Yıl: 2019 Cilt: 46 Sayı: 1 Sayfa Aralığı: 119 - 124 Metin Dili: İngilizce DOI: 10.5798/dicletip.534848 İndeks Tarihi: 25-10-2019

Alternative methods for the diagnosis of macroprolactinemia: urine prolactin level and serum / urine prolactin ratio

Öz:
Objective: The aim of this study was to investigate the urine prolactin and serum/urine prolactin ratio for accuracydiagnosis of macroprolactinemia.Methods: In the retrospective cross-sectional analysis, prolactin levels (high or normal) in the reproductive period ofmen and women were included in the study. Polyethylene glycol (PEG) precipitation method was used for thedetection of macroprolactinemia. Then, patients were divided into three groups as macroprolactinemia, prolactinomaand healthy control group. In patients, prolactin values in spot urine with simultaneous serum prolactin values werecalculated. The non-parametric Kruskal-Wallis test was used to compare the groups. The receiver-operatingcharacteristic (ROC) curve was determined to evaluate the predictive power of serum/urine prolactin ratio.DOI: 10.5798/dicletip.534848Yazışma Adresi / Correspondence Zafer Pekkolay, Dicle University Faculty of Medicine ,Department of Internal Medicine-Endocrinology, Sur,Diyarbakir, Turkey e-mail: drpekkolay@gmail.comResults: A total of 41 patients were included in the study. Female/male:36 (87.8%)/ 5 (12.2%). Urinary prolactinmedian(minimum-maximum) values were macroprolactinemia, prolactinoma and control group, respectively;0.06(0.05-0.10), 0.11(0.02-0.95), 0.08(0.05-0.25) ng/ml. Serum/urine ratio median (minium-maximum) values weremacroprolactinemia, prolactinoma, and control group, respectively; 633(51-1032), 990(104-9635), 395.5(138-953).When the groups were compared, the patients with prolactinoma had higher urinary prolactin levels(p <0.01).Serum/urine prolactin ratio was found to be the highest in prolactinoma patients and the lowest in the control groupand a significant difference was observed in groups (p <0.01).ROC analysis(control-macroprolactin) for serum/urine prolactin ratio (Sensitivity 84.6 specificity 93.7 cut off >549,5AUC=0.83) p<0.01Conclusion: Urinary prolactin level and serum/urine prolactin ratio may be used in diagnosis of macroprolactinemia.
Anahtar Kelime:

Konular: Genel ve Dahili Tıp

Makroprolaktinemi tanısı için alternatif yöntemler: İdrar prolaktin düzeyi ve serum / idrar prolaktin oranı

Öz:
Amaç: Bu çalışmanın amacı makroprolaktinemi tanısında idrar prolaktin ve serum / idrar prolaktin oranının doğruluğunu araştırmaktır. Yöntemler: Kesitsel analiz olan çalışmamızda, reprodüktif dönemdeki kadın ve erkeklerden prolaktin düzeyi bakılan (yüksek veya normal) hastalar çalışmaya alındı. Makroprolaktinemi tespiti için polietilen glikol (PEG) ile çöktürme yöntemi kullanıldı. Daha sonra hastalar makroprolaktinemi, prolaktinoma ve sağlıklı kontrol grubu olmak üzere üç gruba ayrıldı. Hastalarda eş zamanlı serum prolaktin ve spot idrarda prolaktin çalışıldı. Non-parametrik test olan Kruskal-Wallis testi grupların karşılaştırılmasında kullanıldı. Serum/idrar prolaktin oranının prediktif gücünü değerlendirmek için “receiver-operating characteristic (ROC)” eğrisi belirlendi ve bu analizde “cut-off” değeri elde edildi. Sonuçlar: Çalışmaya toplam 41 hasta dahil edildi. Kadın/erkek: 36 (%87,8) / 5 (%12,2). İdrar prolaktin medyan (minimum-maksimum) değerleri makroprolaktinemi, prolaktinoma ve kontrol grubunda sırasıyla; 0.06(0.05-0.10), 0.11(0.02-0.95), 0.08(0.05-0.25) ng/ml idi. Serum/idrar prolaktin oranı medyan (minimum-maksimum) değerleri makroprolaktinemi, prolaktinoma ve kontrol grubunda sırasıyla; 633(51-1032), 990(104-9635), 395.5(138-953) idi. Gruplar karşılaştırıldığında prolaktinoma olan hastalar daha yüksek üriner prolaktin seviyelerine sahipti. Makroprolaktinemili hastalar en düşük idrar prolaktin değerlerine sahipti(p <0.01). Prolaktinoma hastalarında serum / idrar prolaktin oranı en yüksek, kontrol grubunda ise en düşük bulundu ve gruplar arasında anlamlı fark bulundu (p <0.01). Serum/idrar prolaktin oranı için ROC analizi (kontrol-makroprolaktin) (Duyarlılık 84.6 özgüllük 93.7 cut off> 549,5 AUC = 0.83) p <0.01 Sonuç: Makroprolaktinemi tanısında idrar prolaktin düzeyi ve serum/idrar prolaktin oranı kullanılabilir.
Anahtar Kelime:

Konular: Genel ve Dahili Tıp
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA pekkolay z, Tuna M, GÜVEN M, ALTUN TUZCU Ş, kaplan i, AKKUŞ Z, TUZCU A (2019). Alternative methods for the diagnosis of macroprolactinemia: urine prolactin level and serum / urine prolactin ratio. , 119 - 124. 10.5798/dicletip.534848
Chicago pekkolay zafer,Tuna Mazhar Müslüm,GÜVEN MEHMET,ALTUN TUZCU ŞADİYE,kaplan ibrahim,AKKUŞ Zeki,TUZCU ALPASLAN KEMAL Alternative methods for the diagnosis of macroprolactinemia: urine prolactin level and serum / urine prolactin ratio. (2019): 119 - 124. 10.5798/dicletip.534848
MLA pekkolay zafer,Tuna Mazhar Müslüm,GÜVEN MEHMET,ALTUN TUZCU ŞADİYE,kaplan ibrahim,AKKUŞ Zeki,TUZCU ALPASLAN KEMAL Alternative methods for the diagnosis of macroprolactinemia: urine prolactin level and serum / urine prolactin ratio. , 2019, ss.119 - 124. 10.5798/dicletip.534848
AMA pekkolay z,Tuna M,GÜVEN M,ALTUN TUZCU Ş,kaplan i,AKKUŞ Z,TUZCU A Alternative methods for the diagnosis of macroprolactinemia: urine prolactin level and serum / urine prolactin ratio. . 2019; 119 - 124. 10.5798/dicletip.534848
Vancouver pekkolay z,Tuna M,GÜVEN M,ALTUN TUZCU Ş,kaplan i,AKKUŞ Z,TUZCU A Alternative methods for the diagnosis of macroprolactinemia: urine prolactin level and serum / urine prolactin ratio. . 2019; 119 - 124. 10.5798/dicletip.534848
IEEE pekkolay z,Tuna M,GÜVEN M,ALTUN TUZCU Ş,kaplan i,AKKUŞ Z,TUZCU A "Alternative methods for the diagnosis of macroprolactinemia: urine prolactin level and serum / urine prolactin ratio." , ss.119 - 124, 2019. 10.5798/dicletip.534848
ISNAD pekkolay, zafer vd. "Alternative methods for the diagnosis of macroprolactinemia: urine prolactin level and serum / urine prolactin ratio". (2019), 119-124. https://doi.org/10.5798/dicletip.534848
APA pekkolay z, Tuna M, GÜVEN M, ALTUN TUZCU Ş, kaplan i, AKKUŞ Z, TUZCU A (2019). Alternative methods for the diagnosis of macroprolactinemia: urine prolactin level and serum / urine prolactin ratio. Dicle Tıp Dergisi, 46(1), 119 - 124. 10.5798/dicletip.534848
Chicago pekkolay zafer,Tuna Mazhar Müslüm,GÜVEN MEHMET,ALTUN TUZCU ŞADİYE,kaplan ibrahim,AKKUŞ Zeki,TUZCU ALPASLAN KEMAL Alternative methods for the diagnosis of macroprolactinemia: urine prolactin level and serum / urine prolactin ratio. Dicle Tıp Dergisi 46, no.1 (2019): 119 - 124. 10.5798/dicletip.534848
MLA pekkolay zafer,Tuna Mazhar Müslüm,GÜVEN MEHMET,ALTUN TUZCU ŞADİYE,kaplan ibrahim,AKKUŞ Zeki,TUZCU ALPASLAN KEMAL Alternative methods for the diagnosis of macroprolactinemia: urine prolactin level and serum / urine prolactin ratio. Dicle Tıp Dergisi, vol.46, no.1, 2019, ss.119 - 124. 10.5798/dicletip.534848
AMA pekkolay z,Tuna M,GÜVEN M,ALTUN TUZCU Ş,kaplan i,AKKUŞ Z,TUZCU A Alternative methods for the diagnosis of macroprolactinemia: urine prolactin level and serum / urine prolactin ratio. Dicle Tıp Dergisi. 2019; 46(1): 119 - 124. 10.5798/dicletip.534848
Vancouver pekkolay z,Tuna M,GÜVEN M,ALTUN TUZCU Ş,kaplan i,AKKUŞ Z,TUZCU A Alternative methods for the diagnosis of macroprolactinemia: urine prolactin level and serum / urine prolactin ratio. Dicle Tıp Dergisi. 2019; 46(1): 119 - 124. 10.5798/dicletip.534848
IEEE pekkolay z,Tuna M,GÜVEN M,ALTUN TUZCU Ş,kaplan i,AKKUŞ Z,TUZCU A "Alternative methods for the diagnosis of macroprolactinemia: urine prolactin level and serum / urine prolactin ratio." Dicle Tıp Dergisi, 46, ss.119 - 124, 2019. 10.5798/dicletip.534848
ISNAD pekkolay, zafer vd. "Alternative methods for the diagnosis of macroprolactinemia: urine prolactin level and serum / urine prolactin ratio". Dicle Tıp Dergisi 46/1 (2019), 119-124. https://doi.org/10.5798/dicletip.534848