Yıl: 2015 Cilt: 47 Sayı: 3 Sayfa Aralığı: 161 - 164 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Evaluation of Percutaneous Liver Biopsy Complications in Patients with Chronic Viral Hepatitis

Öz:
Amaç: Karaciğer biyopsisi karaciğer fibrozisi ve nekroinflamatuvar aktivitesini belirlemede günümüzde halen altın standart olarak kabul edilmektedir. Ancak invaziv olması nedeniyle ciddi komplikasyonları olabilen bir işlemdir. Bu çalışma ile perkütan karaciğer biyopsisi yapılan kronik viral hepatitli hastalarda biyopsiye bağlı komplikasyonların değerlendirilmesi amaçlanmıştır.Gereç ve Yöntem: Ocak 2000-Şubat 2013 tarihleri arasında İzmir Tepecik Eğitim ve Araştırma Hastanesi Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Kliniğinde kronik viral hepatit tanısı ile izlediğimiz ve karaciğer biyopsisi yapılan 1165 hasta retrospektif olarak incelendi. Bulgular: Karaciğer biyopsisi yapılan 1165 hastanın 196'sı (86 erkek, 110 kadın) kronik hepatit C, 969'sı (559 erkek, 410 kadın) kronik hepatit B tanılı idi. Hastaların yaş ortalaması: 43,3 , %55,4'ü erkek, %11'i kronik böbrek yetmezliği tanısı ile hemodiyalize giriyordu. Hastaların yaklaşık beşte birinde minör komplikasyonlar gözlenirken (%19,8'inde analjezik gereksinimi olan ağrı, %22,6'sında sağ üst kadran ve sağ kola vuran ağrı), majör komplikasyon oranı %1,15 idi (%0,17'sinde pnömotoraks, %0,08'inde hemobiliya, %0,9'unda hematom). Ateş, abse, anaflaksi, bakteriyemi, organ perforasyonu, sepsis, ölüm gibi komplikasyonlar görülmedi.Sonuç: Perkütan karaciğer biyopsisi invaziv bir işlem olmasına rağmen hastalarımızda görülen ciddi komplikasyon oranı düşüktür, bu nedenle güvenli bir işlem olarak kabul edilebilir.
Anahtar Kelime:

Konular: Genel ve Dahili Tıp

Kronik Hepatit Hastalarında Perkütan Karaciğer Biyopsi Komplikasyonlarının Değerlendirilmesi

Öz:
Objective: Liver biopsy is still the gold standard for the determination of liver fibrosis and necroinflammatory activity. It is an invasive method and may lead to severe complications. The aim of this study was to determine the evaluation of percutaneous liver biopsy complications in patients with chronic viral hepatitis.Materials and Methods: 1165 patients, who were followed with the diagnosis of chronic viral hepatitis and who were applied percutaneous liver biopsy between January 2000 and February 2013 at the outpatient clinic of Infectious Diseases and Clinical Microbiology, were included in the study.Results: Of 1165 patients who underwent liver biopsy, 196 (86 male, 110 female) were diagnosed with chronic hepatitis C, 969 (559 male, 410 female) were diagnosed with chronic hepatitis B. The mean age was 43.3 and 55.4% were male. 11% of the patients were diagnosed with chronic renal failure and underwent haemodialysis. Minor complication rate was about 20% (severe pain required usage of analgesic drugs in 19.8%, abdominal pain in 22.6%) whereas major complication rate was 1.15% (pneumothorax in 0.17%, heamobilia in 0.08%, hematoma in 0.9%). We did not observe severe complications such as fever, abscess, anaphylaxis, bacteraemia, organ perforations, sepsis or death.Conclusion: Despite being an invasive procedure, percutaneous liver biopsy can be considered a safe method because of the low rates of severe complications observed in our patients.
Anahtar Kelime:

Konular: Genel ve Dahili Tıp
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
  • Sonsuz A. Karaciğer biyopsisi endikasyonları ve riskleri. Gastroenterolojide Klinik Yaklaşım Sempozyum Dizisi 2004; 38: 73-5.
  • Bravo AA, Sheth SG, Chopra S. Liver biopsy. N Engl J Med 2001; 344: 495-500. [CrossRef]
  • Campbell MS, Reddy KR. Review article: the evolving role of liver biopsy. Aliment Pharmacol Ther 2004; 20: 249-59. [CrossRef]
  • Li GP, Gong GQ, Wang XL, Chen Y, Cheng JM, Chung YL. Fine needle aspirating and cutting is superior to Tru-cut core needle in liver biopsy. Hepatobiliary Pancreat Dis Int 2013; Vol 12, No 5. [CrossRef]
  • Arıbaş BG, Ünlü DN, Dingil G, et al. Yarı-otomatik 16 Gauge Tru- cut iğne ile perkütan karaciğer biyopsileri. Van Tıp Dergisi 2010; 17: 69-76.
  • Arıbal ME, Dingil G, Arıbaş B, Albayrak Y, Yücel K, İnce A. İntraabdominal lezyonların tanısında ultrasonografi eşliğinde ince iğne aspirasyon biyopsisi. Radyoloji ve Tıbbi Görüntüleme Dergisi 1992; 2: 290-3.
  • Arıbaş BK, Dingil G, Koşar S, et al. Ultrasonografi eşliğinde ince iğne aspirasyon biyopsisinin intra-abdominal lezyonlarda tanı değeri. Acta Oncologica Turcica 2005; 38: 18-25.
  • Malnick S, Melzer E. Routine ultrasound-guided liver biopsy: a time whose idea has come? J Clin Gastroenterol 2005; 39: 900. [CrossRef]
  • Bernardino ME. Percutaneous biopsy. AJR 1984; 142: 41-5. [CrossRef]
  • Charboneau JW, Reading CC, Welch TJ. CT and sonographically guided needle biopsy: current techniques and new innovations. AJR 1990; 154: 1-10. [CrossRef]
  • Gazelle GS, Haaga JR. Guided percutaneous biopsy of intra- abdominal lesions. AJR 1989; 153: 929-35. [CrossRef]
  • Fagelman D, Chess Q. Non aspiration fine needle cytology of the liver: a new technique for obtaining diagnostic samples. AJR 1990; 155: 1217-9. [CrossRef]
  • Glaser J, Pausch J. The risk of liver biopsy. Z Gastroenterol. 1995; 33: 673-6.
  • D'Incao RB, Silva MC, Almeida PR, Renon VP, Tovo CV. Percutaneous liver biopsy--2 decades of experience in a public hospital in the South of Brazil. Ann Hepatol 2013; 12: 876-80.
  • Boskovic A, Kitic I, Prokic D, Stankovic I. Sample representative- ness and incidence of liver biopsy complications caused by needles of bigger diameter (1.6 mm) and smaller diameter (1.2 mm) in children with cholestatic syndrome. Med Pregyl 2013; 66: 367-71. [CrossRef]
  • Behrens G, Ferral H. Transjugular liver biopsy. Semin Intervent Radiol 2012; 29: 111-7. [CrossRef]
  • Piccinino F, Sagnelli E, Pasquale G. Complications following per- cutaneous liver biopsy. A multicentre retrospective study on 68, 276 biopsies. J Hepatol 1986; 2: 165. [CrossRef]
  • Lindor KD, Bru C, Jorgensen RA. The role of ultrasonography and automatic-needle biopsy in outpatient percutaneous liver biopsy. Hepatology 1996; 23: 1079. [CrossRef]
  • Padia SA, Baker ME, Schaeffer CJ, et al. Safety and efficacy of sono- graphic-guided random real-time core needle biopsy of the liver. Journal of Clinical Ultrasound 2009; Vol 37, No 3. [CrossRef]
  • Govender P, Jonas MM, Alomari AI, et al. Sonography-guided percutaneous liver biopsies in children. AJR J Roentgenol 2013; 201: 645-50. [CrossRef]
  • Froehlich F, Lamy O, Fried M. Practice and complications of liver biopsy. Results of a nationwide survey in Switzerland. Dig Dis Sci. 1993; 38: 1480-4. [CrossRef]
  • Seeff LB, Everson GT, Morgan TR, HALT-C Trial Group. Complication rate of percutaneous liver biopsies among per- sons with advanced chronic liver disease in the HALT-C trial. Clin Gastroenterol Hepatol 2010; 8: 877-83. [CrossRef]
APA köse ş, Ersan G, Tatar B, Adar P, ERTÜRK ŞENGEL B (2015). Evaluation of Percutaneous Liver Biopsy Complications in Patients with Chronic Viral Hepatitis. , 161 - 164.
Chicago köse şükran,Ersan Gursel,Tatar Bengü,Adar Pelin,ERTÜRK ŞENGEL BUKET Evaluation of Percutaneous Liver Biopsy Complications in Patients with Chronic Viral Hepatitis. (2015): 161 - 164.
MLA köse şükran,Ersan Gursel,Tatar Bengü,Adar Pelin,ERTÜRK ŞENGEL BUKET Evaluation of Percutaneous Liver Biopsy Complications in Patients with Chronic Viral Hepatitis. , 2015, ss.161 - 164.
AMA köse ş,Ersan G,Tatar B,Adar P,ERTÜRK ŞENGEL B Evaluation of Percutaneous Liver Biopsy Complications in Patients with Chronic Viral Hepatitis. . 2015; 161 - 164.
Vancouver köse ş,Ersan G,Tatar B,Adar P,ERTÜRK ŞENGEL B Evaluation of Percutaneous Liver Biopsy Complications in Patients with Chronic Viral Hepatitis. . 2015; 161 - 164.
IEEE köse ş,Ersan G,Tatar B,Adar P,ERTÜRK ŞENGEL B "Evaluation of Percutaneous Liver Biopsy Complications in Patients with Chronic Viral Hepatitis." , ss.161 - 164, 2015.
ISNAD köse, şükran vd. "Evaluation of Percutaneous Liver Biopsy Complications in Patients with Chronic Viral Hepatitis". (2015), 161-164.
APA köse ş, Ersan G, Tatar B, Adar P, ERTÜRK ŞENGEL B (2015). Evaluation of Percutaneous Liver Biopsy Complications in Patients with Chronic Viral Hepatitis. Eurasian Journal of Medicine, 47(3), 161 - 164.
Chicago köse şükran,Ersan Gursel,Tatar Bengü,Adar Pelin,ERTÜRK ŞENGEL BUKET Evaluation of Percutaneous Liver Biopsy Complications in Patients with Chronic Viral Hepatitis. Eurasian Journal of Medicine 47, no.3 (2015): 161 - 164.
MLA köse şükran,Ersan Gursel,Tatar Bengü,Adar Pelin,ERTÜRK ŞENGEL BUKET Evaluation of Percutaneous Liver Biopsy Complications in Patients with Chronic Viral Hepatitis. Eurasian Journal of Medicine, vol.47, no.3, 2015, ss.161 - 164.
AMA köse ş,Ersan G,Tatar B,Adar P,ERTÜRK ŞENGEL B Evaluation of Percutaneous Liver Biopsy Complications in Patients with Chronic Viral Hepatitis. Eurasian Journal of Medicine. 2015; 47(3): 161 - 164.
Vancouver köse ş,Ersan G,Tatar B,Adar P,ERTÜRK ŞENGEL B Evaluation of Percutaneous Liver Biopsy Complications in Patients with Chronic Viral Hepatitis. Eurasian Journal of Medicine. 2015; 47(3): 161 - 164.
IEEE köse ş,Ersan G,Tatar B,Adar P,ERTÜRK ŞENGEL B "Evaluation of Percutaneous Liver Biopsy Complications in Patients with Chronic Viral Hepatitis." Eurasian Journal of Medicine, 47, ss.161 - 164, 2015.
ISNAD köse, şükran vd. "Evaluation of Percutaneous Liver Biopsy Complications in Patients with Chronic Viral Hepatitis". Eurasian Journal of Medicine 47/3 (2015), 161-164.