Endothelial dysfunction induced by chronic inflammation in the central nervous system and associated atherosclerosis increases the risk of cerebrovascular disease in Multiple Sclerosis. A 54 years-old woman with multiple sclerosis (secondary progressive), hypertension (regular) and EDSS score 6 was brought with sudden loss of power on her left side as well as speech and swallowing disturbances after high dose intravenous pulse steroid therapy. Acute infarcts with diffusion restriction were observed in mesencephalon, cerebellar hemispheres and right side of pons in diffusion MR which was requested in the emergency department. Carotid-vertebral Doppler ultrasonography and transthoracic echocardiography performed to investigate etiology of stroke were normal. Arrhythmia was not observed in rhythm Holter evaluation. Routine laboratory tests, thrombosis and vasculitis markers were found to be normal. Multiple Sclerosis and immobility were considered as the cause of stroke for this patient. The possibility of stroke and a non-attack pathology should always be kept in mind when Multiple Sclerosis patients admit with a new onset neurological dysfunction.