İBANDRONİK ASİT VE KALSİYUM-D VİTAMİNİ TEDAVİSİNİN OSTEOİNTEGRASYON ÜZERİNDEKİ ETKİLERİNİN KARŞILAŞTIRILMASI

Serhat DURUSOY, (Yozgat Bozok Üniversitesi)
Meriç ÇIRPAR, (Kırıkkale Üniversitesi)
Mehmet YALÇINOZAN, (Yakın Doğu Üniversitesi)
Arif ASLAN, (Hitit Üniversitesi Erol Olçok Eğitim ve Araştırma Hastanesi)
Mahi BALCI, (Kırıkkale Üniversitesi)
Teyfik DEMİR (TOBB Üniversitesi)
Bozok Tıp Dergisi
19 2
Yıl: 2019 Cilt: 9 Sayı: 2 Sayfa Aralığı: 102 - 111 Metin Dili: Türkçe DOI: 10.16919/bozoktip.492978 İndeks Tarihi: 28-01-2020

İBANDRONİK ASİT VE KALSİYUM-D VİTAMİNİ TEDAVİSİNİN OSTEOİNTEGRASYON ÜZERİNDEKİ ETKİLERİNİN KARŞILAŞTIRILMASI

Öz:
Amaç: Bu çalışmada ibandronik asit ve kalsiyum- D vitamini kompleksinin osteointegrasyon üzerine olanetkilerini histomorfometrik ve mekanik olarak değerlendirmeyi amaçlamaktadır.Gereç ve Yöntem: Çalışma 45 adet dişi Sprague-Dawley cinsi ratın sol femurları üzerinde yapılmıştır. Cerrahiolarak ratların sol femurlarına intramedüller K teli yerleştirilmiştir. Ratlar rasgele eşit sayıda olacak şekildekontrol grubu, ibandronat alan grup ve Ca+D vitamini alan grup olacak şekilde gruplandırılmıştır. Altı haftasonra sakrifiye edilen ratların femurları mekanik teste ve histomorfometrik inceleme tabi tutulmuştur. Eldeedilen veriler istatistiksel olarak kıyaslanmıştır.Bulgular: Grup A (kontrol) ve Grup B (Ca+D vitamini) arasında ortalama maksimum çekme gücü ve osteo-integrasyon endeksi açısından istatistiksel olarak anlamlı bir farklılık yoktu (maksimum çekme için p=0,828,OintE için p=0,172). İbandronik asit verilen Grup C için ortalama maksimum çekme gücü ve osteointegras-yon endeksi Grup A ve Grup B ile kıyaslandığında elde edilen değerin istatistiksel olarak anlamlı derecedeyüksek olduğu saptandı (Maksimum çekme gücü için grup A’da p=0,001, grup B’de p=0,001, OintE için grupA’ da p=0,009, grup B’de p=0,016)Sonuç: Bu çalışma ibandronatın metal implant-kemik tutunumu üzerinde belirgin bir olumlu etkiye sahipolduğunu göstermektedir. Ancak, bu deneysel çalışmanın sonuçlarını destekleyecek ileri klinik çalışmalaraihtiyaç vardır.
Anahtar Kelime:

Comparison Of The Effects Of Ibandronic Acid and Calcium-D Vitamin Treatment On Osteointegration

Öz:
Objective: The aim of this study is to evaluate the effects of ibandronate and calcium-vitamin D complex on osteointegration of metal implants histomorphometrically and mechanically. Material and Method: The study was performed on 45 female Sprague-Dawley rats. Rats were divided into three groups. Intramedullary nailing was performed in all rat’s left femurs with a stainless steel K-wire in 1 mm diameter. The rats in Group A, the control group, didn’t receive any medication after the intramedullary nailing of left femur. The rats in Group B received calcium and 25IU vitamin D daily; in Group C received single dosage ibandronate subcutaneously after intramedullary nailing of left femurs. At the end of six weeks all the rats were sacrificed. Maximum pull out strenghts were measured for all K wires and the mean maximum pull out strenghts were calculated for each group. Hystomorphometrically the thickness of the new bone around the K wire was measured and proportioned to the thickness of the K wire to get the novel osteointegration index(Oint-E) for each group. Results: There were no statistically significantly difference between Group A and Group B with regard to Oint-E (p=0,172) and mean pull out strength(p=0,828). The mean pull out strength and Oint-E for Group C, ibandronate medication group, were higher when compared with Group A and B with a statistically significant difference (for mean pull out strengths p=0,001 for Group A, p=0,001 for Group B; for Oint-E p=0,009 for Group A, p=0,016 for Group B). Conclusion: The results of this study demonstrated that ibandronate has a significant positive effect on bone metal implant integration. We believe that ibandronate can be used postoperatively to augment osteointegration of metal implants. However further clinical studies are needed to support results of this experimental study.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
  • Brånemark PI. Osseointegration and its experimental back- ground. J Prosthet Dent. 1983;50:399–410.
  • Mavrogenis a F, Dimitriou R, Parvizi J, Babis GC. Biology of implant osseointegration. J Musculoskelet Neuronal Interact [Inter- net]. 2009;9:61–71. Available from: http://www.ncbi.nlm.nih.gov/ pubmed/19516081
  • Reid DM. Osteoporosis, Handbook.
  • Clinics RO. Hastalarda Osteoporoz ‹ nsidans ›. 2010;10–3.
  • Fini M, Giavaresi G, Torricelli P, Borsari V, Giardino R, Nicolini a, et al. Osteoporosis and biomaterial osteointegration. Biomed Pharmacother [Internet]. 2004 Dec [cited 2013 Dec 31];58:487–93. Available from: http://www.ncbi.nlm.nih.gov/pubmed/15511604
  • Raisz LG. Physiology and pathophysiology of bone remodeling. Clin Chem [Internet]. 1999 Aug;45(8 Pt 2):1353–8. Available from: http://www.ncbi.nlm.nih.gov/pubmed/10430818
  • Ochsner PE. Osteointegration of orthopaedic devices. Se- min Immunopathol [Internet]. 2011 May [cited 2013 Dec 31];33(3):245–56. Available from: http://www.ncbi.nlm.nih.gov/ pubmed/21253729
  • Macinnes SJ, Gordon A, Wilkinson JM. Risk Factors for Aseptic Loosening Following Total Hip Arthroplasty. 1960;
  • Austin MS, Sharkey PF, Hozack WJ, Rothman RH. Knee failure Mechanisms after Total Knee Arthroplasty. 2004;3(1):55–9.
  • Ulrich SD, Seyler TM, Bennett D, Delanois RE, Saleh KJ, Thong- trangan I, et al. Total hip arthroplasties: what are the reasons for revision? Int Orthop [Internet]. 2008 Oct [cited 2014 Jan 28];32(5):597–604. Available from: http://www.pubmedcentral.nih. gov/articlerender.fcgi?artid=2551710&tool=pmcentrez&rendertyp e=abstract
  • Davies JE. Understanding peri-implant endosseous healing. J Dent Educ [Internet]. 2003 Aug;67(8):932–49. Available from: http://www.ncbi.nlm.nih.gov/pubmed/12959168
  • Franchi M, Fini M, Martini D, Orsini E, Leonardi L, Ruggeri a, et al. Biological fixation of endosseous implants. Micron [Internet]. 2005 Jan [cited 2013 Dec 19];36(7–8):665–71. Available from: http://www.ncbi.nlm.nih.gov/pubmed/16233979
  • Friedman RJ, Hirst P, Poss R, Kelley K, Sledge CB. Results of revi- sion total knee arthroplasty performed for aseptic loosening. Clin Orthop Relat Res [Internet]. 1990 Jun;(255):235–41. Available from: http://www.ncbi.nlm.nih.gov/pubmed/2347157
  • Clement AND. Results of Revision Total Knee Arthroplasty Per- formed for Aseptic Loosening. 1984;235–41.
  • Sundfeldt M, Carlsson L V, Johansson CB, Thomsen P, Gretzer C. Aseptic loosening, not only a question of wear: a review of dif- ferent theories. Acta Orthop [Internet]. 2006 May [cited 2014 Jan 31];77(2):177–97. Available from: http://www.ncbi.nlm.nih.gov/ pubmed/16752278
  • Canale B. Kalça Artroplastisi. In: Campbells Operative Orthopae- dics. p. 313.
  • Köse N. Biyomalzemeler ve İ mplantlara Biyolojik Yan ı t. :1–10.
  • Faensen B, Wildemann B, Hain C, Höhne J, Funke Y, Plank C, et al. Local Application of BMP-2 Specific Plasmids in Fibrin Glue does not Promote Implant Fixation. BMC Musculoskelet Disord [Inter- net]. 2011;12(1):163. Available from: http://www.biomedcentral. com/1471-2474/12/163
  • Abe E. Function of BMPs and BMP antagonists in adult bone. Ann N Y Acad Sci. 2006;1068:41–53.
  • Hunziker EB, Enggist L, Küffer a, Buser D, Liu Y. Osseointegra- tion: the slow delivery of BMP-2 enhances osteoinductivity. Bone [Internet]. 2012 Jul [cited 2014 Feb 9];51(1):98–106. Available from: http://www.ncbi.nlm.nih.gov/pubmed/22534475
  • Naidu A, Dechow PC, Spears R, Wright JM, Kessler HP, Opper- man L a. The effects of bisphosphonates on osteoblasts in vitro. Oral Surg Oral Med Oral Pathol Oral Radiol Endod [Internet]. 2008 Jul [cited 2013 Dec 31];106(1):5–13. Available from: http://www. ncbi.nlm.nih.gov/pubmed/18504149
  • Akhavan A, Noroozi Z, Abbas A, Haghighat A, Jahanshahi GR, Sayed L, et al. The effect of vitamin D supplementation on bone for- mation around titanium implants in diabetic rats. 2012;9(5):582–7.
  • Wu Y, Yu T, Yang X, Li F, Ma L, Yang Y, et al. Vitamin D3 and insu- lin combined treatment promotes titanium implant osseointegra- tion in diabetes mellitus rats. Bone [Internet]. 2013 Jan [cited 2014 Jan 23];52(1):1–8. Available from: http://www.ncbi.nlm.nih.gov/ pubmed/22985888
  • Zhou C, Li Y, Wang X, Shui X, Hu J. 1,25Dihydroxy vitamin D(3) improves titanium implant osseointegration in osteoporotic rats. Oral Surg Oral Med Oral Pathol Oral Radiol [Internet]. 2012 Nov [cited 2014 Feb 9];114(5 Suppl):S174-8. Available from: http:// www.ncbi.nlm.nih.gov/pubmed/23063395
  • Kelly J, Lin A, Wang CJ, Park S, Nishimura I. Vitamin D and bone physiology: demonstration of vitamin D deficiency in an implant osseointegration rat model. J Prosthodont. 2009;18:473–8.
  • Dvorak G, Fügl A, Watzek G, Tangl S, Pokorny P, Gruber R. Impact of dietary vitamin D on osseointegration in the ovariectomized rat. Clin Oral Implants Res [Internet]. 2012;23:1308–13. Available from: http://www.ncbi.nlm.nih.gov/pubmed/22151621
  • Im G-I, Qureshi S a, Kenney J, Rubash HE, Shanbhag AS. Osteo- blast proliferation and maturation by bisphosphonates. Biomaterials [Internet]. 2004 Aug [cited 2013 Dec 31];25(18):4105–15. Available from: http://www.ncbi.nlm.nih.gov/pubmed/15046901
  • Russell RGG. Bisphosphonates: the first 40 years. Bone [Inter- net]. 2011 Jul [cited 2014 Feb 4];49(1):2–19. Available from: http:// www.ncbi.nlm.nih.gov/pubmed/21555003
  • Müller R, Recker RR. Bisphosphonate action on bone structure and strength: Preclinical and clinical evidence for ibandronate. Bone [Internet]. 2007 Nov [cited 2013 Dec 31];41(5):S16–23. Available from: http://linkinghub.elsevier.com/retrieve/pii/ S8756328207006059
  • Wilkinson JM, Little DG. Bisphosphonates in orthopedic applica- tions. Bone [Internet]. 2011 Jul [cited 2013 Dec 31];49(1):95–102. Available from: http://www.ncbi.nlm.nih.gov/pubmed/21256254
  • Eberhardt C, Schwarz M, Kurth AH. High dosage treatment of nitrogen-containing bisphosphonate ibandronate is required for osseointegration of cementless metal implants. J Orthop Sci [In- ternet]. 2005 Dec [cited 2013 Dec 31];10(6):622–6. Available from: http://www.ncbi.nlm.nih.gov/pubmed/16307188
  • Yoshinari M, Oda Y, Inoue T, Matsuzaka K, Shimono M. Bone response to calcium phosphate-coated and bisphosphonate- immobilized titanium implants. Biomaterials [Internet]. 2002 Jul;23(14):2879–85. Available from: http://www.ncbi.nlm.nih.gov/ pubmed/12069328
  • Kajiwara H, Yamaza T, Yoshinari M, Goto T, Iyama S, Atsuta I, et al. The bisphosphonate pamidronate on the surface of titanium stimulates bone formation around tibial implants in rats. Biomateri- als [Internet]. 2005 Mar [cited 2013 Dec 31];26(6):581–7. Available from: http://www.ncbi.nlm.nih.gov/pubmed/15282136
  • Bobyn JD, McKenzie K, Karabasz D, Krygier JJ, Tanzer M. Locally delivered bisphosphonate for enhancement of bone formation and implant fixation. J Bone Joint Surg Am [Internet]. 2009 Nov [cited 2014 Feb 9];91 Suppl 6:23–31. Available from: http://www.ncbi. nlm.nih.gov/pubmed/19884409
  • Fischer D-C, Jensen C, Rahn A, Salewski B, Kundt G, Behets GJ, et al. Ibandronate affects bone growth and mineralization in rats with normal and reduced renal function. Pediatr Nephrol [Internet]. 2011 Jan [cited 2013 Dec 31];26(1):111–7. Available from: http:// www.ncbi.nlm.nih.gov/pubmed/20953634
  • Kurth a H a, Eberhardt C, Müller S, Steinacker M, Schwarz M, Bauss F. The bisphosphonate ibandronate improves implant integra- tion in osteopenic ovariectomized rats. Bone [Internet]. 2005 Aug [cited 2013 Dec 13];37(2):204–10. Available from: http://www.ncbi. nlm.nih.gov/pubmed/15936997
  • Eberhardt C, Stumpf U, Brankamp J, Schwarz M, Kurth AH. Osseointegration of cementless implants with different bisphospho- nate regimens. Clin Orthop Relat Res. 2006;447:195–200.
  • Andersson T, Agholme F, Aspenberg P, Tengvall P. Surface im- mobilized zoledronate improves screw fixation in rat bone: a new method for the coating of metal implants. J Mater Sci Mater Med [Internet]. 2010 Dec [cited 2013 Dec 31];21(11):3029–37. Available from: http://www.ncbi.nlm.nih.gov/pubmed/20857321
  • Bauss F, Dempster DW. Effects of ibandronate on bone quality: preclinical studies. Bone [Internet]. 2007 Mar [cited 2013 Dec 31];40(2):265–73. Available from: http://www.ncbi.nlm.nih.gov/ pubmed/16996333
  • Russell RGG. Ibandronate: pharmacology and preclinical studies. Bone [Internet]. 2006 May [cited 2013 Dec 31];38(4 Suppl 1):S7-12. Available from: http://www.ncbi.nlm.nih.gov/pubmed/16531132
  • Suratwala SJ, Cho SK, van Raalte JJ, Park SH, Seo SW, Chang S-S, et al. Enhancement of periprosthetic bone quality with topical hydroxyapatite-bisphosphonate composite. J Bone Joint Surg Am [Internet]. 2008 Oct [cited 2013 Dec 31];90(10):2189–96. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2 657477&tool=pmcentrez&rendertype=abstract
  • Neviaser AS, Lane JM, Lenart B a, Edobor-Osula F, Lorich DG. Low-energy femoral shaft fractures associated with alendronate use. J Orthop Trauma [Internet]. 2008;22:346–50. Available from: http://www.ncbi.nlm.nih.gov/pubmed/18448990
  • Park-Wyllie LY, Mamdani MM, Juurlink DN, Hawker G a, Gunraj N, Austin PC, et al. Bisphosphonate use and the risk of subtrochan- teric or femoral shaft fractures in older women. JAMA [Internet]. 2011 Feb 23;305:783–9. Available from: http://www.ncbi.nlm.nih. gov/pubmed/21343577
  • Gallagher AM, Rietbrock S, Olson M, Staa TP Van, Al GET. Frac- ture Outcomes Related to Persistence and Compliance With Oral Bisphosphonates. 2008;23.
APA DURUSOY S, Cirpar M, Yalçınozan M, ASLAN A, BALCI M, Demir T (2019). İBANDRONİK ASİT VE KALSİYUM-D VİTAMİNİ TEDAVİSİNİN OSTEOİNTEGRASYON ÜZERİNDEKİ ETKİLERİNİN KARŞILAŞTIRILMASI. , 102 - 111. 10.16919/bozoktip.492978
Chicago DURUSOY Serhat,Cirpar Meric,Yalçınozan Mehmet,ASLAN Arif,BALCI Mahi,Demir Teyfik İBANDRONİK ASİT VE KALSİYUM-D VİTAMİNİ TEDAVİSİNİN OSTEOİNTEGRASYON ÜZERİNDEKİ ETKİLERİNİN KARŞILAŞTIRILMASI. (2019): 102 - 111. 10.16919/bozoktip.492978
MLA DURUSOY Serhat,Cirpar Meric,Yalçınozan Mehmet,ASLAN Arif,BALCI Mahi,Demir Teyfik İBANDRONİK ASİT VE KALSİYUM-D VİTAMİNİ TEDAVİSİNİN OSTEOİNTEGRASYON ÜZERİNDEKİ ETKİLERİNİN KARŞILAŞTIRILMASI. , 2019, ss.102 - 111. 10.16919/bozoktip.492978
AMA DURUSOY S,Cirpar M,Yalçınozan M,ASLAN A,BALCI M,Demir T İBANDRONİK ASİT VE KALSİYUM-D VİTAMİNİ TEDAVİSİNİN OSTEOİNTEGRASYON ÜZERİNDEKİ ETKİLERİNİN KARŞILAŞTIRILMASI. . 2019; 102 - 111. 10.16919/bozoktip.492978
Vancouver DURUSOY S,Cirpar M,Yalçınozan M,ASLAN A,BALCI M,Demir T İBANDRONİK ASİT VE KALSİYUM-D VİTAMİNİ TEDAVİSİNİN OSTEOİNTEGRASYON ÜZERİNDEKİ ETKİLERİNİN KARŞILAŞTIRILMASI. . 2019; 102 - 111. 10.16919/bozoktip.492978
IEEE DURUSOY S,Cirpar M,Yalçınozan M,ASLAN A,BALCI M,Demir T "İBANDRONİK ASİT VE KALSİYUM-D VİTAMİNİ TEDAVİSİNİN OSTEOİNTEGRASYON ÜZERİNDEKİ ETKİLERİNİN KARŞILAŞTIRILMASI." , ss.102 - 111, 2019. 10.16919/bozoktip.492978
ISNAD DURUSOY, Serhat vd. "İBANDRONİK ASİT VE KALSİYUM-D VİTAMİNİ TEDAVİSİNİN OSTEOİNTEGRASYON ÜZERİNDEKİ ETKİLERİNİN KARŞILAŞTIRILMASI". (2019), 102-111. https://doi.org/10.16919/bozoktip.492978
APA DURUSOY S, Cirpar M, Yalçınozan M, ASLAN A, BALCI M, Demir T (2019). İBANDRONİK ASİT VE KALSİYUM-D VİTAMİNİ TEDAVİSİNİN OSTEOİNTEGRASYON ÜZERİNDEKİ ETKİLERİNİN KARŞILAŞTIRILMASI. Bozok Tıp Dergisi, 9(2), 102 - 111. 10.16919/bozoktip.492978
Chicago DURUSOY Serhat,Cirpar Meric,Yalçınozan Mehmet,ASLAN Arif,BALCI Mahi,Demir Teyfik İBANDRONİK ASİT VE KALSİYUM-D VİTAMİNİ TEDAVİSİNİN OSTEOİNTEGRASYON ÜZERİNDEKİ ETKİLERİNİN KARŞILAŞTIRILMASI. Bozok Tıp Dergisi 9, no.2 (2019): 102 - 111. 10.16919/bozoktip.492978
MLA DURUSOY Serhat,Cirpar Meric,Yalçınozan Mehmet,ASLAN Arif,BALCI Mahi,Demir Teyfik İBANDRONİK ASİT VE KALSİYUM-D VİTAMİNİ TEDAVİSİNİN OSTEOİNTEGRASYON ÜZERİNDEKİ ETKİLERİNİN KARŞILAŞTIRILMASI. Bozok Tıp Dergisi, vol.9, no.2, 2019, ss.102 - 111. 10.16919/bozoktip.492978
AMA DURUSOY S,Cirpar M,Yalçınozan M,ASLAN A,BALCI M,Demir T İBANDRONİK ASİT VE KALSİYUM-D VİTAMİNİ TEDAVİSİNİN OSTEOİNTEGRASYON ÜZERİNDEKİ ETKİLERİNİN KARŞILAŞTIRILMASI. Bozok Tıp Dergisi. 2019; 9(2): 102 - 111. 10.16919/bozoktip.492978
Vancouver DURUSOY S,Cirpar M,Yalçınozan M,ASLAN A,BALCI M,Demir T İBANDRONİK ASİT VE KALSİYUM-D VİTAMİNİ TEDAVİSİNİN OSTEOİNTEGRASYON ÜZERİNDEKİ ETKİLERİNİN KARŞILAŞTIRILMASI. Bozok Tıp Dergisi. 2019; 9(2): 102 - 111. 10.16919/bozoktip.492978
IEEE DURUSOY S,Cirpar M,Yalçınozan M,ASLAN A,BALCI M,Demir T "İBANDRONİK ASİT VE KALSİYUM-D VİTAMİNİ TEDAVİSİNİN OSTEOİNTEGRASYON ÜZERİNDEKİ ETKİLERİNİN KARŞILAŞTIRILMASI." Bozok Tıp Dergisi, 9, ss.102 - 111, 2019. 10.16919/bozoktip.492978
ISNAD DURUSOY, Serhat vd. "İBANDRONİK ASİT VE KALSİYUM-D VİTAMİNİ TEDAVİSİNİN OSTEOİNTEGRASYON ÜZERİNDEKİ ETKİLERİNİN KARŞILAŞTIRILMASI". Bozok Tıp Dergisi 9/2 (2019), 102-111. https://doi.org/10.16919/bozoktip.492978
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