Assessment of Corneal Endothelial Cell Status in Aging Eye
Yıl: 2019 Cilt: 28 Sayı: 1 Sayfa Aralığı: 16 - 22 Metin Dili: İngilizce DOI: 10.5336/ophthal.2018-60329 İndeks Tarihi: 12-05-2020
Assessment of Corneal Endothelial Cell Status in Aging Eye
Öz: Objective: To describe the corneal endothelial cell density and morphology in normaladult eyes, and determine the influence of aging on these parameters. Material and Methods: Inthis cross-sectional study, specular microscopy was performed in 547 eyes of 547 healthy volunteersaged 20 to 85 years. Of these, 279 were female, and 268 were male. The study parameters includedendothelial cell density (ECD), cell area (CA), the coefficient of variation (CoV) and percentage ofhexagonal cells (Hex%). The influence of age and gender on these parameters were evaluated. Results: The mean ECD and mean CA in the study population were 2607±323 cells/mm2 and389.6±51.2 μm2, respectively. In the correlation analysis, there was a decrease in mean ECD (r= -0.305, p<0.001), and an increase in mean CA (r=0.295, p<0.001) with increasing age. The mean CoVin cell size and the mean Hex% were 35.7±6.06% and 56.8±9.1%, respectively. There was a weakcorrelation between increasing age and CoV in cell size (r=0.075, p=0.021), and the percentage ofhexagonal was not correlated with age (p=0.088). There were no statistically significant differencesin mean ECD, mean CoV in cell size, or hexagonality between genders (all p values>0.05). Conclusion: Our data for the corneal endothelial structure in Turkish population showed that age but notgender, has a negative impact on endothelial cell density. Age was not a determinant in the pleomorphic changes of the endothelium.
Anahtar Kelime: Konular:
Yaşlanmanın Kornea Endotel Hücre Özellikleri Üzerine Etkisinin Değerlendirilmesi
Öz: Amaç: Sağlıklı ve yetişkin gözlerde kornea endotel hücre yoğunluğunu ve morfolojisini tanımlamak ve yaşlanmanın bu parametreler üzerindeki etkisini incelemek. Gereç ve Yöntemler: Bu kesitsel çalışmada, 20-85 yaş arasındaki 547 sağlıklı olgunun 547 gözü çalışmaya dahil edildi. Olguların 279'u kadın, 268'i erkek idi. Speküler mikroskopi ile santral korneada yapılan analizlerde endotel hücre yoğunluğu (EHY), endotel hücre alanı (HA), endotel hücre varyasyon katsayısı (VK) ve altıgen hücrelerin yüzdesi (%Hex) değerlendirildi. Yaş ve cinsiyetin bu parametreler üzerindeki etkisi araştırıldı. Bulgular: Çalışma grubundaki ortalama EHY ve ortalama endotel HA, sırasıyla 2607±323 hücre/mm2 ve 389,6±51,2 μm2 idi. Korelasyon analizinde yaşın artması ile ortalama EHY'da (r=-0,305, p<0,001) ve ortalama endotel HA'nda (r=0,295, p<0,001) azalma tespit edildi. Endotel hücre varyasyon katsayısı ve altıgen hücre yüzdesi sırasıyla %35,7±6,06 ve %56,8±9,1 idi. Yaşın ilerlemesi ile endotel hücre VK arasında zayıf korelasyon bulundu (r=0,075, p=0,021). Altıgen hücrelerin yüzdesi (%Hex) yaş ile korele bulunmadı (p=0,088). Her iki cinsiyet arasında ortalama EHY, endotel hücre varyasyon katsayısı ve altıgen hücre yüzdesi açısından anlamlı fark bulunmadı (tüm parametreler için p>0,05). Sonuç: Türk popülasyonundaki kornea endotel hücre sayısı, yaşlanma ile olumsuz yönde etkilenmekle birlikte, pleomorfik değişikliklerin yaşla ilgisi bulunmamıştır. Her iki cins arasında ortalama endotel hücre yoğunluğu ve hücre morfolojisi açısından tüm yaş gruplarında bir fark saptanmamıştır.
Anahtar Kelime: Konular:
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | KAYAARASI OZTURKER Z, akar s, Imamoglu S, ÖZBEK FİGUEROA A, YAZGAN S, YILMAZ Ö (2019). Assessment of Corneal Endothelial Cell Status in Aging Eye. , 16 - 22. 10.5336/ophthal.2018-60329 |
| Chicago | KAYAARASI OZTURKER Zeynep,akar serpil,Imamoglu Serhat,ÖZBEK FİGUEROA Aslı,YAZGAN Serpil,YILMAZ Ömer Faruk Assessment of Corneal Endothelial Cell Status in Aging Eye. (2019): 16 - 22. 10.5336/ophthal.2018-60329 |
| MLA | KAYAARASI OZTURKER Zeynep,akar serpil,Imamoglu Serhat,ÖZBEK FİGUEROA Aslı,YAZGAN Serpil,YILMAZ Ömer Faruk Assessment of Corneal Endothelial Cell Status in Aging Eye. , 2019, ss.16 - 22. 10.5336/ophthal.2018-60329 |
| AMA | KAYAARASI OZTURKER Z,akar s,Imamoglu S,ÖZBEK FİGUEROA A,YAZGAN S,YILMAZ Ö Assessment of Corneal Endothelial Cell Status in Aging Eye. . 2019; 16 - 22. 10.5336/ophthal.2018-60329 |
| Vancouver | KAYAARASI OZTURKER Z,akar s,Imamoglu S,ÖZBEK FİGUEROA A,YAZGAN S,YILMAZ Ö Assessment of Corneal Endothelial Cell Status in Aging Eye. . 2019; 16 - 22. 10.5336/ophthal.2018-60329 |
| IEEE | KAYAARASI OZTURKER Z,akar s,Imamoglu S,ÖZBEK FİGUEROA A,YAZGAN S,YILMAZ Ö "Assessment of Corneal Endothelial Cell Status in Aging Eye." , ss.16 - 22, 2019. 10.5336/ophthal.2018-60329 |
| ISNAD | KAYAARASI OZTURKER, Zeynep vd. "Assessment of Corneal Endothelial Cell Status in Aging Eye". (2019), 16-22. https://doi.org/10.5336/ophthal.2018-60329 |
| APA | KAYAARASI OZTURKER Z, akar s, Imamoglu S, ÖZBEK FİGUEROA A, YAZGAN S, YILMAZ Ö (2019). Assessment of Corneal Endothelial Cell Status in Aging Eye. Türkiye Klinikleri Oftalmoloji Dergisi, 28(1), 16 - 22. 10.5336/ophthal.2018-60329 |
| Chicago | KAYAARASI OZTURKER Zeynep,akar serpil,Imamoglu Serhat,ÖZBEK FİGUEROA Aslı,YAZGAN Serpil,YILMAZ Ömer Faruk Assessment of Corneal Endothelial Cell Status in Aging Eye. Türkiye Klinikleri Oftalmoloji Dergisi 28, no.1 (2019): 16 - 22. 10.5336/ophthal.2018-60329 |
| MLA | KAYAARASI OZTURKER Zeynep,akar serpil,Imamoglu Serhat,ÖZBEK FİGUEROA Aslı,YAZGAN Serpil,YILMAZ Ömer Faruk Assessment of Corneal Endothelial Cell Status in Aging Eye. Türkiye Klinikleri Oftalmoloji Dergisi, vol.28, no.1, 2019, ss.16 - 22. 10.5336/ophthal.2018-60329 |
| AMA | KAYAARASI OZTURKER Z,akar s,Imamoglu S,ÖZBEK FİGUEROA A,YAZGAN S,YILMAZ Ö Assessment of Corneal Endothelial Cell Status in Aging Eye. Türkiye Klinikleri Oftalmoloji Dergisi. 2019; 28(1): 16 - 22. 10.5336/ophthal.2018-60329 |
| Vancouver | KAYAARASI OZTURKER Z,akar s,Imamoglu S,ÖZBEK FİGUEROA A,YAZGAN S,YILMAZ Ö Assessment of Corneal Endothelial Cell Status in Aging Eye. Türkiye Klinikleri Oftalmoloji Dergisi. 2019; 28(1): 16 - 22. 10.5336/ophthal.2018-60329 |
| IEEE | KAYAARASI OZTURKER Z,akar s,Imamoglu S,ÖZBEK FİGUEROA A,YAZGAN S,YILMAZ Ö "Assessment of Corneal Endothelial Cell Status in Aging Eye." Türkiye Klinikleri Oftalmoloji Dergisi, 28, ss.16 - 22, 2019. 10.5336/ophthal.2018-60329 |
| ISNAD | KAYAARASI OZTURKER, Zeynep vd. "Assessment of Corneal Endothelial Cell Status in Aging Eye". Türkiye Klinikleri Oftalmoloji Dergisi 28/1 (2019), 16-22. https://doi.org/10.5336/ophthal.2018-60329 |
