(MERS-CoV) Enfeksiyonu: Ortadoğu Solunum Yetmezliği Sendromu-Koronavirüs Enfeksiyonu

İNAL, AYŞE SEZA

(MERS-CoV) Enfeksiyonu: Ortadoğu Solunum Yetmezliği Sendromu-Koronavirüs Enfeksiyonu

AYŞE SEZA İNAL (Çukurova Üniversitesi, Tıp Fakültesi, Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Anabilim Dalı, Adana, Türkiye)

Okmeydanı Tıp Dergisi

20 2

Yıl: 2016 Cilt: 32 Sayı: ek Sayfa Aralığı: 37 - 45 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

(MERS-CoV) Enfeksiyonu: Ortadoğu Solunum Yetmezliği Sendromu-Koronavirüs Enfeksiyonu

Öz:

"Middle East Respiratory Syndrome-Coronavirus" (MERSCoV) 2012 yılında şiddetli solunum yolu enfeksiyonu nedeniyle Suudi Arabistan'da ölen bir hastadan izole edilen yeni bir virüstür. Arap Yarımadası'ndaki develerde ortaya çıkan MERS-CoV enfeksiyonu, pandemi yapma potansiyeli nedeniyle, bütün insanlığı tehdit eder hale gelmiştir. Koronavirüsler yıllar boyunca insanların üst solunum yolunda ve gastrointestinal sistemde hafif enfeksiyon etkeni olarak bilinirken, ölümcül ve insandan insana yayılabilme özelliği nedeniyle yeni bir üye olarak MERS-CoV dünya için korkulan bir salgın etkeni olmuştur. Genomik çalışmalar MERS-CoV'un yarasalarda etken olan betacoronaviruslardan köken aldığını ve daha sonra develere adapte olduğunu düşündürmektedir. Virüs develerden insana veya insandan insana bulaşabilmektedir, ancak virüsün bulaşma yolları halen açık değildir. Dünya Sağlık Örgütü bu güne kadar laboratuvar tanısı doğrulanmış 1791 MERS-CoV olgusu tespit edildiğini ve bunların 640'ının öldüğünü (olgu fatalite hızı %36) bildirmiştir. İlk MERS-CoV olgusu bildirildikten sonraki 4 yıl içinde ortaya çıkan bu hastalar, Avrupa, Asya ülkeleri ve ABD dahil, 26 farklı ülkeden bildirilmiş, bu ülkelere Orta Doğu ülkelerinden gelmiş veya gelenlerle temas etmiş olgulardır. Hastalığın klinik tablosu asemptomatik enfeksiyondan ölüme yol açabilen ağır solunum yetmezliği ve multiorgan disfonksiyonuna kadar değişebilen bir yelpazededir. Bugün MERS-CoV enfeksiyonuna özgü bir tedavi mevcut değildir. Bu nedenle yeni enfeksiyon gelişmesini önlemek ve özellikle de sağlık kurumlarında enfeksiyon kontrolünü sağlamak için yapılacak çalışmalar, MERS-CoV ile mücadelenin temelini oluşturmaktadır. MERS-CoV enfeksiyon salgını zaman içinde şiddetini kaybetmiş gibi görünse de, hala dünyanın uzak bölgelerine yayılma potansiyeli taşımaktadır. Bu makalede, MERS-CoV enfeksiyonu hakkında epidemiyolojik, virolojik, klinik, tanısal, tedavi ve korunmaya ilişkin yeni tıbbi bilgiler gözden geçirilerek derlenmiştir.

Anahtar Kelime:

Konular: Genel ve Dahili Tıp

Middle East Respiratory Syndrome-Coronavirus (MERSCoV) Infection

Öz:

The Middle East respiratory syndrome coronavirus (MERSCoV) is a new virus isolated from a fatal respiratory infection patient in Saudi Arabia, in 2012. After MERS-CoV infection had originated from dromedary camels as a zoonotic disease in Arabian Peninsula, it became a threat for humankind with pandemic potential with an evil face of coronaviruses, known as pathogens for mild diseases involving upper respiratory or gastrointestinal tract in humans. Genomic researches suggested that, the MERS-CoV, the new and nasty member of coronaviruses, was originated from bat betacoronaviruses, before the pathogen has adapted to dromedary camels. Humans can acquire the virus from both camels and humans, although the mode of transmission still is not well understood. The WHO announced 1791 laboratory confirmed MERS-CoV cases with 640 deaths (case fatality rate 36%) in 26 countries, from Europe, USA and Asia in people who traveled from the Middle East or their contacts, after the first MERS-CoV case was reported four years ago. Clinical manifestations have a wide spectrum from asymptomatic disease to acute respiratory failure and multiorgan dysfunction leading to death. There is no specific treatment modality for MERS-CoV infection. Thus, infection prevention and control measures are essential to prevent transmission, especially in health care settings. Although MERS-CoV outbreak has subsided in time, it still carries a potential to spread to remote parts of the world. In this article, we reviewed current knowledge on epidemiology, virology, clinical manifestations, diagnostic, therapeutic and preventive medicine for MERS-CoV infection.

Anahtar Kelime:

Konular: Genel ve Dahili Tıp

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	İNAL A (2016). (MERS-CoV) Enfeksiyonu: Ortadoğu Solunum Yetmezliği Sendromu-Koronavirüs Enfeksiyonu. , 37 - 45.
Chicago	İNAL AYŞE SEZA (MERS-CoV) Enfeksiyonu: Ortadoğu Solunum Yetmezliği Sendromu-Koronavirüs Enfeksiyonu. (2016): 37 - 45.
MLA	İNAL AYŞE SEZA (MERS-CoV) Enfeksiyonu: Ortadoğu Solunum Yetmezliği Sendromu-Koronavirüs Enfeksiyonu. , 2016, ss.37 - 45.
AMA	İNAL A (MERS-CoV) Enfeksiyonu: Ortadoğu Solunum Yetmezliği Sendromu-Koronavirüs Enfeksiyonu. . 2016; 37 - 45.
Vancouver	İNAL A (MERS-CoV) Enfeksiyonu: Ortadoğu Solunum Yetmezliği Sendromu-Koronavirüs Enfeksiyonu. . 2016; 37 - 45.
IEEE	İNAL A "(MERS-CoV) Enfeksiyonu: Ortadoğu Solunum Yetmezliği Sendromu-Koronavirüs Enfeksiyonu." , ss.37 - 45, 2016.
ISNAD	İNAL, AYŞE SEZA. "(MERS-CoV) Enfeksiyonu: Ortadoğu Solunum Yetmezliği Sendromu-Koronavirüs Enfeksiyonu". (2016), 37-45.

APA	İNAL A (2016). (MERS-CoV) Enfeksiyonu: Ortadoğu Solunum Yetmezliği Sendromu-Koronavirüs Enfeksiyonu. Okmeydanı Tıp Dergisi, 32(ek), 37 - 45.
Chicago	İNAL AYŞE SEZA (MERS-CoV) Enfeksiyonu: Ortadoğu Solunum Yetmezliği Sendromu-Koronavirüs Enfeksiyonu. Okmeydanı Tıp Dergisi 32, no.ek (2016): 37 - 45.
MLA	İNAL AYŞE SEZA (MERS-CoV) Enfeksiyonu: Ortadoğu Solunum Yetmezliği Sendromu-Koronavirüs Enfeksiyonu. Okmeydanı Tıp Dergisi, vol.32, no.ek, 2016, ss.37 - 45.
AMA	İNAL A (MERS-CoV) Enfeksiyonu: Ortadoğu Solunum Yetmezliği Sendromu-Koronavirüs Enfeksiyonu. Okmeydanı Tıp Dergisi. 2016; 32(ek): 37 - 45.
Vancouver	İNAL A (MERS-CoV) Enfeksiyonu: Ortadoğu Solunum Yetmezliği Sendromu-Koronavirüs Enfeksiyonu. Okmeydanı Tıp Dergisi. 2016; 32(ek): 37 - 45.
IEEE	İNAL A "(MERS-CoV) Enfeksiyonu: Ortadoğu Solunum Yetmezliği Sendromu-Koronavirüs Enfeksiyonu." Okmeydanı Tıp Dergisi, 32, ss.37 - 45, 2016.
ISNAD	İNAL, AYŞE SEZA. "(MERS-CoV) Enfeksiyonu: Ortadoğu Solunum Yetmezliği Sendromu-Koronavirüs Enfeksiyonu". Okmeydanı Tıp Dergisi 32/ek (2016), 37-45.