Yıl: 2019 Cilt: 15 Sayı: 1 Sayfa Aralığı: 70 - 76 Metin Dili: İngilizce DOI: 10.5505/yeditepe.2019.83792 İndeks Tarihi: 07-11-2019

The effects of a single high-dose injection of vitamin-D on healing of condylar fractures in osteoporotic rats

Öz:
Aim: In this study we have tried to show the effects of a singlehigh-dose ınjection of vitamin d on healing of condylar fractures in osteoporotic rats.Materials and method: This study included sixteen femalewistar rats. All rats were overiectomized. Osteoporotic ratswere randomly divided into two groups of eight animals/group. Group D animals received a single high dose of vitamin D (50.000 IU/kg) intraperitoneally and group C (control)animals received saline (0.05 mL) intraperitoneally. All injections were given immediately after condylar fracture. All ratswere euthanized after 28 days, examined histopathologicaland immunohistochemical.Results: Histopathological and immunohistochemical evaluations were done. Histopathological scores between groupD and C were found statistically significant. TGFβ1 and osteopentin levels in group D were found higher than group C.Conclusion: We have determined that a single high-dose injection of vitamin D given immediately after surgery increasedTGFβ and osteopontin levels and enhanced new bone formation at condylar fractures of osteoporotic rats.
Anahtar Kelime:

Konular: Diş Hekimliği

Osteoporotik sıçanlarda tek yüksek doz D-vitamini enjeksiyonunun kondil kırığı iyileşmesine etkisi

Öz:
Amaç: Bu çalışmada, osteoporotik sıçanlarda kondiler kırıkların iyileşmesinde tek yüksek doz verilen D vitamininin etkilerini göstermeye çalıştık. Gereç ve Yöntem: Bu çalışmada 16 dişi wistar sıçanı kullanıldı. Tüm sıçanlara overiektomi uygulandı. Osteoporotik sıçanlar rastgele her grupta sekiz hayvan olacak şekilde iki gruba ayrıldı. Grup D hayvanlarına intraperitoneal olarak tek doz D vitamini (50,000 IU / kg) verildi ve grup C (kontrol) hayvanlara intraperitoneal olarak serum fizyolojik (0,05 mL) verildi. Tüm enjeksiyonlar, kondiler kırıktan hemen sonra yapıldı. Bütün sıçanlar 28 gün sonra sakrifiye edildi, Histopatolojik ve immünohistokimyasal olarak incelendi. Bulgular: Histopatolojik ve immünohistokimyasal değerlendirmeler yapıldı. D ve C grubu arasındaki histopatolojik veriler istatistiksel olarak anlamlı bulundu. Grup D' de TGFβ1 ve osteopentin düzeyleri C grubundan daha yüksek bulundu. Sonuç: Cerrahi müdahaleden hemen sonra verilen tek yüksek doz D vitamini enjeksiyonunun, osteoporotik sıçanların kondiler kırıklarında TGFβ ve osteopontin seviyelerini ve yeni kemik oluşumunu arttırdığını tespit ettik.
Anahtar Kelime:

Konular: Diş Hekimliği
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA Mercan U, KABAK Y, TÜRER A, KELAHMETOĞLU O, MERAL D (2019). The effects of a single high-dose injection of vitamin-D on healing of condylar fractures in osteoporotic rats. , 70 - 76. 10.5505/yeditepe.2019.83792
Chicago Mercan Ugur,KABAK Yonca Betil,TÜRER Akif,KELAHMETOĞLU Osman,MERAL Deniz Gokce The effects of a single high-dose injection of vitamin-D on healing of condylar fractures in osteoporotic rats. (2019): 70 - 76. 10.5505/yeditepe.2019.83792
MLA Mercan Ugur,KABAK Yonca Betil,TÜRER Akif,KELAHMETOĞLU Osman,MERAL Deniz Gokce The effects of a single high-dose injection of vitamin-D on healing of condylar fractures in osteoporotic rats. , 2019, ss.70 - 76. 10.5505/yeditepe.2019.83792
AMA Mercan U,KABAK Y,TÜRER A,KELAHMETOĞLU O,MERAL D The effects of a single high-dose injection of vitamin-D on healing of condylar fractures in osteoporotic rats. . 2019; 70 - 76. 10.5505/yeditepe.2019.83792
Vancouver Mercan U,KABAK Y,TÜRER A,KELAHMETOĞLU O,MERAL D The effects of a single high-dose injection of vitamin-D on healing of condylar fractures in osteoporotic rats. . 2019; 70 - 76. 10.5505/yeditepe.2019.83792
IEEE Mercan U,KABAK Y,TÜRER A,KELAHMETOĞLU O,MERAL D "The effects of a single high-dose injection of vitamin-D on healing of condylar fractures in osteoporotic rats." , ss.70 - 76, 2019. 10.5505/yeditepe.2019.83792
ISNAD Mercan, Ugur vd. "The effects of a single high-dose injection of vitamin-D on healing of condylar fractures in osteoporotic rats". (2019), 70-76. https://doi.org/10.5505/yeditepe.2019.83792
APA Mercan U, KABAK Y, TÜRER A, KELAHMETOĞLU O, MERAL D (2019). The effects of a single high-dose injection of vitamin-D on healing of condylar fractures in osteoporotic rats. 7tepe Klinik, 15(1), 70 - 76. 10.5505/yeditepe.2019.83792
Chicago Mercan Ugur,KABAK Yonca Betil,TÜRER Akif,KELAHMETOĞLU Osman,MERAL Deniz Gokce The effects of a single high-dose injection of vitamin-D on healing of condylar fractures in osteoporotic rats. 7tepe Klinik 15, no.1 (2019): 70 - 76. 10.5505/yeditepe.2019.83792
MLA Mercan Ugur,KABAK Yonca Betil,TÜRER Akif,KELAHMETOĞLU Osman,MERAL Deniz Gokce The effects of a single high-dose injection of vitamin-D on healing of condylar fractures in osteoporotic rats. 7tepe Klinik, vol.15, no.1, 2019, ss.70 - 76. 10.5505/yeditepe.2019.83792
AMA Mercan U,KABAK Y,TÜRER A,KELAHMETOĞLU O,MERAL D The effects of a single high-dose injection of vitamin-D on healing of condylar fractures in osteoporotic rats. 7tepe Klinik. 2019; 15(1): 70 - 76. 10.5505/yeditepe.2019.83792
Vancouver Mercan U,KABAK Y,TÜRER A,KELAHMETOĞLU O,MERAL D The effects of a single high-dose injection of vitamin-D on healing of condylar fractures in osteoporotic rats. 7tepe Klinik. 2019; 15(1): 70 - 76. 10.5505/yeditepe.2019.83792
IEEE Mercan U,KABAK Y,TÜRER A,KELAHMETOĞLU O,MERAL D "The effects of a single high-dose injection of vitamin-D on healing of condylar fractures in osteoporotic rats." 7tepe Klinik, 15, ss.70 - 76, 2019. 10.5505/yeditepe.2019.83792
ISNAD Mercan, Ugur vd. "The effects of a single high-dose injection of vitamin-D on healing of condylar fractures in osteoporotic rats". 7tepe Klinik 15/1 (2019), 70-76. https://doi.org/10.5505/yeditepe.2019.83792