Yıl: 2004 Cilt: 24 Sayı: 1 Sayfa Aralığı: 52 - 56 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Effects of propofol and tramadol on cholinergic receptor-mediated responses of the isolated rat ileum

Öz:
Amaç: Bu çalışma, izole sıçan ileumunda propofol ve tramadolun bazal gerilim ve kolinerjik-reseptör-aracılı yanıtlar üzerindeki etkilerini araştırmak için planlandı. Gereç ve Yöntemler: Wistar sıçanlardan (n=8) alınan tam tabaka ileum segmentleri 10 ml'lik organ banyolarına longitudinal şekilde yerleştirildi. Bazal gerilim üzerinde propofol $10^{-8}$-$10^{-5}$ M) ve tramadol ($10^{-6}$-$10^{-3}$ M) etkilerine bakıldıktan sonra, propofol ($10^{-7}$-$10^{-6}$ M) ve tramadolun ($10^{-5}$-$10^{-4}$ M) varlığında ve yokluğunda karbakol'ün ($10^{-9}$-$10^{-4}$ M) artan konsantrasyonlarına karşı alınan cevaplar Grass model 79 E poligraf ile izometrik olarak kaydedildi. Bulgular: Propofol, $10^{-5}$ M konsantrasyonda ileal düz kasın bazal gerilimini belirgin olarak azalttı. Tramadol $10^{-3}$ M konsantrasyonda bazal gerilimi az miktarda azalttı. $10^{-7}$ M propofol varlığında karbakolün ileumdaki kasılma cevapları değişmez iken, $10^{-6}$ M propofolün varlığında anlamlı şekilde inhibe olmaktadır (p<0.05). $10^{-6}$ M propofol varlığında karbakolün konsantrasyon-cevap eğrisi, kontrol değerler ile karşılaştırıldığında belirgin olarak azalmış, Emax ve pD2 değerleri ise sağa kaymıştır. $10^{-5}$ ve $10^{-4}$ M tramadol varlığında ise karbakolün konsantrasyon-cevap eğrisinde belirgin bir değişiklik olmamıştır. Sonuç: Çalışmadan elde edilen bulgulara göre rat ileal düz kasında propofol bazal gerilimi ve kolinerjik cevapları azaltırken, tramadol'ün belirgin bir etkisine rastlanmamıştır.
Anahtar Kelime: Sıçanlar Anestezikler Propofol İleum Tramadol

Konular: Genel ve Dahili Tıp

İzole sıçan ileumunun kolinerjik-reseptör-aracılı yanıtları üzerinde propofol ve tramadolun etkileri

Öz:
Objective: The present study was designed to evaluate the direct effects on basal tension and its effects on the cholinergic receptor-mediated responses of propofol and tramadol in the isolated rat ileum. Material and Methods: Full thickness segments of ileum were obtained from rats (n=8) and placed in longitudinal direction in a 10 ml organ bath. The direct effects of propofol ($10^{-8}$-$10^{-5}$ M) and tramadol ($10^{-6}$-$10^{-3}$M) at basal tension and the concentration-response curves for carbachol ($10^{-9}$-$10^{-4}$ M) in the presence and absence of propofol ($10^{-7}$-$10^{-6}$ M) and tramadol ($10^{-5}$-$10^{-4}$ M) were recorded isometrically with a Grass model 79 E polygraph. Results: Propofol significantly reduced basal tension of ileal smooth muscle at $10^{-5}$ M concentration. Tramadol slightly reduced basal tension only at $10^{-3}$ M concentration. The contractile response of the ileum to exogenously applied carbachol was not influenced by propofol at concentration of $10^{-7}$ M, but was inhibited at $10^{-6}$ M concentration. In the presence of $10^{-6}$ M propofol, the concentration-response curve for carbachol was shifted to the right with significantly lower Emax and pD2 values when compared to control values. Carbachol-induced concentration-response curve did not significantly change in the presence of $10^{-5}$ and $10^{-4}$ M tramadol. Conclusion: Results obtained suggest that propofol reduces basal tension and cholinergic response on the rat ileum in vitro, but tramadol does not.
Anahtar Kelime: Propofol Ileum Tramadol Rats Anesthetics

Konular: Genel ve Dahili Tıp
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Bibliyografik
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APA KAYA T, Köylüoğlu G, GÜRSOY S, KUNT N, KAFALI H, SOYDAN A (2004). Effects of propofol and tramadol on cholinergic receptor-mediated responses of the isolated rat ileum. , 52 - 56.
Chicago KAYA Tijen,Köylüoğlu Gökhan,GÜRSOY Sinan,KUNT Nur,KAFALI Haluk,SOYDAN Ahmet Serdar Effects of propofol and tramadol on cholinergic receptor-mediated responses of the isolated rat ileum. (2004): 52 - 56.
MLA KAYA Tijen,Köylüoğlu Gökhan,GÜRSOY Sinan,KUNT Nur,KAFALI Haluk,SOYDAN Ahmet Serdar Effects of propofol and tramadol on cholinergic receptor-mediated responses of the isolated rat ileum. , 2004, ss.52 - 56.
AMA KAYA T,Köylüoğlu G,GÜRSOY S,KUNT N,KAFALI H,SOYDAN A Effects of propofol and tramadol on cholinergic receptor-mediated responses of the isolated rat ileum. . 2004; 52 - 56.
Vancouver KAYA T,Köylüoğlu G,GÜRSOY S,KUNT N,KAFALI H,SOYDAN A Effects of propofol and tramadol on cholinergic receptor-mediated responses of the isolated rat ileum. . 2004; 52 - 56.
IEEE KAYA T,Köylüoğlu G,GÜRSOY S,KUNT N,KAFALI H,SOYDAN A "Effects of propofol and tramadol on cholinergic receptor-mediated responses of the isolated rat ileum." , ss.52 - 56, 2004.
ISNAD KAYA, Tijen vd. "Effects of propofol and tramadol on cholinergic receptor-mediated responses of the isolated rat ileum". (2004), 52-56.
APA KAYA T, Köylüoğlu G, GÜRSOY S, KUNT N, KAFALI H, SOYDAN A (2004). Effects of propofol and tramadol on cholinergic receptor-mediated responses of the isolated rat ileum. Türkiye Klinikleri Tıp Bilimleri Dergisi, 24(1), 52 - 56.
Chicago KAYA Tijen,Köylüoğlu Gökhan,GÜRSOY Sinan,KUNT Nur,KAFALI Haluk,SOYDAN Ahmet Serdar Effects of propofol and tramadol on cholinergic receptor-mediated responses of the isolated rat ileum. Türkiye Klinikleri Tıp Bilimleri Dergisi 24, no.1 (2004): 52 - 56.
MLA KAYA Tijen,Köylüoğlu Gökhan,GÜRSOY Sinan,KUNT Nur,KAFALI Haluk,SOYDAN Ahmet Serdar Effects of propofol and tramadol on cholinergic receptor-mediated responses of the isolated rat ileum. Türkiye Klinikleri Tıp Bilimleri Dergisi, vol.24, no.1, 2004, ss.52 - 56.
AMA KAYA T,Köylüoğlu G,GÜRSOY S,KUNT N,KAFALI H,SOYDAN A Effects of propofol and tramadol on cholinergic receptor-mediated responses of the isolated rat ileum. Türkiye Klinikleri Tıp Bilimleri Dergisi. 2004; 24(1): 52 - 56.
Vancouver KAYA T,Köylüoğlu G,GÜRSOY S,KUNT N,KAFALI H,SOYDAN A Effects of propofol and tramadol on cholinergic receptor-mediated responses of the isolated rat ileum. Türkiye Klinikleri Tıp Bilimleri Dergisi. 2004; 24(1): 52 - 56.
IEEE KAYA T,Köylüoğlu G,GÜRSOY S,KUNT N,KAFALI H,SOYDAN A "Effects of propofol and tramadol on cholinergic receptor-mediated responses of the isolated rat ileum." Türkiye Klinikleri Tıp Bilimleri Dergisi, 24, ss.52 - 56, 2004.
ISNAD KAYA, Tijen vd. "Effects of propofol and tramadol on cholinergic receptor-mediated responses of the isolated rat ileum". Türkiye Klinikleri Tıp Bilimleri Dergisi 24/1 (2004), 52-56.