Can compulsions be associated with problems in forming an internal model of the completed state of an action?

KAFADAR, Tugay; KIRKICI, BİLAL; Koçak, Orhan Murat; YILMAZ ÖZPOLATA, Ayşe Gül; dagli, mustafa

Can compulsions be associated with problems in forming an internal model of the completed state of an action?

Orhan Murat KOÇAK, (Department of Psychiatry, Faculty of Medicine, Kırıkkale University, Kırıkkale,)

Bilal KIRKICI, (Department of Foreign Language Education, Faculty of Education, Middle East Technical University, Ankara,)

Mustafa DAĞLI, (Department of Psychiatry, Darıca State Hospital, Kocaeli)

Tugay KAFADAR, (Department of Psychiatry, Giresun Bulancak State Hospital, Giresun, TURKEY)

Ayşe Gül YILMAZ ÖZPOLATA (Department of Psychiatry, Faculty of Medicine, Kırıkkale University, Kırıkkale,)

Turkish Journal of Clinics and Laboratory

1 0

Yıl: 2017 Cilt: 8 Sayı: 2 Sayfa Aralığı: 35 - 42 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Can compulsions be associated with problems in forming an internal model of the completed state of an action?

Öz:

Amaç: Bu çalışmanın amacı, Obsesif Kompulsif Bozukluğun (OKB) bir hareketi tamamlama durumu için oluşturulan ileriye dönük bir modeli, uygun şekilde oluşturamayacağına yönelik bozuk işlevli bir hareket sistemi ile bağlantılı olduğu hipotezin test edilmesidir.Gereç veYöntemler: Çalışmada üç bilgisayar deneyi sunulmaktadır. Her üç deneyde de, farkı durumları ifade eden kelimelere reaksiyon zamanları, ana bağımlı değişkeni oluşturmuştur. Deneyler, OKB'li hastaların mükemmeliyetçilik yönü olan cümlelerde ve/veya tamamlanmış hareketlerde zorluklar yaşadıkları ve bu nedenle bağlantılı bir uyarıya daha uzun reaksiyon zamanları gösterdikleri hipotezini test etmek için yürütüldü. OKB'li toplam 40 katılımcı (Deney 1 de 16, Deney 2 ve 3 de 24'er kişi) ve yaş, cinsiyet, ve eğitimleri uyumlu 40 non-obsesif kontrol katılımcı çalışmaya dahil edildi. Deney 1, katılımcının kelime/kelime dışı bir duruma karar verme konusunda talimat verildiği ve eş zamanlı olarak ekrandaki gösterilen uyarı tarafından kodlanmış temporal referansta, kelimelere ait bir karar verme görevi idi. Deney 2'de katılımcılar bir dizi hareketi yerine getirmek ve kendilerinin yaptıkları hareketlerin bütünlüğünün uygun veya uygunsuz olarak tanımlanıp yansıtıldığı uyarı cümlelerini oranlamak zorunda idi. Deney 3'de katılımcılar, Deney 2'de daha önce yaptıkları görevle bağlantılı olarak, uyarı cümlelerinin doğruluk değerlerini oranladılar.Bulgular: Bulgular bir bütün olarak, OKB'li hastaların kontrol grubu ile karşılaştırıldığında, mükemmeliyetçilik yönü olan hareketlerle ilgili cümlelere daha uzun reaksiyon zamanları gösterdiklerini ortaya koymuştur.Sonuçlar: Elde edilen bulgular, OKB'da ileri beslemeli hareket denetiminin problemli olduğu varsayımını destekleyici olarak ele alınabilir

Anahtar Kelime:

Konular: Tıbbi Araştırmalar Deneysel Tıbbi Laboratuar Teknolojisi

Kompulsiyonlar bir eylemin sonlanması durumunda içsel bir model oluşmasındaki problemle ilişkili olabilir mi?

Öz:

Aim: The aim of this study was to test Obsessive Compulsive Disorder (OCD) is associated with a dysfunctional motor system that cannot appropriately form a forward model of the completed state of an action.Material and Methods: In three computerized experiments, reaction times to verbs denoting different aspects constituted the main dependent variable. They were conducted to test the hypothesis that patients with OCD would have difficulties in sentences with perfective aspect and/or completed actions and, hence, display longer reaction times to associated stimuli. 40 participants with OCD and 40 non-obsessive controls were included in the study. Experiment 1 was a visual lexical decision task in which participants were instructed to decide on the word/non-word status and, simultaneously, on the temporal reference encoded by stimuli presented on the screen. In Experiment 2, participants had to carry out a number of actions and to rate stimulus sentences that represented either accurate or inaccurate descriptions of the completeness of the actions they themselves carried out. In Experiment 3, participants rated the truth-values of stimulus sentences in relation to the tasks that they had previously carried out in Experiment 2.Results: Patients with OCD displayed significantly longer reaction times to sentences with actions in the perfective aspect.Conclusion: The results obtained may be taken as support for the assumption that the feedforward motor control of actions in OCD is problematic

Anahtar Kelime:

Konular: Tıbbi Araştırmalar Deneysel Tıbbi Laboratuar Teknolojisi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

1. Coles ME, Frost RO, Heimberg RG, Rheaume J. "Not just right experiences": perfectionism, obsessive-compulsive features and general psychopathology. Behav Res Ther 2003; 41: 681-700.
2. Summerfeldt LJ. Understanding and treating incompleteness in obsessive-compulsive disorder. J Clin Psychol 2004; 60: 1155-68.
3. Gehring WJ, Himle J, Nisenson LG. Action-monitoring dysfunction in obsessive-compulsive disorder. Psychol Sci 2000; 11: 1-6.
4. Van Veen V, Carter CS. The timing of action-monitoring processes in the anterior cingulate cortex. Physiol Behav 2002; 77: 477-82.
5. Cavanagh JF, Cohen MX, Allen JJ. Prelude to and resolution of an error: EEG phase synchrony reveals cognitive control dynamics during action monitoring. J Neurosci 2009; 29: 98-105.
6. Alexander WH, Brown JW. Computational models of performance monitoring and cognitive control. Top Cogn Sci 2010; 2: 658-77.
7. Hajcak G, Simons RF. Error-related brain activity in obsessivecompulsive undergraduates. Psychiatry Res 2002; 110: 63-72.
8. Maltby N, Tolin DF, Worhunsky P, O'Keefe TM, Kiehl KA. Dysfunctional action monitoring hyperactivates frontal-striatal circuits in obsessive-compulsive disorder: an event-related fMRI study. Neuroimage 2005; 24: 495-503.
9. Fitzgerald KD, Welsh RC, Gehring WJ, et al. Error-related hyperactivity of the anterior cingulate cortex in obsessivecompulsive disorder. Biol Psychiatry 2005;57: 287-94.
10. Beucke JC, Kaufmann C, Linnman C, et al. Altered cingulostriatal coupling in obsessive-compulsive disorder. Brain Connect 2012; 2:191-202.
11. Ciesielski KT, Rauch SL, Ahlfors SP, et al. Role of medial cortical networks for anticipatory processing in obsessive-compulsive disorder. Hum Brain Mapp 2012;33: 2125-34.
12. Koch K, Wagner G, Schachtzabel C, et al. Aberrant anterior cingulate activation in obsessive-compulsive disorder is related to task complexity. Neuropsychologia 2012; 50:958-64.
13. Jeannerod M. The Handbook of Brain Theory and Neural Networks (2nd Ed). In: Arbib M, Editor. Action Monitoring and Forward Control of Movements. Cambridge, MA: MIT Press, 2003, p. 83-84.
14. Frith CD, Blakemore SJ, Wolpert DM. Abnormalities in the awareness and control of action. Philos Trans R Soc Lond B Biol Sci 2000;355: 1771-88.
15. Wolpert DM, Ghahramani Z, Jordan MI. An internal model for sensorimotor integration. Science 1995;269: 1880-2.
16. Flanagan JR, Wing AM. The role of internal models in motion planning and control: evidence from grip force adjustments during movements of hand-held loads. J Neurosci 1997;17: 1519-28.
17. Jordan MI, Wolpert DM. The Cognitive Neurosciences. In: Gazzaniga MS, Editor. Computational Motor Control.Cambridge, MA: MIT Press, 1999, p. 601-620.
18. Modirrousta M, Fellows LK. Dorsal medial prefrontal cortex plays a necessary role in rapid error prediction in humans. J Neurosci 2008;28: 14000-5.
19. Wessel JR, Klein TA, Ott DV, Ullsperger M. Lesions to the prefrontal performance-monitoring network disrupt neural processing and adaptive behaviours after both errors and novelty. Cortex 2014; 50:45-54.
20. Çorapçıoğlu A, Aydemir O, Yıldız M. DSM-IV Structured Clinical Interview for DSM-IV (SCID-IV), Turkish Version (Turkish). Ankara: Hekimler Yayin Birligi; 1999.
21. Goodman WK, Price LH, Rasmussen SA, et al. The Yale-Brown Obsessive Compulsive Scale. I. Development, use, and reliability. Arch Gen Psychiatry 1989;46: 1006-11.
22. Ullman MT. Contributions of memory circuits to language: the declarative/procedural model. Cognition 2004;92: 231-70.
23. Teichmann M, Dupoux E, Kouider S, Bachoud-Lévi AC. The role of the striatum in processing language rules: evidence from word perception in Huntington's disease. J Cogn Neurosci 2006;18: 1555-69.
24. Sammler D, Novembre G, Koelsch S, Keller PE. Syntax in a pianist's hand: ERP signatures of "embodied" syntax processing in music. Cortex 2013;49: 1325-39.
25. Kim MS, Kim YY, Yoo SY, Kwon JS. Electrophysiological correlates of behavioral response inhibition in patients with obsessivecompulsive disorder. Depress Anxiety 2007; 24:22-31.
26. Zor R, Szechtman H, Hermesh H, Fineberg NA, Eilam D. Manifestation of incompleteness in obsessive-compulsive disorder (OCD) as reduced functionality and extended activity beyond task completion. PLoS One 2011;6: e25217.
27. Melcher T, Falkai P, Gruber O. Functional brain abnormalities in psychiatric disorders: neural mechanisms to detect and resolve cognitive conflict and interference. Brain Res Rev 2008; 59:96-124.
28. Endrass T, Klawohn J, Schuster F, Kathmann N. Overactive performance monitoring in obsessive - compulsive disorder: ERP evidence from correct and erroneous reactions. Neuropsychologia 2008;46: 1877-87.
29. Pitman RK. A cybernetic model of obsessive-compulsive psychopathology. Compr Psychiatry 1987;28: 334-43.
30. Gehring WJ, Fencsik DE. Functions of the medial frontal cortex in the processing of conflict and errors. J Neuroscience 2001;21: 9430-7.
31. Riesel A, Endrass T, Kaufmann C, Kathmann N. Overactive error-related brain activity as a candidate endophenotype for obsessive-compulsive disorder: evidence from unaffected firstdegree relatives. Am J Psychiatry 2011; 168:317-24.

APA	Koçak O, KIRKICI B, dagli m, KAFADAR T, YILMAZ ÖZPOLATA A (2017). Can compulsions be associated with problems in forming an internal model of the completed state of an action?. , 35 - 42.
Chicago	Koçak Orhan Murat,KIRKICI BİLAL,dagli mustafa,KAFADAR Tugay,YILMAZ ÖZPOLATA Ayşe Gül Can compulsions be associated with problems in forming an internal model of the completed state of an action?. (2017): 35 - 42.
MLA	Koçak Orhan Murat,KIRKICI BİLAL,dagli mustafa,KAFADAR Tugay,YILMAZ ÖZPOLATA Ayşe Gül Can compulsions be associated with problems in forming an internal model of the completed state of an action?. , 2017, ss.35 - 42.
AMA	Koçak O,KIRKICI B,dagli m,KAFADAR T,YILMAZ ÖZPOLATA A Can compulsions be associated with problems in forming an internal model of the completed state of an action?. . 2017; 35 - 42.
Vancouver	Koçak O,KIRKICI B,dagli m,KAFADAR T,YILMAZ ÖZPOLATA A Can compulsions be associated with problems in forming an internal model of the completed state of an action?. . 2017; 35 - 42.
IEEE	Koçak O,KIRKICI B,dagli m,KAFADAR T,YILMAZ ÖZPOLATA A "Can compulsions be associated with problems in forming an internal model of the completed state of an action?." , ss.35 - 42, 2017.
ISNAD	Koçak, Orhan Murat vd. "Can compulsions be associated with problems in forming an internal model of the completed state of an action?". (2017), 35-42.

APA	Koçak O, KIRKICI B, dagli m, KAFADAR T, YILMAZ ÖZPOLATA A (2017). Can compulsions be associated with problems in forming an internal model of the completed state of an action?. Turkish Journal of Clinics and Laboratory, 8(2), 35 - 42.
Chicago	Koçak Orhan Murat,KIRKICI BİLAL,dagli mustafa,KAFADAR Tugay,YILMAZ ÖZPOLATA Ayşe Gül Can compulsions be associated with problems in forming an internal model of the completed state of an action?. Turkish Journal of Clinics and Laboratory 8, no.2 (2017): 35 - 42.
MLA	Koçak Orhan Murat,KIRKICI BİLAL,dagli mustafa,KAFADAR Tugay,YILMAZ ÖZPOLATA Ayşe Gül Can compulsions be associated with problems in forming an internal model of the completed state of an action?. Turkish Journal of Clinics and Laboratory, vol.8, no.2, 2017, ss.35 - 42.
AMA	Koçak O,KIRKICI B,dagli m,KAFADAR T,YILMAZ ÖZPOLATA A Can compulsions be associated with problems in forming an internal model of the completed state of an action?. Turkish Journal of Clinics and Laboratory. 2017; 8(2): 35 - 42.
Vancouver	Koçak O,KIRKICI B,dagli m,KAFADAR T,YILMAZ ÖZPOLATA A Can compulsions be associated with problems in forming an internal model of the completed state of an action?. Turkish Journal of Clinics and Laboratory. 2017; 8(2): 35 - 42.
IEEE	Koçak O,KIRKICI B,dagli m,KAFADAR T,YILMAZ ÖZPOLATA A "Can compulsions be associated with problems in forming an internal model of the completed state of an action?." Turkish Journal of Clinics and Laboratory, 8, ss.35 - 42, 2017.
ISNAD	Koçak, Orhan Murat vd. "Can compulsions be associated with problems in forming an internal model of the completed state of an action?". Turkish Journal of Clinics and Laboratory 8/2 (2017), 35-42.