Aim: These large destructive tumors, usually called Giant condyloma accuminata (GCA), are typically perianal or under the foreskin. Histopatology of GCA is usually benign. Treatment of GCA was usually unsuccessful and a real problem. The case who underwent electrodesiccation with interferon alpha2b (INF-alpha2b) for giant condylo-mata acuminata of the pubis is presented. Case Report: Fourty five year old man developed a perianal tumor that rapidly increased in size. Two cauliflower-like tumors which were 7x4 cm and 3x4 cm were in-spected on pubis and penis. Histopathology of the lesions showed GCA and there was no malignant transforma-tion. We treated patients with electrodesiccation in combination with interferon-alpha2b. Condylomas were removed by electrodesiccation and 3 million IU interferon alpha2b (INF-alpha2b) was applied subcutaneusly 3 times a week. A total 100 million IU of INF-alpha2b was given and no evidence of recurrence was observed for nine months of follow up. Results: Finally we observed that combination of electrodes-iccation with INF-alpha2b is a good alternative treatment for GCA with geed cosmetic results