Investigation of Antiulcer and Antioxidant Activity of Moclobemide in Rats. Eurasian Journal of Medicine 47, no.1 (2015): 32 - 40.
MLA	ALBAYRAK ABDULMECİT,ALP Hamit H,Suleyman Halis Investigation of Antiulcer and Antioxidant Activity of Moclobemide in Rats. Eurasian Journal of Medicine, vol.47, no.1, 2015, ss.32 - 40.
AMA	ALBAYRAK A,ALP H,Suleyman H Investigation of Antiulcer and Antioxidant Activity of Moclobemide in Rats. Eurasian Journal of Medicine. 2015; 47(1): 32 - 40.
Vancouver	ALBAYRAK A,ALP H,Suleyman H Investigation of Antiulcer and Antioxidant Activity of Moclobemide in Rats. Eurasian Journal of Medicine. 2015; 47(1): 32 - 40.
IEEE	ALBAYRAK A,ALP H,Suleyman H "Investigation of Antiulcer and Antioxidant Activity of Moclobemide in Rats." Eurasian Journal of Medicine, 47, ss.32 - 40, 2015.
ISNAD	ALBAYRAK, ABDULMECİT vd. "Investigation of Antiulcer and Antioxidant Activity of Moclobemide in Rats". Eurasian Journal of Medicine 47/1 (2015), 32-40.