Determination of anticancer and antibacterial activities of disubstituted tacrine derivatives
Yıl: 2019 Cilt: 23 Sayı: 5 Sayfa Aralığı: 824 - 830 Metin Dili: İngilizce DOI: 10.16984/saufenbilder.469273 İndeks Tarihi: 26-11-2019
Determination of anticancer and antibacterial activities of disubstituted tacrine derivatives
Öz: The present study describes the biological features of disubstituted tacrine derivatives using cell proliferation andcell cytotoxicity assays. The abilities of tacrine derivatives to inhibit microbial growth and to interact with DNA werealso investigated. Here, the tested compounds (1-4) exhibited selective antiproliferative activity against the cancercell lines (IC50 values 1.1 – 38.9 μg/mL) and showed a similar non-toxic property to cells such as positive control(percent cytotoxicity 7% - 27%). Studies on human pathogenic bacteria showed that the novel tacrine analoguesexhibited significant antimicrobial activities between concentrations of 31.25 μg/mL and 250 μg/mL. The data showthat they can bind to DNA with the groove binding mode with Kb range of 7.4 × 10⁴ - 2.9 × 10⁴ Mˉ¹. As a result, thepreliminary data showed that disubstituted tacrine derivatives exhibited effective pharmacological properties.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | Ökten S, Aydın A, TUTAR A (2019). Determination of anticancer and antibacterial activities of disubstituted tacrine derivatives. , 824 - 830. 10.16984/saufenbilder.469273 |
| Chicago | Ökten Salih,Aydın Ali,TUTAR Ahmet Determination of anticancer and antibacterial activities of disubstituted tacrine derivatives. (2019): 824 - 830. 10.16984/saufenbilder.469273 |
| MLA | Ökten Salih,Aydın Ali,TUTAR Ahmet Determination of anticancer and antibacterial activities of disubstituted tacrine derivatives. , 2019, ss.824 - 830. 10.16984/saufenbilder.469273 |
| AMA | Ökten S,Aydın A,TUTAR A Determination of anticancer and antibacterial activities of disubstituted tacrine derivatives. . 2019; 824 - 830. 10.16984/saufenbilder.469273 |
| Vancouver | Ökten S,Aydın A,TUTAR A Determination of anticancer and antibacterial activities of disubstituted tacrine derivatives. . 2019; 824 - 830. 10.16984/saufenbilder.469273 |
| IEEE | Ökten S,Aydın A,TUTAR A "Determination of anticancer and antibacterial activities of disubstituted tacrine derivatives." , ss.824 - 830, 2019. 10.16984/saufenbilder.469273 |
| ISNAD | Ökten, Salih vd. "Determination of anticancer and antibacterial activities of disubstituted tacrine derivatives". (2019), 824-830. https://doi.org/10.16984/saufenbilder.469273 |
| APA | Ökten S, Aydın A, TUTAR A (2019). Determination of anticancer and antibacterial activities of disubstituted tacrine derivatives. Sakarya Üniversitesi Fen Bilimleri Enstitüsü Dergisi, 23(5), 824 - 830. 10.16984/saufenbilder.469273 |
| Chicago | Ökten Salih,Aydın Ali,TUTAR Ahmet Determination of anticancer and antibacterial activities of disubstituted tacrine derivatives. Sakarya Üniversitesi Fen Bilimleri Enstitüsü Dergisi 23, no.5 (2019): 824 - 830. 10.16984/saufenbilder.469273 |
| MLA | Ökten Salih,Aydın Ali,TUTAR Ahmet Determination of anticancer and antibacterial activities of disubstituted tacrine derivatives. Sakarya Üniversitesi Fen Bilimleri Enstitüsü Dergisi, vol.23, no.5, 2019, ss.824 - 830. 10.16984/saufenbilder.469273 |
| AMA | Ökten S,Aydın A,TUTAR A Determination of anticancer and antibacterial activities of disubstituted tacrine derivatives. Sakarya Üniversitesi Fen Bilimleri Enstitüsü Dergisi. 2019; 23(5): 824 - 830. 10.16984/saufenbilder.469273 |
| Vancouver | Ökten S,Aydın A,TUTAR A Determination of anticancer and antibacterial activities of disubstituted tacrine derivatives. Sakarya Üniversitesi Fen Bilimleri Enstitüsü Dergisi. 2019; 23(5): 824 - 830. 10.16984/saufenbilder.469273 |
| IEEE | Ökten S,Aydın A,TUTAR A "Determination of anticancer and antibacterial activities of disubstituted tacrine derivatives." Sakarya Üniversitesi Fen Bilimleri Enstitüsü Dergisi, 23, ss.824 - 830, 2019. 10.16984/saufenbilder.469273 |
| ISNAD | Ökten, Salih vd. "Determination of anticancer and antibacterial activities of disubstituted tacrine derivatives". Sakarya Üniversitesi Fen Bilimleri Enstitüsü Dergisi 23/5 (2019), 824-830. https://doi.org/10.16984/saufenbilder.469273 |
