Yıl: 2019 Cilt: 20 Sayı: 6 Sayfa Aralığı: 519 - 523 Metin Dili: İngilizce DOI: 10.4274/imj.galenos.2019.10170 İndeks Tarihi: 21-04-2020

Clinical Uses of Lactate and Lactate Clearance in Carbon Monoxide Poisoning

Öz:
Introduction: This study aimed to investigate lactate andlactate clearance and to determine the feasibility of the useof lactate clearance for assessing treatment efficacy in carbonmonoxide (CO) poisoning.Methods: All patients aged 18 years and older with COintoxication between 01.06.2016 and 28.02.2018 wereincluded. COHb levels, initial (lactate-1), and post-treatmentcontrol lactate (lactate-2) levels, lactate clearance, type oftreatment [normobaric, or hyperbaric oxygen therapy (HBOT)]were recorded. The receiver operating characteristic curve wasconfigured to establish a cut-off point of initial lactate levelwith the calculated area under the curve (AUC) to predict theneed for HBOT.Results: A total of 103 patients were included. There was amoderate correlation between COHb and lactate-1 (r=0.49;p<0.001) and a weak correlation between COHb and lactateclearance (r=0.291; p=0.003). A significantly higher increasewas observed in lactate clearance in the HBOT group (p=0.017).The AUC value of initial lactate in predicting the need for HBOTwas 0.708.Conclusion: The initial lactate level and lactate clearance arerapidly performed and effective markers that may be usedin CO intoxication. Especially lactate clearance may providevaluable information in predicting the need for HBOT andassessing treatment efficacy as a monitorization marker.
Anahtar Kelime:

Konular: Tıbbi Araştırmalar Deneysel Genel ve Dahili Tıp

Karbon Monoksit Zehirlenmesinde Laktat ve Laktat Klirensinin Klinik Kullanımı

Öz:
Amaç: Çalışmamızda karbonmonoksit (CO) zehirlenmesinde laktat ve laktat klirensi düzeylerinin araştırılması ve laktat klirensinin tedavi etkinliğini değerlendirmede kullanılabilirliğinin belirlenmesi amaçlanmıştır. Yöntemler: 01.06.2016-28.02.2018 tarihleri arasında acil serviste CO zehirlenmesi tanısı alan 18 yaş ve üzeri tüm hastalar çalışmaya dahil edildi. COHb düzeyi, başvuru (laktat-1) ve tedavi sonrası laktat (laktat-2) değerleri, laktat klirensi, uygulanan tedavi türü [gereksinime göre normobarik veya hiperbarik oksijen tedavisi (HBOT)] kaydedildi. Receiver Operating Characteristic (ROC) eğrisi çizilerek HBOT ihtiyacını öngörmek için başvuru laktatın eşik değeri ve eğri altında kalan alan (AUC) hesaplandı. Bulgular: Toplam 103 hasta çalışmaya dahil edildi. COHb ve laktat-1 arasında orta düzeyde korelasyon (r=0,49; p<0,001) varken; COHb ve laktat klirensi arasında ise zayıf bir korelasyon (r=0,291; p=0,003) saptandı. HBOT alan grupta laktat klirensi istatistiksel olarak anlamlı düzeyde daha yüksekti (p=0,017). HBOT ihtiyacını öngörmede başvuru laktat düzeyinin AUC değeri 0,78 olarak saptandı. Sonuç: Başvuru laktat düzeyi ve laktat klirensi CO zehirlenmesinde kullanılabilecek hızlı ve etkin belirteçlerdir. Özellikle laktat klirensinin, HBOT ihtiyacını öngörmede ve tedavi etkinliğinin değerlendirilmesinde bir izlem parametresi olarak klinisyene faydalı bilgiler sunabileceğini düşünmekteyiz.
Anahtar Kelime:

Konular: Tıbbi Araştırmalar Deneysel Genel ve Dahili Tıp
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA DAGAR S, EMEKTAR E, UZUNOSMANOĞLU H, ÇORBACIOĞLU Ş, Öztekin Ö, ÇEVİK Y (2019). Clinical Uses of Lactate and Lactate Clearance in Carbon Monoxide Poisoning. , 519 - 523. 10.4274/imj.galenos.2019.10170
Chicago DAGAR Seda,EMEKTAR Emine,UZUNOSMANOĞLU HÜSEYİN,ÇORBACIOĞLU Şeref Kerem,Öztekin Özge,ÇEVİK Yunsur Clinical Uses of Lactate and Lactate Clearance in Carbon Monoxide Poisoning. (2019): 519 - 523. 10.4274/imj.galenos.2019.10170
MLA DAGAR Seda,EMEKTAR Emine,UZUNOSMANOĞLU HÜSEYİN,ÇORBACIOĞLU Şeref Kerem,Öztekin Özge,ÇEVİK Yunsur Clinical Uses of Lactate and Lactate Clearance in Carbon Monoxide Poisoning. , 2019, ss.519 - 523. 10.4274/imj.galenos.2019.10170
AMA DAGAR S,EMEKTAR E,UZUNOSMANOĞLU H,ÇORBACIOĞLU Ş,Öztekin Ö,ÇEVİK Y Clinical Uses of Lactate and Lactate Clearance in Carbon Monoxide Poisoning. . 2019; 519 - 523. 10.4274/imj.galenos.2019.10170
Vancouver DAGAR S,EMEKTAR E,UZUNOSMANOĞLU H,ÇORBACIOĞLU Ş,Öztekin Ö,ÇEVİK Y Clinical Uses of Lactate and Lactate Clearance in Carbon Monoxide Poisoning. . 2019; 519 - 523. 10.4274/imj.galenos.2019.10170
IEEE DAGAR S,EMEKTAR E,UZUNOSMANOĞLU H,ÇORBACIOĞLU Ş,Öztekin Ö,ÇEVİK Y "Clinical Uses of Lactate and Lactate Clearance in Carbon Monoxide Poisoning." , ss.519 - 523, 2019. 10.4274/imj.galenos.2019.10170
ISNAD DAGAR, Seda vd. "Clinical Uses of Lactate and Lactate Clearance in Carbon Monoxide Poisoning". (2019), 519-523. https://doi.org/10.4274/imj.galenos.2019.10170
APA DAGAR S, EMEKTAR E, UZUNOSMANOĞLU H, ÇORBACIOĞLU Ş, Öztekin Ö, ÇEVİK Y (2019). Clinical Uses of Lactate and Lactate Clearance in Carbon Monoxide Poisoning. İstanbul Medical Journal, 20(6), 519 - 523. 10.4274/imj.galenos.2019.10170
Chicago DAGAR Seda,EMEKTAR Emine,UZUNOSMANOĞLU HÜSEYİN,ÇORBACIOĞLU Şeref Kerem,Öztekin Özge,ÇEVİK Yunsur Clinical Uses of Lactate and Lactate Clearance in Carbon Monoxide Poisoning. İstanbul Medical Journal 20, no.6 (2019): 519 - 523. 10.4274/imj.galenos.2019.10170
MLA DAGAR Seda,EMEKTAR Emine,UZUNOSMANOĞLU HÜSEYİN,ÇORBACIOĞLU Şeref Kerem,Öztekin Özge,ÇEVİK Yunsur Clinical Uses of Lactate and Lactate Clearance in Carbon Monoxide Poisoning. İstanbul Medical Journal, vol.20, no.6, 2019, ss.519 - 523. 10.4274/imj.galenos.2019.10170
AMA DAGAR S,EMEKTAR E,UZUNOSMANOĞLU H,ÇORBACIOĞLU Ş,Öztekin Ö,ÇEVİK Y Clinical Uses of Lactate and Lactate Clearance in Carbon Monoxide Poisoning. İstanbul Medical Journal. 2019; 20(6): 519 - 523. 10.4274/imj.galenos.2019.10170
Vancouver DAGAR S,EMEKTAR E,UZUNOSMANOĞLU H,ÇORBACIOĞLU Ş,Öztekin Ö,ÇEVİK Y Clinical Uses of Lactate and Lactate Clearance in Carbon Monoxide Poisoning. İstanbul Medical Journal. 2019; 20(6): 519 - 523. 10.4274/imj.galenos.2019.10170
IEEE DAGAR S,EMEKTAR E,UZUNOSMANOĞLU H,ÇORBACIOĞLU Ş,Öztekin Ö,ÇEVİK Y "Clinical Uses of Lactate and Lactate Clearance in Carbon Monoxide Poisoning." İstanbul Medical Journal, 20, ss.519 - 523, 2019. 10.4274/imj.galenos.2019.10170
ISNAD DAGAR, Seda vd. "Clinical Uses of Lactate and Lactate Clearance in Carbon Monoxide Poisoning". İstanbul Medical Journal 20/6 (2019), 519-523. https://doi.org/10.4274/imj.galenos.2019.10170