Effect of Multiple-Dose Administration of Cefquinome on Hematological and Biochemical Parameters in Horse

Altan, Semih; ÜNEY, Kamil; ARICAN, Mustafa; ELMAS, Muammer; ALTAN, Feray; EROL, HANIFI

Effect of Multiple-Dose Administration of Cefquinome on Hematological and Biochemical Parameters in Horse

Feray ALTAN, (Dicle Üniversitesi)

Hanifi EROL, (Erciyes Üniversitesi)

Semih ALTAN, (Dicle Üniversitesi)

Mustafa ARICAN, (Selçuk Üniversitesi)

MUAMMER ELMAS, (Selçuk Üniversitesi)

Kamil ÜNEY (Selçuk Üniversitesi)

Dicle Üniversitesi Veteriner Fakültesi Dergisi

8 0

Yıl: 2019 Cilt: 12 Sayı: 1 Sayfa Aralığı: 46 - 52 Metin Dili: İngilizce İndeks Tarihi: 28-02-2020

Effect of Multiple-Dose Administration of Cefquinome on Hematological and Biochemical Parameters in Horse

Öz:

The negative impact of multiple ascending doses of cefquinome (CFQ) on hematological and serum biochemical profile of horseunknown. The objective of this study was to evaluate the effect of multiple ascending doses of cefquinome (CFQ) in horses on thefollowing hematological (WBCs, LYM, MON, GRA, RBCs, HB, HT, MCV, MCH, MCHC, RDW, and PLT) and biochemical parameters (ALB,ALP, ALT, AST, CH, CR, GGT, LDH, TB, TP, TRIG, and BUN). The study was performed on the sixteen mature horses (4.6 ± 2.1 years, 302 ±38 kg). Four dosages of CFQ were applied as Group I; 1 mg/kg, Group II; 2 mg/kg, Group III; 4 mg/kg and Group IV; 6 mg/kg, and eachanimal received intravenously a total of 13 injections, administered every 12 h for 7 days. The hematological and biochemicalparameters of horses were monitored on the before 0 day and 1, 3, 7, and 14 days after the administration of the first CFQ. Nosignificant differences in serum biochemical parameters were found amongst the groups (p>0.05). Significant differences were found incertain hematological parameters (MONO, GRAN, RBC, HB, HCT, MCH, and PCT) amongst the groups (p<0.05) within the referenceranges. These results indicate that the administration of multiple doses of up to 6 mg/kg of CFQ in the horse had no clinically significantimpact on the blood parameters measured.

Anahtar Kelime:

Konular: Biyoloji Balıkçılık Viroloji Veterinerlik Biyoloji Çeşitliliğinin Korunması Zooloji Entomoloji

Atlarda Sefkuinomun Çoklu Doz Uygulamalarının Hematolojik ve Biyokimyasal Parametreler Üzerine Etkisi

Öz:

Sefkuinomun (CFQ) çoklu doz uygulamalarının, atların hematolojik ve biyokimyasal profilleri üzerinde bir etkisi olup olmadığı bilinmemektedir. Bu çalışmanın amacı, atlarda çoklu artan CFQ dozlarının bazı hematolojik (WBC, LYM, MON, GRA, RBC, HB, HT, MCV, MCH, MCHC, RDW ve PLT) ve biyokimyasal parametreler üzerine (ALB, ALP, ALT, AST, CH, CR, GGT, LDH, TB, TP, TRIG ve BUN) etkisini belirlemektir. Araştırma 16 adet erişkin at (4.6 ± 2.1 yaş, 302 ± 38 kg) üzerinde gerçekleştirildi. Atlara damar içi olarak 7 gün boyunca her 12 saatte dört doz seviyesinde CFQ uygulandı: Grup I; 1 mg/kg, Grup II; 2 mg/kg, Grup III; 4 mg/kg, Grup IV; 6 mg/kg) uygulanan toplam 13 enjeksiyon gerçekleştirildi. Belirlenen hematolojik ve biyokimyasal parametreler ilaç uygulamasından önce (0 gün) ve ilk CFQ dozunun uygulanmasından 1, 3, 7 ve 14 gün sonra izlendi. Tedavi günlerinde gruplar arasında serum biyokimyasal parametrelerinde anlamlı bir fark bulunmadı (p> 0.05). Hematolojik parametrelerde (MONO, GRAN, RBC, HB, HCT, MCH ve PCT) doz grupları arasında referans değerler içinde anlamlı farklar bulundu (p <0.05). Bu sonuçlar, atlarda CFQ’un 6 mg/kg kadar çoklu doz uygulamalarının, değerlendirilen kan parametreleri üzerinde klinik olarak önemli bir etkisi olmadığını göstermektedir.

Anahtar Kelime:

Konular: Biyoloji Balıkçılık Viroloji Veterinerlik Biyoloji Çeşitliliğinin Korunması Zooloji Entomoloji

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	ALTAN F, EROL H, Altan S, ARICAN M, ELMAS M, ÜNEY K (2019). Effect of Multiple-Dose Administration of Cefquinome on Hematological and Biochemical Parameters in Horse. , 46 - 52.
Chicago	ALTAN Feray,EROL HANIFI,Altan Semih,ARICAN Mustafa,ELMAS Muammer,ÜNEY Kamil Effect of Multiple-Dose Administration of Cefquinome on Hematological and Biochemical Parameters in Horse. (2019): 46 - 52.
MLA	ALTAN Feray,EROL HANIFI,Altan Semih,ARICAN Mustafa,ELMAS Muammer,ÜNEY Kamil Effect of Multiple-Dose Administration of Cefquinome on Hematological and Biochemical Parameters in Horse. , 2019, ss.46 - 52.
AMA	ALTAN F,EROL H,Altan S,ARICAN M,ELMAS M,ÜNEY K Effect of Multiple-Dose Administration of Cefquinome on Hematological and Biochemical Parameters in Horse. . 2019; 46 - 52.
Vancouver	ALTAN F,EROL H,Altan S,ARICAN M,ELMAS M,ÜNEY K Effect of Multiple-Dose Administration of Cefquinome on Hematological and Biochemical Parameters in Horse. . 2019; 46 - 52.
IEEE	ALTAN F,EROL H,Altan S,ARICAN M,ELMAS M,ÜNEY K "Effect of Multiple-Dose Administration of Cefquinome on Hematological and Biochemical Parameters in Horse." , ss.46 - 52, 2019.
ISNAD	ALTAN, Feray vd. "Effect of Multiple-Dose Administration of Cefquinome on Hematological and Biochemical Parameters in Horse". (2019), 46-52.

APA	ALTAN F, EROL H, Altan S, ARICAN M, ELMAS M, ÜNEY K (2019). Effect of Multiple-Dose Administration of Cefquinome on Hematological and Biochemical Parameters in Horse. Dicle Üniversitesi Veteriner Fakültesi Dergisi, 12(1), 46 - 52.
Chicago	ALTAN Feray,EROL HANIFI,Altan Semih,ARICAN Mustafa,ELMAS Muammer,ÜNEY Kamil Effect of Multiple-Dose Administration of Cefquinome on Hematological and Biochemical Parameters in Horse. Dicle Üniversitesi Veteriner Fakültesi Dergisi 12, no.1 (2019): 46 - 52.
MLA	ALTAN Feray,EROL HANIFI,Altan Semih,ARICAN Mustafa,ELMAS Muammer,ÜNEY Kamil Effect of Multiple-Dose Administration of Cefquinome on Hematological and Biochemical Parameters in Horse. Dicle Üniversitesi Veteriner Fakültesi Dergisi, vol.12, no.1, 2019, ss.46 - 52.
AMA	ALTAN F,EROL H,Altan S,ARICAN M,ELMAS M,ÜNEY K Effect of Multiple-Dose Administration of Cefquinome on Hematological and Biochemical Parameters in Horse. Dicle Üniversitesi Veteriner Fakültesi Dergisi. 2019; 12(1): 46 - 52.
Vancouver	ALTAN F,EROL H,Altan S,ARICAN M,ELMAS M,ÜNEY K Effect of Multiple-Dose Administration of Cefquinome on Hematological and Biochemical Parameters in Horse. Dicle Üniversitesi Veteriner Fakültesi Dergisi. 2019; 12(1): 46 - 52.
IEEE	ALTAN F,EROL H,Altan S,ARICAN M,ELMAS M,ÜNEY K "Effect of Multiple-Dose Administration of Cefquinome on Hematological and Biochemical Parameters in Horse." Dicle Üniversitesi Veteriner Fakültesi Dergisi, 12, ss.46 - 52, 2019.
ISNAD	ALTAN, Feray vd. "Effect of Multiple-Dose Administration of Cefquinome on Hematological and Biochemical Parameters in Horse". Dicle Üniversitesi Veteriner Fakültesi Dergisi 12/1 (2019), 46-52.