The relationship one-hour glycemia level at oral glucose tolerance test and non-alcoholic fatty liver disease

MENEKSE, Elif; demir, hatice; Demirci, Hüseyin; ÇAKIR, Evrim

The relationship one-hour glycemia level at oral glucose tolerance test and non-alcoholic fatty liver disease

Evrim ÇAKIR, (Haseki Eğitim ve Araştırma Hastanesi, Endokrinoloji ve Metabolik Hastalıklar Bölümü, İstanbul, Türkiye)

Hüseyin DEMİRCİ, (Kırıkkale Üniversitesi, Tıp Fakültesi, Endokrinoloji ve Metabolizma Hastalıkları Bölümü, İç Hastalıkları Bölümü, Kırıkkale, Türkiye)

Elif MENEKSE, (Amasya Üniversitesi, Eğitim ve Araştırma Hastanesi, Biyokimya Anabilim Dalı, Amasya, Türkiye)

Hatice DEMİR (Amasya Üniversitesi, Eğitim ve Araştırma Hastanesi, Biyokimya Anabilim Dalı, Amasya, Türkiye)

İnönü Üniversitesi Turgut Özal Tıp Merkezi Dergisi

0 0

Yıl: 2016 Cilt: 23 Sayı: 3 Sayfa Aralığı: 297 - 301 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

The relationship one-hour glycemia level at oral glucose tolerance test and non-alcoholic fatty liver disease

Öz:

Amaç: Non-alkolik yağlı karaciğer hastalığının (NAYKH) etyolojisi henüz net aydınlatılamamıştır. Prediyabetten diyabete karbohidrat metabolizma bozuklukları NAYKH'nın temelini oluşturmaktadır. Ancak, NAYKH ve glisemik bozukluklar arasındaki ilişkiye dair yayınlar yetersiz kalmaktadır. Yakın zamanda yapılan çalışmalarda alanin transaminaz (ALT) ve gama-glutamil transferaz (GGT)'nin NAYKH için belirteç olduğu gösterilmiştir. Hepatik testlerle prediabet arasındaki ilişki de yeterince tanımlanmamıştır. Bu nedenle, çalışmamızda oral glukoz tolerans testinde ara basamaklarının NAFLD ve hepatik fonksiyon testleri ile ilişkili olup olmadığı değerlendirildi. Gereç ve Yöntemler: 75 gr oral glukoz tolerans testi ve hepatik fonksiyon testleri 367 hastada değerlendirildi. Hepatosteatoz seviyesi ultrasonografi ile değerlendirildi. Bulgular: Hepatosteatoz yaş, BMI, 60. dk kan glukozu, ALT, GGT ile pozitif korelasyon göstermektedir. Açlık kan glukozu ve 0. dk kan glukozu ile zayıf pozitif korelasyon göstermektedir. Lineer regresyon analizinde, 60. dk glukoz NAYKH için bağımsız bir risk faktörü olarak saptanmıştır. Sonuç: NAYKH karbonhidrat metabolizma bozukluğu olan kişilerde sık rastlanmaktadır ve temel olarak glisemi düzeyleri ile ilişkilidir. NAYKH etyolojisinde glukoz tolerans testi 60. dk glukoz seviyelerinin rolü olabilir. ALT ve GGT seviyeleri de çalışmamızda 1.saat glukoz düzeyleri ve hepatosteatoz seviyeleri ile ilişkilendirilmiştir

Anahtar Kelime:

Konular: Genel ve Dahili Tıp

Oral glukoz tolerans testinde 1. saat glukoz seviyesi ve non-alkolik yağlı karaciğer hastalığı

Öz:

Objective: The etiology of non-alcoholic fatty liver disease (NAFLD) is still not clearly defined. Carbohydrate metabolism disorder including prediabetes to overt diabetes constitutes the main stone of the NAFLD. However; data on the relationship between glycemic disorders and NAFLD is scarce. Recent studies show that alanine transaminase (ALT) and gamma-glutamyl transferase (GGT) levels can be predictor factors for NAFLD. The relationship between hepatic test and prediabetes has not been defined clearly, yet. Therefore; we evaluated whether the intermediate stages of oral glucose tolerance test have association with NAFLD and with hepatic function test. Materials and Methods: 75 gr oral glucose loading test and hepatic function levels were evaluated in 367 participants. Hepatosteatosis level were assessed with ultrasonographic evaluation. Results: Grade of hepatic steatosis was positively correlated with age, body mass index (BMI), 60. min blood glucose, ALT, GGT and weakly positively correlated with fasting blood glucose, 0. min blood glucose. In lineer regression analysis, 60. min blood glucose after glucose loading were obtained to be an independent risk factor for NAFLD regardless of age, BMI. Conclusion: NAFLD is extremely common in people with carbohydrate metabolism disorder and is mainly associated with glucose levels. The 60. min blood glucose levels after post challenge test might have been a role in etiopathogenesis of NAFLD. ALT and GGT levels are also associated with glucose levelsat one-hour glucose loading and hepatosteatosis degree

Anahtar Kelime:

Konular: Genel ve Dahili Tıp

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

Martinez-Larrad MT, Corbaton-Anchuelo A, Fernandez- Perez C, Lazcano-Redondo Y, Escobar-Jimenez F, Serrano-Rios M. Metabolic syndrome, glucose tolerance categories and the cardiovascular risk in Spanish population. Diabetes research and clinical practice 2016;114:23-31.
Levitzky YS, Pencina MJ, D'Agostino RB, Meigs JB, Murabito JM, Vasan RS, Impact of impaired fasting glucose on cardiovascular disease: the Framingham Heart Study. J Am Coll Cardiol 2008;51:264-70.
Meigs JB, Nathan DM, D'Agostino RB, Sr, Wilson PW, Framingham Offspring Study. Fasting and postchallenge glycemia and cardiovascular disease risk: the Framingham Offspring Study. Diabetes care 2002;25:1845-50.
Schneider AL, Kalyani RR, Golden S, Stearns SC, Wruck L, Yeh HC, Diabetes and Prediabetes and Risk of Hospitalization: The Atherosclerosis Risk in Communities (ARIC) Study. Diabetes care 2016;39(5):772-9.
Deng FE, Shivappa N, Tang Y, Mann JR, Hebert JR.
Association between diet-related inflammation, all- cause, all-cancer, and cardiovascular disease mortality, with special focus on prediabetics: findings from NHANES III. Eur J Nutr. 2016;29.
Targher G, Marra F, Marchesini G. Increased risk of cardiovascular disease in non-alcoholic fatty liver disease: causal effect or epiphenomenon? Diabetologia 2008;51(11):1947-53.
Pascale A, Pais R, Ratziu V. An overview of nonalcoholic steatohepatitis: past, present and future directions. J Gastrointestin Liver Dis 2010;19(4):415-23.
Bellentani S, Saccoccio G, Masutti F, Croce LS, Brandi G, Sasso F, et al. Prevalence of and risk factors for hepatic steatosis in Northern Italy. Ann Intern Med 2000;18;132(2):112-7.
Onat A, Can G, Kaya A, Akbas T, Ozpamuk-Karadeniz F, Simsek B, et al. Fatty liver disease: Disparate predictive ability for cardiometabolic risk and all-cause mortality. World JGastroenterol 2015;21(48):13555-65.
Siddiqui MS, Fuchs M, Idowu MO, Luketic VA, Boyett S, Sargeant C, et al. Severity of nonalcoholic fatty liver disease and progression to cirrhosis are associated with atherogenic lipoprotein profile. Clin Gastroenterol Hepatol 2015;13(5):1000-8.e3.
Ong JP, Pitts A, Younossi ZM. Increased overall mortality and liver-related mortality in non-alcoholic fatty liver disease. J Hepatol 2008;49(4):608-12.
Marchesini G, Marzocchi R, Agostini F, Bugianesi E. Nonalcoholic fatty liver disease and the metabolic syndrome. Curr. Opin. Lipidol 2005;16(4): 421-7.
Clark JM, Brancati FL, Diehl AM. The prevalence and etiology of elevated aminotransferase levels in the United States. Am. J. Gastroenterol 2003;98(5):960-7.
Bedogni G, Miglioli L, Masutti F, Tiribelli C, Marchesini G, Bellentani S. Prevalence of and risk factors for nonalcoholic fatty liver disease: the Dionysos nutrition and liver study. Hepatology 2005;42(1):44-52.
Cakir E, Ozbek M, Colak N, Cakal E, Delibasi T. Is NAFLD an independent risk factor for increased IMT in T2DM? Minerva Endocrinol. 2012;37(2):187-93.
Bhatt HB,Smith RJ. Fatty liver disease in diabetes mellitus. Hepatobiliary surg Nutr 2015;4(2):101-8.
Adams LA, Waters OR, Knuiman MW, Elliott RR, Olynyk JK. NAFLD as a risk factor for the development of diabetes and the metabolic syndrome: an eleven-year follow-up study. Am. J. Gastroenterol 2009;104(4):861- 7.
Hossain N, Afendy A, Stepanova M, Nader F, Srishord M, Rafiq N, et al. Independent predictors of fibrosis in patients with nonalcoholic fatty liver disease. Clin Gstroenterol Hepatol 2009;7(11):1224-9,1229.e1-2.
Matsumoto N, Arase Y, Kawamura Y, Ohmoto-Sekine M, Amakawa K, Ogawa K, et al. Significance of oral glucose tolerance tests in non-alcoholic fatty liver disease patients with a fasting plasma glucose level of Intern Med 2015;54(8):875-80.
Succurro E, Arturi F, Grembiale A, Iorio F, Fiorentino TV, Andreozzi F, et al. One-hour post-load plasma glucose levels are associated with elevated liver enzymes. Nutrition, metabolism, and cardiovascular diseases: NMCD 2011;21:713-8.
Fiorentino TV, Marini MA, Andreozzi F, Arturi F, Succurro E, Perticone M, et al. One-hour post-load hyperglycemia is a stronger predictor of type 2 diabetes than impaired fasting glucose. J Clin Endocrinol Metab 2015;100(10):3744-51.
Tanaka K, Kanazawa I, Yamaguchi T, Sugimoto T. One- hour post-load hyperglycemia by 75g oral glucose tolerance test as a novel risk factor of atherosclerosis. Endocr J 2014;61(4):329-34.
Doi Y, Kubo M, Yonemoto K, Ninomiya T, Iwase M, Tanizaki Y, et al. Liver enzymes as a predictor for incident diabetes in a Japanese population: the Hisayama study. Obesity (Silver Spring) 2007;15(7):1841- 50.
Dee Pei, Te-Lin Hsia, Chao TT, Lin JD, Hsu CH, Wu CZ, et al. y-Glutamyl transpeptidase in men and alanine aminotransferase in women are the most suitable parameters among liver function tests for the prediction of metabolic syndrome in nonviral hepatitis and nonfatty liver in the elderly. Saudi J Gastroenterol 2015;21(3):158-64.
Liu X, Hamnvik OP, Chamberland JP, Petrou M, Gong H, Christophi CA, et al. Circulating alanine transaminase (ALT) and gamma-glutamyl transferase (GGT), but not fetuin-A, are associated with metabolic risk factors, at baseline and at two-year follow-up: the prospective Cyprus Metabolism Study. Metabolism. 2014;63(6):773- 82.
Arinc H, Sarli B, Baktir AO, Saglam H, Demirci E, Dogan Y, et al. Serum gamma glutamyl transferase and alanine transaminase concentrations predict endothelial dysfunction in patients with non-alcoholic steatohepatitis. Ups J Med Sci 2013;118(4):228-34.
Alonso A, Misialek JR, Amiin MA, Hoogeveen RC, Chen LY, Agarwal SK, et al. Circulating levels of liver enzymes and incidence of atrial fibrillation: the Atherosclerosis Risk in Communities cohort. Heart 2014;100(19):1511-6.
Wannamethee SG, Whincup PH, Shaper AG, Lennon L, Sattar N. Gamma-glutamyltransferase, hepatic enzymes, and risk of incident heart failure in older men. Arterioscler. Thromb. Vasc. Biol 2012;32(3):830-5.
Deetman PE, Alkhalaf A, Landman GW, Groenier KH, Kootstra-Ros JE, Navis G, et al. Alanine aminotransferase and mortality in patients with type 2 diabetes (ZODIAC-38). Eur. J. Clin. Invest. 2015;45(8)807-14.
Ruhl CE, Everhart JE. Elevated serum alanine aminotransferase and gamma-glutamyltransferase and mortality in the United States population. Gastroenterology 2009;136(2)477-85.e11.
Targher G, Bertolini L, Chonchol M, Rodella S, Zoppini G, Lippi G, et al. Non-alcoholic fatty liver disease is independently associated with an increased prevalence of chronic kidney disease and retinopathy in type 1 diabetic patients. Diabetologia 2010;53(7):1341-8.

APA	ÇAKIR E, Demirci H, MENEKSE E, demir h (2016). The relationship one-hour glycemia level at oral glucose tolerance test and non-alcoholic fatty liver disease. , 297 - 301.
Chicago	ÇAKIR Evrim,Demirci Hüseyin,MENEKSE Elif,demir hatice The relationship one-hour glycemia level at oral glucose tolerance test and non-alcoholic fatty liver disease. (2016): 297 - 301.
MLA	ÇAKIR Evrim,Demirci Hüseyin,MENEKSE Elif,demir hatice The relationship one-hour glycemia level at oral glucose tolerance test and non-alcoholic fatty liver disease. , 2016, ss.297 - 301.
AMA	ÇAKIR E,Demirci H,MENEKSE E,demir h The relationship one-hour glycemia level at oral glucose tolerance test and non-alcoholic fatty liver disease. . 2016; 297 - 301.
Vancouver	ÇAKIR E,Demirci H,MENEKSE E,demir h The relationship one-hour glycemia level at oral glucose tolerance test and non-alcoholic fatty liver disease. . 2016; 297 - 301.
IEEE	ÇAKIR E,Demirci H,MENEKSE E,demir h "The relationship one-hour glycemia level at oral glucose tolerance test and non-alcoholic fatty liver disease." , ss.297 - 301, 2016.
ISNAD	ÇAKIR, Evrim vd. "The relationship one-hour glycemia level at oral glucose tolerance test and non-alcoholic fatty liver disease". (2016), 297-301.

APA	ÇAKIR E, Demirci H, MENEKSE E, demir h (2016). The relationship one-hour glycemia level at oral glucose tolerance test and non-alcoholic fatty liver disease. İnönü Üniversitesi Turgut Özal Tıp Merkezi Dergisi, 23(3), 297 - 301.
Chicago	ÇAKIR Evrim,Demirci Hüseyin,MENEKSE Elif,demir hatice The relationship one-hour glycemia level at oral glucose tolerance test and non-alcoholic fatty liver disease. İnönü Üniversitesi Turgut Özal Tıp Merkezi Dergisi 23, no.3 (2016): 297 - 301.
MLA	ÇAKIR Evrim,Demirci Hüseyin,MENEKSE Elif,demir hatice The relationship one-hour glycemia level at oral glucose tolerance test and non-alcoholic fatty liver disease. İnönü Üniversitesi Turgut Özal Tıp Merkezi Dergisi, vol.23, no.3, 2016, ss.297 - 301.
AMA	ÇAKIR E,Demirci H,MENEKSE E,demir h The relationship one-hour glycemia level at oral glucose tolerance test and non-alcoholic fatty liver disease. İnönü Üniversitesi Turgut Özal Tıp Merkezi Dergisi. 2016; 23(3): 297 - 301.
Vancouver	ÇAKIR E,Demirci H,MENEKSE E,demir h The relationship one-hour glycemia level at oral glucose tolerance test and non-alcoholic fatty liver disease. İnönü Üniversitesi Turgut Özal Tıp Merkezi Dergisi. 2016; 23(3): 297 - 301.
IEEE	ÇAKIR E,Demirci H,MENEKSE E,demir h "The relationship one-hour glycemia level at oral glucose tolerance test and non-alcoholic fatty liver disease." İnönü Üniversitesi Turgut Özal Tıp Merkezi Dergisi, 23, ss.297 - 301, 2016.
ISNAD	ÇAKIR, Evrim vd. "The relationship one-hour glycemia level at oral glucose tolerance test and non-alcoholic fatty liver disease". İnönü Üniversitesi Turgut Özal Tıp Merkezi Dergisi 23/3 (2016), 297-301.