Evaluation of platelet activating factor in neonatal calves with sepsis

ÖZÇELİK M, Merve; YILDIZ, Ramazan; BESLEK, Mustafa; BİÇİCİ, Özlem; BEYDİLLİ, Yasemin

Evaluation of platelet activating factor in neonatal calves with sepsis

Ramazan YILDIZ, (Faculty of Veterinary Medicine, University of Mehmet Akif Ersoy, Burdur, Turkey)

Mustafa BESLEK, (Faculty of Veterinary Medicine, University of Mehmet Akif Ersoy, Burdur, Turkey)

Yasemin BEYDİLLİ, (Faculty of Veterinary Medicine, University of Mehmet Akif Ersoy, Burdur, Turkey)

Merve ÖZÇELİK M, (Faculty of Veterinary Medicine, University of Mehmet Akif Ersoy, Burdur, Turkey)

Özlem BİÇİCİ (Faculty of Veterinary Medicine, University of Siirt, Siirt, Turkey)

Veteriner Hekimler Derneği Dergisi

11 0

Yıl: 2018 Cilt: 89 Sayı: 2 Sayfa Aralığı: 66 - 73 Metin Dili: İngilizce İndeks Tarihi: 11-12-2018

Evaluation of platelet activating factor in neonatal calves with sepsis

Öz:

Early diagnosis and treatment of sepsis are very important conditions in patients for their survival. Novel biomarkers such as platelet activating factor (PAF) have been found that it has an important role in sepsis process. The aim of this study is to determine the role of PAF in pathogenesis and the diagnosis importance in calves with sepsis. For this purposes, 30 neonatal calves with sepsis (sepsis group) and 10 healthy neonatal calves (control group) were used. Plasma samples were used to determine the PAF level with using bovine specific ELISA kits. Plasma concentration of PAF was found significantly higher (P < 0.01) in sepsis group compare to control group. We concluded that PAF has an important role in sepsis and it may have diagnostic value in calves with sepsis. Further studies are required to determine the importance of PAF as diagnostic and prognostic biomarker in calves with sepsis and evaluate the concentrations of these biomarker also in other disease states.

Anahtar Kelime:

Konular: Veterinerlik

Sepsis şüphesi bulunan neonatal buzağılarda platelet aktive edici faktörün değerlendirilmesi

Öz:

Sepsisin erken tanısı ve tedavisi, hastaların hayatta kalmaları için çok büyük önem arzeder. Sepsis sürecinde önemli rol oynayan trombosit aktive edici faktör (PAF) gibi yeni biyolojik belirteçler bulunmuştur. Bu çalışmanın amacı sepsisli buzağılarda PAF’ın patogenezdeki rolünü ve diagnostik önemini belirlemektir. Bu amaçla sepsisli 30 yeni doğan buzağı ve 10 sağlıklı neonatal buzağı kullanıldı. Buzağılardan alınan plazma örneklerinde sığır spesifik ELISA kiti kullanılarak PAF plazma konsantrasyonu belirlendi. PAF plazma konsantrasyonu sepsis grubunda kontrol grubuna göre anlamlı derecede yüksekti (P < 0.01). PAF’ın sepsisde önemli bir rolü olduğu ve sepsisli buzağılarda tanısal değeri olabileceği sonucuna varıldı. Öte yandan, sepsisli buzağılarda PAF’ın tanısal ve prognostik önemini belirlemek için diğer biyolojik biyomarkırlarla birlikte değerlendirildiği ileri çalışmalara ihtiyaç olduğu görüldü.

Anahtar Kelime:

Konular: Veterinerlik

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	YILDIZ R, BESLEK M, BEYDİLLİ Y, ÖZÇELİK M M, BİÇİCİ Ö (2018). Evaluation of platelet activating factor in neonatal calves with sepsis. , 66 - 73.
Chicago	YILDIZ Ramazan,BESLEK Mustafa,BEYDİLLİ Yasemin,ÖZÇELİK M Merve,BİÇİCİ Özlem Evaluation of platelet activating factor in neonatal calves with sepsis. (2018): 66 - 73.
MLA	YILDIZ Ramazan,BESLEK Mustafa,BEYDİLLİ Yasemin,ÖZÇELİK M Merve,BİÇİCİ Özlem Evaluation of platelet activating factor in neonatal calves with sepsis. , 2018, ss.66 - 73.
AMA	YILDIZ R,BESLEK M,BEYDİLLİ Y,ÖZÇELİK M M,BİÇİCİ Ö Evaluation of platelet activating factor in neonatal calves with sepsis. . 2018; 66 - 73.
Vancouver	YILDIZ R,BESLEK M,BEYDİLLİ Y,ÖZÇELİK M M,BİÇİCİ Ö Evaluation of platelet activating factor in neonatal calves with sepsis. . 2018; 66 - 73.
IEEE	YILDIZ R,BESLEK M,BEYDİLLİ Y,ÖZÇELİK M M,BİÇİCİ Ö "Evaluation of platelet activating factor in neonatal calves with sepsis." , ss.66 - 73, 2018.
ISNAD	YILDIZ, Ramazan vd. "Evaluation of platelet activating factor in neonatal calves with sepsis". (2018), 66-73.

APA	YILDIZ R, BESLEK M, BEYDİLLİ Y, ÖZÇELİK M M, BİÇİCİ Ö (2018). Evaluation of platelet activating factor in neonatal calves with sepsis. Veteriner Hekimler Derneği Dergisi, 89(2), 66 - 73.
Chicago	YILDIZ Ramazan,BESLEK Mustafa,BEYDİLLİ Yasemin,ÖZÇELİK M Merve,BİÇİCİ Özlem Evaluation of platelet activating factor in neonatal calves with sepsis. Veteriner Hekimler Derneği Dergisi 89, no.2 (2018): 66 - 73.
MLA	YILDIZ Ramazan,BESLEK Mustafa,BEYDİLLİ Yasemin,ÖZÇELİK M Merve,BİÇİCİ Özlem Evaluation of platelet activating factor in neonatal calves with sepsis. Veteriner Hekimler Derneği Dergisi, vol.89, no.2, 2018, ss.66 - 73.
AMA	YILDIZ R,BESLEK M,BEYDİLLİ Y,ÖZÇELİK M M,BİÇİCİ Ö Evaluation of platelet activating factor in neonatal calves with sepsis. Veteriner Hekimler Derneği Dergisi. 2018; 89(2): 66 - 73.
Vancouver	YILDIZ R,BESLEK M,BEYDİLLİ Y,ÖZÇELİK M M,BİÇİCİ Ö Evaluation of platelet activating factor in neonatal calves with sepsis. Veteriner Hekimler Derneği Dergisi. 2018; 89(2): 66 - 73.
IEEE	YILDIZ R,BESLEK M,BEYDİLLİ Y,ÖZÇELİK M M,BİÇİCİ Ö "Evaluation of platelet activating factor in neonatal calves with sepsis." Veteriner Hekimler Derneği Dergisi, 89, ss.66 - 73, 2018.
ISNAD	YILDIZ, Ramazan vd. "Evaluation of platelet activating factor in neonatal calves with sepsis". Veteriner Hekimler Derneği Dergisi 89/2 (2018), 66-73.