Objective: This study was conducted to determine the occurrence of domestic accidents in children aged 1-6 years and the first aid practices of their mothers. Material and Methods: The sample of this descriptive study consisted of 300 mothers with 1-6 years old children living in the center of Trabzon and who were registered at three family health centers and selected based on their socioeconomic level classified as high, middle and low. The data were collected using a Questionnaire form consisting of 25 questions including the socio-demographic characteristics of the mothers and the factors associated with domestic accidents. Results: As a result of the research, it was determined that 46.7% of the children had at least one domestic accident, the children in the 4-6 age group had more domestic accidents and the most frequent domestic accident was slip and fall. When children had a domestic accident, the most frequently applied first aid practice by their mothers was going to hospital (49.4%) in case of fall, ice and cream application (37.1%) in burns/scalds, going to hospital (60.0%) in choking with a foreign object, going to hospital (28.6%) in injuries/cuts, ice and cream application (66.7%) and dressing the wound at home (33.3%) in electric shocks. Conclusion: The study demonstrated that nearly half of the children experienced at least one domestic accident. In this context, it may be suggested that health professionals working in primary health care institutions should organize awareness trainings parents on the 1-6 years child development and risk factors for domestic accidents.