Determinants of hypoxemia in cirrhosis

HACIEVLİYAGİL, Süleyman S.; KOŞAR, Feridun; Gunen, Hakan; Yıldırım, Bülent; SEÇKİN, Yüksel

Determinants of hypoxemia in cirrhosis

Hakan GÜNEN, (İnönü Üniversitesi, Turgut Özal Tıp Merkezi, Göğüs Hastalıkları Anabilim Dalı, Malatya, Türkiye)

Bülent YILDIRIM, (Girilmedi)

Yüksel SEÇKİN, (Girilmedi)

Süleyman S. HACIEVLİYAGİL, (Girilmedi)

Feridun KOŞAR (Girilmedi)

Turkish Respiratory Journal

4 0

Yıl: 2002 Cilt: 3 Sayı: 2 Sayfa Aralığı: 58 - 63 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

Determinants of hypoxemia in cirrhosis

Öz:

Background and Objectives: Mechanisms of the development of hypoxemia in cirrhosis are still not well understood. In this study, we aimed to investigate and determine the factors contributing to hypoxemia in patients with cirrhosis. Patients and Measurements: A total of 52 biopsy proven cirrhotic patients without any cardiopulmonary disorder and encephalopathy were studied prospectively. Blood gases were measured in supine, sitting positions and also while inhaling 100% O2. for 15 minutes. In the supine position, PaO2 values between 79-60 mmHg were evaluated as mild to moderate hypoxemia and any value below 60 mmHg as severe. Hemoglobin, albumin, AST and ALT levels, prothrombin time, presence of orthodeoxia, ascites, results of spirometric tests, duration of the disease and smoking habits were recorded in all patients. Contrast echocardiography (CE) was also performed in all patients. The results of these parameters were analysed to elucidate the determinants of hypoxemia in cirrhosis. hypoxemic Hypoxemia was mild to moderate in 18 patients (mean 72.3 mmHg) and severe in 3 patients (mean 52.2 mmHg). All patients responded well to 100% O2 inhalation with expected elevations in PaO2, thus excluding real anatomic and portopulmonary shunts as the causes of hypoxemia. Hypoxemic patients showed significant differences from normoxemic patients with cirrhosis in frequency of ascites (p<0.001) and AST levels (relatively lower levels) (p<0.05). Positive CE findings and orthodeoxia (a sign representatives of hepatopulmonary syndrome) showed an association with severe hypoxemia (p<0.001 and p<0.01 respectively). Conclusion: Presence of ascites and relatively low levels of serum AST appear to be predictors of hypoxemia in cirrhotic patients without cardiopulmonary disorder or encephalopathy. We suggest that all cirrhotic patients meeting one or both of these criteria be routinely investigated for hypoxemia.

Anahtar Kelime: Echocardiography Ascites Biopsy Fibrosis Blood Gas Analysis Anoxemia Hepatopulmonary Syndrome

Konular: Solunum Sistemi

Belge Türü: Makale Makale Türü: Diğer Erişim Türü: Erişime Açık

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APA	Gunen H, Yıldırım B, SEÇKİN Y, HACIEVLİYAGİL S, KOŞAR F (2002). Determinants of hypoxemia in cirrhosis. , 58 - 63.
Chicago	Gunen Hakan,Yıldırım Bülent,SEÇKİN Yüksel,HACIEVLİYAGİL Süleyman S.,KOŞAR Feridun Determinants of hypoxemia in cirrhosis. (2002): 58 - 63.
MLA	Gunen Hakan,Yıldırım Bülent,SEÇKİN Yüksel,HACIEVLİYAGİL Süleyman S.,KOŞAR Feridun Determinants of hypoxemia in cirrhosis. , 2002, ss.58 - 63.
AMA	Gunen H,Yıldırım B,SEÇKİN Y,HACIEVLİYAGİL S,KOŞAR F Determinants of hypoxemia in cirrhosis. . 2002; 58 - 63.
Vancouver	Gunen H,Yıldırım B,SEÇKİN Y,HACIEVLİYAGİL S,KOŞAR F Determinants of hypoxemia in cirrhosis. . 2002; 58 - 63.
IEEE	Gunen H,Yıldırım B,SEÇKİN Y,HACIEVLİYAGİL S,KOŞAR F "Determinants of hypoxemia in cirrhosis." , ss.58 - 63, 2002.
ISNAD	Gunen, Hakan vd. "Determinants of hypoxemia in cirrhosis". (2002), 58-63.

APA	Gunen H, Yıldırım B, SEÇKİN Y, HACIEVLİYAGİL S, KOŞAR F (2002). Determinants of hypoxemia in cirrhosis. Turkish Respiratory Journal, 3(2), 58 - 63.
Chicago	Gunen Hakan,Yıldırım Bülent,SEÇKİN Yüksel,HACIEVLİYAGİL Süleyman S.,KOŞAR Feridun Determinants of hypoxemia in cirrhosis. Turkish Respiratory Journal 3, no.2 (2002): 58 - 63.
MLA	Gunen Hakan,Yıldırım Bülent,SEÇKİN Yüksel,HACIEVLİYAGİL Süleyman S.,KOŞAR Feridun Determinants of hypoxemia in cirrhosis. Turkish Respiratory Journal, vol.3, no.2, 2002, ss.58 - 63.
AMA	Gunen H,Yıldırım B,SEÇKİN Y,HACIEVLİYAGİL S,KOŞAR F Determinants of hypoxemia in cirrhosis. Turkish Respiratory Journal. 2002; 3(2): 58 - 63.
Vancouver	Gunen H,Yıldırım B,SEÇKİN Y,HACIEVLİYAGİL S,KOŞAR F Determinants of hypoxemia in cirrhosis. Turkish Respiratory Journal. 2002; 3(2): 58 - 63.
IEEE	Gunen H,Yıldırım B,SEÇKİN Y,HACIEVLİYAGİL S,KOŞAR F "Determinants of hypoxemia in cirrhosis." Turkish Respiratory Journal, 3, ss.58 - 63, 2002.
ISNAD	Gunen, Hakan vd. "Determinants of hypoxemia in cirrhosis". Turkish Respiratory Journal 3/2 (2002), 58-63.