Preventive Role of Hilar Parasympathetic ganglia on Pulmonary Artery Vasospasm in Subarachnoid Hemorrhage: An experimental Study

atalay, canan; ÇAKIR, Mürteza; Gündoğdu, Cemal; GÜNDOĞDU, Betül; Aras, Omer; AYDIN, Mehmet Dumlu; ALTAŞ, Ender; ÇALIKOĞLU, ÇAĞATAY

Preventive Role of Hilar Parasympathetic ganglia on Pulmonary Artery Vasospasm in Subarachnoid Hemorrhage: An experimental Study

Ömer ARAZ, (Ataturk University, School of Medicine, Department of Pulmonary Diseases, Erzurum, Turkey)

Mehmet Dumlu AYDIN, (Ataturk University, School of Medicine, Department of Neurosurgery, Erzurum, Turkey)

Betül GÜNDOĞDU, (Ataturk University, School of Medicine, Department of Pathology, Erzurum, Turkey)

Ender ALTAŞ, (Palandoken Government Hospital, Department of Cardiology, Erzurum, Turkey)

Mürteza ÇAKIR, (Ataturk University, School of Medicine, Department of Neurosurgery, Erzurum, Turkey)

ÇAĞATAY ÇALIKOĞLU, (Ataturk University, School of Medicine, Department of Neurosurgery, Erzurum, Turkey)

Canan ATALAY, (Ataturk University, School of Medicine, Department of Anesthesiology and Reanimation, Erzurum, Turkey)

Cemal GÜNDOĞDU (Ataturk University, School of Medicine, Department of Pathology, Erzurum, Turkey)

Turkish Neurosurgery

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Yıl: 2015 Cilt: 25 Sayı: 4 Sayfa Aralığı: 519 - 525 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Preventive Role of Hilar Parasympathetic ganglia on Pulmonary Artery Vasospasm in Subarachnoid Hemorrhage: An experimental Study

Öz:

AmAÇ: Pulmoner arterlerin ana inervasyonunu sempatik vazokonstriktör ve parasempatik vazodilatatör lifler tarafından yapılır. Biz subaraknoid kanamada (SAK) pulmoner arter vazospazmı ile hilar parasempatik gangliyon nöron dansitesi arasındaki ilişkiyi değerlendirdik. yÖNTem ve GeReÇLeR: Yirmi dört tavşan iki gruba bölündü: 8'i kontrol ve 16'sı SAK oluşturulan gruptu. Hayvanlar 20 gün boyunca takip edildi. Hilar parasempatik gangliyon sayıları ve nöron dansiteleri tespit edildi. Pulmoner arterin dış çapı ile iç yüzey çapı oranı vazospazm indeksi olarak (VSİ) kabul edildi. Nöron dansitesi ile VSİ istatiksel olarak karşılaştırıldı. BuLGuLAR: SAK grupta altı hayvanda hafif, 10 hayvanda şiddetli vazospazm tespit edildi. Kontrol grubunda tahmini olarak hilar gangliyon nöron dansitesi 12,100±2,010/mm3 ve VSİ 0,777±0,048 olarak tespit edildi. Yine hafif derecede pulmoner arter vazospazmı olan SAK' lı grupta hilar gangliyon nöron dansitesi 10,110±1,430/mm3 ve VSİ=1,148±0,090, şiddetli spazmı olan grupta ise hilar gangliyon nöron dansitesi 7,340±990/mm3 ve VSİ=1,500±0,120 tahmini olarak tespit edildi. soNuÇ: Hilar gangliyon nöron dansitesi ile vazospazm indeksi arasında ters ilişki vardır. Subaraknoid kanamada az sayıda ve düşük dansitesi olan parasempatik gangliyonlar şiddetli pulmoner arter vazospazmının sebebi olabilirler.

Anahtar Kelime:

Konular: Cerrahi

Subaraknoid Kanamada Hilar Parasempatik Ganglionun Pulmoner Arter Vazospazmı Üzerindeki Önleyici Rolü: Deneysel Bir Çalışma

Öz:

AIm: Pulmonary arteries are mainly innervated by sympathetic vasoconstrictor and parasympathetic vasodilatory fibers. We examined whether there is a relationship between the neuron densities of hilar parasympathetic ganglia and pulmonary vasospasm in subarachnoid hemorrhage (SAH). mATeRIAL and meTHods: Twenty-four rabbits were divided into two groups: control (n=8) and SAH (n=16). The animals were observed for 20 days following experimental SAH. The number of hilar parasympathetic ganglia and their neuron densities were determined. Proportion of pulmonary artery ring surface to lumen surface values was accepted as vasospasm index (VSI). Neuron densities of the hilar ganglia and VSI values were compared statistically. ResuLTs: Animals in the SAH group experienced either mild (n=6) or severe (n=10) pulmonary artery vasospasm. In the control group, the mean VSI of pulmonary arteries was 0.777±0.048 and the hilar ganglion neuron density was estimated as 12.100±2.010/mm3. In SAH animals with mild vasospasm, VSI=1.148±0.090 and neuron density was estimated as 10.110±1.430/mm3; in animals with severe vasospasm, VSI=1.500±0.120 and neuron density was estimated as 7.340±990/mm3. CoNCLusIoN: There was an inverse correlation between quantity and neuron density of hilar ganglia and vasospasm index value. The low numbers and low density of hilar parasympathetic ganglia may be responsible for the more severe artery vasospasm in SAH.

Anahtar Kelime:

Konular: Cerrahi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Aras O, AYDIN M, GÜNDOĞDU B, ALTAŞ E, ÇAKIR M, ÇALIKOĞLU Ç, atalay c, Gündoğdu C (2015). Preventive Role of Hilar Parasympathetic ganglia on Pulmonary Artery Vasospasm in Subarachnoid Hemorrhage: An experimental Study. , 519 - 525.
Chicago	Aras Omer,AYDIN Mehmet Dumlu,GÜNDOĞDU Betül,ALTAŞ Ender,ÇAKIR Mürteza,ÇALIKOĞLU ÇAĞATAY,atalay canan,Gündoğdu Cemal Preventive Role of Hilar Parasympathetic ganglia on Pulmonary Artery Vasospasm in Subarachnoid Hemorrhage: An experimental Study. (2015): 519 - 525.
MLA	Aras Omer,AYDIN Mehmet Dumlu,GÜNDOĞDU Betül,ALTAŞ Ender,ÇAKIR Mürteza,ÇALIKOĞLU ÇAĞATAY,atalay canan,Gündoğdu Cemal Preventive Role of Hilar Parasympathetic ganglia on Pulmonary Artery Vasospasm in Subarachnoid Hemorrhage: An experimental Study. , 2015, ss.519 - 525.
AMA	Aras O,AYDIN M,GÜNDOĞDU B,ALTAŞ E,ÇAKIR M,ÇALIKOĞLU Ç,atalay c,Gündoğdu C Preventive Role of Hilar Parasympathetic ganglia on Pulmonary Artery Vasospasm in Subarachnoid Hemorrhage: An experimental Study. . 2015; 519 - 525.
Vancouver	Aras O,AYDIN M,GÜNDOĞDU B,ALTAŞ E,ÇAKIR M,ÇALIKOĞLU Ç,atalay c,Gündoğdu C Preventive Role of Hilar Parasympathetic ganglia on Pulmonary Artery Vasospasm in Subarachnoid Hemorrhage: An experimental Study. . 2015; 519 - 525.
IEEE	Aras O,AYDIN M,GÜNDOĞDU B,ALTAŞ E,ÇAKIR M,ÇALIKOĞLU Ç,atalay c,Gündoğdu C "Preventive Role of Hilar Parasympathetic ganglia on Pulmonary Artery Vasospasm in Subarachnoid Hemorrhage: An experimental Study." , ss.519 - 525, 2015.
ISNAD	Aras, Omer vd. "Preventive Role of Hilar Parasympathetic ganglia on Pulmonary Artery Vasospasm in Subarachnoid Hemorrhage: An experimental Study". (2015), 519-525.

APA	Aras O, AYDIN M, GÜNDOĞDU B, ALTAŞ E, ÇAKIR M, ÇALIKOĞLU Ç, atalay c, Gündoğdu C (2015). Preventive Role of Hilar Parasympathetic ganglia on Pulmonary Artery Vasospasm in Subarachnoid Hemorrhage: An experimental Study. Turkish Neurosurgery, 25(4), 519 - 525.
Chicago	Aras Omer,AYDIN Mehmet Dumlu,GÜNDOĞDU Betül,ALTAŞ Ender,ÇAKIR Mürteza,ÇALIKOĞLU ÇAĞATAY,atalay canan,Gündoğdu Cemal Preventive Role of Hilar Parasympathetic ganglia on Pulmonary Artery Vasospasm in Subarachnoid Hemorrhage: An experimental Study. Turkish Neurosurgery 25, no.4 (2015): 519 - 525.
MLA	Aras Omer,AYDIN Mehmet Dumlu,GÜNDOĞDU Betül,ALTAŞ Ender,ÇAKIR Mürteza,ÇALIKOĞLU ÇAĞATAY,atalay canan,Gündoğdu Cemal Preventive Role of Hilar Parasympathetic ganglia on Pulmonary Artery Vasospasm in Subarachnoid Hemorrhage: An experimental Study. Turkish Neurosurgery, vol.25, no.4, 2015, ss.519 - 525.
AMA	Aras O,AYDIN M,GÜNDOĞDU B,ALTAŞ E,ÇAKIR M,ÇALIKOĞLU Ç,atalay c,Gündoğdu C Preventive Role of Hilar Parasympathetic ganglia on Pulmonary Artery Vasospasm in Subarachnoid Hemorrhage: An experimental Study. Turkish Neurosurgery. 2015; 25(4): 519 - 525.
Vancouver	Aras O,AYDIN M,GÜNDOĞDU B,ALTAŞ E,ÇAKIR M,ÇALIKOĞLU Ç,atalay c,Gündoğdu C Preventive Role of Hilar Parasympathetic ganglia on Pulmonary Artery Vasospasm in Subarachnoid Hemorrhage: An experimental Study. Turkish Neurosurgery. 2015; 25(4): 519 - 525.
IEEE	Aras O,AYDIN M,GÜNDOĞDU B,ALTAŞ E,ÇAKIR M,ÇALIKOĞLU Ç,atalay c,Gündoğdu C "Preventive Role of Hilar Parasympathetic ganglia on Pulmonary Artery Vasospasm in Subarachnoid Hemorrhage: An experimental Study." Turkish Neurosurgery, 25, ss.519 - 525, 2015.
ISNAD	Aras, Omer vd. "Preventive Role of Hilar Parasympathetic ganglia on Pulmonary Artery Vasospasm in Subarachnoid Hemorrhage: An experimental Study". Turkish Neurosurgery 25/4 (2015), 519-525.